Full Text Journal Articles by
Author Alex Tipping

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Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma.

Indu Ramachandran, Daniel E Lowther, Rebecca Dryer-Minnerly, Ruoxi Wang, Svetlana Fayngerts, Daniel Nunez, Gareth Betts, Natalie Bath, Alex J Tipping, Luca Melchiori, Jean-Marc Navenot, John Glod, Crystal L Mackall, Sandra P D'Angelo, Dejka M Araujo, Warren A Chow, George D Demetri, Mihaela Druta, Brian A Van Tine, Stephan A Grupp, Albiruni R Abdul Razak, Breelyn Wilky, Malini Iyengar, Trupti Trivedi, Erin Van Winkle, Karen Chagin, Rafael Amado, Gwendolyn K Binder, Samik Basu,

BACKGROUND:Gene-modified autologous T cells expressing NY-ESO-1c259, an affinity-enhanced T-cell receptor (TCR) reactive against the NY-ESO-1-specific HLA-A*02-restricted peptide SLLMWITQC (NY-ESO-1 SPEAR T-cells; GSK 794), have demonstrated clinical activity in patients with advanced synovial sarcoma (SS). The factors contributing to gene-modified T-cell expansion and the changes within the tumor microenvironment (TME) following ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2019, 7(1):276]

Cited: 1 time

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Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1 c259T Cells in Synovial Sarcoma.

Sandra P D'Angelo, Luca Melchiori, Melinda S Merchant, Donna Bernstein, John Glod, Rosandra Kaplan, Stephan Grupp, William D Tap, Karen Chagin, Gwendolyn K Binder, Samik Basu, Daniel E Lowther, Ruoxi Wang, Natalie Bath, Alex Tipping, Gareth Betts, Indu Ramachandran, Jean-Marc Navenot, Hua Zhang, Daniel K Wells, Erin Van Winkle, Gabor Kari, Trupti Trivedi, Tom Holdich, Lini Pandite, Rafael Amado, Crystal L Mackall,

We evaluated the safety and activity of autologous T cells expressing NY-ESO-1c259, an affinity-enhanced T-cell receptor (TCR) recognizing an HLA-A2-restricted NY-ESO-1/LAGE1a-derived peptide, in patients with metastatic synovial sarcoma (NY-ESO-1c259T cells). Confirmed antitumor responses occurred in 50% of patients (6/12) and were characterized by tumor shrinkage over several months. Circulating NY-ESO-1c259T ... Read more >>

Cancer Discov (Cancer discovery)
[2018, 8(8):944-957]

Cited: 30 times

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Distinct gene expression program dynamics during erythropoiesis from human induced pluripotent stem cells compared with adult and cord blood progenitors.

Alison T Merryweather-Clarke, Alex J Tipping, Abigail A Lamikanra, Rui Fa, Basel Abu-Jamous, Hoi Pat Tsang, Lee Carpenter, Kathryn J H Robson, Asoke K Nandi, David J Roberts,

Human-induced pluripotent stem cells (hiPSCs) are a potentially invaluable resource for regenerative medicine, including the in vitro manufacture of blood products. HiPSC-derived red blood cells are an attractive therapeutic option in hematology, yet exhibit unexplained proliferation and enucleation defects that presently preclude such applications. We hypothesised that substantial differential regulation ... Read more >>

BMC Genomics (BMC genomics)
[2016, 17(1):817]

Cited: 3 times

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A network including TGFβ/Smad4, Gata2, and p57 regulates proliferation of mouse hematopoietic progenitor cells.

Matilda Billing, Emma Rörby, Gillian May, Alex J Tipping, Shamit Soneji, John Brown, Marjo Salminen, Göran Karlsson, Tariq Enver, Stefan Karlsson,

Transforming growth factor β (TGFβ) is a potent inhibitor of hematopoietic stem and progenitor cell proliferation. However, the precise mechanism for this effect is unknown. Here, we have identified the transcription factor Gata2, previously described as an important regulator of hematopoietic stem cell function, as an early and direct target ... Read more >>

Exp. Hematol. (Experimental hematology)
[2016, 44(5):399-409.e5]

Cited: 2 times

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Distinct mechanisms of inadequate erythropoiesis induced by tumor necrosis factor alpha or malarial pigment.

Abigail A Lamikanra, Alison T Merryweather-Clarke, Alex J Tipping, David J Roberts,

The role of infection in erythropoietic dysfunction is poorly understood. In children with P. falciparum malaria, the by-product of hemoglobin digestion in infected red cells (hemozoin) is associated with the severity of anemia which is independent of circulating levels of the inflammatory cytokine tumor necrosis alpha (TNF-α). To gain insight ... Read more >>

PLoS ONE (PloS one)
[2015, 10(3):e0119836]

Cited: 8 times

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Correction: distinct mechanisms of inadequate erythropoiesis induced by tumor necrosis factor alpha or malarial pigment.

Abigail A Lamikanra, Alison T Merryweather-Clarke, Alex J Tipping, David J Roberts,

PLoS ONE (PloS one)
[2015, 10(4):e0127124]

Cited: 0 times

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Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors.

Gillian May, Shamit Soneji, Alex J Tipping, Jose Teles, Simon J McGowan, Mengchu Wu, Yanping Guo, Cristina Fugazza, John Brown, Göran Karlsson, Cristina Pina, Victor Olariu, Stephen Taylor, Daniel G Tenen, Carsten Peterson, Tariq Enver,

We used the paradigmatic GATA-PU.1 axis to explore, at the systems level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells differentiate. We combined global ChIP-seq of GATA1, GATA2, and PU.1 with expression profiling during differentiation to erythroid and neutrophil lineages. Our analysis reveals ... Read more >>

Cell Stem Cell (Cell stem cell)
[2013, 13(6):754-768]

Cited: 41 times

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Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments.

Quin F Wills, Kenneth J Livak, Alex J Tipping, Tariq Enver, Andrew J Goldson, Darren W Sexton, Chris Holmes,

Gene expression in multiple individual cells from a tissue or culture sample varies according to cell-cycle, genetic, epigenetic and stochastic differences between the cells. However, single-cell differences have been largely neglected in the analysis of the functional consequences of genetic variation. Here we measure the expression of 92 genes affected ... Read more >>

Nat. Biotechnol. (Nature biotechnology)
[2013, 31(8):748-752]

Cited: 111 times

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Methods for qPCR gene expression profiling applied to 1440 lymphoblastoid single cells.

Kenneth J Livak, Quin F Wills, Alex J Tipping, Krishnalekha Datta, Rowena Mittal, Andrew J Goldson, Darren W Sexton, Chris C Holmes,

The stochastic nature of generating eukaryotic transcripts challenges conventional methods for obtaining and analyzing single-cell gene expression data. In order to address the inherent noise, detailed methods are described on how to collect data on multiple genes in a large number of single cells using microfluidic arrays. As part of ... Read more >>

Methods (Methods (San Diego, Calif.))
[2013, 59(1):71-79]

Cited: 65 times

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Inferring rules of lineage commitment in haematopoiesis.

Cristina Pina, Cristina Fugazza, Alex J Tipping, John Brown, Shamit Soneji, Jose Teles, Carsten Peterson, Tariq Enver,

How the molecular programs of differentiated cells develop as cells transit from multipotency through lineage commitment remains unexplored. This reflects the inability to access cells undergoing commitment or located in the immediate vicinity of commitment boundaries. It remains unclear whether commitment constitutes a gradual process, or else represents a discrete ... Read more >>

Nat. Cell Biol. (Nature cell biology)
[2012, 14(3):287-294]

Cited: 92 times

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GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia.

Neil P Rodrigues, Alex J Tipping, Zhengke Wang, Tariq Enver,

Unremitting blood cell production throughout the lifetime of an organism is reliant on hematopoietic stem cells (HSCs). A rare and relatively quiescent cell type, HSCs are, on entry into cell cycle fated to self-renew, undergo apoptosis or differentiate to progenitors (HPCs) that eventually yield specific classes of blood cells. Disruption ... Read more >>

Int. J. Biochem. Cell Biol. (The international journal of biochemistry & cell biology)
[2012, 44(3):457-460]

Cited: 28 times

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High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle.

Alex J Tipping, Cristina Pina, Anders Castor, Dengli Hong, Neil P Rodrigues, Lorenza Lazzari, Gillian E May, Sten Eirik W Jacobsen, Tariq Enver,

Evidence suggests the transcription factor GATA-2 is a critical regulator of murine hematopoietic stem cells. Here, we explore the relation between GATA-2 and cell proliferation and show that inducing GATA-2 increases quiescence (G(0) residency) of murine and human hematopoietic cells. In human cord blood, quiescent fractions (CD34(+)CD38(-)Hoechst(lo)Pyronin Y(lo)) express more ... Read more >>

Blood (Blood)
[2009, 113(12):2661-2672]

Cited: 56 times

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GATA-2 regulates granulocyte-macrophage progenitor cell function.

Neil P Rodrigues, Ashleigh S Boyd, Cristina Fugazza, Gillian E May, Yanping Guo, Alex J Tipping, David T Scadden, Paresh Vyas, Tariq Enver,

The zinc finger transcription factor GATA-2 has been implicated in the regulation of hematopoietic stem cells. Herein, we explored the role of GATA-2 as a candidate regulator of the hematopoietic progenitor cell compartment. We showed that bone marrow from GATA-2 heterozygote (GATA-2(+/-)) mice displayed attenuated granulocyte-macrophage progenitor function in colony-forming ... Read more >>

Blood (Blood)
[2008, 112(13):4862-4873]

Cited: 48 times

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Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

Alex Robert-Moreno, Jordi Guiu, Cristina Ruiz-Herguido, M Eugenia López, Julia Inglés-Esteve, Lluis Riera, Alex Tipping, Tariq Enver, Elaine Dzierzak, Thomas Gridley, Lluis Espinosa, Anna Bigas,

Specific deletion of Notch1 and RBPjkappa in the mouse results in abrogation of definitive haematopoiesis concomitant with the loss of arterial identity at embryonic stage. As prior arterial determination is likely to be required for the generation of embryonic haematopoiesis, it is difficult to establish the specific haematopoietic role of ... Read more >>

EMBO J. (The EMBO journal)
[2008, 27(13):1886-1895]

Cited: 91 times

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Novel compounds with antiproliferative activity against imatinib-resistant cell lines.

Enrica I Lerma, Viet-Anh Nguyen, Tao Wang, Alex Tipping, Junia V Melo, Donald Kufe, David J Austin, Albert Deisseroth,

Chronic myelogenous leukemia is caused by the Bcr-Abl hybrid gene that encodes the p210Bcr-Abl chimeric oncoprotein. Although it reduces the total body burden of leukemia cells, the use of imatinib mesylate as a single agent may be accompanied by the evolution of resistance due mainly to the acquisition of point ... Read more >>

Mol. Cancer Ther. (Molecular cancer therapeutics)
[2007, 6(2):655-666]

Cited: 3 times

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Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C.

Víctor Javier Sánchez-Arévalo Lobo, Clara Isabel Aceves Luquero, Luis Alvarez-Vallina, Alex J Tipping, Juan Guinea Viniegra, Javier Hernández Losa, Carlos Parada Cobo, Eva María Galán Moya, Jorge Gayoso Cruz, Junia V Melo, Santiago Ramón y Cajal, Ricardo Sánchez-Prieto,

The chimaeric protein Bcr/Abl, the hallmark of chronic myeloid leukaemia, has been connected with several signalling pathways, such as those involving protein kinase B/Akt, JNK (c-Jun N-terminal kinase) or ERKs (extracellular-signal-regulated kinases) 1 and 2. However, no data about the p38 MAPK (mitogen-activated protein kinase) have been reported. Here, we ... Read more >>

Biochem. J. (The Biochemical journal)
[2005, 387(Pt 1):231-238]

Cited: 15 times

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Molecular diagnosis of Fanconi anemia and dyskeratosis congenita.

Alex J Tipping, Tom J Vulliamy, Neil V Morgan, Inderjeet Dokal,

Methods Mol. Med. (Methods in molecular medicine)
[2004, 91:3-17]

Cited: 1 time

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Comparative gene expression profile of chronic myeloid leukemia cells innately resistant to imatinib mesylate.

Alex J Tipping, Michael W Deininger, John M Goldman, Junia V Melo,

OBJECTIVE: Resistance to imatinib mesylate monotherapy is clearly a barrier to successful treatment of chronic myeloid leukemia (CML) patients. In some patients, resistance arises due to powerful selective pressure on rare cells that carry amplified copies of the BCR-ABL fusion oncogene or point mutations in the Bcr-Abl tyrosine kinase domain ... Read more >>

Exp. Hematol. (Experimental hematology)
[2003, 31(11):1073-1080]

Cited: 34 times

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Comparative gene expression profile of p185(Bcr-Abl) versus p210(Bcr-Abl) expressing cells.

Alex J Tipping, Junia V Melo,

Leuk. Res. (Leukemia research)
[2004, 28(3):219-220]

Cited: 0 times

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Imatinib mesylate in combination with other chemotherapeutic drugs: in vitro studies.

Alex J Tipping, Junia V Melo,

Imatinib mesylate (Gleevec) (formerly STI571) has secured a definitive role in the treatment of chronic myeloid leukemia (CML) due to its specificity and efficacy. Although some patients become resistant to the drug, it may still be possible to control the leukemia with imatinib-containing regimens. Front-line treatment with such combinations may ... Read more >>

Semin. Hematol. (Seminars in hematology)
[2003, 40(2 Suppl 2):83-91]

Cited: 6 times

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High frequency of large intragenic deletions in the Fanconi anemia group A gene.

N V Morgan, A J Tipping, H Joenje, C G Mathew,

Fanconi anemia (FA) is an autosomal recessive disorder exhibiting chromosomal fragility, bone-marrow failure, congenital abnormalities, and cancer. At least eight complementation groups have been described, with group A accounting for 60%-65% of FA patients. Mutation screening of the group A gene (FANCA) is complicated by its highly interrupted genomic structure ... Read more >>

Am. J. Hum. Genet. (American journal of human genetics)
[1999, 65(5):1330-1341]

Cited: 60 times

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