Full Text Journal Articles by
Author Alexander D Lemenze


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Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair glutamatergic synaptic transmission.

Tao Yin, Wen Yao, Alexander D Lemenze, Luciano D'Adamio,

Mutations in integral membrane protein 2B (ITM2b/BRI2) gene cause familial British and Danish dementia (FBD and FDD), autosomal dominant disorders characterized by progressive cognitive deterioration. Two pathogenic mechanisms, which may not be mutually exclusive, have been proposed for FDD and FBD: 1) loss of BRI2 function; 2) accumulation of amyloidogenic ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2021, 296:100054]

Cited: 1 time

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Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition.

Juan M Inclan-Rico, John J Ponessa, Nuriban Valero-Pacheco, Christina M Hernandez, Chandler B Sy, Alexander D Lemenze, Aimee M Beaulieu, Mark C Siracusa,

Type 2 cytokine responses promote parasitic immunity and initiate tissue repair; however, they can also result in immunopathologies when not properly restricted. Although basophilia is recognized as a common feature of type 2 inflammation, the roles basophils play in regulating these responses are unknown. Here, we demonstrate that helminth-induced group ... Read more >>

Nat Immunol (Nature immunology)
[2020, 21(10):1181-1193]

Cited: 6 times

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Trichinella spiralis-induced mastocytosis and erythropoiesis are simultaneously supported by a bipotent mast cell/erythrocyte precursor cell.

Juan M Inclan-Rico, Christina M Hernandez, Everett K Henry, Hannah G Federman, Chandler B Sy, John J Ponessa, Alexander D Lemenze, Nathanael Joseph, Patricia Soteropoulos, Aimee M Beaulieu, George S Yap, Mark C Siracusa,

Anti-helminth responses require robust type 2 cytokine production that simultaneously promotes worm expulsion and initiates the resolution of helminth-induced wounds and hemorrhaging. However, how infection-induced changes in hematopoiesis contribute to these seemingly distinct processes remains unknown. Recent studies have suggested the existence of a hematopoietic progenitor with dual mast cell-erythrocyte ... Read more >>

PLoS Pathog (PLoS pathogens)
[2020, 16(5):e1008579]

Cited: 2 times

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Transcriptomic studies provide insights into the tumor suppressive role of miR-146a-5p in non-small cell lung cancer (NSCLC) cells.

Joseph R Iacona, Nicholas J Monteleone, Alexander D Lemenze, Ashley L Cornett, Carol S Lutz,

Non-small cell lung cancer (NSCLC) is a complex disease in need of new methods of therapeutic intervention. Recent interest has focused on using microRNAs (miRNAs) as a novel treatment method for various cancers. miRNAs negatively regulate gene expression post-transcriptionally, and have become attractive candidates for cancer treatment because they often ... Read more >>

RNA Biol (RNA biology)
[2019, 16(12):1721-1732]

Cited: 5 times

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