Full Text Journal Articles by
Author Alex Griffiths

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Disparate healthcare experiences of people living with overweight or obesity in England.

Stuart W Flint, Meghan Leaver, Alex Griffiths, Mohammad Kaykanloo,

<h4>Background</h4>Ensuring that patients have high quality, equitable experiences in healthcare is a high priority in the UK. As such, identifying and addressing areas where patient experiences are unsatisfactory and inequitable is of high priority, and has been included as part of the National Health Service (NHS) England equity objectives.<h4>Methods</h4>The healthcare ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2021, 41:101140]

Cited: 0 times

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The Mediterranean dietary pattern for optimising health and performance in competitive athletes: a narrative review.

Alex Griffiths, Jamie Matu, Eleanor Whyte, Petros Akin-Nibosun, Tom Clifford, Emma Stevenson, Oliver Michael Shannon,

Nutrition plays a key role in training for, and competing in, competitive sport, and is essential for reducing risk of injury and illness, recovering and adapting between bouts of activity, and enhancing performance. Consumption of a Mediterranean diet (MedDiet) has been demonstrated to reduce risk of various non-communicable diseases and ... Read more >>

Br J Nutr (The British journal of nutrition)
[2021, :1-14]

Cited: 0 times

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Effects of a Mediterranean diet on blood pressure: a systematic review and meta-analysis of randomized controlled trials and observational studies.

Owen R Cowell, Nathan Mistry, Kevin Deighton, Jamie Matu, Alex Griffiths, Anne Marie Minihane, John C Mathers, Oliver M Shannon, Mario Siervo,

<h4>Objective</h4>To conduct a systematic review and meta-analysis investigating effects of MedDiet on blood pressure in randomized controlled trials (RCTs) and associations of MedDiet with risk of hypertension in observational studies.<h4>Methods</h4>PubMed, The Cochrane Library and EBSCOhost were searched from inception until January 2020 for studies that met the following criteria: participants ... Read more >>

J Hypertens (Journal of hypertension)
[2021, 39(4):729-739]

Cited: 6 times

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Carbohydrate Supplementation and the Influence of Breakfast on Fuel Use in Hypoxia.

Alex Griffiths, Kevin Deighton, Christopher J Boos, Joshua Rowe, Douglas J Morrison, Tom Preston, Roderick King, John P O'Hara,

<h4>Purpose</h4>This study investigated the effect of carbohydrate supplementation on substrate oxidation during exercise in hypoxia after preexercise breakfast consumption and omission.<h4>Methods</h4>Eleven men walked in normobaric hypoxia (FiO2 ~11.7%) for 90 min at 50% of hypoxic V˙O2max. Participants were supplemented with a carbohydrate beverage (1.2 g·min-1 glucose) and a placebo beverage ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2021, 53(4):785-795]

Cited: 0 times

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Mediterranean diet and the hallmarks of ageing.

Oliver M Shannon, Ammar W Ashor, Filippo Scialo, Gabriele Saretzki, Carmen Martin-Ruiz, Jose Lara, Jamie Matu, Alex Griffiths, Natassia Robinson, Lionetti Lillà, Emma Stevenson, Blossom C M Stephan, Anne Marie Minihane, Mario Siervo, John C Mathers,

Ageing is a multifactorial process associated with reduced function and increased risk of morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have been identified, which characterise the ageing process, and collectively, may be key determinants of the ageing trajectory. These include genomic instability, telomere attrition, epigenetic alterations, ... Read more >>

Eur J Clin Nutr (European journal of clinical nutrition)
[2021, 75(8):1176-1192]

Cited: 4 times

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The Effects of Exercise on Indirect Markers of Gut Damage and Permeability: A Systematic Review and Meta-analysis.

Sarah Chantler, Alex Griffiths, Jamie Matu, Glen Davison, Ben Jones, Kevin Deighton,

<h4>Aim</h4>Exercise appears to cause damage to the endothelial lining of the human gastrointestinal tract and elicit a significant increase in gut permeability.<h4>Objective</h4>The aim of this review was to determine the effect of an acute bout of exercise on gut damage and permeability outcomes in healthy populations using a meta-analysis.<h4>Methods</h4>PubMed, The ... Read more >>

Sports Med (Sports medicine (Auckland, N.Z.))
[2021, 51(1):113-124]

Cited: 3 times

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Isotope tracer assessment of exogenous glucose oxidation during aerobic exercise in hypoxia.

Lee M Margolis, John P O'Hara, Alex Griffiths, Robert W Wolfe, Andrew J Young, Stefan M Pasiakos,

Physiol Rep (Physiological reports)
[2020, 8(18):e14594]

Cited: 0 times

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Evaluation of Optimized Procedures for High-Precision Lead Isotope Analyses of Seawater by Multiple Collector Inductively Coupled Plasma Mass Spectrometry.

Alex Griffiths, Hollie Packman, Yee-Lap Leung, Barry J Coles, Katharina Kreissig, Susan H Little, Tina van de Flierdt, Mark Rehkämper,

The application of Pb isotopes to marine geochemistry is currently hindered by challenges associated with the analysis of Pb isotopes in seawater. The current study evaluates the performance of multiple collector inductively coupled plasma mass spectrometry (MC-ICP-MS) measurements of seawater Pb isotope compositions following Pb separation by either solid-phase extraction ... Read more >>

Anal Chem (Analytical chemistry)
[2020, 92(16):11232-11241]

Cited: 0 times

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Steering by their own lights: Why regulators across Europe use different indicators to measure healthcare quality.

Anne-Laure Beaussier, David Demeritt, Alex Griffiths, Henry Rothstein,

Despite widespread faith that quality indicators are key to healthcare improvement and regulation, surprisingly little is known about what is actually measured in different countries, nor how, nor why. To address that gap, this article compares the official indicator sets--comprising some 1100 quality measures-- used by statutory hospital regulators in ... Read more >>

Health Policy (Health policy (Amsterdam, Netherlands))
[2020, 124(5):501-510]

Cited: 3 times

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Appetite and energy intake responses to breakfast consumption and carbohydrate supplementation in hypoxia.

Alex Griffiths, Kevin Deighton, Oliver M Shannon, Chris Boos, Joshua Rowe, Jamie Matu, Roderick King, John P O'Hara,

<h4>Purpose</h4>The purpose of experiment one was to determine the appetite, acylated ghrelin and energy intake response to breakfast consumption and omission in hypoxia and normoxia. Experiment two aimed to determine the appetite, acylated ghrelin and energy intake response to carbohydrate supplementation after both breakfast consumption and omission in hypoxia.<h4>Methods</h4>In experiment ... Read more >>

Appetite (Appetite)
[2020, 147:104564]

Cited: 1 time

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Response: Commentary on the effects of hypoxia on energy substrate use during exercise.

Alex Griffiths, Oliver Shannon, Jamie Matu, Roderick King, Kevin Deighton, John P O'Hara,

<h4>Background</h4>A recent commentary has been published on our meta-analysis, which investigated substrate oxidation during exercise matched for relative intensities in hypoxia compared with normoxia. Within this commentary, the authors proposed that exercise matched for absolute intensities in hypoxia compared with normoxia, should have been included within the analysis, as this ... Read more >>

J Int Soc Sports Nutr (Journal of the International Society of Sports Nutrition)
[2019, 16(1):61]

Cited: 1 time

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Substrate oxidation and the influence of breakfast in normobaric hypoxia and normoxia.

Alex Griffiths, Kevin Deighton, Oliver M Shannon, Jamie Matu, Roderick King, John P O'Hara,

<h4>Purpose</h4>Previous research has reported inconsistent effects of hypoxia on substrate oxidation, which may be due to differences in methodological design, such as pre-exercise nutritional status and exercise intensity. This study investigated the effect of breakfast consumption on substrate oxidation at varying exercise intensities in normobaric hypoxia compared with normoxia.<h4>Methods</h4>Twelve participants ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2019, 119(9):1909-1920]

Cited: 0 times

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The effects of environmental hypoxia on substrate utilisation during exercise: a meta-analysis.

Alex Griffiths, Oliver M Shannon, Jamie Matu, Roderick King, Kevin Deighton, John P O'Hara,

BACKGROUND:A better understanding of hypoxia-induced changes in substrate utilisation can facilitate the development of nutritional strategies for mountaineers, military personnel and athletes during exposure to altitude. However, reported metabolic responses are currently divergent. As such, this systematic review and meta-analysis aims to determine the changes in substrate utilisation during exercise ... Read more >>

J Int Soc Sports Nutr (Journal of the International Society of Sports Nutrition)
[2019, 16(1):10]

Cited: 4 times

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Near Misses in Financial Trading: Skills for Capturing and Averting Error.

Meghan Leaver, Alex Griffiths, Tom Reader,

<h4>Objective</h4>The aims of this study were (a) to determine whether near-miss incidents in financial trading contain information on the operator skills and systems that detect and prevent near misses and the patterns and trends revealed by these data and (b) to explore if particular operator skills and systems are found ... Read more >>

Hum Factors (Human factors)
[2018, 60(5):640-657]

Cited: 1 time

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Wisdom of patients: predicting the quality of care using aggregated patient feedback.

Alex Griffiths, Meghan P Leaver,

<h4>Background</h4>The Care Quality Commission (CQC) is responsible for ensuring the quality of healthcare in England. To that end, CQC has developed statistical surveillance tools that periodically aggregate large numbers of quantitative performance measures to identify risks to the quality of care and prioritise its limited inspection resource. These tools have, ... Read more >>

BMJ Qual Saf (BMJ quality & safety)
[2018, 27(2):110-118]

Cited: 38 times

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Intelligent Monitoring? Assessing the ability of the Care Quality Commission's statistical surveillance tool to predict quality and prioritise NHS hospital inspections.

Alex Griffiths, Anne-Laure Beaussier, David Demeritt, Henry Rothstein,

<h4>Background</h4>The Care Quality Commission (CQC) is responsible for ensuring the quality of the health and social care delivered by more than 30 000 registered providers in England. With only limited resources for conducting on-site inspections, the CQC has used statistical surveillance tools to help it identify which providers it should prioritise ... Read more >>

BMJ Qual Saf (BMJ quality & safety)
[2017, 26(2):120-130]

Cited: 12 times

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Vitamin D for the management of asthma.

Adrian R Martineau, Christopher J Cates, Mitsuyoshi Urashima, Megan Jensen, Alex P Griffiths, Ulugbek Nurmatov, Aziz Sheikh, Chris J Griffiths,

<h4>Background</h4>Several clinical trials of vitamin D to prevent asthma exacerbation and improve asthma control have been conducted in children and adults, but a meta-analysis restricted to double-blind, randomised, placebo-controlled trials of this intervention is lacking.<h4>Objectives</h4>To evaluate the efficacy of administration of vitamin D and its hydroxylated metabolites in reducing the ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2016, 9:CD011511]

Cited: 74 times

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Accounting for failure: risk-based regulation and the problems of ensuring healthcare quality in the NHS.

Anne-Laure Beaussier, David Demeritt, Alex Griffiths, Henry Rothstein,

In this paper, we examine why risk-based policy instruments have failed to improve the proportionality, effectiveness, and legitimacy of healthcare quality regulation in the National Health Service (NHS) in England. Rather than trying to prevent all possible harms, risk-based approaches promise to rationalise and manage the inevitable limits of what ... Read more >>

Health Risk Soc (Health, risk & society)
[2016, 18(3-4):205-224]

Cited: 5 times

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Re-evaluation of accelerometer thresholds for MVPA at age 16 in subjects previously studied at age 12.

Alex Griffiths, Calum Mattocks, Andy Robert Ness, Kate Tilling, Chris Riddoch, Sam Leary,

<h4>Background</h4>A study deriving a threshold for moderate- to vigorous-intensity physical activity (MVPA) in terms of accelerometer counts in 12-year-old children was repeated with a subset of the same children at 16 years.<h4>Methods</h4>Fifteen girls and thirty boys took part in 6 activities (lying, sitting, slow walking, walking, hopscotch and jogging) while ... Read more >>

J Phys Act Health (Journal of physical activity & health)
[2012, 9(8):1163-1167]

Cited: 3 times

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Drawing causal inferences in epidemiologic studies of early life influences.

Andy R Ness, Alex E Griffiths, Laura D Howe, Sam D Leary,

Observational studies can describe associations between early life exposures and subsequent outcomes in human populations. It is challenging to draw causal inferences from these associations because exposures often occur many years before the outcome and are related to other early life exposures. An approach is required that combines traditional epidemiologic ... Read more >>

Am J Clin Nutr (The American journal of clinical nutrition)
[2011, 94(6 Suppl):1959S-1963S]

Cited: 7 times

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Energy absorption and hardness of chair-side denture soft lining materials.

Theodorus Tasopoulos, Robert G Jagger, Daryll C Jagger, Alex E Griffiths,

The purpose of this study was to evaluate the hardness and energy absorption properties of four commercially available chairside silicone denture soft lining materials and to compare their properties with those of a heat-polymerized silicone denture liner. The denture lining materials investigated were four auto-polymerising silicone soft liners (GC Reline ... Read more >>

Eur J Prosthodont Restor Dent (The European journal of prosthodontics and restorative dentistry)
[2010, 18(4):189-194]

Cited: 0 times

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The prevalence of dental, facial and head injuries sustained by schoolboy rugby players. A pilot study.

Robert G Jagger, Ali Abbasbhai, Dilan Patel, Daryll C Jagger, Alex Griffiths,

<h4>Aim</h4>The aim of the study was to determine the prevalence of dental, orofacial and head injuries and of mouthguard use among schoolboy rugby players.<h4>Materials and methods</h4>All members of the first and second XV rugby squads at three secondary schools (two in England and one in Australia) were included in the ... Read more >>

Prim Dent Care (Primary dental care : journal of the Faculty of General Dental Practitioners (UK))
[2010, 17(3):143-146]

Cited: 4 times

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Prospective associations between objective measures of physical activity and fat mass in 12-14 year old children: the Avon Longitudinal Study of Parents and Children (ALSPAC).

Chris J Riddoch, Sam D Leary, Andy R Ness, Steven N Blair, Kevin Deere, Calum Mattocks, Alex Griffiths, George Davey Smith, Kate Tilling,

<h4>Objective</h4>To investigate associations between physical activity at age 12 and subsequent adiposity at age 14.<h4>Design</h4>Prospective birth cohort study with data collected between 2003 and 2007.<h4>Setting</h4>Original recruitment in 1991-2 of 14,541 pregnant women living in the former County of Avon (United Kingdom).<h4>Participants</h4>At age 12, 11,952 children were invited to attend the ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2009, 339:b4544]

Cited: 100 times

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Associations between sex-typed behaviour at age 31/2 and levels and patterns of physical activity at age 12: the Avon Longitudinal Study of Parents and Children.

Calum Mattocks, Melissa Hines, Andy Ness, Sam Leary, Alex Griffiths, Kate Tilling, Steven N Blair, Chris Riddoch,

<h4>Background</h4>Differences in sex-typed behaviour, including physical activity, are already apparent among preschool children.<h4>Purpose</h4>To examine the associations between early sex-typed behaviour and later physical activity.<h4>Methods</h4>Children from the Avon Longitudinal Study of Parents and Children were asked to wear an accelerometer for 7 days at age 12. Physical activity outcomes were counts ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2010, 95(7):509-512]

Cited: 5 times

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