Full Text Journal Articles by
Author Alessio Aghemo

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Return to Work After Coronavirus Disease 2019 Acute Respiratory Distress Syndrome and Intensive Care Admission: Prospective, Case Series at 6 Months From Hospital Discharge.

Luca Carenzo, Francesca Dalla Corte, Ryan W Haines, Chiara Palandri, Angelo Milani, Alessio Aghemo, Daniela Pini, Alessandro Protti, Maurizio Cecconi,

<h4>Objectives</h4>Joblessness is common in survivors from critical care. Our aim was to describe rates of return to work versus unemployment following coronavirus disease 2019 acute respiratory distress syndrome requiring intensive care admission.<h4>Design</h4>Single-center, prospective case series.<h4>Setting</h4>Critical Care Follow-Up Clinic, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy.<h4>Patients</h4>One hundred and one consecutive laboratory-confirmed ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):e1157-e1162]

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Optimizing diagnostic algorithms to advance Hepatitis C elimination in Italy: A cost effectiveness evaluation.

Andrea Marcellusi, Francesco Saverio Mennini, Murad Ruf, Claudio Galli, Alessio Aghemo, Maurizia R Brunetto, Sergio Babudieri, Antonio Craxi, Massimo Andreoni, Loreta A Kondili,

<h4>Objectives</h4>Optimized diagnostic algorithms to detect active infections are crucial to achieving HCV elimination. We evaluated the cost effectiveness and sustainability of different algorithms for HCV active infection diagnosis, in a context of a high endemic country for HCV infection.<h4>Methods</h4>A Markov disease progression model, simulating six diagnostic algorithms in the birth ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, :]

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Correction to: Real-World Outcomes in Historically Underserved Patients with Chronic Hepatitis C Infection Treated with Glecaprevir/Pibrentasvir.

Alessio Aghemo, Yves Horsmans, Stefan Bourgeois, Mark Bondin, Michael Gschwantler, Harald Hofer, Nasser Semmo, Francesco Negro, Zhenzhen Zhang, John Marcinak, Ella Veitsman, Rawi Hazzan, Konstantinos Mimidis, Ioannis Goulis, Nuno Marques, Robert Flisiak, Wlodzimierz Mazur, Carlos Roncero, Fiona Marra, Georges Philippe Pageaux, Tarik Asselah, Pietro Lampertico,

Infect Dis Ther (Infectious diseases and therapy)
[2021, :]

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Management of liver disease in Italy after one year of the SARS-CoV-2 pandemic: A web-based survey.

Francesca Romana Ponziani, Alessio Aghemo, Giuseppe Cabibbo, Mario Masarone, Sara Montagnese, Salvatore Petta, Francesco Paolo Russo, Quirino Lai, ,

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, 41(9):2228-2232]

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COVID-19 and the liver: A 2021 update.

Catherine W Spearman, Alessio Aghemo, Luca Valenti, Mark W Sonderup,

In December 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China and has since resulted in a global pandemic in excess of 165 million reported infections and 3.4 million attributable deaths. COVID-19 is primarily a respiratory illness, which may be complicated by pneumonia ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, 41(9):1988-1998]

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Clinical update on the efficacy of anti-SARS-CoV-2 mRNA vaccines in patients on the waiting list for liver transplantation and in liver transplant recipients.

Pierluigi Toniutto, Alessio Aghemo, Paolo Grossi, Patrizia Burra, ,

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2021, 53(10):1232-1234]

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Is there an 'ideal' diet for patients with NAFLD?

Nicola Pugliese, Maria Corina Plaz Torres, Salvatore Petta, Luca Valenti, Edoardo G Giannini, Alessio Aghemo,

Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic that encompasses three distinct clinical phenotypes: uncomplicated fatty liver, nonalcoholic steatohepatitis (NASH) and NASH-related cirrhosis with its complications, including hepatocellular carcinoma. To date, no pharmacological treatments have been approved and lifestyle modifications including reduced caloric intake targeting a 7%-10% weight loss ... Read more >>

Eur J Clin Invest (European journal of clinical investigation)
[2021, :e13659]

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New susceptibility loci for severe COVID-19 by detailed GWAS analysis in European populations

Frauke Degenhardt, David Ellinghaus, Simonas Juzenas, Jon Lerga-Jaso, Mareike Wendorff, Douglas Maya-Miles, Florian Uellendahl-Werth, Hesham ElAbd, Jatin Arora, Onur Özer, Ole Bernt Lenning, Ronny Myhre, May Sissel Vadla, Lars Wienbrandt, Aaron Blandino Ortiz, Adolfo de Salazar, Adolfo Garrido Chercoles, Adriana Palom, Agustín Ruiz, Alberto Mantovani, Alberto Zanella, Aleksander Rygh Holten, Alena Mayer, Alessandra Bandera, Alessandro Cherubini, Alessandro Protti, Alessio Aghemo, Alessio Gerussi, Alexander Popov, Alfredo Ramirez, Alice Braun, Almut Nebel, Ana Barreira, Ana Lleo, Ana Teles, Anders Benjamin Kildal, Andrea Biondi, Andrea Ganna, Andrea Gori, Andreas Glück, Andreas Lind, Anke Hinney, Anna Carreras Nolla, Anna Ludovica Fracanzani, Annalisa Cavallero, Anne Ma Dyrhol-Riise, Antonella Ruello, Antonio Julià, Antonio Muscatello, Antonio Pesenti, Antonio Voza, Ariadna Rando-Segura, Aurora Solier, Beatriz Cortes, Beatriz Mateos, Beatriz Nafria-Jimenez, Benedikt Schaefer, Björn Jensen, Carla Bellinghausen, Carlo Maj, Carlos Ferrando, Carmen de la Horra, Carmen Quereda, Carsten Skurk, Charlotte Thibeault, Chiara Scollo, Christian Herr, Christoph Spinner, Christoph Lange, Cinzia Hu, Clara Lehmann, Claudio Cappadona, Clinton Azuure, Cristiana Bianco, Cristina Sancho, Dag Arne Lihaug Hoff, Daniela Galimberti, Daniele Prati, David Haschka, David Jiménez, David Pestaña, David Toapanta, Eike Wacker, Elena Azzolini, Elio Scarpini, Elisa Helbig, Eloisa Urrechaga, Elvezia Maria Paraboschi, Emanuele Pontali, Enric Reverter, Enrique Calderón, Enrique Navas, Erik Solligård, Ernesto Contro, Eunate Arana, Federico Garcia, Félix García Sánchez, Ferruccio Ceriotti, Filippo Martinelli-Boneschi, Flora Peyvandi, Florian Kurth, Francesco Blasi, Francesco Malvestiti, Francisco Medrano, Francisco Mesonero, Francisco Rodriguez-Frias, Frank Hanses, Fredrik Müller, Giacomo Bellani, Giacomo Grasselli, Gianni Pezzoli, Giorgio Costantino, Giovanni Albano, Giuseppe Bellelli, Giuseppe Citerio, Giuseppe Foti, Giuseppe Lamorte, Holger Neb, Ilaria My, Ingo Kurth, Isabel Hernández, Isabell Pink, Itziar de Rojas, Iván Galván-Femenia, Jan Holter, Jan Egil Afset, Jan Heyckendorf, Jan Kristian Damås, Jan Rybniker, Janine Altmüller, Javier Ampuero, Jesus Banales, Joan Ramon Badia, Joaquin Dopazo, Jochen Schneider, Johannes Hov, Jonas Bergan, Jordi Barretina, Jörn Walter, Jose Hernández Quero, Josune Goikoetxea, Juan Delgado, Juan Guerrero, Julia Fazaal, Julia Kraft, Julia Schröder, Kari Risnes, Karina Banasik, Karl Erik Müller, Karoline Gaede, Koldo Garcia-Etxebarria, Kristian Tonby, Lars Heggelund, Laura Izquierdo-Sanchez, Laura Rachele Bettini, Lauro Sumoy, Leif Erik Sander, Lena Lippert, Leonardo Terranova, Lindokuhle Nkambule, Lisa Knopp, Lise Tuset Gustad, Lucia Garbarino, Luigi Santoro, Luis Téllez, Luisa Roade, Mahnoosh Ostadreza, Maider Intxausti, Malte Rühlemann, Manolis Kogevinas, Mar Riveiro-Barciela, Marc Berger, Mari E.K. Niemi, María Gutiérrez-Stampa, Maria Grazia Valsecchi, María Hernandez-Tejero, Maria J.G.T. Vehreschild, Maria Manunta, Mariella D’Angiò, Marina Cazzaniga, Marit Grimsrud, Marit Grimsrud, Markus Cornberg, Markus Nöthen, Marta Marquié, Massimo Castoldi, Mattia Cordioli, Maurizio Cecconi, Mauro D’Amato, Max Augustin, Melissa Tomasi, Mercè Boada, Michael Dreher, Michael Seilmaier, Michael Joannidis, Michael Wittig, Michela Mazzocco, Miguel Rodríguez-Gandía, Natale Imaz Ayo, Natalia Blay, Natalia Chueca, Nicola Montano, Nicole Ludwig, Nikolaus Marx, Nilda Martínez, Oliver Cornely, Oliver Witzke, Orazio Palmieri, Paola Faverio, Paolo Bonfanti, Paolo Tentorio, Pedro Castro, Pedro Rodrigues, Pedro Pablo España, Per Hoffmann, Philip Rosenstiel, Philipp Schommers, Phillip Suwalski, Raúl de Pablo, Ricard Ferrer, Robert Bals, Roberta Gualtierotti, Rocío Gallego-Durán, Rosa Nieto, Rossana Carpani, Rubén Morilla, Salvatore Badalamenti, Sammra Haider, Sandra Ciesek, Sandra May, Sara Bomba,

<h4>ABSTRACT</h4> Due to the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), deepening the host genetic contribution to severe COVID-19 may further improve our understanding about underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, ... Read more >>

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Virtual Biopsy for Diagnosis of Chemotherapy-Associated Liver Injuries and Steatohepatitis: A Combined Radiomic and Clinical Model in Patients with Colorectal Liver Metastases.

Guido Costa, Lara Cavinato, Chiara Masci, Francesco Fiz, Martina Sollini, Letterio Salvatore Politi, Arturo Chiti, Luca Balzarini, Alessio Aghemo, Luca di Tommaso, Francesca Ieva, Guido Torzilli, Luca Viganò,

Non-invasive diagnosis of chemotherapy-associated liver injuries (CALI) is still an unmet need. The present study aims to elucidate the contribution of radiomics to the diagnosis of sinusoidal dilatation (SinDil), nodular regenerative hyperplasia (NRH), and non-alcoholic steatohepatitis (NASH). Patients undergoing hepatectomy for colorectal metastases after chemotherapy (January 2018-February 2020) were retrospectively ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(12):]

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Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19.

Luca Carenzo, Alessandro Protti, Francesca Dalla Corte, Romina Aceto, Giacomo Iapichino, Angelo Milani, Alessandro Santini, Chiara Chiurazzi, Michele Ferrari, Enrico Heffler, Claudio Angelini, Alessio Aghemo, Michele Ciccarelli, Arturo Chiti, Theodore J Iwashyna, Margaret S Herridge, Maurizio Cecconi, ,

<h4>Background</h4>Survivors of severe COVID-19 are at risk of impaired health-related quality of life (HRQoL) and persistent physical and psychological disability after ICU and hospital discharge. The subsequent social burden is a major concern. We aimed to assess the short-term HRQoL, physical function and prevalence of post-traumatic stress symptoms of invasively ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):91]

Cited: 1 time

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Challenges on the achievement of World Health Organization goals for HCV elimination in Italy: need for a Regional programmatic approach on screening and linkage to care. Commentary.

Loreta A Kondili, Alessio Aghemo, Massimo Andreoni,

Italy has been one of the countries with the greatest burden of HCV in Western Europe and with the highest number of HCV liver-related deaths. In order to achieve HCV elimination by 2030 Italy, like many other countries, will need to succeed in tackling the undiagnosed individuals with active HCV ... Read more >>

Ann Ist Super Sanita (Annali dell'Istituto superiore di sanita)
[2021, 57(3):201-204]

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Bulevirtide for treatment of patients with HDV infection and compensated cirrhosis: A (huge?) step in the right direction.

Chiara Masetti, Alessio Aghemo,

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, 41(7):1441-1442]

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Directly acting antivirals are safe and effective in HCV positive patients aged 80 years and older: a multicenter real-life study.

Nicola Pugliese, Alessia Giorgini, Daniela Maggi, Antonio Capogreco, Clara Dibenedetto, Federica Lubrano Lobianco, Arianna Dal Buono, Sara Monico, Rossella Meli, Pier Maria Battezzati, Ana Lleo, Adriano De Santis, Massimo Zuin, Alessio Aghemo,

<b>Background</b>: Treatment of chronic Hepatitis C with directly acting antivirals (DAAs) can bring to sustained virologic response (SVR) in approximately 95% of patients. Efficacy and safety of DAAs in aging patients has not been widely analyzed. We aimed to determine safety and efficacy of DAA-based regimens in a cohort of ... Read more >>

Expert Opin Drug Saf (Expert opinion on drug safety)
[2021, 20(7):839-843]

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Real-World Outcomes in Historically Underserved Patients with Chronic Hepatitis C Infection Treated with Glecaprevir/Pibrentasvir.

Alessio Aghemo, Yves Horsmans, Stefan Bourgeois, Mark Bondin, Michael Gschwantler, Harald Hofer, Nasser Semmo, Francesco Negro, Zhenzhen Zhang, John Marcinak, Ella Veitsman, Rawi Hazzan, Konstantinos Mimidis, Ioannis Goulis, Nuno Marques, Robert Flisiak, Wlodzimierz Mazur, Carlos Roncero, Fiona Marra, Georges Philippe Pageaux, Tarik Asselah, Pietro Lampertico,

<h4>Introduction</h4>Glecaprevir/pibrentasvir is approved for treating chronic hepatitis C virus (HCV) genotypes (GT) 1-6. We evaluated real-world effectiveness, safety, and patient-reported outcomes of glecaprevir/pibrentasvir in underserved patient populations, focusing on persons who use drugs infected with HCV.<h4>Methods</h4>Data were pooled from nine countries (13 November 2017-31 January 2020). Patients had HCV GT1-6, with or without ... Read more >>

Infect Dis Ther (Infectious diseases and therapy)
[2021, :]

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The effect of COVID-19 epidemic on vital signs in hospitalized patients: a pre-post heat-map study from a large teaching hospital.

Pier Francesco Caruso, Giovanni Angelotti, Massimiliano Greco, Marco Albini, Victor Savevski, Elena Azzolini, Martina Briani, Michele Ciccarelli, Alessio Aghemo, Hayato Kurihara, Antonio Voza, Salvatore Badalamenti, Michele Lagioia, Maurizio Cecconi, ,

The Lombardy SARS-CoV-2 outbreak in February 2020 represented the beginning of COVID-19 epidemic in Italy. Hospitals were flooded by thousands of patients with bilateral pneumonia and severe respiratory, and vital sign derangements compared to the standard hospital population. We propose a new visual analysis technique using heat maps to describe ... Read more >>

J Clin Monit Comput (Journal of clinical monitoring and computing)
[2021, :]

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Outcome of Sars-COV-2-related thyrotoxicosis in survivors of Covid-19: a prospective study.

Alessandro Pizzocaro, Paolo Colombo, Walter Vena, Salvatore Ariano, Paola Magnoni, Francesco Reggiani, Giuseppe Favacchio, Marco Mirani, Elisabetta Lavezzi, Antonio Voza, Marta Calatroni, Gherardo Mazziotti, Andrea Lania, ,

<h4>Purpose</h4>To evaluate the post- coronavirus disease-19 (COVID-19) outcome of thyroid function in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related thyrotoxicosis.<h4>Methods</h4>This was a single-center prospective study involving 29 patients (11 females, 18 males; median age 64 years, range: 43-85) with thyrotoxicosis diagnosed after hospitalization for COVID-19 and then followed-up ... Read more >>

Endocrine (Endocrine)
[2021, 73(2):255-260]

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Fr492 SIGNIFICANTLY REDUCED MORTALITY IN COVID-19 PATIENTS WITH GASTROINTESTINAL MANIFESTATIONS

Alexandra E. Livanos, Francesca Cossarini, Tommaso Parigi, Katie A. Dunleavy, Rebekah E. Dixon, Divya Jha, Minami Tokuyama, Steven T. Chen, Jean Frederic Colombel, Miriam Merad, Sacha Gnjatic, Silvio Danese, Alessio Aghemo, Nikhil A. Kumta, Francesca Petralia, Saurabh Mehandru,

Gastroenterology (Gastroenterology)
[2021, 160(6):S-330-S-330]

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High prevalence of multidrug-resistant bacteria in patients with pyogenic liver abscess following liver cancer loco-regional treatments.

Francesca Colapietro, Chiara Masetti, Roberto Ceriani, Paola Morelli, Dario Poretti, Vittorio Pedicini, Nicola Pugliese, Antonio Voza, Ana Lleo, Alessio Aghemo,

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, 41(8):1909-1912]

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Milestones to reach Hepatitis C Virus (HCV) elimination in Italy: From free-of-charge screening to regional roadmaps for an HCV-free nation.

Loreta A Kondili, Alessio Aghemo, Massimo Andreoni, Massimo Galli, Alessandro Rossi, Sergio Babudieri, Felice Nava, Claudio Leonardi, Francesco Saverio Mennini, Ivan Gardini, Francesco Paolo Russo,

Although Italy has been on track for Hepatitis C Virus (HCV) elimination since 2019, it fell off track due to the decrease in the number of treated patients. HCV elimination in Italy will be possible if immediate action is taken. A health policy was implemented beginning in 2021, consisting of ... Read more >>

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2021, :]

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Critical Care Outreach Team During COVID-19: Ventilatory Support in the Ward and Outcomes.

Antonio Messina, Andrea Pradella, Valeria Alicino, Maxim Neganov, Giacomo De Mattei, Giacomo Coppalini, Katerina Negri, Elena Costantini, Alessandro Protti, Elena Azzolini, Michele Ciccarelli, Alessio Aghemo, Antonio Voza, Massimiliano Greco, Michele Lagioia, Maurizio Cecconi,

<h4>Background</h4>During the coronavirus disease 2019 (COVID-19) outbreak, a critical care outreach team was implemented in our hospital to guarantee multidisciplinary patient assessment at admission and prompt ICU support in medical wards. In this paper, we report the activity plan results and describe the baseline characteristics of the referred subjects.<h4>Methods</h4>We retrospectively ... Read more >>

Respir Care (Respiratory care)
[2021, 66(6):928-935]

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Sofosbuvir in HCV patients with chronic kidney disease: No time for caution.

Virginia Solitano, Alessio Aghemo,

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, 41(4):646-648]

Cited: 1 time

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Disease burden and economic impact of diagnosed non-alcoholic steatohepatitis in five European countries in 2018: A cost-of-illness analysis.

Jörn M Schattenberg, Jeffrey V Lazarus, Philip N Newsome, Lawrence Serfaty, Alessio Aghemo, Salvador Augustin, Emmanuel Tsochatzis, Victor de Ledinghen, Elisabetta Bugianesi, Manuel Romero-Gomez, Heike Bantel, Stephen D Ryder, Jerome Boursier, Vincent Leroy, Javier Crespo, Laurent Castera, Lefteris Floros, Vincenzo Atella, Jorge Mestre-Ferrandiz, Rachel Elliott, Achim Kautz, Alice Morgan, Sally Hartmanis, Sharad Vasudevan, Lynne Pezzullo, Aldo Trylesinski, Sandrine Cure, Victoria Higgins, Vlad Ratziu,

<h4>Background and aims</h4>Non-alcoholic steatohepatitis (NASH) is a chronic disease that can progress to end-stage liver disease (ESLD). A large proportion of early-stage NASH patients remain undiagnosed compared to those with advanced fibrosis, who are more likely to receive disease management interventions. This study estimated the disease burden and economic impact ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, 41(6):1227-1242]

Cited: 4 times

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A risk score based on baseline risk factors for predicting mortality in COVID-19 patients.

Ze Chen, Jing Chen, Jianghua Zhou, Fang Lei, Feng Zhou, Juan-Juan Qin, Xiao-Jing Zhang, Lihua Zhu, Ye-Mao Liu, Haitao Wang, Ming-Ming Chen, Yan-Ci Zhao, Jing Xie, Lijun Shen, Xiaohui Song, Xingyuan Zhang, Chengzhang Yang, Weifang Liu, Xiao Zhang, Deliang Guo, Youqin Yan, Mingyu Liu, Weiming Mao, Liming Liu, Ping Ye, Bing Xiao, Pengcheng Luo, Zixiong Zhang, Zhigang Lu, Junhai Wang, Haofeng Lu, Xigang Xia, Daihong Wang, Xiaofeng Liao, Gang Peng, Liang Liang, Jun Yang, Guohua Chen, Elena Azzolini, Alessio Aghemo, Michele Ciccarelli, Gianluigi Condorelli, Giulio G Stefanini, Xiang Wei, Bing-Hong Zhang, Xiaodong Huang, Jiahong Xia, Yufeng Yuan, Zhi-Gang She, Jiao Guo, Yibin Wang, Peng Zhang, Hongliang Li,

<h4>Background</h4>To develop a sensitive and clinically applicable risk assessment tool identifying coronavirus disease 2019 (COVID-19) patients with a high risk of mortality at hospital admission. This model would assist frontline clinicians in optimizing medical treatment with limited resources.<h4>Methods</h4>6415 patients from seven hospitals in Wuhan city were assigned to the training ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, 37(6):917-927]

Cited: 1 time

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Long COVID hallmarks on [18F]FDG-PET/CT: a case-control study

Martina Sollini, Silvia Morbelli, Michele Ciccarelli, Maurizio Cecconi, Alessio Aghemo, Paola Morelli, Silvia Chiola, Fabrizia Gelardi, Arturo Chiti,

<h4>Purpose</h4> The present study hypothesised that whole-body [18F]FDG-PET/CT might provide insight into the pathophysiology of long COVID. <h4>Methods</h4> We prospectively enrolled 13 adult long COVID patients who complained for at least one persistent symptom for >30 days after infection recovery. A group of 26 melanoma patients with negative PET/CT matched for ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, :1-11]

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Long COVID hallmarks on [18F]FDG-PET/CT: a case-control study.

Martina Sollini, Silvia Morbelli, Michele Ciccarelli, Maurizio Cecconi, Alessio Aghemo, Paola Morelli, Silvia Chiola, Fabrizia Gelardi, Arturo Chiti,

<h4>Purpose</h4>The present study hypothesised that whole-body [18F]FDG-PET/CT might provide insight into the pathophysiology of long COVID.<h4>Methods</h4>We prospectively enrolled 13 adult long COVID patients who complained for at least one persistent symptom for >30 days after infection recovery. A group of 26 melanoma patients with negative PET/CT matched for sex/age was used ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, 48(10):3187-3197]

Cited: 10 times

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