Full Text Journal Articles by
Author Alessandro Loppini

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Breaking down calcium timing in heterogenous cells populations.

Alessandro Loppini, Christian Cherubini, Marta Bertolaso, Simonetta Filippi,

Calcium controls a large number of cellular processes at different scales. Decades of studies have pointed out the importance of calcium signaling in regulating differentiation, apoptosis, mitosis and functions such as secretion, muscle contraction and memory. The space-time structure of calcium signaling is central to this complex regulation. In particular, ... Read more >>

BioSystems (Bio Systems)
[2020, 191-192:104117]

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Spatiotemporal correlation uncovers characteristic lengths in cardiac tissue.

Alessandro Loppini, Alessio Gizzi, Christian Cherubini, Elizabeth M Cherry, Flavio H Fenton, Simonetta Filippi,

Complex spatiotemporal patterns of action potential duration have been shown to occur in many mammalian hearts due to period-doubling bifurcations that develop with increasing frequency of stimulation. Here, through high-resolution optical mapping experiments and mathematical modeling, we introduce a characteristic spatial length of cardiac activity in canine ventricular wedges via ... Read more >>

Phys Rev E (Physical review. E)
[2019, 100(2-1):020201]

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Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD.

Martina Nicoletti, Alessandro Loppini, Letizia Chiodo, Viola Folli, Giancarlo Ruocco, Simonetta Filippi,

C. elegans neuronal system constitutes the ideal framework for studying simple, yet realistic, neuronal activity, since the whole nervous system is fully characterized with respect to the exact number of neurons and the neuronal connections. Most recent efforts are devoted to investigate and clarify the signal processing and functional connectivity, ... Read more >>

PLoS One (PloS one)
[2019, 14(7):e0218738]

Cited: 2 times

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Critical transitions in heterogeneous networks: Loss of low-degree nodes as an early warning signal.

Alessandro Loppini, Simonetta Filippi, H Eugene Stanley,

A large number of real networks show abrupt phase transition phenomena in response to environmental changes. In this case, cascading phenomena can induce drastic and discontinuous changes in the system state and lead to collapse. Although complex network theory has been used to investigate these drastic events, we are still ... Read more >>

Phys Rev E (Physical review. E)
[2019, 99(4-1):040301]

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Gap-junction coupling can prolong beta-cell burst period by an order of magnitude via phantom bursting.

Alessandro Loppini, Morten Gram Pedersen,

Pancreatic β-cells show multiple intrinsic modes of oscillation with bursting electrical activity playing a crucial role. Bursting is seen both in experimentally isolated β-cells as well as in electrically coupled cells in the pancreatic islets, but the burst period is typically an order of magnitude greater in coupled cells. This ... Read more >>

Chaos (Chaos (Woodbury, N.Y.))
[2018, 28(6):063111]

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Systems Biology Modeling of Nonlinear Cancer Dynamics.

Christian Cherubini, Simonetta Filippi, Alessandro Loppini,

Systems Biology represents nowadays a promising standard framework for natural and human sciences to attack complicated problems involving Life. Here a particular application of such a program is discussed in the case of Cancer, by using a basic toy model for solid tumor spread for framing together two apparently different ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2018, 1702:203-213]

Cited: 1 time

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Towards a comprehensive understanding of emerging dynamics and function of pancreatic islets: A complex network approach: Comment on "Network science of biological systems at different scales: A review" by Gosak et al.

Alessandro Loppini,

Phys Life Rev (Physics of life reviews)
[2018, 24:140-142]

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Mathematical modeling of gap junction coupling and electrical activity in human β-cells.

Alessandro Loppini, Matthias Braun, Simonetta Filippi, Morten Gram Pedersen,

Coordinated insulin secretion is controlled by electrical coupling of pancreatic β-cells due to connexin-36 gap junctions. Gap junction coupling not only synchronizes the heterogeneous β-cell population, but can also modify the electrical behavior of the cells. These phenomena have been widely studied with mathematical models based on data from mouse ... Read more >>

Phys Biol (Physical biology)
[2015, 12(6):066002]

Cited: 4 times

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Role of topology in complex functional networks of beta cells.

Christian Cherubini, Simonetta Filippi, Alessio Gizzi, Alessandro Loppini,

The activity of pancreatic β cells can be described by biological networks of coupled nonlinear oscillators that, via electrochemical synchronization, release insulin in response to augmented glucose levels. In this work, we analyze the emergent behavior of regular and percolated β-cells clusters through a stochastic mathematical model where "functional" networks ... Read more >>

Phys Rev E Stat Nonlin Soft Matter Phys (Physical review. E, Statistical, nonlinear, and soft matter physics)
[2015, 92(4):042702]

Cited: 1 time

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The role of coherence in emergent behavior of biological systems.

Marta Bertolaso, Antonio Capolupo, Christian Cherubini, Simonetta Filippi, Alessio Gizzi, Alessandro Loppini, Giuseppe Vitiello,

In his research activity, Emilio Del Giudice explored the possibility to move towards a unified view of some long-range dynamics in nature, ranging from quantum field theory in physics up to biology. Such a view is adopted in this contribution by discussing a mathematical model for synchronized electrical behavior of ... Read more >>

Electromagn Biol Med (Electromagnetic biology and medicine)
[2015, 34(2):138-140]

Cited: 2 times

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