Full Text Journal Articles by
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Return to Work After Coronavirus Disease 2019 Acute Respiratory Distress Syndrome and Intensive Care Admission: Prospective, Case Series at 6 Months From Hospital Discharge.

Luca Carenzo, Francesca Dalla Corte, Ryan W Haines, Chiara Palandri, Angelo Milani, Alessio Aghemo, Daniela Pini, Alessandro Protti, Maurizio Cecconi,

<h4>Objectives</h4>Joblessness is common in survivors from critical care. Our aim was to describe rates of return to work versus unemployment following coronavirus disease 2019 acute respiratory distress syndrome requiring intensive care admission.<h4>Design</h4>Single-center, prospective case series.<h4>Setting</h4>Critical Care Follow-Up Clinic, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy.<h4>Patients</h4>One hundred and one consecutive laboratory-confirmed ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):e1157-e1162]

Cited: 1 time

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Lung response to a higher positive end-expiratory pressure in mechanically ventilated patients with COVID-19

Alessandro Protti, Alessandro Santini, Francesca Pennati, Chiara Chiurazzi, Massimo Cressoni, Michele Ferrari, Giacomo E. Iapichino, Luca Carenzo, Ezio Lanza, Giorgio Picardo, Pietro Caironi, Andrea Aliverti, Maurizio Cecconi,

<h4>Background</h4> International guidelines suggest using a higher (>10 cmH2O) positive end-expiratory pressure (PEEP) in patients with moderate-to-severe acute respiratory distress syndrome (ARDS) due to the novel coronavirus disease (COVID-19). However, even if oxygenation generally improves with a higher PEEP, compliance and arterial carbon dioxide tension (PaCO2) frequently do not, as ... Read more >>

Chest (Chest)
[2021, :]

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A PTX3/LDH/CRP signature correlates with lung injury CTs scan severity and disease progression in paucisymptomatic COVID-19

Marco Folci, Enrico Brunetta, Ezio Lanza, Barbara Bottazzi, Alessandro Protti, Gaia Messana, Costanza Lisi, Roberto Leone, Marina Sironi, Elena Generali, Stefano Rodolfi, Michele Sagasta, Antonio Voza, Michele Ciccarelli, Cecilia Garlanda, Luca Balzarini, Alberto Mantovani, Maurizio Cecconi, ,

<h4>Background</h4> Quantitative CT (QCT) analysis is an invaluable diagnostic tool to assess lung injury and predict prognosis of patients affected by COVID-19 pneumonia. PTX3 was recently described as one of the most reliable serological predictors of clinical deterioration and short-term mortality. The present study was designed to evaluate a correlation ... Read more >>

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Synergistic Effect of Static Compliance and D-dimers to Predict Outcome of Patients with COVID-19-ARDS: A Prospective Multicenter Study.

Tommaso Tonetti, Giacomo Grasselli, Paola Rucci, Francesco Alessandri, Alessio Dell'Olio, Annalisa Boscolo, Laura Pasin, Nicolò Sella, Chiara Mega, Rita Maria Melotti, Massimo Girardis, Stefano Busani, Giacomo Bellani, Giuseppe Foti, Domenico Luca Grieco, Vittorio Scaravilli, Alessandro Protti, Thomas Langer, Luciana Mascia, Francesco Pugliese, Maurizio Cecconi, Roberto Fumagalli, Stefano Nava, Massimo Antonelli, Arthur S Slutsky, Paolo Navalesi, Antonio Pesenti, Vito Marco Ranieri,

The synergic combination of D-dimer (as proxy of thrombotic/vascular injury) and static compliance (as proxy of parenchymal injury) in predicting mortality in COVID-19-ARDS has not been systematically evaluated. The objective is to determine whether the combination of elevated D-dimer and low static compliance can predict mortality in patients with COVID-19-ARDS. ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(9):]

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Time course of risk factors associated with mortality of 1260 critically ill patients with COVID-19 admitted to 24 Italian intensive care units.

Alberto Zanella, Gaetano Florio, Massimo Antonelli, Giacomo Bellani, Angela Berselli, Tiziana Bove, Luca Cabrini, Eleonora Carlesso, Gian Paolo Castelli, Maurizio Cecconi, Giuseppe Citerio, Irene Coloretti, Daniele Corti, Francesca Dalla Corte, Edoardo De Robertis, Giuseppe Foti, Roberto Fumagalli, Massimo Girardis, Riccardo Giudici, Lorenzo Guiotto, Thomas Langer, Lucia Mirabella, Daniela Pasero, Alessandro Protti, Marco V Ranieri, Roberto Rona, Luigia Scudeller, Paolo Severgnini, Savino Spadaro, Nino Stocchetti, Martina Viganò, Antonio Pesenti, Giacomo Grasselli, ,

<h4>Purpose</h4>To evaluate the daily values and trends over time of relevant clinical, ventilatory and laboratory parameters during the intensive care unit (ICU) stay and their association with outcome in critically ill patients with coronavirus disease 19 (COVID-19).<h4>Methods</h4>In this retrospective-prospective multicentric study, we enrolled COVID-19 patients admitted to Italian ICUs from ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(9):995-1008]

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Variations in end-of-life practices in intensive care units worldwide (Ethicus-2): a prospective observational study.

Alexander Avidan, Charles L Sprung, Joerg C Schefold, Bara Ricou, Christiane S Hartog, Joseph L Nates, Ulrich Jaschinski, Suzana M Lobo, Gavin M Joynt, Olivier Lesieur, Manfred Weiss, Massimo Antonelli, Hans-Henrik Bülow, Maria G Bocci, Annette Robertsen, Matthew H Anstey, Belén Estébanez-Montiel, Alexandre Lautrette, Anastasiia Gruber, Angel Estella, Sudakshina Mullick, Roshni Sreedharan, Andrej Michalsen, Charles Feldman, Kai Tisljar, Martin Posch, Steven Ovu, Barbara Tamowicz, Alexandre Demoule, Freda DeKeyser Ganz, Hans Pargger, Alberto Noto, Philipp Metnitz, Laszlo Zubek, Veronica de la Guardia, Christopher M Danbury, Orsolya Szűcs, Alessandro Protti, Mario Filipe, Steven Q Simpson, Cameron Green, Alberto M Giannini, Ivo W Soliman, Claudio Piras, Eliana B Caser, Manuel Hache-Marliere, Spyros D Mentzelopoulos, ,

<h4>Background</h4>End-of-life practices vary among intensive care units (ICUs) worldwide. Differences can result in variable use of disproportionate or non-beneficial life-sustaining interventions across diverse world regions. This study investigated global disparities in end-of-life practices.<h4>Methods</h4>In this prospective, multinational, observational study, consecutive adult ICU patients who died or had a limitation of life-sustaining ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(10):1101-1110]

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Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study.

Tài Pham, Antonio Pesenti, Giacomo Bellani, Gordon Rubenfeld, Eddy Fan, Guillermo Bugedo, José Angel Lorente, Antero do Vale Fernandes, Frank Van Haren, Alejandro Bruhn, Fernando Rios, Andres Esteban, Luciano Gattinoni, Anders Larsson, Daniel F McAuley, Marco Ranieri, B Taylor Thompson, Hermann Wrigge, Laurent J Brochard, John G Laffey, ,

<h4>Background</h4>Current incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS).<h4>Methods</h4>An international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(6):]

Cited: 6 times

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New susceptibility loci for severe COVID-19 by detailed GWAS analysis in European populations

Frauke Degenhardt, David Ellinghaus, Simonas Juzenas, Jon Lerga-Jaso, Mareike Wendorff, Douglas Maya-Miles, Florian Uellendahl-Werth, Hesham ElAbd, Jatin Arora, Onur Özer, Ole Bernt Lenning, Ronny Myhre, May Sissel Vadla, Lars Wienbrandt, Aaron Blandino Ortiz, Adolfo de Salazar, Adolfo Garrido Chercoles, Adriana Palom, Agustín Ruiz, Alberto Mantovani, Alberto Zanella, Aleksander Rygh Holten, Alena Mayer, Alessandra Bandera, Alessandro Cherubini, Alessandro Protti, Alessio Aghemo, Alessio Gerussi, Alexander Popov, Alfredo Ramirez, Alice Braun, Almut Nebel, Ana Barreira, Ana Lleo, Ana Teles, Anders Benjamin Kildal, Andrea Biondi, Andrea Ganna, Andrea Gori, Andreas Glück, Andreas Lind, Anke Hinney, Anna Carreras Nolla, Anna Ludovica Fracanzani, Annalisa Cavallero, Anne Ma Dyrhol-Riise, Antonella Ruello, Antonio Julià, Antonio Muscatello, Antonio Pesenti, Antonio Voza, Ariadna Rando-Segura, Aurora Solier, Beatriz Cortes, Beatriz Mateos, Beatriz Nafria-Jimenez, Benedikt Schaefer, Björn Jensen, Carla Bellinghausen, Carlo Maj, Carlos Ferrando, Carmen de la Horra, Carmen Quereda, Carsten Skurk, Charlotte Thibeault, Chiara Scollo, Christian Herr, Christoph Spinner, Christoph Lange, Cinzia Hu, Clara Lehmann, Claudio Cappadona, Clinton Azuure, Cristiana Bianco, Cristina Sancho, Dag Arne Lihaug Hoff, Daniela Galimberti, Daniele Prati, David Haschka, David Jiménez, David Pestaña, David Toapanta, Eike Wacker, Elena Azzolini, Elio Scarpini, Elisa Helbig, Eloisa Urrechaga, Elvezia Maria Paraboschi, Emanuele Pontali, Enric Reverter, Enrique Calderón, Enrique Navas, Erik Solligård, Ernesto Contro, Eunate Arana, Federico Garcia, Félix García Sánchez, Ferruccio Ceriotti, Filippo Martinelli-Boneschi, Flora Peyvandi, Florian Kurth, Francesco Blasi, Francesco Malvestiti, Francisco Medrano, Francisco Mesonero, Francisco Rodriguez-Frias, Frank Hanses, Fredrik Müller, Giacomo Bellani, Giacomo Grasselli, Gianni Pezzoli, Giorgio Costantino, Giovanni Albano, Giuseppe Bellelli, Giuseppe Citerio, Giuseppe Foti, Giuseppe Lamorte, Holger Neb, Ilaria My, Ingo Kurth, Isabel Hernández, Isabell Pink, Itziar de Rojas, Iván Galván-Femenia, Jan Holter, Jan Egil Afset, Jan Heyckendorf, Jan Kristian Damås, Jan Rybniker, Janine Altmüller, Javier Ampuero, Jesus Banales, Joan Ramon Badia, Joaquin Dopazo, Jochen Schneider, Johannes Hov, Jonas Bergan, Jordi Barretina, Jörn Walter, Jose Hernández Quero, Josune Goikoetxea, Juan Delgado, Juan Guerrero, Julia Fazaal, Julia Kraft, Julia Schröder, Kari Risnes, Karina Banasik, Karl Erik Müller, Karoline Gaede, Koldo Garcia-Etxebarria, Kristian Tonby, Lars Heggelund, Laura Izquierdo-Sanchez, Laura Rachele Bettini, Lauro Sumoy, Leif Erik Sander, Lena Lippert, Leonardo Terranova, Lindokuhle Nkambule, Lisa Knopp, Lise Tuset Gustad, Lucia Garbarino, Luigi Santoro, Luis Téllez, Luisa Roade, Mahnoosh Ostadreza, Maider Intxausti, Malte Rühlemann, Manolis Kogevinas, Mar Riveiro-Barciela, Marc Berger, Mari E.K. Niemi, María Gutiérrez-Stampa, Maria Grazia Valsecchi, María Hernandez-Tejero, Maria J.G.T. Vehreschild, Maria Manunta, Mariella D’Angiò, Marina Cazzaniga, Marit Grimsrud, Marit Grimsrud, Markus Cornberg, Markus Nöthen, Marta Marquié, Massimo Castoldi, Mattia Cordioli, Maurizio Cecconi, Mauro D’Amato, Max Augustin, Melissa Tomasi, Mercè Boada, Michael Dreher, Michael Seilmaier, Michael Joannidis, Michael Wittig, Michela Mazzocco, Miguel Rodríguez-Gandía, Natale Imaz Ayo, Natalia Blay, Natalia Chueca, Nicola Montano, Nicole Ludwig, Nikolaus Marx, Nilda Martínez, Oliver Cornely, Oliver Witzke, Orazio Palmieri, Paola Faverio, Paolo Bonfanti, Paolo Tentorio, Pedro Castro, Pedro Rodrigues, Pedro Pablo España, Per Hoffmann, Philip Rosenstiel, Philipp Schommers, Phillip Suwalski, Raúl de Pablo, Ricard Ferrer, Robert Bals, Roberta Gualtierotti, Rocío Gallego-Durán, Rosa Nieto, Rossana Carpani, Rubén Morilla, Salvatore Badalamenti, Sammra Haider, Sandra Ciesek, Sandra May, Sara Bomba,

<h4>ABSTRACT</h4> Due to the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), deepening the host genetic contribution to severe COVID-19 may further improve our understanding about underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, ... Read more >>

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Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19.

Luca Carenzo, Alessandro Protti, Francesca Dalla Corte, Romina Aceto, Giacomo Iapichino, Angelo Milani, Alessandro Santini, Chiara Chiurazzi, Michele Ferrari, Enrico Heffler, Claudio Angelini, Alessio Aghemo, Michele Ciccarelli, Arturo Chiti, Theodore J Iwashyna, Margaret S Herridge, Maurizio Cecconi, ,

<h4>Background</h4>Survivors of severe COVID-19 are at risk of impaired health-related quality of life (HRQoL) and persistent physical and psychological disability after ICU and hospital discharge. The subsequent social burden is a major concern. We aimed to assess the short-term HRQoL, physical function and prevalence of post-traumatic stress symptoms of invasively ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):91]

Cited: 1 time

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Paradoxical Effect of Chest Wall Compression on Respiratory System Compliance: A Multicenter Case Series of Patients With ARDS, With Multimodal Assessment.

Emanuele Rezoagli, Luca Bastia, Alice Grassi, Arturo Chieregato, Thomas Langer, Giacomo Grasselli, Pietro Caironi, Andrea Pradella, Alessandro Santini, Alessandro Protti, Roberto Fumagalli, Giuseppe Foti, Giacomo Bellani,

Chest (Chest)
[2021, 160(4):1335-1339]

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Artificial Intelligence to Predict Mortality in Critically ill COVID-19 Patients Using Data from the First 24h: A Case Study from Lombardy Outbreak

Massimiliano Greco, Giovanni Angelotti, Pier Francesco Caruso, Alberto Zanella, Niccolò Stomeo, Elena Costantini, Alessandro Protti, Antonio Pesenti, Giacomo Grasselli, Maurizio Cecconi,

<h4>Introduction: </h4> SARS-CoV-2 infection was first identified at the end of 2019 in China, and subsequently spread globally. COVID-19 disease frequently affects the lungs leading to bilateral viral pneumonia, progressing in some cases to severe respiratory failure requiring ICU admission and mechanical ventilation. Risk stratification at ICU admission is fundamental ... Read more >>

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Critical Care Outreach Team During COVID-19: Ventilatory Support in the Ward and Outcomes.

Antonio Messina, Andrea Pradella, Valeria Alicino, Maxim Neganov, Giacomo De Mattei, Giacomo Coppalini, Katerina Negri, Elena Costantini, Alessandro Protti, Elena Azzolini, Michele Ciccarelli, Alessio Aghemo, Antonio Voza, Massimiliano Greco, Michele Lagioia, Maurizio Cecconi,

<h4>Background</h4>During the coronavirus disease 2019 (COVID-19) outbreak, a critical care outreach team was implemented in our hospital to guarantee multidisciplinary patient assessment at admission and prompt ICU support in medical wards. In this paper, we report the activity plan results and describe the baseline characteristics of the referred subjects.<h4>Methods</h4>We retrospectively ... Read more >>

Respir Care (Respiratory care)
[2021, 66(6):928-935]

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Death in hospital following ICU discharge: insights from the LUNG SAFE study.

Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, John G Laffey, Giacomo Bellani, , ,

<h4>Background</h4>To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward.<h4>Methods</h4>The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):144]

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Response from Authors.

Valerio Rendiniello, Manuela Mainetti, Luca Carenzo, Daniela Elli, Elena Costantini, Alessandro Protti, Federica Sartori, Maurizio Cecconi,

Intensive Crit Care Nurs (Intensive & critical care nursing)
[2021, 65:103053]

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Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients.

Thomas Langer, Matteo Brioni, Amedeo Guzzardella, Eleonora Carlesso, Luca Cabrini, Gianpaolo Castelli, Francesca Dalla Corte, Edoardo De Robertis, Martina Favarato, Andrea Forastieri, Clarissa Forlini, Massimo Girardis, Domenico Luca Grieco, Lucia Mirabella, Valentina Noseda, Paola Previtali, Alessandro Protti, Roberto Rona, Francesca Tardini, Tommaso Tonetti, Fabio Zannoni, Massimo Antonelli, Giuseppe Foti, Marco Ranieri, Antonio Pesenti, Roberto Fumagalli, Giacomo Grasselli, ,

<h4>Background</h4>Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave.<h4>Methods</h4>Retrospective, multicentre, national cohort study conducted between February 24 ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):128]

Cited: 7 times

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Extubate Before Venovenous Extracorporeal Membranous Oxygenation Decannulation or Decannulate While Remaining on the Ventilator? The EuroELSO 2019 Weaning Survey.

Justyna Swol, Justyna Swol, Kiran Shekar, Alessandro Protti, Monika Tukacs, Lars Mikael Broman, Nicholas A Barrett, Thomas Mueller, Giles J Peek, Hergen Buscher,

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(4):e86-e89]

Cited: 1 time

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Mini fluid chAllenge aNd End-expiratory occlusion test to assess flUid responsiVEness in the opeRating room (MANEUVER study): A multicentre cohort study.

Antonio Messina, Giulia Lionetti, Lorenzo Foti, Enrico Bellotti, Nicole Marcomini, Gianmaria Cammarota, Victoria Bennett, Laura Saderi, Giovanni Sotgiu, Francesco Della Corte, Alessandro Protti, Manuel I Monge García, Stefano Romagnoli, Maurizio Cecconi,

<h4>Background</h4>The fluid challenge response in surgical patients can be predicted by functional haemodynamic tests. Two tests, the mini-fluid challenge (mini-FC) and end-expiratory occlusion test (EEOT), have been assessed in a few small single-centre studies with conflicting results. In general, functional haemodynamic tests have not performed reliably in predicting fluid responsiveness ... Read more >>

Eur J Anaesthesiol (European journal of anaesthesiology)
[2021, 38(4):422-431]

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Extracorporeal life support in COVID-19-related acute respiratory distress syndrome: A EuroELSO international survey.

Sebastian Mang, Armin Kalenka, Lars Mikael Broman, Alexander Supady, Justyna Swol, Guy Danziger, André Becker, Sabrina I Hörsch, Thilo Mertke, Ralf Kaiser, Hendrik Bracht, Viviane Zotzmann, Frederik Seiler, Robert Bals, Fabio Silvio Taccone, Onnen Moerer, Roberto Lorusso, Jan Bělohlávek, Ralf M Muellenbach, Philipp M Lepper, ,

Extracorporeal life support (ECLS) is a means to support patients with acute respiratory failure. Initially, recommendations to treat severe cases of pandemic coronavirus disease 2019 (COVID-19) with ECLS have been restrained. In the meantime, ECLS has been shown to produce similar outcomes in patients with severe COVID-19 compared to existing ... Read more >>

Artif Organs (Artificial organs)
[2021, 45(5):495-505]

Cited: 2 times

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Circulating pentraxin 3 in severe COVID-19 or other pulmonary sepsis.

Alessandro Protti, Jennifer Meessen, Barbara Bottazzi, Cecilia Garlanda, Angelo Milani, Monica Bacci, Alberto Mantovani, Maurizio Cecconi, Roberto Latini, Pietro Caironi,

Eur J Clin Invest (European journal of clinical investigation)
[2021, 51(5):e13530]

Cited: 1 time

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Family access to critically ill patients with COVID-19: a noble but demanding goal.

Alessandro Protti, Virginia Porta, Paolo Severgnini, Gianpaola Monti, Nicola Bottino, Egle Rondelli, Marco Dei Poli, Nino Stocchetti, ,

Minerva Anestesiol (Minerva anestesiologica)
[2021, 87(8):956-958]

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Barotrauma in mechanically ventilated patients with Coronavirus disease 2019: a survey of 38 hospitals in Lombardy, Italy.

Alessandro Protti, Massimiliano Greco, Matteo Filippini, Anna M Vilardo, Thomas Langer, Martina Villa, Fernando Frutos-Vivar, Alessandro Santini, Pier F Caruso, Sofia Spano, Antonio Anzueto, Giuseppe Citerio, Giacomo Bellani, Giuseppe Foti, Roberto Fumagalli, Antonio Pesenti, Giacomo Grasselli, Maurizio Cecconi,

<h4>Background</h4>The aim was to describe the incidence and risk factors of barotrauma in patients with the Coronavirus disease 2019 (COVID-19) on invasive mechanical ventilation, during the outbreak in our region (Lombardy, Italy).<h4>Methods</h4>The study was an electronic survey open from March 27<sup>th</sup> to May 2<sup>nd</sup>, 2020. Patients with COVID-19 who developed ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2021, 87(2):193-198]

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Prone Position in Intubated, Mechanically Ventilated Patients with Coronavirus Disease-19.

Thomas Langer, Matteo Brioni, Amedeo Guzzardella, Eleonora Carlesso, Luca Cabrini, Gianpaolo Castelli, Francesca Dalla Corte, Edoardo De Robertis, Martina Favarato, Andrea Forastieri, Clarissa Forlini, Massimo Girardis, Domenico Luca Grieco, Lucia Mirabella, Valentina Noseda, Paola Previtali, Alessandro Protti, Roberto Rona, Francesca Tardini, Tommaso Tonetti, Fabio Zannoni, Massimo Antonelli, Giuseppe Foti, Marco Ranieri, Antonio Pesenti, Roberto Fumagalli, Giacomo GRASSELLI,

<h4>Background: </h4> Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave. <h4>Methods: </h4>: Retrospective, multicentre, national cohort ... Read more >>

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Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19.

Enrico Brunetta, Marco Folci, Barbara Bottazzi, Maria De Santis, Giuseppe Gritti, Alessandro Protti, Sarah N Mapelli, Stefanos Bonovas, Daniele Piovani, Roberto Leone, Ilaria My, Veronica Zanon, Gianmarco Spata, Monica Bacci, Domenico Supino, Silvia Carnevale, Marina Sironi, Sadaf Davoudian, Clelia Peano, Francesco Landi, Fabiano Di Marco, Federico Raimondi, Andrea Gianatti, Claudio Angelini, Alessandro Rambaldi, Cecilia Garlanda, Michele Ciccarelli, Maurizio Cecconi, Alberto Mantovani,

Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation<sup>1-3</sup>. The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)<sup>4-7</sup>. RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell ... Read more >>

Nat Immunol (Nature immunology)
[2021, 22(1):19-24]

Cited: 19 times

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Increased ratio of P[v-a]CO2 to C[a-v]O2 without global hypoxia: the case of metformin-induced lactic acidosis.

Davide T Andreis, Jihad Mallat, Mauro Tettamanti, Carlo Chiarla, Ivo Giovannini, Stefano Gatti, Alessandro Protti,

The ratio of venoarterial CO<sub>2</sub> tension to arteriovenous O<sub>2</sub> content difference (P[v-a]CO<sub>2</sub>/C[a-v]O<sub>2</sub>) increases when lactic acidosis is due to inadequate oxygen supply (hypoxia); we aimed to verify whether it also increases when lactic acidosis develops because of mitochondrial dysfunction (dysoxia) with constant oxygen delivery. Twelve anaesthetised, mechanically ventilated pigs were ... Read more >>

Respir Physiol Neurobiol (Respiratory physiology & neurobiology)
[2021, 285:103586]

Cited: 1 time

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Management of critically ill patients with COVID-19: suggestions and instructions from the coordination of intensive care units of Lombardy.

Giuseppe Foti, Alberto Giannini, Nicola Bottino, Gian Paolo Castelli, Maurizio Cecconi, Giacomo Grasselli, Luca Guatteri, Nicola Latronico, Thomas Langer, Giacomo Monti, Stefano Muttini, Antonio Pesenti, Danilo Radrizzani, Marco Ranucci, Vincenzo Russotto, Roberto Fumagalli, ,

With 63,098 confirmed cases on 17 April 2020 and 11,384 deaths, Lombardy has been the most affected region in Italy by coronavirus disease 2019 (COVID-19). To cope with this emergency, the COVID-19 Lombardy intensive care units (ICU) network was created. The network identified the need of defining a list of ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2020, 86(11):1234-1245]

Cited: 3 times

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