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Author Alessandra Pigni

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Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients.

Francesca Colombo, Giulia Pintarelli, Antonella Galvan, Sara Noci, Oscar Corli, Frank Skorpen, Pål Klepstad, Stein Kaasa, Alessandra Pigni, Cinzia Brunelli, Anna Roberto, Rocco Piazza, Alessandra Pirola, Carlo Gambacorti-Passerini, Augusto Tommaso Caraceni,

Nausea and vomiting are often associated with opioid analgesia in cancer patients; however, only a subset of patients develop such side effects. Here, we tested the hypothesis that the occurrence of nausea and vomiting is modulated by the genetic background of the patients. Whole exome sequencing of DNA pools from ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):542]

Cited: 0 times

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Effect of Opioid Exposure on Efficacy and Tolerability of Sublingual Fentanyl and Subcutaneous Morphine for Severe Cancer Pain Episodes. Secondary Analysis From a Double-Blind Double-Dummy, Randomized Trial.

Francesca Ricchini, Augusto Caraceni, Ernesto Zecca, Alessandra Pigni, Fabio Centurioni, Andrea Manzoni, Stein Kaasa, Cinzia Brunelli,

CONTEXT:Few studies have addressed the impact of previous opioid exposure on the effect of opioids for the treatment of severe cancer pain episodes. OBJECTIVES:We aimed to test whether previous exposure to higher opioid doses was associated with a reduced analgesic effect of fentanyl sublingual tablets (FST) and subcutaneous morphine (SCM) ... Read more >>

J Pain Symptom Manage (Journal of pain and symptom management)
[2019, 58(4):587-595]

Cited: 0 times

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Depression-A Major Contributor to Poor Quality of Life in Patients With Advanced Cancer.

Kjersti S Grotmol, Hanne C Lie, Marianne J Hjermstad, Nina Aass, David Currow, Stein Kaasa, Torbjørn Å Moum, Alessandra Pigni, Jon Håvard Loge, ,

CONTEXT:Quality of life (QoL) and depression are important patient-reported outcomes in cancer care. However, the relative importance of depression severity in predicting QoL remains unclear because of few methodologically sound studies. OBJECTIVES:To examine whether depression contributes to impairment of QoL irrespective of prognostic factors and symptom burden. METHODS:A total of ... Read more >>

J Pain Symptom Manage (Journal of pain and symptom management)
[2017, 54(6):889-897]

Cited: 2 times

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Fentanyl Sublingual Tablets Versus Subcutaneous Morphine for the Management of Severe Cancer Pain Episodes in Patients Receiving Opioid Treatment: A Double-Blind, Randomized, Noninferiority Trial.

Ernesto Zecca, Cinzia Brunelli, Fabio Centurioni, Andrea Manzoni, Alessandra Pigni, Augusto Caraceni,

Purpose Fentanyl sublingual tablets (FST) are a potentially useful alternative to parenteral opioids such as subcutaneous morphine (SCM) to treat severe cancer pain episodes. No direct comparison between FST and SCM is available. The aim of this study was to test noninferiority of FST versus SCM during the first 30 ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2017, 35(7):759-765]

Cited: 3 times

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Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS).

Sebastiano Mercadante, Paolo Marchetti, Arturo Cuomo, Augusto Caraceni, Rocco Domenico Mediati, Massimo Mammucari, Silvia Natoli, Marzia Lazzari, Mario Dauri, Mario Airoldi, Giuseppe Azzarello, Mauro Bandera, Livio Blasi, Giacomo Cartenì, Bruno Chiurazzi, Benedetta Veruska Pierpaola Costanzo, Daniela Degiovanni, Flavio Fusco, Vittorio Guardamagna, Vincenzo Iaffaioli, Simeone Liguori, Vito Lorusso, Sergio Mameli, Rodolfo Mattioli, Teresita Mazzei, Rita Maria Melotti, Valentino Menardo, Danilo Miotti, Stefano Moroso, Stefano De Santis, Remo Orsetti, Alfonso Papa, Sergio Ricci, Alessandro Fabrizio Sabato, Elvira Scelzi, Michele Sofia, Giuseppe Tonini, Federica Aielli, Alessandro Valle, ,

INTRODUCTION:An ongoing national multicenter survey [Italian Oncologic Pain multiSetting Multicentric Survey (IOPS-MS)] is evaluating the characteristics of breakthrough cancer pain (BTP) in different clinical settings. Preliminary data from the first 1500 cancer patients with BTP enrolled in this study are presented here. METHODS:Thirty-two clinical centers are involved in the survey. ... Read more >>

Adv Ther (Advances in therapy)
[2017, 34(1):120-135]

Cited: 7 times

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Evidence on the analgesic role of bisphosphonates and denosumab in the treatment of pain due to bone metastases: A systematic review within the European Association for Palliative Care guidelines project.

Josep Porta-Sales, Cristina Garzón-Rodríguez, Silvia Llorens-Torromé, Cinzia Brunelli, Alessandra Pigni, Augusto Caraceni,

Bisphosphonates and denosumab are well-established therapies to reduce the frequency and severity of skeletal-related events in patients with bone metastasis. However, the analgesic effect of these medications on bone pain is uncertain.To identify, critically appraise and synthesize existing evidence to answer the following questions: 'In adult patients with metastatic bone ... Read more >>

Palliat Med (Palliative medicine)
[2017, 31(1):5-25]

Cited: 13 times

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Minimally invasive procedures for the management of vertebral bone pain due to cancer: The EAPC recommendations.

Sebastiano Mercadante, Pål Klepstad, Geana Paula Kurita, Per Sjøgren, Alessandra Pigni, Augusto Caraceni,

Image-guided percutaneous ablation methods have proved effective for treatment of benign bone tumors and for palliation of metastases involving the bone. However, the role of these techniques is controversial and has to be better defined in the setting of palliative care.A systematic review of the existing data regarding minimally invasive ... Read more >>

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2016, 55(2):129-133]

Cited: 1 time

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Italian Oncological Pain Survey (IOPS): a multicentre Italian study of breakthrough pain performed in different settings.

Sebastiano Mercadante, Marzia Lazzari, Carlo Reale, Arturo Cuomo, Flavio Fusco, Paolo Marchetti, Rocco D Mediati, Bruno Chiurazzi, Libero Ciuffedra, Augusto Caraceni, Vincenzo Iaffaioli, Massimo Luzzani, Giuseppe Micheletto, Alfonso Papa, William Raffaeli, Alessandro Valle, Michele Caruso, Francesco Di Costanzo, Gianpaolo Pinato, Filippo Nardi, Sandro Barni, Silvia Natoli, Massimo Mammucari, Alessandro F Sabato, Mario Dauri, ,

A survey of breakthrough pain (BTP) was performed in five palliative care units (PCU), seven oncology departments (ONC), and nine pain clinics (OPC).A standard algorithm was used to confirm the diagnosis of BTP of patients refereed to different settings.1,412 evaluable cancer patients were enrolled. 53.9% were males and the mean ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2015, 31(3):214-221]

Cited: 17 times

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Comparisons of patient and physician assessment of pain-related domains in cancer pain classification: results from a large international multicenter study.

Cinzia Brunelli, Stein Kaasa, Anne Kari Knudsen, Marianne Jensen Hjermstad, Alessandra Pigni, Augusto Caraceni,

The aim of the present study is to compare physician clinical assessment with patient-rated evaluations in the classification of cancer pain patients into groups with different pain levels, according to the presence of incident/breakthrough pain, neuropathic pain, and psychological distress. Average pain in the previous 24 hours was used as the ... Read more >>

J Pain (The journal of pain : official journal of the American Pain Society)
[2014, 15(1):59-67]

Cited: 9 times

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Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC.

Augusto Caraceni, Geoffrey Hanks, Stein Kaasa, Michael I Bennett, Cinzia Brunelli, Nathan Cherny, Ola Dale, Franco De Conno, Marie Fallon, Magdi Hanna, Dagny Faksvåg Haugen, Gitte Juhl, Samuel King, Pål Klepstad, Eivor A Laugsand, Marco Maltoni, Sebastiano Mercadante, Maria Nabal, Alessandra Pigni, Lukas Radbruch, Colette Reid, Per Sjogren, Patrick C Stone, Davide Tassinari, Giovambattista Zeppetella, , ,

Here we provide the updated version of the guidelines of the European Association for Palliative Care (EAPC) on the use of opioids for the treatment of cancer pain. The update was undertaken by the European Palliative Care Research Collaborative. Previous EAPC guidelines were reviewed and compared with other currently available ... Read more >>

Lancet Oncol. (The Lancet. Oncology)
[2012, 13(2):e58-68]

Cited: 393 times

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The role of paracetamol and nonsteroidal anti-inflammatory drugs in addition to WHO Step III opioids in the control of pain in advanced cancer. A systematic review of the literature.

Maria Nabal, Silvia Librada, Maria Josè Redondo, Alessandra Pigni, Cinzia Brunelli, Augusto Caraceni,

BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol are used widely in the management of mild to moderate cancer pain and are frequently combined with opioids in the treatment of moderate to severe pain. AIM: To perform a systematic literature review of the evidence of the efficacy and toxicity of NSAIDs ... Read more >>

Palliat Med (Palliative medicine)
[2012, 26(4):305-312]

Cited: 37 times

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The role of hydromorphone in cancer pain treatment: a systematic review.

Alessandra Pigni, Cinzia Brunelli, Augusto Caraceni,

The aim of this systematic review is to evaluate the scientific evidence for the efficacy and side effects of hydromorphone in the management of moderate to severe cancer pain. Randomized and non-randomized clinical trials, reporting data on efficacy and/or side effects of hydromorphone, were identified. Thirteen eligible studies, involving 1208 ... Read more >>

Palliat Med (Palliative medicine)
[2011, 25(5):471-477]

Cited: 16 times

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Is oral morphine still the first choice opioid for moderate to severe cancer pain? A systematic review within the European Palliative Care Research Collaborative guidelines project.

Augusto Caraceni, Alessandra Pigni, Cinzia Brunelli,

The aim of this systematic review was to evaluate the evidence that oral morphine can be recommended as the first choice opioid in the treatment of moderate to severe cancer pain in updating the European Association for Palliative Care opioid recommendations. A systematic literature review was performed to update the ... Read more >>

Palliat Med (Palliative medicine)
[2011, 25(5):402-409]

Cited: 34 times

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Multiple Loci modulate opioid therapy response for cancer pain.

Antonella Galvan, Frank Skorpen, Pål Klepstad, Anne Kari Knudsen, Torill Fladvad, Felicia S Falvella, Alessandra Pigni, Cinzia Brunelli, Augusto Caraceni, Stein Kaasa, Tommaso A Dragani,

PURPOSE: Patients treated with opioid drugs for cancer pain experience different relief responses, raising the possibility that genetic factors play a role in opioid therapy outcome. In this study, we tested the hypothesis that genetic variations may control individual response to opioid drugs in cancer patients. EXPERIMENTAL DESIGN: We tested ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2011, 17(13):4581-4587]

Cited: 16 times

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Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients.

P Klepstad, T Fladvad, F Skorpen, K Bjordal, A Caraceni, O Dale, A Davies, M Kloke, S Lundström, M Maltoni, L Radbruch, R Sabatowski, V Sigurdardottir, F Strasser, P M Fayers, S Kaasa, , ,

Cancer pain patients need variable opioid doses. Preclinical and clinical studies suggest that opioid efficacy is related to genetic variability. However, the studies have small samples, findings are not replicated, and several candidate genes have not been studied. Therefore, a study of genetic variability with opioid doses in a large ... Read more >>

Pain (Pain)
[2011, 152(5):1139-1145]

Cited: 89 times

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The validity of average 8-h pain intensity assessment in cancer patients.

Augusto Caraceni, Ernesto Zecca, Cinzia Martini, Cinzia Brunelli, Alessandra Pigni, Giovanna Gorni, Anna Galbiati, Myrta Ibazeta, Marianne Hjermstad, Stein Kaasa,

Aim of this study was to validate the use of subjective average pain assessment over an 8-h time period to evaluate cancer pain intensity. A sample of 95 consecutive cancer inpatients were asked to score on 0-10 numerical scales the intensity of their pain at hourly intervals, and then, at ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2010, 14(4):441-445]

Cited: 3 times

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Decreases in pain at rest and movement-related pain during zoledronic acid treatment in patients with bone metastases due to breast or prostate cancer: a pilot study.

Carla Ripamonti, Elena Fagnoni, Tiziana Campa, Vincenzo Giardina, Cinzia Brunelli, Alessandra Pigni, Franco De Conno,

In patients with bone metastases, pain may be absent or moderate at rest, but may be exacerbated by different movements or positions. No study has evaluated separately pain at rest and on movement in patients with bone metastases undergoing treatment with zoledronic acid (ZA).The aim of this prospective observational study ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2007, 15(10):1177-1184]

Cited: 13 times

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Prognostic value of bcl-6, CD10 and CD38 immunoreactivity in stage I-II gastric lymphomas: identification of a subset of CD10+ large B-cell lymphomas with a favorable outcome.

Maurilio Ponzoni, Andrés J M Ferreri, Giancarlo Pruneri, Barbara Pozzi, Stefania Dell'Oro, Alessandra Pigni, Graziella Pinotti, Eugenio Villa, Massimo Freschi, Giuseppe Viale, Carlo Capella,

bcl-6, CD10 and CD38 are useful markers for identifying 2 molecularly and prognostically distinct profiles of diffuse large B-cell lymphomas (LCLs), defined as germinal-center B-like and activated B-like. We investigated the prognostic role of bcl-6, CD10 and CD38 immunoreactivity in 102 gastrectomized patients with primary gastric lymphomas (PGLs). There were ... Read more >>

Int. J. Cancer (International journal of cancer)
[2003, 106(2):288-291]

Cited: 16 times

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