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Author Alessio Gasperetti

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Echocardiography in COVID-19 pandemic: clinical findings and the importance of emerging technology

Alberto Barosi, Luca Bergamaschi, Ignazio Cusmano, Alessio Gasperetti, Marco Schiavone, Elisa Gherbesi,

SYNOPSIS Coronavirus disease 2019 (COVID-19) could have a direct or indirect effect on the cardiovascular system. To detect cardiac involvement, trans-thoracic echocardiography (TTE), as a widely available and cost-effective tool, is highly recommended and can provide important information that can affect the clinical management of COVID-19 patients. Despite that, considering ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study

Alessio Gasperetti, Cynthia A. James, Liang Chen, Niklas Schenker, Michela Casella, Shinwan Kany, Shibu Mathew, Paolo Compagnucci, Andreas Müssigbrodt, Henrik K. Jensen, Anneli Svensson, Sarah Costa, Giovanni B. Forleo, Pyotr G. Platonov, Claudio Tondo, Jiang-Ping Song, Antonio Dello Russo, Frank Ruschitzka, Corinna Brunckhorst, Hugh Calkins, Firat Duru, Ardan M. Saguner,

Background: Atrial arrhythmias are present in up to 20% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Catheter ablation (CA) is an effective treatment for atrial arrhythmias in the general population. Data regarding CA for atrial arrhythmias in ARVC are scarce. Objective: To assess the safety and efficacy of CA ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy-A Multicenter Study.

Alessio Gasperetti, Cynthia A James, Liang Chen, Niklas Schenker, Michela Casella, Shinwan Kany, Shibu Mathew, Paolo Compagnucci, Andreas Müssigbrodt, Henrik K Jensen, Anneli Svensson, Sarah Costa, Giovanni B Forleo, Pyotr G Platonov, Claudio Tondo, Jiang-Ping Song, Antonio Dello Russo, Frank Ruschitzka, Corinna Brunckhorst, Hugh Calkins, Firat Duru, Ardan M Saguner,

<b>Background:</b> Atrial arrhythmias are present in up to 20% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Catheter ablation (CA) is an effective treatment for atrial arrhythmias in the general population. Data regarding CA for atrial arrhythmias in ARVC are scarce. <b>Objective</b>: To assess the safety and efficacy of CA ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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Arrhythmogenic Risk and Mechanisms of QT Prolonging Drugs to Treat COVID-19

Marco Schiavone, Alessio Gasperetti, Elisa Gherbesi, Luca Bergamaschi, Roberto Arosio, Gianfranco Mitacchione, Maurizio Viecca, Giovanni B. Forleo,

While looking for a “magic bullet” to treat COVID-19, the massive off-label use of several of drugs in COVID-19, including repurposed antimalarial drugs, immunosuppressive agents, anti-virals and antibacterial agents, have generated concerns in the early phase of the pandemic due a possible arrhythmogenic effects in relation to QTc interval prolongation. ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Etiology and device therapy in complete atrioventricular block in pediatric and young adult population: Contemporary review and new perspectives.

Giacomo M Cioffi, Alessio Gasperetti, Gregorio Tersalvi, Marco Schiavone, Paolo Compagnucci, Fabiola B Sozzi, Michela Casella, Federico Guerra, Antonio Dello Russo, Giovanni Battista Forleo,

Complete atrioventricular block (CAVB) is a total dissociation between the atrial and ventricular activity, in the absence of atrioventricular conduction. Several diseases may result in CAVB in the pediatric and young-adult population. Permanent right ventricular (RV) pacing is required in permanent CAVB, when the cause is neither transient nor reversible. ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(11):3082-3094]

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Implantation of cardiac electronic devices in active COVID-19 patients: Results from an international survey.

Oholi Tovia-Brodie, Moshe Rav Acha, Bernard Belhassen, Alessio Gasperetti, Marco Schiavone, Giovanni Battista Forleo, Milton E Guevara-Valdivia, David Valdeolivar Ruiz, Nicolas Lellouche, David Hamon, Davide Castagno, Matteo Bellettini, Gaetano M De Ferrari, Mikael Laredo, Jean-Baptiste Carvès, Barbara Ignatiuk, Giampaolo Pasquetto, Paolo De Filippo, Giovanni Malanchini, Behzad B Pavri, Craig Raphael, Luigi Rivetti, Roberto Mantovan, Jason Chinitz, Melissa Harding, Giuseppe Boriani, Edoardo Casali, Elaine Y Wan, Angelo Biviano, Carlos Macias, Stepan Havranek, Pietro Enea Lazzerini, Antonio M Canu, Marco Zardini, Giulio Conte, Óscar Cano, Michela Casella, Boris Rudic, Alexander Omelchenko, Nilesh Mathuria, Gaurav A Upadhyay, Asaf Danon, Arie Lorin Schwartz, Philippe Maury, Shiro Nakahara, Gustavo Goldenberg, Nicolas Schaerli, Sergiy Bereza, Angelo Auricchio, Michael Glikson, Yoav Michowitz,

<h4>Background</h4>Cardiac implantable electronic device (CIED) implantation rates as well as the clinical and procedural characteristics and outcomes in patients with known active coronavirus disease 2019 (COVID-19) are unknown.<h4>Objective</h4>The purpose of this study was to gather information regarding CIED procedures during active COVID-19, performed with personal protective equipment, based on an ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, :]

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Intraprocedural PRAETORIAN score for early assessment of S-ICD implantation: A proof-of-concept study.

Alessio Gasperetti, Marco Schiavone, Mauro Biffi, Michela Casella, Paolo Compagnucci, Gianfranco Mitacchione, Andrea Angeletti, Julia Vogler, Riccardo Proietti, Matteo Ziacchi, Antonio Dello Russo, Andrea Natale, Roland R Tilz, Giovanni B Forleo,

<h4>Introduction</h4>The PRAETORIAN score (PS) was developed to assess the implant position and predict defibrillation success of the subcutaneous implantable cardioverter defibrillators (S-ICD). The main critique moved to the routine use of PS has been its postprocedural timing, that limits its usefulness on procedure guidance. The aim of this proof-of-concept study ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(11):3035-3041]

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Micra-AV leadless pacemaker and atrioventricular (dys)synchrony: A stepwise process.

Gianfranco Mitacchione, Marco Schiavone, Alessio Gasperetti, Diego Ruggiero, Marialessia Denora, Maurizio Viecca, Giovanni Battista Forleo,

Leadless pacemakers have become a major breakthrough in the management of bradyarrhythmia as an attractive alternative to the standard transvenous pacemakers, but safety and long-term outcomes of the new Micra-AV, which is capable guarantee atrioventricular (AV) synchrony, have been poorly described. Hence, we describe how we managed a 57-year-old patient ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(10):1738-1742]

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The prevalence of left and right bundle branch block morphology ventricular tachycardia amongst patients with arrhythmogenic cardiomyopathy and sustained ventricular tachycardia: insights from the European Survey on Arrhythmogenic Cardiomyopathy.

Bernard Belhassen, Mikael Laredo, Rob W Roudijk, Giovanni Peretto, Guy Zahavi, Srijita Sen-Chowdhry, Nicolas Badenco, Anneline S J M Te Riele, Simone Sala, Guillaume Duthoit, J Peter van Tintelen, Gabriele Paglino, Jean-Marc Sellal, Alessio Gasperetti, Elena Arbelo, Antoine Andorin, Sandro Ninni, Anne Rollin, Petr Peichl, Xavier Waintraub, Laurens P Bosman, Bertrand Pierre, Eyal Nof, Chris Miles, Jacob Tfelt-Hansen, Alexandros Protonotarios, Carla Giustetto, Frederic Sacher, Jean-Sylvain Hermida, Stepan Havranek, Leonardo Calo, Ruben Casado-Arroyo, Giulio Conte, Konstantinos P Letsas, Esther Zorio, Francisco J Bermúdez-Jiménez, Elijah R Behr, Roy Beinart, Laurent Fauchier, Josef Kautzner, Philippe Maury, Dominique Lacroix, Vincent Probst, Josep Brugada, Firat Duru, Christian de Chillou, Paolo Della Bella, Estelle Gandjbakhch, Richard Hauer, Anat Milman,

<h4>Aims</h4>In arrhythmogenic cardiomyopathy (ACM), sustained ventricular tachycardia (VT) typically displays a left bundle branch block (LBBB) morphology while a right bundle branch block (RBBB) morphology is rare. The present study assesses the VT morphology in ACM patients with sustained VT and their clinical and genetic characteristics.<h4>Methods and results</h4>Twenty-six centres from ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, :]

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Second-generation laser balloon ablation for the treatment of atrial fibrillation assessed by continuous rhythm monitoring: the LIGHT-AF study.

Giovanni Rovaris, Giuseppe Ciconte, Marco Schiavone, Gianfranco Mitacchione, Alessio Gasperetti, Elena Piazzi, Gabriele Negro, Elisabetta Montemerlo, Roberto Rondine, Mattia Pozzi, Mirko Casiraghi, Sergio De Ceglia, Daniele Giacopelli, Maurizio Viecca, Gabriele Vicedomini, Giovanni B Forleo, Carlo Pappone,

<h4>Aims</h4>Balloon-based technologies have been developed to simplify catheter ablation of atrial fibrillation (AF), to improve the clinical outcome of the procedure and to achieve durable pulmonary vein isolation (PVI). The objective of this study is to evaluate the safety and efficacy of second-generation laser balloon (LB2) ablation in the treatment ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, 23(9):1380-1390]

Cited: 1 time

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Congenital Coronary Artery Anomalies and Sudden Cardiac Death.

Marco Schiavone, Cecilia Gobbi, Alessio Gasperetti, Andrea Zuffi, Giovanni Battista Forleo,

Coronary artery anomalies (CAAs) are a heterogeneous group of rare congenital diseases whose features and pathophysiological mechanisms are extremely variable, ranging from silent anomalies to sudden cardiac death (SCD) in the most severe cases. Although rare, congenital CAAs confer a high risk of myocardial ischemia and SCD, especially in young, ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2021, 42(8):1676-1687]

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Endomyocardial Biopsy: The Forgotten Piece in the Arrhythmogenic Cardiomyopathy Puzzle.

Michela Casella, Marco Bergonti, Antonio Dello Russo, Riccardo Maragna, Alessio Gasperetti, Paolo Compagnucci, Valentina Catto, Filippo Trombara, Antonio Frappampina, Edoardo Conte, Marco Fogante, Elena Sommariva, Stefania Rizzo, Monica De Gaspari, Andrea Giovagnoni, Daniele Andreini, Giulio Pompilio, Luigi Di Biase, Andrea Natale, Cristina Basso, Claudio Tondo,

Background Endomyocardial biopsy (EMB) is part of 2010 Task Force Criteria (TFC) for arrhythmogenic right ventricular cardiomyopathy (ARVC). However, its usage has been curtailed because of its low presumed diagnostic yield, and it is now a poorly used tool. This study aims to analyze the contribution of EMB to the ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(19):e021370]

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Cardiac magnetic resonance features of left dominant arrhythmogenic cardiomyopathy: differential diagnosis with myocarditis.

Daniele Andreini, Edoardo Conte, Michela Casella, Saima Mushtaq, Gianluca Pontone, Antonio Dello Russo, Flavia Nicoli, Patrizia Carità, Valentina Catto, Giulia Vettor, Alessio Gasperetti, Elena Sommariva, Stefania Rizzo, Cristina Basso, Claudio Tondo, Mauro Pepi,

Cardiac magnetic resonance (CMR) findings suggesting a suspected left-dominant arrhythmogenic cardiomyopathy (LDAC) may be difficult to distinguish from those related to previous myocarditis; however, especially in patients with ventricular arrhythmias (VA) with ECG morphology consistent with a left ventricle (LV) origin differential diagnosis is fundamental. Aim of the study was ... Read more >>

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2021, :]

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Ventricular arrhythmias in athletes: Role of a comprehensive diagnostic workup.

Antonio Dello Russo, Paolo Compagnucci, Michela Casella, Alessio Gasperetti, Stefania Riva, Maria Antonietta Dessanai, Francesca Pizzamiglio, Valentina Catto, Federico Guerra, Giulia Stronati, Daniele Andreini, Gianluca Pontone, Alice Bonomi, Stefania Rizzo, Luigi Di Biase, Alessandro Capucci, Andrea Natale, Cristina Basso, Cesare Fiorentini, Paolo Zeppilli, Claudio Tondo,

<h4>Background</h4>Ventricular arrhythmias (VAs) represent a critical issue with regard to sports eligibility assessment in athletes. The ideal diagnostic evaluation of competitive and leisure-time athletes with complex VAs has not been clearly defined.<h4>Objective</h4>The purpose of this study was to assess the clinical implications of invasive electrophysiological assessments and endomyocardial biopsy (EMB) ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, :]

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A Novel Diagnostic Score Integrating Atrial Dimensions to Differentiate between the Athlete's Heart and Arrhythmogenic Right Ventricular Cardiomyopathy.

Valentina A Rossi, David Niederseer, Justyna M Sokolska, Boldizsar Kovacs, Sarah Costa, Alessio Gasperetti, Corinna Brunckhorst, Deniz Akdis, Felix C Tanner, Firat Duru, Christian M Schmied, Ardan M Saguner,

<h4>Objective</h4>The 2010 Task Force Criteria (TFC) have not been tested to differentiate ARVC from the athlete's heart. Moreover, some criteria are not available (myocardial biopsy, genetic testing, morphology of ventricular tachycardia) or subject to interobserver variability (right ventricular regional wall motion abnormalities) in clinical practice. We hypothesized that atrial dimensions ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(18):]

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Echocardiographic assessment of the right ventricle in COVID-19: a systematic review.

Simone Ghidini, Alessio Gasperetti, Dario Winterton, Marco Vicenzi, Mattia Busana, Giovanni Pedrazzini, Luigi Biasco, Gregorio Tersalvi,

Cardiac involvement has been frequently reported in COVID-19 as responsible of increased morbidity and mortality. Given the importance of right heart function in acute and chronic respiratory diseases, its assessment in SARS-CoV-2 infected patients may add prognostic accuracy. Transthoracic echocardiography has been proposed to early predict myocardial injury and risk ... Read more >>

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2021, 37(12):3499-3512]

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Long-term complications in patients implanted with subcutaneous implantable cardioverter-defibrillators: Real-world data from the extended ELISIR experience.

Alessio Gasperetti, Marco Schiavone, Matteo Ziacchi, Julia Vogler, Alexander Breitenstein, Mikael Laredo, Pietro Palmisano, Danilo Ricciardi, Gianfranco Mitacchione, Paolo Compagnucci, Antonio Bisignani, Andrea Angeletti, Michela Casella, Francesco Picarelli, Thomas Fink, Lukas Kaiser, Samer Hakmi, Leonardò Calò, Carlo Pignalberi, Luca Santini, Carlo Lavalle, Ennio Pisanò, Iacopo Olivotto, Claudio Tondo, Antonio Curnis, Antonio Dello Russo, Nicolas Badenco, Jan Steffel, Charles J Love, Roland Tilz, Giovanni Forleo, Mauro Biffi,

<h4>Background</h4>Recently, the Food and Drug Administration issued a recall for the subcutaneous implantable cardioverter-defibrillator (S-ICD) because of the possibility of lead ruptures and accelerated battery depletion.<h4>Objective</h4>The aim of this study was to evaluate device-related complications over time in a large real-world multicenter S-ICD cohort.<h4>Methods</h4>Patients implanted with an S-ICD from January ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(12):2050-2058]

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Clinical characteristics and risk stratification of desmoplakin cardiomyopathy.

Weijia Wang, Brittney Murray, Crystal Tichnell, Nisha A Gilotra, Stefan L Zimmerman, Alessio Gasperetti, Paul Scheel, Harikrishna Tandri, Hugh Calkins, Cynthia A James,

<h4>Aims</h4>Desmoplakin (DSP) cardiomyopathy is an increasingly recognized form of arrhythmogenic cardiomyopathy. With a genotype-specific approach, we characterized the diagnosis, natural history, and risk for ventricular arrhythmia and heart failure in DSP cardiomyopathy.<h4>Methods and results</h4>We followed 91 individuals [45 probands, 34% male, median age 27.5 years (interquartile interval 20.0-43.9)] with pathogenic or ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, :]

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Additional diagnostic value of cardiac magnetic resonance feature tracking in patients with biopsy-proven arrhythmogenic cardiomyopathy.

Giuseppe Muscogiuri, Laura Fusini, Francesca Ricci, Rita Sicuso, Marco Guglielmo, Andrea Baggiano, Alessio Gasperetti, Michela Casella, Saima Mushtaq, Edoardo Conte, Andrea Annoni, Alberto Formenti, Maria Elisabetta Mancini, Mario Babbaro, Rocco Mollace, Ada Collevecchio, Stefano Scafuri, Deni Kukavica, Daniele Andreini, Cristina Basso, Stefania Rizzo, Monica De Gaspari, Silvia Priori, Antonio Dello Russo, Claudio Tondo, Mauro Pepi, Elena Sommariva, Mark Rabbat, Andrea Igoren Guaricci, Gianluca Pontone,

<h4>Background</h4>We aim to evaluate the value of Cardiac magnetic resonance (CMR) feature tracking (CMR-FT) in addition to Task Force Criteria(TFC) in patients with (arrhythmogenic cardiomyopathy) AC biopsy-proved.<h4>Methods</h4>Thirty-five patients with AC histologically proven who performed CMR with late gadolinium enhancement (LGE) acquisition were enrolled. The study population was divided in Group1 ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 339:203-210]

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Subcutaneous implantable cardioverter-defibrillator and defibrillation testing: A propensity-matched pilot study.

Giovanni B Forleo, Alessio Gasperetti, Alexander Breitenstein, Mikael Laredo, Marco Schiavone, Matteo Ziacchi, Julia Vogler, Danilo Ricciardi, Pietro Palmisano, Agostino Piro, Paolo Compagnucci, Xavier Waintraub, Gianfranco Mitacchione, Gianmarco Carrassa, Giulia Russo, Silvana De Bonis, Andrea Angeletti, Antonio Bisignani, Francesco Picarelli, Michela Casella, Edoardo Bressi, Giovanni Rovaris, Leonardo Calò, Luca Santini, Carlo Pignalberi, Carlo Lavalle, Maurizio Viecca, Ennio Pisanò, Iacopo Olivotto, Antonio Curnis, Antonio Dello Russo, Claudio Tondo, Charles J Love, Luigi Di Biase, Jan Steffel, Roland Tilz, Nicolas Badenco, Mauro Biffi,

<h4>Background</h4>To date, only a few comparisons between subcutaneous implantable cardioverter-defibrillator (S-ICD) patients undergoing and those not undergoing defibrillation testing (DT) at implantation (DT+ vs DT-) have been reported.<h4>Objective</h4>The purpose of this study was to compare long-term clinical outcomes of 2 propensity-matched cohorts of DT+ and DT- patients.<h4>Methods</h4>Among consecutive S-ICD patients ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(12):2072-2079]

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Anti-arrhythmic drugs in arrhythmogenic right ventricular cardiomyopathy: The importance of optimal beta-blocker dose titration.

Alessio Gasperetti, Mattia Targetti, Iacopo Olivotto,

Int J Cardiol (International journal of cardiology)
[2021, 338:150-151]

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Atrioventricular and intraventricular blocks in the setting of acute coronary syndromes: a narrative review.

Marco Schiavone, Federica Sabato, Cecilia Gobbi, Marialessia Denora, Lucrezia Zanchi, Alessio Gasperetti, Giovanni B Forleo,

Acute coronary syndromes (ACS) might be complicated by atrioventricular (AV) and intraventricular (IV) blocks in a significant number of cases, and often represent a diagnostic and a therapeutic challenge. These conduction disturbances are predictors of adverse prognosis, with complete AV blocks presenting the most severe outcomes, showing an increased in-hospital ... Read more >>

Rev Cardiovasc Med (Reviews in cardiovascular medicine)
[2021, 22(2):287-294]

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Acute heart failure in elderly patients: a review of invasive and non-invasive management.

Gregorio Tersalvi, Alessio Gasperetti, Marco Schiavone, Jeroen Dauw, Cecilia Gobbi, Marialessia Denora, Joel Daniel Krul, Giacomo Maria Cioffi, Gianfranco Mitacchione, Giovanni B Forleo,

Acute heart failure (AHF) is a major cause of unplanned hospitalisations in the elderly and is associated with high mortality. Its prevalence has grown in the last years due to population aging and longer life expectancy of chronic heart failure patients. Although international societies have provided guidelines for the management ... Read more >>

J Geriatr Cardiol (Journal of geriatric cardiology : JGC)
[2021, 18(7):560-576]

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Funding of Studies Supporting IA Guideline Recommendations in Cardiovascular Medicine-A Systematic Review.

Emily P Zeitler, Alessio Gasperetti, Shayne E Dodge, Lauren B Cooper, Aaron V Kaplan,

Each guideline recommendation from the American Heart Association and the American College of Cardiology includes an indication of the level of supporting evidence and the associated strength of recommendation with "IA" recommendations representing those with the highest quality supporting evidence and the least amount of uncertainty for benefit. In this ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(10):e019513]

Cited: 1 time

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Atrioventricular synchronous leadless pacemaker: state of art and broadened indications.

Gianfranco Mitacchione, Marco Schiavone, Alessio Gasperetti, Maurizio Viecca, Antonio Curnis, Giovanni B Forleo,

Leadless pacemakers (LLPMs) have become a major breakthrough in the management of bradyarrhythmia as an attractive alternative to the standard transvenous pacemakers (TV-PMs). Recently, the introduction of a second-generation LLPMs (Micra AV-MC1AVR1) has expanded pacing modes to obtain atrioventricular (AV) synchronous pacing, providing an interesting alternative in the actual scenario ... Read more >>

Rev Cardiovasc Med (Reviews in cardiovascular medicine)
[2021, 22(2):395-401]

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