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Author Alessandro Scacchetti

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Loss of nucleosome remodelers CHRAC/ACF does not sensitize early Drosophila embryos to X-rays.

Alessandro Scacchetti, Peter B Becker,

(microPublication biology)
[2020, 2020:]

Cited: 0 times

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Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia.

Anica M Wandler, Benjamin J Huang, Jeffrey W Craig, Kathryn Hayes, Hannah Yan, Lauren K Meyer, Alessandro Scacchetti, Gabriela Monsalve, Monique Dail, Qing Li, Jasmine C Wong, Olga Weinberg, Robert P Hasserjian, Scott C Kogan, Philip Jonsson, Keith Yamamoto, Deepak Sampath, Joy Nakitandwe, James R Downing, Jinghui Zhang, Jon C Aster, Barry S Taylor, Kevin Shannon,

Despite decades of clinical use, mechanisms of glucocorticoid resistance are poorly understood. We treated primary murine T lineage acute lymphoblastic leukemias (T-ALLs) with the glucocorticoid dexamethasone (DEX) alone and in combination with the pan-PI3 kinase inhibitor GDC-0941 and observed a robust response to DEX that was modestly enhanced by GDC-0941. ... Read more >>

Leukemia (Leukemia)
[2020, 34(8):2025-2037]

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Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms

Alessandro Scacchetti, Tamas Schauer, Alexander Reim, Zivkos Apostolou, Aline Campos Sparr, Silke Krause, Patrick Heun, Michael Wierer, Peter Becker,

SUMMARY Histone acetylation and deposition of H2A.Z variant are integral aspects of active transcription. In Drosophila , the single DOMINO chromatin regulator complex is thought to combine both activities via an unknown mechanism. Here we show that alternative isoforms of the DOMINO nucleosome remodeling ATPase, DOM-A and DOM-B, directly specify ... Read more >>

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CHRAC/ACF contribute to the repressive ground state of chromatin.

Alessandro Scacchetti, Laura Brueckner, Dhawal Jain, Tamas Schauer, Xu Zhang, Frank Schnorrer, Bas van Steensel, Tobias Straub, Peter B Becker,

The chromatin remodeling complexes chromatin accessibility complex and ATP-utilizing chromatin assembly and remodeling factor (ACF) combine the ATPase ISWI with the signature subunit ACF1. These enzymes catalyze well-studied nucleosome sliding reactions in vitro, but how their actions affect physiological gene expression remains unclear. Here, we explored the influence of Drosophila ... Read more >>

Life Sci Alliance (Life science alliance)
[2018, 1(1):e201800024]

Cited: 2 times

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CHRAC/ACF Contribute to the Repressive Ground State of Chromatin

Alessandro Scacchetti, Laura Brueckner, Dhawal Jain, Tamas Schauer, Xu Zhang, Frank Schnorrer, Bas van Steensel, Tobias Straub, Peter Becker,

ABSTRACT The chromatin remodeling complexes CHRAC and ACF combine the ATPase ISWI with the signature subunit ACF1. These enzymes catalyze well-studied nucleosome sliding reactions in vitro , but how their actions affect physiological gene expression is unclear. Here we explored the influence of Drosophila CHRAC/ACF on transcription by complementary gain- ... Read more >>

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