Full Text Journal Articles by
Author Alexander C Langheinrich

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Neovascularization of osteoporotic metaphyseal bone defects: A morphometric micro-CT study.

Marian Kampschulte, Gabriele A Krombach, Dana C Richards, Jonas Sender, Katrin S Lips, Ulrich Thormann, Thaqif El Khassawna, Seemun Ray, Volker Alt, Alexander C Langheinrich,

<h4>Purpose</h4>Neovascularization is essential for bone regeneration in fractures. This study aimed to investigate the microvascular morphology and distribution in the non-injured femur and the neovascularization of the metaphyseal critical size defect in a small animal model of osteoporosis.<h4>Materials and methods</h4>Female rats (n=7) were ovariectomized (OVX) and received a multideficiency diet. ... Read more >>

Microvasc Res (Microvascular research)
[2016, 105:7-14]

Cited: 4 times

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Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis.

Marian Kampschulte, Christiane Stöckl, Alexander C Langheinrich, Ulrike Althöhn, Rainer M Bohle, Gabriele A Krombach, Philipp Stieger, Yuri Churin, Sandra Kremer, Christian Dierkes, Timo Rath, Elke Roeb, Martin Roderfeld,

Nonalcoholic fatty liver disease has been linked to cardiovascular diseases and atherosclerosis. The aim of the current study was to characterize the hepatic pathology leading to fibrosis and tumors in a murine model of atherosclerosis. Male apolipoprotein E/low-density lipoprotein receptor double-knockout mice (AL) mice were fed with a high fat ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2014, 94(11):1273-1282]

Cited: 16 times

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Small changes in bone structure of female α7 nicotinic acetylcholine receptor knockout mice.

Katrin S Lips, Özcan Yanko, Mathias Kneffel, Imke Panzer, Vivien Kauschke, Maria Madzharova, Anja Henss, Peter Schmitz, Marcus Rohnke, Tobias Bäuerle, Yifei Liu, Marian Kampschulte, Alexander C Langheinrich, Lutz Dürselen, Anita Ignatius, Christian Heiss, Reinhard Schnettler, Olaf Kilian,

<h4>Background</h4>Recently, analysis of bone from knockout mice identified muscarinic acetylcholine receptor subtype M3 (mAChR M3) and nicotinic acetylcholine receptor (nAChR) subunit α2 as positive regulator of bone mass accrual whereas of male mice deficient for α7-nAChR (α7KO) did not reveal impact in regulation of bone remodeling. Since female sex hormones ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2015, 16:5]

Cited: 4 times

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Systemic atherosclerosis causes detrusor overactivity: functional and morphological changes in hyperlipoproteinemic apoE-/-LDLR-/- mice.

Thomas Bschleipfer, Anne-Kathrin Dannenmaier, Christian Illig, Melanie Kreisel, Stefan Gattenlöhner, Alexander C Langheinrich, Gabriele A Krombach, Wolfgang Weidner, Marian Kampschulte,

<h4>Purpose</h4>The prevalence of systemic atherosclerosis and overactive bladder/detrusor overactivity increases almost simultaneously with age but an association between these diseases has not yet been proved. We evaluated changes in bladder function and morphology, including vascularization, in apoE(-/-)LDLR(-/-) double knockout mice with systemic atherosclerosis but without central nervous system involvement.<h4>Materials and ... Read more >>

J Urol (The Journal of urology)
[2015, 193(1):345-351]

Cited: 9 times

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Thalidomide influences atherogenesis in aortas of ApoE(-/-)/LDLR (-/-) double knockout mice: a nano-CT study.

Marian Kampschulte, Irina Gunkel, Philipp Stieger, Daniel G Sedding, Anne Brinkmann, Erik L Ritman, Gabriele A Krombach, Alexander C Langheinrich,

Plaque progression in atherosclerosis is closely connected to angiogenesis due to vasa vasorum (VV) growth. Objective of this study was to determine the unknown long-term effect of thalidomide on adventitial VV neovascularization and plaque progression using nano-focussed computed tomography (nano-CT). Proliferation and migration assays in human coronary artery endothelial cells ... Read more >>

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2014, 30(4):795-802]

Cited: 10 times

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Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model.

Robert Müller, Marian Kampschulte, Thaqif El Khassawna, Gudrun Schlewitz, Britta Hürter, Wolfgang Böcker, Manfred Bobeth, Alexander C Langheinrich, Christian Heiss, Andreas Deutsch, Gianaurelio Cuniberti,

For assessing mechanical properties of osteoporotic bone, biomechanical testing combined with in silico modeling plays a key role. The present study focuses on microscopic mechanical bone properties in a rat model of postmenopausal osteoporosis. Female Sprague-Dawley rats were (1) euthanized without prior interventions, (2) sham-operated, and (3) subjected to ovariectomy ... Read more >>

Med Biol Eng Comput (Medical & biological engineering & computing)
[2014, 52(4):405-414]

Cited: 6 times

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Differences of bone healing in metaphyseal defect fractures between osteoporotic and physiological bone in rats.

Ulrich Thormann, Thaqif El Khawassna, Seemun Ray, Lutz Duerselen, Marian Kampschulte, Katrin Lips, Helena von Dewitz, Sascha Heinemann, Christian Heiss, Gabor Szalay, Alexander C Langheinrich, Anita Ignatius, Reinhard Schnettler, Volker Alt,

Discrepancies in bone healing between osteoporotic and non-osteoporotic bone remain uncertain. The focus of the current work is to evaluate potential healing discrepancies in a metaphyseal defect model in rat femora. Female Sprague-Dawley rats were either ovariectomized (OVX, n=14) and combined with a calcium-, phosphorus- and vitamin D3-, soy- and ... Read more >>

Injury (Injury)
[2014, 45(3):487-493]

Cited: 18 times

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Implications of combined ovariectomy/multi-deficiency diet on rat bone with age-related variation in bone parameters and bone loss at multiple skeletal sites by DEXA.

Parameswari Govindarajan, Gudrun Schlewitz, Nathalie Schliefke, David Weisweiler, Volker Alt, Ulrich Thormann, Katrin Susanne Lips, Sabine Wenisch, Alexander C Langheinrich, Daniel Zahner, Nasr Y Hemdan, Wolfgang Böcker, Reinhard Schnettler, Christian Heiss,

<h4>Background</h4>Osteoporosis is a multi-factorial, chronic, skeletal disease highly prevalent in post-menopausal women and is influenced by hormonal and dietary factors. Because animal models are imperative for disease diagnostics, the present study establishes and evaluates enhanced osteoporosis obtained through combined ovariectomy and deficient diet by DEXA (dual-energy X-ray absorptiometry) for a ... Read more >>

Med Sci Monit Basic Res (Medical science monitor basic research)
[2013, 19:76-86]

Cited: 16 times

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Induction of osteoporosis with its influence on osteoporotic determinants and their interrelationships in rats by DEXA.

Christian Heiss, Parameswari Govindarajan, Gudrun Schlewitz, Nasr Y A Hemdan, Nathalie Schliefke, Volker Alt, Ulrich Thormann, Katrin Susanne Lips, Sabine Wenisch, Alexander C Langheinrich, Daniel Zahner, Reinhard Schnettler,

<h4>Background</h4>As women are the population most affected by multifactorial osteoporosis, research is focused on unraveling the underlying mechanism of osteoporosis induction in rats by combining ovariectomy (OVX) either with calcium, phosphorus, vitamin C and vitamin D2/D3 deficiency, or by administration of glucocorticoid (dexamethasone).<h4>Material/methods</h4>Different skeletal sites of sham, OVX-Diet and OVX-Steroid ... Read more >>

Med Sci Monit (Medical science monitor : international medical journal of experimental and clinical research)
[2012, 18(6):BR199-207]

Cited: 22 times

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Quantitative analyses of bone composition in acetylcholine receptor M3R and alpha7 knockout mice.

Karin Kliemann, Mathias Kneffel, Ivonne Bergen, Marian Kampschulte, Alexander C Langheinrich, Lutz Dürselen, Anita Ignatius, Olaf Kilian, Reinhard Schnettler, Katrin S Lips,

<h4>Aims</h4>Increasing collagen synthesis was observed in lung after stimulation of nicotinic and muscarinic acetylcholine receptors (nAChR and mAChR) on fibroblasts. Since collagen synthesis is an important process during fracture healing and bone remodelling, we asked whether cholinergic receptors are involved in bone collagen production.<h4>Main methods</h4>In the present study we analysed ... Read more >>

Life Sci (Life sciences)
[2012, 91(21-22):997-1002]

Cited: 11 times

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Assessment of angiogenesis in osseointegration of a silica-collagen biomaterial using 3D-nano-CT.

Volker Alt, Daniela Vera Kögelmaier, Katrin S Lips, Vera Witt, Sabine Pacholke, Christian Heiss, Marian Kampschulte, Sascha Heinemann, Thomas Hanke, Ulrich Thormann, Reinhard Schnettler, Alexander C Langheinrich,

Bony integration of biomaterials is a complex process in which angiogenesis plays a crucial role. We evaluated micro- and nano-CT imaging to demonstrate and quantify neovascularization in bony integration of a biomaterial and to give an image based estimation for the needed resolution for imaging angiogenesis in an animal model ... Read more >>

Acta Biomater (Acta biomaterialia)
[2011, 7(10):3773-3779]

Cited: 15 times

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Combined contrast-enhanced ultrasound and rt-PA treatment is safe and improves impaired microcirculation after reperfusion of middle cerebral artery occlusion

Max Nedelmann, Nouha Ritschel, Simone Doenges, Alexander C Langheinrich, Till Acker, Peter Reuter, Mesut Yeniguen, Jan Pukropski, Manfred Kaps, Clemens Mueller, Georg Bachmann, Tibo Gerriets,

J Cereb Blood Flow Metab (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2011, 31(7):1660-1660]

Cited: 0 times

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Combined contrast-enhanced ultrasound and rt-PA treatment is safe and improves impaired microcirculation after reperfusion of middle cerebral artery occlusion.

Max Nedelmann, Nouha Ritschel, Simone Doenges, Alexander C Langheinrich, Till Acker, Peter Reuter, Mesut Yeniguen, Jan Pukropski, Manfred Kaps, Clemens Mueller, Georg Bachmann, Tibo Gerriets,

In monitoring of recanalization and in sonothrombolysis, contrast-enhanced ultrasound (CEUS) is applied in extended time protocols. As extended use may increase the probability of unwanted effects, careful safety evaluation is required. We investigated the safety profile and beneficial effects of CEUS in a reperfusion model. Wistar rats were subjected to ... Read more >>

J Cereb Blood Flow Metab (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2010, 30(10):1712-1720]

Cited: 22 times

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Angioarchitectural changes in subacute cerebral venous thrombosis. A synchrotron-based micro- and nano-CT study.

Erwin Stolz, Mesut Yeniguen, Melanie Kreisel, Marian Kampschulte, Simone Doenges, Daniel Sedding, Erik L Ritman, Tibo Gerriets, Alexander C Langheinrich,

It is well known that recanalization of thrombosed cerebral sinuses occurs early but without marked influence on the long-term outcome and on final venous infarct volume on magnetic resonance imaging. To better understand the possible microvascular mechanisms behind these clinical observations, we evaluated the sequels of subacute superior sagittal sinus ... Read more >>

Neuroimage (NeuroImage)
[2011, 54(3):1881-1886]

Cited: 16 times

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Synchrotron-based micro-CT imaging of the human lung acinus.

Horst Detlef Litzlbauer, Kathrin Korbel, Timothy L Kline, Steven M Jorgensen, Diane R Eaker, Rainer M Bohle, Erik L Ritman, Alexander C Langheinrich,

Structural data about the human lung fine structure are mainly based on stereological methods applied to serial sections. As these methods utilize 2D images, which are often not contiguous, they suffer from inaccuracies which are overcome by analysis of 3D micro-CT images of the never-sectioned specimen. The purpose of our ... Read more >>

Anat Rec (Hoboken) (Anatomical record (Hoboken, N.J. : 2007))
[2010, 293(9):1607-1614]

Cited: 11 times

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Atherosclerosis, inflammation and lipoprotein glomerulopathy in kidneys of apoE-/-/LDL-/- double knockout mice.

Alexander C Langheinrich, Marian Kampschulte, Franziska Scheiter, Christian Dierkes, Philip Stieger, Rainer M Bohle, Wolfgang Weidner,

<h4>Background</h4>The apoE-/-/LDL-/- double knockout mice are bearing considerable structural homology to human atherosclerosis. We hypothesized, that advanced lesion formation in the renal artery is associated with kidney alterations in these mice.<h4>Methods</h4>Kidneys from apoE-/-/LDL-/- double knockout mice at the age of 80 weeks (n = 6) and C57/BL control mice (n ... Read more >>

BMC Nephrol (BMC nephrology)
[2010, 11:18]

Cited: 10 times

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Evaluation of the middle cerebral artery occlusion techniques in the rat by in-vitro 3-dimensional micro- and nano computed tomography.

Alexander C Langheinrich, Mesut Yeniguen, Anne Ostendorf, Simone Marhoffer, Marian Kampschulte, Georg Bachmann, Erwin Stolz, Tibo Gerriets,

<h4>Background</h4>Animal models of focal cerebral ischemia are widely used in stroke research. The purpose of our study was to evaluate and compare the cerebral macro- and microvascular architecture of rats in two different models of permanent middle cerebral artery occlusion using an innovative quantitative micro- and nano-CT imaging technique.<h4>Methods</h4>4h of ... Read more >>

BMC Neurol (BMC neurology)
[2010, 10:36]

Cited: 11 times

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Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression.

Florian H Seeger, Daniel Sedding, Alexander C Langheinrich, Judith Haendeler, Andreas M Zeiher, Stefanie Dimmeler,

Initial trials suggest that bone marrow-derived vasculogenic cells augment neovascularization in patients after myocardial infarction. Moreover, in some experimental settings, they also provide an anti-atherosclerotic effect by maintaining the integrity of the endothelium. Risk factors for coronary artery disease were shown to reduce the number and functional activity of vasculogenic ... Read more >>

Basic Res Cardiol (Basic research in cardiology)
[2010, 105(3):389-397]

Cited: 39 times

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Quantification of vasa vasorum density in multi-slice computed tomographic coronary angiograms: role of computed tomographic image voxel size.

Regina Moritz, Diane R Eaker, Alexander C Langheinrich, Steven M Jorgensen, Rainer M Bohle, Erik L Ritman,

<h4>Objective</h4>This study is motivated by the possibility of using computed tomography (CT) to detect early coronary atherosclerosis by the increased CT values within the arterial wall resulting from vasa vasorum proliferation.<h4>Methods</h4>Coronary arteries (n = 5) with early atherosclerotic changes were injected with Microfil and scanned (micro-CT). Noise was added to ... Read more >>

J Comput Assist Tomogr (Journal of computer assisted tomography)
[2010, 34(2):273-278]

Cited: 6 times

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Role of computed tomography voxel size in detection and discrimination of calcium and iron deposits in atherosclerotic human coronary artery specimens.

Alexander C Langheinrich, Marian Kampschulte, Christine Crössmann, Regina Moritz, Wigbert S Rau, Rainer M Bohle, Erik L Ritman,

<h4>Objective</h4>This study evaluated the influence of voxel size on its ability to discriminate calcium from iron deposits in ex vivo coronary arteries.<h4>Methods</h4>Postmortem human coronary arteries underwent multislice computed tomographic scan at (600-microm) voxel size to provide an index of computed tomography (CT) image noise and synchrotron-based micro-CT at (4-microm) voxel ... Read more >>

J Comput Assist Tomogr (Journal of computer assisted tomography)
[2009, 33(4):517-522]

Cited: 9 times

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3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE(-/-)/LDL(-/-) double knockout mice.

Alexander C Langheinrich, Daniel G Sedding, Marian Kampschulte, Regina Moritz, Jochen Wilhelm, Werner G Haberbosch, Erik L Ritman, Rainer M Bohle,

<h4>Background</h4>Atherosclerosis and inflammation/angiogenesis are strongly associated including growth of vasa vasorum (VV) and plaque neovascularization, but a causative role for neovascularization has still not been established. Hence, we investigated the effect of 3-deazaadenosine (c(3)Ado), an anti-inflammatory and anti-proliferative drug, on plaque progression and VV neovascularization in apoE(-/-)/LDL(-/-) double knockout mice.<h4>Methods</h4>The ... Read more >>

Atherosclerosis (Atherosclerosis)
[2009, 202(1):103-110]

Cited: 11 times

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3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling.

Daniel G Sedding, Monique Tröbs, Fabian Reich, Gerhard Walker, Ludger Fink, Werner Haberbosch, Wigbert Rau, Harald Tillmanns, Klaus T Preissner, Rainer M Bohle, Alexander C Langheinrich,

3-Deazaadenosine (c3Ado) is a potent inhibitor of S-adenosylhomocysteine hydrolase, which regulates cellular methyltransferase activity. In the present study, we sought to determine the effect of c3Ado on vascular smooth muscle cell (VSMC) function and neointima formation in vivo. c3Ado dose-dependently prevented the proliferation and migration of human coronary VSMCs in ... Read more >>

Circ Res (Circulation research)
[2009, 104(10):1192-1200]

Cited: 18 times

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Quantitative X-ray imaging of intraplaque hemorrhage in aortas of apoE(-/-)/LDL(-/-) double knockout mice.

Alexander C Langheinrich, Agata Michniewicz, Daniel G Sedding, Barry Lai, Steven M Jorgensen, Rainer M Bohle, Erik L Ritman,

<h4>Objectives</h4>To determine if hemorrhage into an arterial wall can be detected in CT images by virtue of the iron content.<h4>Materials and methods</h4>Aortas from male apoE(-/-)/LDL(-/-) mice (n = 31) were infused in situ with contrast agent, for micro-CT scanning and histology. Roentgen-opacities within the aortic walls were identified by histology ... Read more >>

Invest Radiol (Investigative radiology)
[2007, 42(5):263-273]

Cited: 27 times

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Vasa vasorum and atherosclerosis - Quid novi?

Alexander C Langheinrich, Marian Kampschulte, Thomas Buch, Rainer M Bohle,

The role of vasa vasorum (VV) in atherosclerosis is hotly debated, and new experimental techniques have recently opened an opportunity to take a fresh look at this important topic. Although the proliferation of VV due to atherogenic stimuli is controversial, experimental and clinical evidence strongly suggest the potential of VV ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2007, 97(6):873-879]

Cited: 54 times

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Vasa vasorum neovascularization and lesion distribution among different vascular beds in ApoE-/-/LDL-/- double knockout mice.

Alexander C Langheinrich, Agata Michniewicz, Rainer M Bohle, Erik L Ritman,

<h4>Objective</h4>To increase understanding of the substantial variation in the incidence and distribution of atherosclerotic lesions among different vascular beds. In view of some evidence that there are different distributions of adventitial vasa vasorum (VV) in different vascular beds, and that this correlates with lesion formation, we explored this possible linkage ... Read more >>

Atherosclerosis (Atherosclerosis)
[2007, 191(1):73-81]

Cited: 43 times

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