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Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder.

Kristine Farmen, Sara K Nissen, Morten G Stokholm, Alex Iranzo, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B Svendsen, Alicia Garrido, Dolores Vilas, Per Borghammer, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Eduardo Tolosa, Nicola Pavese, Marina Romero-Ramos,

Synucleinopathies are neurodegenerative diseases with both central and peripheral immune responses. However, whether the peripheral immune changes occur early in disease and their relation to brain events is yet unclear. Isolated rapid-eye-movement (REM) sleep behavior disorder (iRBD) can precede synucleinopathy-related parkinsonism and provides a prodromal phenotype to study early Parkinson's ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(10):]

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Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.

Alex Iranzo, Graham Fairfoul, Anutra Chumbala Na Ayudhaya, Monica Serradell, Ellen Gelpi, Isabel Vilaseca, Raquel Sanchez-Valle, Carles Gaig, Joan Santamaria, Eduard Tolosa, Renata L Riha, Alison J E Green,

<h4>Background</h4>Isolated rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF has high sensitivity and specificity for the detection of misfolded α-synuclein in patients with Parkinson's disease and dementia with ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):203-212]

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The elementary sleep habits of Sherlock Holmes.

Alex Iranzo,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):179-180]

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Magnetic resonance imaging abnormalities as a marker of multiple system atrophy in isolated rapid eye movement sleep behavior disorder.

Amaia Muñoz-Lopetegi, Joan Berenguer, Alex Iranzo, Monica Serradell, Teresa Pujol, Carles Gaig, Esteban Muñoz, Eduard Tolosa, Joan Santamaría,

<h4>Study objectives</h4>Patients with isolated rapid eye movement (REM) sleep behavior disorder (IRBD) develop Parkinson disease (PD), dementia with Lewy bodies (DLB), or multiple system atrophy (MSA). Magnetic resonance imaging (MRI) is abnormal in MSA showing abnormalities in the putamen, cerebellum, and brainstem. Our objective was to evaluate the usefulness of ... Read more >>

Sleep (Sleep)
[2021, 44(1):]

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Dopamine transporter imaging predicts clinically-defined α-synucleinopathy in REM sleep behavior disorder.

Lana M Chahine, Michael C Brumm, Chelsea Caspell-Garcia, Wolfgang Oertel, Brit Mollenhauer, Amy Amara, Ana Fernandez-Arcos, Eduardo Tolosa, Cristina Simonet, Birgit Hogl, Aleksandar Videnovic, Samantha J Hutten, Caroline Tanner, Daniel Weintraub, Elliot Burghardt, Christopher Coffey, Hyunkeun R Cho, Karl Kieburtz, Kathleen L Poston, Kalpana Merchant, Douglas Galasko, Tatiana Foroud, Andrew Siderowf, Kenneth Marek, Tanya Simuni, Alex Iranzo,

<h4>Introduction</h4>Individuals with idiopathic rapid eye movement sleep behavior disorder (iRBD) are at high risk for a clinical diagnosis of an α-synucleinopathy (aSN). They could serve as a key population for disease-modifying trials. Abnormal dopamine transporter (DAT) imaging is a strong candidate biomarker for risk of aSN diagnosis in iRBD. Our ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2021, 8(1):201-212]

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Did inspector Kurt Wallander develop dementia with Lewy bodies?

Alex Iranzo, Joan Santamaría,

Sleep Med (Sleep medicine)
[2021, 78:36-37]

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Evaluation of the Effectiveness of the Risk Minimization Measures of Sodium Oxybate in the European Union.

Alex Iranzo, Pedro Serralheiro, Jan-Christof Schuller, Anne-Françoise Schlit, Jürgen W G Bentz,

<h4>Background</h4>Sodium oxybate (Xyrem<sup>®</sup>), approved by the European Medicines Agency (EMA) for narcolepsy with cataplexy, is only available through risk mitigation programs due to potential adverse effects including respiratory and central nervous system depression, neuropsychiatric events, and misuse.<h4>Objective</h4>We report findings from a survey evaluating effectiveness of the European Union Xyrem<sup>®</sup> Risk ... Read more >>

Drugs Real World Outcomes (Drugs - real world outcomes)
[2020, 7(4):307-315]

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Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

Ramita Dewan, Ruth Chia, Jinhui Ding, Richard A Hickman, Thor D Stein, Yevgeniya Abramzon, Sarah Ahmed, Marya S Sabir, Makayla K Portley, Arianna Tucci, Kristina Ibáñez, F N U Shankaracharya, Pamela Keagle, Giacomina Rossi, Paola Caroppo, Fabrizio Tagliavini, Maria L Waldo, Per M Johansson, Christer F Nilsson, , , , , , , , , James B Rowe, Luisa Benussi, Giuliano Binetti, Roberta Ghidoni, Edwin Jabbari, Coralie Viollet, Jonathan D Glass, Andrew B Singleton, Vincenzo Silani, Owen A Ross, Mina Ryten, Ali Torkamani, Toshiko Tanaka, Luigi Ferrucci, Susan M Resnick, Stuart Pickering-Brown, Christopher B Brady, Neil Kowal, John A Hardy, Vivianna Van Deerlin, Jean Paul Vonsattel, Matthew B Harms, Huw R Morris, Raffaele Ferrari, John E Landers, Adriano Chiò, J Raphael Gibbs, Clifton L Dalgard, Sonja W Scholz, Bryan J Traynor,

We examined the role of repeat expansions in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) by analyzing whole-genome sequence data from 2,442 FTD/ALS patients, 2,599 Lewy body dementia (LBD) patients, and 3,158 neurologically healthy subjects. Pathogenic expansions (range, 40-64 CAG repeats) in the huntingtin (HTT) gene ... Read more >>

Neuron (Neuron)
[2021, 109(3):448-460.e4]

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Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder.

Kristian Stær, Alex Iranzo, Morten G Stokholm, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B Svendsen, Alicia Garrido, Dolores Vilas, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Per Borghammer, Eduardo Tolosa, Nicola Pavese,

<h4>Introduction</h4>In vivo PET studies in patients with isolated REM sleep behavior disorder (iRBD) have shown presence of neuroinflammation (microglial activation) in the substantia nigra, and reduced cortical acetylcholinesterase activity, suggestive of cholinergic dysfunction, that was more widespread in patients with poorer cognitive performances. This study aimed to explore whether reduced ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 81:89-93]

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Stridor during sleep: description of 81 consecutive cases diagnosed in a tertiary sleep disorders center.

Cristiana Silva, Alex Iranzo, Gerard Maya, Mónica Serradell, Amaia Muñoz-Lopetegi, Paula Marrero-González, Carles Gaig, Joan Santamaría, Isabel Vilaseca,

<h4>Objective</h4>To describe the characteristics of stridor during sleep (SDS) in a series of adults identified by video-polysomnography (V-PSG).<h4>Methods</h4>Retrospective clinical, V-PSG, laryngoscopic and therapeutic data of patients diagnosed with SDS in a tertiary referral sleep disorders center between 1997 and 2017.<h4>Results</h4>Eighty-one patients were identified (56.8% males, age 61.8 ± 11.2 years). ... Read more >>

Sleep (Sleep)
[2020, :]

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Significance of hyposmia in isolated REM sleep behavior disorder.

Alex Iranzo, Paula Marrero-González, Mónica Serradell, Carles Gaig, Joan Santamaria, Isabel Vilaseca,

<h4>Objective</h4>To determine if hyposmia in isolated REM sleep behavior disorder (IRBD) predicts short-term conversion to any α-synucleinopathy and declines with time.<h4>Methods</h4>Olfaction was tested using the University of Pennsylvania Smell Identification Test (UPSIT-40) in 140 consecutive patients with polysomnography-confirmed IRBD and in 77 matched controls. Patients were followed-up during 5.6 ± 3.9 (range ... Read more >>

J Neurol (Journal of neurology)
[2021, 268(3):963-966]

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Alpha-synuclein seeds in olfactory mucosa of patients with isolated rapid-eye-movement sleep behaviour disorder

Ambra Stefani, Alex Iranzo, Evi Holzknecht, Daniela Perra, Matilde Bongianni, Carles Gaig, Beatrice Heim, Monica Serradell, Luca Sacchetto, Alicia Garrido, Stefano Capaldi, Almudena Sánchez-Gómez, Michele Fiorini, Joachim Schmutzhard, Pietro Cocchiara, Isabel Vilaseca, Lorenzo Brozzetti, Salvatore Monaco, Jose Marti, Klaus Seppi, Eduardo Tolosa, Joan Santamaria, Birgit Högl, Werner Poewe, Gianluigi Zanusso, ,

<h4>ABSTRACT</h4> Isolated REM sleep behaviour disorder is an early-stage α-synucleinopathy in most, if not all, affected subjects. Detection of pathological alpha-synuclein in peripheral tissues of isolated REM sleep behaviour disorder patients may identify those progressing to Parkinson’s disease, dementia with Lewy bodies or multiple system atrophy, with the ultimate goal ... Read more >>

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Prodromal Parkinson disease in patients with idiopathic hyposmia.

Paula Marrero-González, Alex Iranzo, David Bedoya, Mònica Serradell, Aida Niñerola-Baizán, Andrés Perissinotti, Carles Gaig, Isabel Vilaseca, Isam Alobid, Joan Santamaría, Joaquim Mullol,

<h4>Background</h4>Idiopathic hyposmia (IH) is a prodromal marker of Parkinson disease (PD). However, IH is common in the general population and only a minority will develop PD. Identification of individuals with IH at prodromal stage of PD would serve to select them to implement neuroprotective agents, when available.<h4>Objective</h4>To identify prodromal PD ... Read more >>

J Neurol (Journal of neurology)
[2020, 267(12):3673-3682]

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Alpha-Synuclein Pathology in the Submandibular Gland of LRRK2 p.G2019S Mutation Carriers.

Dolores Vilas, Eduardo Tolosa, Iban Aldecoa, Joan Berenguer, Isabel Vilaseca, Alex Iranzo, Maria Marti, Carles Martí, Francisco Lomeña, Llucia Alós, Ellen Gelpi,

<h4>Background: </h4> The presence of intraneuronal aggregates of phosphorylated alpha-synuclein (pAS), the histological hallmark of Parkinson disease (PD), has been already demonstrated to be present in the autonomic nerve fibres that innervate the submandibular gland in approximately 75% of living PD patients. The presence of pAS in the peripheral autonomic ... Read more >>

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Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers.

Morten Gersel Stokholm, Alicia Garrido, Eduardo Tolosa, Mónica Serradell, Alex Iranzo, Karen Østergaard, Per Borghammer, Arne Møller, Peter Parbo, Kristian Stær, David J Brooks, Maria José Martí, Nicola Pavese,

Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had <sup>11</sup>C-PK11195 and <sup>18</sup>F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectively. Comparisons were made with healthy controls. Five LRRK2-NMCs had subclinical reductions ... Read more >>

J Neurol (Journal of neurology)
[2020, 267(8):2296-2300]

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Left-hemispheric predominance of nigrostriatal deficit in isolated REM sleep behavior disorder.

Alex Iranzo, Ambra Stefani, Aida Niñerola-Baizan, Heike Stokner, Monica Serradell, Dolores Vilas, Evi Holzknecht, Carles Gaig, Javier Pavia, Francesc Lomeña, David Reyes, Klaus Seppi, Joan Santamaria, Birgit Högl, Eduard Tolosa, Werner Poewe, ,

OBJECTIVE:Unilateral onset of parkinsonism due to nigrostriatal damage of the contralateral hemisphere is frequent in Parkinson disease (PD). There is evidence for a left-hemispheric bias of motor asymmetry in right-handed patients with PD indicating a hemispheric dominance. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of PD and ... Read more >>

Neurology (Neurology)
[2020, 94(15):e1605-e1613]

Cited: 3 times

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Lack of Asymmetry of Nigrostriatal Dopaminergic Function in Healthy Subjects.

Alicia Garrido, Alex Iranzo, Ambra Stefani, Mònica Serradell, Amaia Muñoz-Lopetegi, Paula Marrero, Birgit Högl, Carles Gaig, Joan Santamaria, Eduard Tolosa, Werner Poewe, ,

OBJECTIVE:In right-handed patients with Parkinson's disease (PD) or isolated rapid eye movement sleep behavior disorder, dopamine transporter (DAT) [(123)I]β-carboxymethyoxy-3-β-(4-iodophenyl) tropane single photon emission computed tomography (SPECT) shows predominant nigrostriatal deficit in the left striatum. This suggests that in PD patients, the nigrostriatal system of the dominant hemisphere is more susceptible ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2020, 35(6):1072-1076]

Cited: 1 time

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The genetic architecture of the human cerebral cortex.

Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucía Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Christopher R K Ching, Mary Agnes B McMahon, Natalia Shatokhina, Leo C P Zsembik, Sophia I Thomopoulos, Alyssa H Zhu, Lachlan T Strike, Ingrid Agartz, Saud Alhusaini, Marcio A A Almeida, Dag Alnæs, Inge K Amlien, Micael Andersson, Tyler Ard, Nicola J Armstrong, Allison Ashley-Koch, Joshua R Atkins, Manon Bernard, Rachel M Brouwer, Elizabeth E L Buimer, Robin Bülow, Christian Bürger, Dara M Cannon, Mallar Chakravarty, Qiang Chen, Joshua W Cheung, Baptiste Couvy-Duchesne, Anders M Dale, Shareefa Dalvie, Tânia K de Araujo, Greig I de Zubicaray, Sonja M C de Zwarte, Anouk den Braber, Nhat Trung Doan, Katharina Dohm, Stefan Ehrlich, Hannah-Ruth Engelbrecht, Susanne Erk, Chun Chieh Fan, Iryna O Fedko, Sonya F Foley, Judith M Ford, Masaki Fukunaga, Melanie E Garrett, Tian Ge, Sudheer Giddaluru, Aaron L Goldman, Melissa J Green, Nynke A Groenewold, Dominik Grotegerd, Tiril P Gurholt, Boris A Gutman, Narelle K Hansell, Mathew A Harris, Marc B Harrison, Courtney C Haswell, Michael Hauser, Stefan Herms, Dirk J Heslenfeld, New Fei Ho, David Hoehn, Per Hoffmann, Laurena Holleran, Martine Hoogman, Jouke-Jan Hottenga, Masashi Ikeda, Deborah Janowitz, Iris E Jansen, Tianye Jia, Christiane Jockwitz, Ryota Kanai, Sherif Karama, Dalia Kasperaviciute, Tobias Kaufmann, Sinead Kelly, Masataka Kikuchi, Marieke Klein, Michael Knapp, Annchen R Knodt, Bernd Krämer, Max Lam, Thomas M Lancaster, Phil H Lee, Tristram A Lett, Lindsay B Lewis, Iscia Lopes-Cendes, Michelle Luciano, Fabio Macciardi, Andre F Marquand, Samuel R Mathias, Tracy R Melzer, Yuri Milaneschi, Nazanin Mirza-Schreiber, Jose C V Moreira, Thomas W Mühleisen, Bertram Müller-Myhsok, Pablo Najt, Soichiro Nakahara, Kwangsik Nho, Loes M Olde Loohuis, Dimitri Papadopoulos Orfanos, John F Pearson, Toni L Pitcher, Benno Pütz, Yann Quidé, Anjanibhargavi Ragothaman, Faisal M Rashid, William R Reay, Ronny Redlich, Céline S Reinbold, Jonathan Repple, Geneviève Richard, Brandalyn C Riedel, Shannon L Risacher, Cristiane S Rocha, Nina Roth Mota, Lauren Salminen, Arvin Saremi, Andrew J Saykin, Fenja Schlag, Lianne Schmaal, Peter R Schofield, Rodrigo Secolin, Chin Yang Shapland, Li Shen, Jean Shin, Elena Shumskaya, Ida E Sønderby, Emma Sprooten, Katherine E Tansey, Alexander Teumer, Anbupalam Thalamuthu, Diana Tordesillas-Gutiérrez, Jessica A Turner, Anne Uhlmann, Costanza Ludovica Vallerga, Dennis van der Meer, Marjolein M J van Donkelaar, Liza van Eijk, Theo G M van Erp, Neeltje E M van Haren, Daan van Rooij, Marie-José van Tol, Jan H Veldink, Ellen Verhoef, Esther Walton, Mingyuan Wang, Yunpeng Wang, Joanna M Wardlaw, Wei Wen, Lars T Westlye, Christopher D Whelan, Stephanie H Witt, Katharina Wittfeld, Christiane Wolf, Thomas Wolfers, Jing Qin Wu, Clarissa L Yasuda, Dario Zaremba, Zuo Zhang, Marcel P Zwiers, Eric Artiges, Amelia A Assareh, Rosa Ayesa-Arriola, Aysenil Belger, Christine L Brandt, Gregory G Brown, Sven Cichon, Joanne E Curran, Gareth E Davies, Franziska Degenhardt, Michelle F Dennis, Bruno Dietsche, Srdjan Djurovic, Colin P Doherty, Ryan Espiritu, Daniel Garijo, Yolanda Gil, Penny A Gowland, Robert C Green, Alexander N Häusler, Walter Heindel, Beng-Choon Ho, Wolfgang U Hoffmann, Florian Holsboer, Georg Homuth, Norbert Hosten, Clifford R Jack, MiHyun Jang, Andreas Jansen, Nathan A Kimbrel, Knut Kolskår, Sanne Koops, Axel Krug, Kelvin O Lim, Jurjen J Luykx, Daniel H Mathalon, Karen A Mather, Venkata S Mattay, Sarah Matthews, Jaqueline Mayoral Van Son, Sarah C McEwen, Ingrid Melle, Derek W Morris, Bryon A Mueller, Matthias Nauck, Jan E Nordvik, Markus M Nöthen, Daniel S O'Leary, Nils Opel, Marie-Laure Paillère Martinot, G Bruce Pike, Adrian Preda, Erin B Quinlan, Paul E Rasser, Varun Ratnakar, Simone Reppermund, Vidar M Steen, Paul A Tooney, Fábio R Torres, Dick J Veltman, James T Voyvodic, Robert Whelan, Tonya White, Hidenaga Yamamori, Hieab H H Adams, Joshua C Bis, Stephanie Debette, Charles Decarli, Myriam Fornage, Vilmundur Gudnason, Edith Hofer, M Arfan Ikram, Lenore Launer, W T Longstreth, Oscar L Lopez, Bernard Mazoyer, Thomas H Mosley, Gennady V Roshchupkin, Claudia L Satizabal, Reinhold Schmidt, Sudha Seshadri, Qiong Yang, , , , , , , Marina K M Alvim, David Ames, Tim J Anderson, Ole A Andreassen, Alejandro Arias-Vasquez, Mark E Bastin, Bernhard T Baune, Jean C Beckham, John Blangero, Dorret I Boomsma, Henry Brodaty, Han G Brunner, Randy L Buckner, Jan K Buitelaar, Juan R Bustillo, Wiepke Cahn, Murray J Cairns, Vince Calhoun, Vaughan J Carr, Xavier Caseras, Svenja Caspers, Gianpiero L Cavalleri, Fernando Cendes, Aiden Corvin, Benedicto Crespo-Facorro, John C Dalrymple-Alford, Udo Dannlowski, Eco J C de Geus, Ian J Deary, Norman Delanty, Chantal Depondt, Sylvane Desrivières, Gary Donohoe, Thomas Espeseth, Guillén Fernández, Simon E Fisher, Herta Flor, Andreas J Forstner, Clyde Francks, Barbara Franke, David C Glahn, Randy L Gollub, Hans J Grabe, Oliver Gruber, Asta K Håberg, Ahmad R Hariri, Catharina A Hartman, Ryota Hashimoto, Andreas Heinz, Frans A Henskens, Manon H J Hillegers, Pieter J Hoekstra, Avram J Holmes, L Elliot Hong, William D Hopkins, Hilleke E Hulshoff Pol, Terry L Jernigan, Erik G Jönsson, René S Kahn, Martin A Kennedy, Tilo T J Kircher, Peter Kochunov, John B J Kwok, Stephanie Le Hellard, Carmel M Loughland, Nicholas G Martin, Jean-Luc Martinot, Colm McDonald, Katie L McMahon, Andreas Meyer-Lindenberg, Patricia T Michie, Rajendra A Morey, Bryan Mowry, Lars Nyberg, Jaap Oosterlaan, Roel A Ophoff, Christos Pantelis, Tomas Paus, Zdenka Pausova, Brenda W J H Penninx, Tinca J C Polderman, Danielle Posthuma, Marcella Rietschel, Joshua L Roffman, Laura M Rowland, Perminder S Sachdev, Philipp G Sämann, Ulrich Schall, Gunter Schumann, Rodney J Scott, Kang Sim, Sanjay M Sisodiya, Jordan W Smoller, Iris E Sommer, Beate St Pourcain, Dan J Stein, Arthur W Toga, Julian N Trollor, Nic J A Van der Wee, Dennis van 't Ent, Henry Völzke, Henrik Walter, Bernd Weber, Daniel R Weinberger, Margaret J Wright, Juan Zhou, Jason L Stein, Paul M Thompson, Sarah E Medland, ,

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area ... Read more >>

Science (Science (New York, N.Y.))
[2020, 367(6484):]

Cited: 14 times

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Olfaction in patients with isolated REM sleep behavior disorder who eventually develop multiple system atrophy.

Ambra Stefani, Luigi Ferini-Strambi, Ronald B Postuma, Alex Iranzo, Aleksandar Videnovic, Birgit Högl, Gregor K Wenning,

Sleep (Sleep)
[2020, 43(4):]

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Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults.

Oriol Grau-Rivera, Grégory Operto, Carles Falcón, Gonzalo Sánchez-Benavides, Raffaele Cacciaglia, Anna Brugulat-Serrat, Nina Gramunt, Gemma Salvadó, Marc Suárez-Calvet, Carolina Minguillon, Álex Iranzo, Juan Domingo Gispert, José Luis Molinuevo, ,

<h4>Background</h4>Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study aims were to characterize the cognitive performance and brain structural pattern of cognitively unimpaired adults at increased risk for Alzheimer's disease (AD) ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2020, 12(1):4]

Cited: 2 times

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A new incidence peak of childhood narcolepsy type 1 in 2013: a new perspective on the role of influenza virus?

Zhongxing Zhang, Jari Gool, Rolf Fronczek, Claudio Bassetti, Yves Dauvilliers, Geert Mayer, Giuseppe Plazzi, Fabio Pizza, Joan Santamaria, Markku Partinen, Sebastiaan Overeem, Rosa Peraita-Adrados, Antonio Martins da Silva, Karel Sonka, Rafael del Rio-Villegas, Raphael Heinzer, Aleksandra Wierzbicka, Peter Young, Birgit Högl, Mauro Manconi, Eva Feketeova, Johannes Mathis, Teresa Paiva, Francesca Canellas, Michel Lecendreux, Christian Baumann, Lucie Barateau, Carole Pesenti, Elena Antelmi, Carles Gaig, Alex Iranzo, Laura Lillo-Triguero, Pablo Medrano-Martínez, José Haba-Rubio, Corina Gorban, Gert-Jan Lammers, Ramin Khatami,

Increased incidence rates of narcolepsy type 1 (NT1) after the 2009-2010 H1N1 influenza pandemic (pH1N1) have been reported world-wide. While some European countries found an association between the NT1 increase and H1N1 vaccination Pandemrix, reports from Asian countries suggested the H1N1 virus rather than Pandemrix to be linked with the ... Read more >>

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Isolated rapid eye movement sleep behavior disorder and cyclic alternating pattern: is sleep microstructure a predictive parameter of neurodegeneration?

Andrea Melpignano, Liborio Parrino, Joan Santamaria, Carles Gaig, Irene Trippi, Monica Serradell, Carlotta Mutti, Matteo Riccò, Alex Iranzo,

<h4>Objective</h4>To evaluate the role of sleep cyclic alternating pattern (CAP) in patients with isolated REM sleep behavior disorder (IRBD) and ascertain whether CAP metrics might represent a marker of phenoconversion to a defined neurodegenerative condition.<h4>Methods</h4>Sixty-seven IRBD patients were included and classified into patients who phenoconverted to a neurodegenerative disease (RBD ... Read more >>

Sleep (Sleep)
[2019, 42(10):]

Cited: 1 time

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Stridor in multiple system atrophy: Consensus statement on diagnosis, prognosis, and treatment.

Pietro Cortelli, Giovanna Calandra-Buonaura, Eduardo E Benarroch, Giulia Giannini, Alex Iranzo, Phillip A Low, Paolo Martinelli, Federica Provini, Niall Quinn, Eduardo Tolosa, Gregor K Wenning, Giovanni Abbruzzese, Pamela Bower, Enrico Alfonsi, Imad Ghorayeb, Tetsutaro Ozawa, Claudio Pacchetti, Nicolò Gabriele Pozzi, Claudio Vicini, Angelo Antonini, Kailash P Bhatia, Jacopo Bonavita, Horacio Kaufmann, Maria Teresa Pellecchia, Nicole Pizzorni, Antonio Schindler, François Tison, Luca Vignatelli, Wassilios G Meissner,

Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by a combination of autonomic failure, cerebellar ataxia, and parkinsonism. Laryngeal stridor is an additional feature for MSA diagnosis, showing a high diagnostic positive predictive value, and its early occurrence might contribute to shorten survival. A consensus definition of stridor in ... Read more >>

Neurology (Neurology)
[2019, 93(14):630-639]

Cited: 4 times

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Characterization of the sleep disorder of anti-IgLON5 disease.

Carles Gaig, Alex Iranzo, Christian Cajochen, Isabel Vilaseca, Cristina Embid, Josep Dalmau, Francesc Graus, Joan Santamaria,

<h4>Study objective</h4>To characterize the sleep disorder of anti-IgLON5 disease.<h4>Methods</h4>We reviewed 27 video-polysomnographies (V-PSG), 6 multiple sleep latency tests (MSLT), 2 videsomnoscopies with dexmedetomidine, and 10 actigraphies recorded during the disease course of five patients. Due to severe sleep architecture abnormalities, we used a novel modified sleep scoring system combining conventional ... Read more >>

Sleep (Sleep)
[2019, 42(9):]

Cited: 2 times

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HLA and microtubule-associated protein tau H1 haplotype associations in anti-IgLON5 disease.

Carles Gaig, Guadalupe Ercilla, Xavier Daura, Mario Ezquerra, Ruben Fernández-Santiago, Eduard Palou, Lidia Sabater, Romana Höftberger, Anna Heidbreder, Birgit Högl, Alex Iranzo, Joan Santamaria, Josep Dalmau, Francesc Graus,

<h4>Objectives</h4>We investigated the associations with HLA and microtubule-associated protein tau (<i>MAPT</i>) H1 haplotype in anti-IgLON5 disease, a recently identified disorder characterized by gait instability, brainstem dysfunction, and a prominent sleep disorder in association with IgLON5 antibodies and pathologic findings of a novel neuronal-specific tauopathy.<h4>Methods</h4>We compared the HLA alleles and <i>MAPT</i> ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2019, 6(6):]

Cited: 4 times

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