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Author Alex G Ortega Loayza

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Treatment of pyoderma gangrenosum: A multicenter survey-based study assessing satisfaction and quality of life.

Misty M Hobbs, Rebecca Byler, Emile Latour, Lauren Bonomo, Kerry Hennessy, Carla N Cruz-Diaz, Michi M Shinohara, Lucia Seminario-Vidal, Kanade Shinkai, Alex G Ortega-Loayza,

Pyoderma gangrenosum (PG) lacks consensus regarding treatment, and no prior studies assess treatment satisfaction in PG. The objective of this study was to determine patient-reported satisfaction in the treatment of PG, and associations with satisfaction. Methodology was a multicenter cross-sectional survey for patients who received systemic medication(s) to treat PG. ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2021, :e14736]

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Synergistic induction of IL-23 by TNFα, IL-17A, and EGF in keratinocytes.

Benjamin Ehst, Zhiping Wang, Justin Leitenberger, Danielle McClanahan, Rachel De La Torre, Erika Sawka, Alex G Ortega-Loayza, Jennifer Strunck, Teri Greiling, Eric Simpson, Yuangang Liu,

IL-23 is an inflammatory cytokine that plays an essential role in Th17 immunity by enhancing Th17 cell proliferation and survival, and Th17 cytokine production. IL-23 has pathogenic roles in the development of Th17-mediated inflammatory diseases including psoriasis. Despite successful treatment of psoriasis by blocking IL-23, the regulation of IL-23 expression ... Read more >>

Cytokine (Cytokine)
[2020, :155357]

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Pyoderma gangrenosum: proposed pathogenesis and current use of biologics with an emphasis on complement C5a inhibitor IFX-1.

Justin D Lu, Milica Milakovic, Alex G Ortega-Loayza, Angelo V Marzano, Afsaneh Alavi,

<h4>Introduction</h4>Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis with no FDA-approved treatment. The complement pathway has received renewed attention because it is elevated in inflammatory cutaneous conditions such as hidradenitis suppurativa (HS) and psoriasis. IFX-1 is a complement C5a inhibitor which inhibits neutrophil activation, chemotaxis, and reduces inflammatory signaling and ... Read more >>

Expert Opin Investig Drugs (Expert opinion on investigational drugs)
[2020, 29(11):1179-1185]

Cited: 1 time

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Management of classic ulcerative pyoderma gangrenosum.

Ladan Afifi, Alex G Ortega-Loayza, Kanade Shinkai,

Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis with unclear etiology and is associated with notable morbidity. Due to the rarity of PG, there are limited large, multicentered, randomized trials to guide management. We aim to highlight best practices in PG management through survey responses from expert medical dermatologists. ... Read more >>

Cutis (Cutis)
[2020, 106(3):119-123;E2;E3]

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Comparison of Three Diagnostic Frameworks for Pyoderma Gangrenosum.

Carter Haag, Trevor Hansen, Tamar Hajar, Emile Latour, Jesse Keller, Kanade Shinkai, Alex G Ortega-Loayza,

Pyoderma gangrenosum (PG) is an inflammatory condition characterized by chronic cutaneous ulcerations. There are three proposed PG diagnostic frameworks (Su, PARACELSUS, Delphi); however, they lack consensus, and their performance has not yet been validated in a well-defined cohort of patients with PG. In this cross-sectional retrospective cohort study, we sought ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2021, 141(1):59-63]

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Adverse cutaneous reactions to chemotherapeutic drugs.

Dylan Haynes, Alex G Ortega-Loayza,

Drug reactions resulting from chemotherapy agents are common and frequently affect the skin. Although often benign, a select few of these cutaneous reactions may necessitate immediate changes to the antineoplastic regimens. Given the diversity of chemotherapeutic skin reactions and their complex implications on patient management, an organized conceptual schema is ... Read more >>

Clin Dermatol (Clinics in dermatology)
[2020, 38(6):712-728]

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Evaluation of Ixekizumab Treatment for Patients With Pityriasis Rubra Pilaris: A Single-Arm Trial.

Dylan Haynes, Jennifer L Strunck, Christina A Topham, Alex G Ortega-Loayza, Gail Kent, Pamela B Cassidy, Ronghua Hu, Keith Choate, Zhiping Wang, Yuangang Liu, Teri M Greiling,

<h4>Importance</h4>Pityriasis rubra pilaris is a rare and disabling cutaneous disease that is frequently recalcitrant to conventional therapies and appears to involve interleukin (IL)-17 overexpression.<h4>Objective</h4>To investigate the clinical response and safety of ixekizumab in treating pityriasis rubra pilaris.<h4>Design, setting, and participants</h4>Single-arm, investigator-initiated trial conducted in adult patients with moderate to severe ... Read more >>

JAMA Dermatol (JAMA dermatology)
[2020, 156(6):668-675]

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Pyoderma gangrenosum: From historical perspectives to emerging investigations.

Misty M Hobbs, Alex G Ortega-Loayza,

Pyoderma gangrenosum (PG) is a rare disease of unknown aetiology, first described over a century ago. Initially thought to have an infectious cause, and now primarily considered an autoinflammatory condition, PG continues to be poorly understood, commonly misdiagnosed, and difficult to treat. In this review, we discuss the journey of ... Read more >>

Int Wound J (International wound journal)
[2020, 17(5):1255-1265]

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A Treatment-Refractory, Perianal Tumor Arising in an Otherwise Healthy Older Adult Woman.

Erika L Hagstrom, Dylan Haynes, Alex G Ortega-Loayza,

JAMA Dermatol (JAMA dermatology)
[2020, 156(4):453-454]

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Successful Mastectomy and Chemotherapy in a Patient with Breast Cancer and Active Generalized Pyoderma Gangrenosum.

Daniel C Morse, Payal M Patel, Carter Haag, Alex G Ortega-Loayza,

<h4>Introduction</h4>Pyoderma gangrenosum (PG) is a rare, ulcerating neutrophilic dermatosis often associated with inflammatory bowel disease, rheumatoid arthritis, and myeloproliferative disorders. The classic description of PG includes irregularly shaped ulcers with undermined edges with a gun-metal gray or violaceous hue. The etiology remains unclear but appears to be related to genetically ... Read more >>

Wounds (Wounds : a compendium of clinical research and practice)
[2020, 32(4):E19-E22]

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Society of Dermatology Hospitalists supportive care guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults.

Lucia Seminario-Vidal, Daniela Kroshinsky, Stephen J Malachowski, James Sun, Alina Markova, Thomas M Beachkofsky, Benjamin H Kaffenberger, Elizabeth N Ergen, Melissa Mauskar, Alina Bridges, Cody Calhoun, Adela R Cardones, Steven T Chen, James Chodosh, Jonathan Cotliar, Mark D P Davis, Katherine L DeNiro, Arturo R Dominguez, Juliana Eljure-Téllez, Alisa Femia, Lindy P Fox, Anisha Guda, Caroline Mitchell, Arash Mostaghimi, Alex G Ortega-Loayza, Cindy Owen, Helena Pasieka, Sahand Rahnama-Moghadam, Hajirah N Saeed, Rebecca B Saunderson, Swapna Shanbhag, Victoria R Sharon, Lindsay Strowd, Samantha Venkatesh, Karolyn A Wanat, David A Wetter, Scott Worswick, Robert G Micheletti,

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening conditions with high morbidity and mortality. Supportive care management of SJS/TEN is highly variable. A systematic review of the literature was performed by dermatologists, ophthalmologists, intensivists, and gynecologists with expertise in SJS/TEN to generate statements for supportive care guideline development. ... Read more >>

J Am Acad Dermatol (Journal of the American Academy of Dermatology)
[2020, 82(6):1553-1567]

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Ulcerative C2 neurocutaneous dysesthesia (trigeminal trophic syndrome in an alternative distribution).

Dylan Haynes, Christina Topham, Tamar Hajar, Alex G Ortega-Loayza, Kevin P White, Jesse J Keller,

Trigeminal trophic syndrome is an uncommon condition characterized by paresthesia, itch, and self-inflicted wounds following the trigeminal dermatome(s). Similar processes adhering to cervical nerve distributions have been reported, calling into question the specificity of trigeminal trophic syndrome for the trigeminal network. Herein, we report patient with trigeminal trophic syndrome adhering ... Read more >>

Dermatol Online J (Dermatology online journal)
[2020, 26(1):]

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Pyoderma gangrenosum underrepresentation in non-dermatological literature.

Ashley M Reese, Carter K Haag, Enjae Jung, Allison C Nauta, Robert A Swerlick, Alex G Ortega-Loayza,

Background Pyoderma gangrenosum (PG) is a chronic, ulcerative neutrophilic dermatosis. PG presents a diagnostic challenge, largely due to the many mimicking diseases, the lack of confirmatory laboratory or biological markers, and the absence of widely accepted diagnostic criteria. In particular, PG is often mistaken for necrotizing soft tissue infections (NSTI). ... Read more >>

Diagnosis (Berl) (Diagnosis (Berlin, Germany))
[2020, :]

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Perioperative management of pyoderma gangrenosum.

Carter K Haag, Lindsay Bacik, Emile Latour, Daniel C Morse, Nicole M Fett, Alex G Ortega-Loayza,

Pyoderma gangrenosum (PG) classically presents with an acute inflammatory stage, characterized by rapid evolution of painful ulcerations. The pathergy associated with PG lesions complicates disease management. Although PG is commonly treated with immunosuppression, some patients have refractory noninflammatory ulcers. In this subpopulation, there are case reports of successful surgical treatment. However, ... Read more >>

J Am Acad Dermatol (Journal of the American Academy of Dermatology)
[2020, 83(2):369-374]

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Diagnosis and novel clinical treatment strategies for pyoderma gangrenosum.

Mohamad Goldust, Erika L Hagstrom, Dipali Rathod, Alex G Ortega-Loayza,

<b>Introduction</b>: Pyoderma gangrenosum (PG) is a noninfectious, reactive inflammatory neutrophilic dermatosis that is commonly associated with autoimmune and neoplastic disorders. There are emerging diagnostic tools and treatment options for PG.<b>Area covered</b>: The diagnosis of PG should be seriously considered when managing ulcers to avoid unnecessary medical and surgical complications with ... Read more >>

Expert Rev Clin Pharmacol (Expert review of clinical pharmacology)
[2020, 13(2):157-161]

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Pyoderma gangrenosum: a review with special emphasis on Latin America literature.

Milton José Max Rodríguez-Zúñiga, Michael S Heath, João Renato Vianna Gontijo, Alex G Ortega-Loayza,

Pyoderma gangrenosum is a neutrophilic dermatosis characterized by chronic ulcers due to an abnormal immune response. Despite the existence of diagnostic criteria, there is no gold standard for diagnosis or treatment. In Latin America, recognizing and treating pyoderma gangrenosum is even more challenging since skin and soft tissue bacterial and ... Read more >>

An Bras Dermatol (Anais brasileiros de dermatologia)
[2019, 94(6):729-743]

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The utility and challenges of histopathologic evaluation in the diagnosis of nonmalignant skin ulcers.

Phoebe Hammer, Emile Latour, Mary C Bohnett, Fatima McKenzie, Veselina B Korcheva, Stephanie Mengden, Kevin P White, Alex G Ortega-Loayza,

Histopathologic evaluation of cutaneous ulcers is indicated when the clinical diagnosis is unclear or when ulcers have not responded to standard of care. Many nonmalignant skin ulcers lack specific histologic findings on biopsy and pose a diagnostic challenge. While the usefulness of skin biopsies to diagnose underlying malignancy in ulcerated ... Read more >>

Wound Repair Regen (Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society)
[2020, 28(2):219-223]

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Characterisation and diagnosis of ulcers in inpatient dermatology consultation services: A multi-centre study.

Dylan Haynes, Phoebe Hammer, Stephen J Malachowski, Benjamin Kaffenberger, Jonathan S Yi, Nora Vera, Cody Calhoun, Michi M Shinohara, Lucia Seminario-Vidal, John C Trinidad, Jesse J Keller, Alex G Ortega-Loayza,

Accurate and prompt diagnosis of skin ulcers is critical to optimise management; however, studies in hospitalised patients are limited. This retrospective review of dermatologic consultations included 272 inpatients with skin ulcers between July 2015 and July 2018 in four U.S. academic hospitals. The median age was 54 years and 45% were ... Read more >>

Int Wound J (International wound journal)
[2019, 16(6):1440-1444]

Cited: 1 time

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Carcinoma Erysipeloides From Metastatic Cutaneous Squamous Cell Carcinoma Initially Mistaken for Intralymphatic Histiocytosis.

Michael S Heath, Christa Slaught, Alex G Ortega-Loayza, Stephanie Mengden,

Intralymphatic histiocytosis is a rare dermatologic disorder, commonly associated with inflammatory disorders and rarely malignancy. Carcinoma erysipeloides (CE) is a rare pseudoinflammatory cutaneous eruption that resembles soft -tissue infections as result of intralymphatic metastasis and subsequent lymphatic obstruction. Breast carcinoma represents most of the CE cases, but rarely other malignancies ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2019, 41(7):522-525]

Cited: 0 times

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Primary Immunodeficiency, a Possible Cause of Neutrophilic Necrotizing Dermatosis-Reply.

Sara A Hylwa, Alex G Ortega-Loayza, Kanade Shinkai,

JAMA Dermatol (JAMA dermatology)
[2019, 155(7):864-865]

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Do I Have Calciphylaxis?

Jesse J Keller, Alex G Ortega-Loayza,

JAMA Dermatol (JAMA dermatology)
[2019, 155(7):872]

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Pyoderma gangrenosum: a too often overlooked facultative paraneoplastic disease.

Angela S Gupta, Alex G Ortega-Loayza,

Ann Hematol (Annals of hematology)
[2019, 98(9):2247-2248]

Cited: 1 time

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A Comprehensive Review of Local Pharmacologic Therapy for Pyoderma Gangrenosum.

David Baltazar, Carter Haag, Angela S Gupta, Angelo Marzano Marzano, Alex G Ortega Loayza,

Pyoderma gangrenosum (PG) is a rare, ulcerative inflammatory skin disease that most commonly occurs in patients with inflammatory bowel disease, rheumatologic diseases, or hematologic diseases. Successful treatment of PG often requires immunosuppression and appropriate wound care. Systemic corticosteroids and cyclosporine are the first-line treatments for PG. However, chronic use of ... Read more >>

Wounds (Wounds : a compendium of clinical research and practice)
[2019, 31(6):151-157]

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Extracutaneous involvement of pyoderma gangrenosum.

Luis J Borda, Lulu L Wong, Angelo V Marzano, Alex G Ortega-Loayza,

Pyoderma Gangrenosum (PG) is an inflammatory neutrophilic dermatosis (ND) associated with underlying chronic inflammation and/or malignancy. Diagnosis remains to be challenging as a gold standard diagnostic test is lacking. Initial manifestations may include papules, vesicles, or pustules that subsequently develop into ulceration with features of undermining and violaceous borders. Timely ... Read more >>

Arch Dermatol Res (Archives of dermatological research)
[2019, 311(6):425-434]

Cited: 3 times

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Mechanisms of Inflammation in Neutrophil-Mediated Skin Diseases.

Angelo V Marzano, Alex G Ortega-Loayza, Michael Heath, Daniel Morse, Giovanni Genovese, Massimo Cugno,

Neutrophil-mediated skin diseases, originally named neutrophilic dermatoses (NDs), are a group of conditions due to an altered neutrophil recruitment and activation, characterized by polymorphic cutaneous manifestations with possible internal organ involvement. Although a number of diseases are included in this setting, the two prototypic forms are pyoderma gangrenosum (PG) and ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:1059]

Cited: 5 times

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