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Author Alessandra C Martini

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Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.

David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P Matheos, Xinyi Ma, Celia Da Cunha, Ken C Walls, Rahasson R Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J Tenner, Grant R MacGregor, Marcelo Wood, Kim N Green, Frank M LaFerla,

The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtype human Aβ under control of the mouse App locus. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2421]

Cited: 0 times

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Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome.

Alessandra C Martini, Alex M Helman, Katie L McCarty, Ira T Lott, Eric Doran, Frederick A Schmitt, Elizabeth Head,

<h4>Introduction</h4>Microglial cells play an important role in the development of Alzheimer's disease (AD). People with Down syndrome (DS) inevitably develop AD neuropathology (DSAD) by 40 years of age. We characterized the distribution of different microglial phenotypes in the brains of people with DS and DSAD.<h4>Methods</h4>Autopsy tissue from the posterior cingulate ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2020, 12(1):e12113]

Cited: 2 times

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Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer's disease.

Alessandra C Martini, David Baglietto-Vargas, Rodrigo Medeiros, Frank M LaFerla,

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(8):3917-3919]

Cited: 0 times

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Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.

Laura Trujillo-Estrada, Cassidy Nguyen, Celia da Cunha, Lena Cai, Stefania Forner, Alessandra C Martini, Rahasson R Ager, Gilberto Aleph Prieto, Carl W Cotman, David Baglietto-Vargas, Frank M LaFerla,

Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on cognition. New findings have shown that the microtubule-associated protein tau is pathologically processed in DM; ... Read more >>

Aging Cell (Aging cell)
[2019, 18(3):e12919]

Cited: 4 times

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Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease.

David Baglietto-Vargas, Gilberto Aleph Prieto, Agenor Limon, Stefania Forner, Carlos J Rodriguez-Ortiz, Kenji Ikemura, Rahasson R Ager, Rodrigo Medeiros, Laura Trujillo-Estrada, Alessandra C Martini, Masashi Kitazawa, Jose C Davila, Carl W Cotman, Antonia Gutierrez, Frank M LaFerla,

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impairs memory and causes cognitive and psychiatric deficits. New evidences indicate that AD is conceptualized as a disease of synaptic failure, although the molecular and cellular mechanisms underlying these defects remain to be elucidated. Determining the timing and nature of the ... Read more >>

Aging Cell (Aging cell)
[2018, 17(4):e12791]

Cited: 20 times

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Past to Future: What Animal Models Have Taught Us About Alzheimer's Disease.

Alessandra C Martini, Stefania Forner, Laura Trujillo-Estrada, David Baglietto-Vargas, Frank M LaFerla,

Alzheimer's disease (AD) impairs memory and causes significant cognitive deficits. The disease course is prolonged, with a poor prognosis, and thus exacts an enormous economic and social burden. Over the past two decades, genetically engineered mouse models have proven indispensable for understanding AD pathogenesis, as well as for discovering new ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2018, 64(s1):S365-S378]

Cited: 4 times

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Synaptic Impairment in Alzheimer's Disease: A Dysregulated Symphony.

Stefania Forner, David Baglietto-Vargas, Alessandra C Martini, Laura Trujillo-Estrada, Frank M LaFerla,

Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and devastating neurodegeneration, not only as a result of the extracellular accumulation of beta-amyloid peptide (Aβ) and intracellular accumulation of tau, but also as a consequence of the dysfunction and loss of synapses. Although significant advances have been made in ... Read more >>

Trends Neurosci (Trends in neurosciences)
[2017, 40(6):347-357]

Cited: 92 times

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Temporal and Regional Expression of Glucose-Dependent Insulinotropic Peptide and Its Receptor in Spinal Cord Injured Rats.

Ana Beatriz W Marcos, Stefania Forner, Alessandra C Martini, Eliziane S Patrício, Julia R Clarke, Robson Costa, João Felix-Alves, Vilberto José Vieira, Edinéia Lemos de Andrade, Tânia Longo Mazzuco, João Batista Calixto, Claudia Pinto Figueiredo,

Spinal cord injury (SCI) results in loss of movement, sensibility, and autonomic control at the level of the lesion and at lower parts of the body. Several experimental strategies have been used in attempts to increase endogenous mechanisms of neuroprotection, neuroplasticity, and repair, but with limited success. It is known ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2016, 33(3):261-268]

Cited: 2 times

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Inhibition of spinal c-Jun-NH2-terminal kinase (JNK) improves locomotor activity of spinal cord injured rats.

Alessandra C Martini, Stefânia Forner, Janice Koepp, Giles Alexander Rae,

Mitogen-activated protein kinases (MAPKs) have been implicated in central nervous system injuries, yet the roles within neurodegeneration following spinal cord injury (SCI) still remain partially elucidated. We aimed to investigate the changes in expression of the three MAPKs following SCI and the role of spinal c-jun-NH2-terminal kinase (JNK) in motor ... Read more >>

Neurosci Lett (Neuroscience letters)
[2016, 621:54-61]

Cited: 3 times

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Peripheral substance P and neurokinin-1 receptors have a role in inflammatory and neuropathic orofacial pain models.

Fernanda C Teodoro, Marcos F Tronco Júnior, Aleksander R Zampronio, Alessandra C Martini, Giles A Rae, Juliana G Chichorro,

There is accumulating evidence that substance P released from peripheral sensory neurons participates in inflammatory and neuropathic pain. In this study it was investigated the ability of substance P to induce orofacial nociception and thermal and mechanical hyperalgesia, as well as the role of NK1 receptors on models of orofacial ... Read more >>

Neuropeptides (Neuropeptides)
[2013, 47(3):199-206]

Cited: 22 times

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Effects of kinin B(1) and B(2) receptor antagonists on overactive urinary bladder syndrome induced by spinal cord injury in rats.

Stefânia Forner, Edinéia L Andrade, Alessandra C Martini, Allisson F Bento, Rodrigo Medeiros, Janice Koepp, João B Calixto,

<h4>Background and purpose</h4>Kinin B(1) and B(2) receptors have been implicated in physiological and pathological conditions of the urinary bladder. However, their role in overactive urinary bladder (OAB) syndrome following spinal cord injury (SCI) remains elusive.<h4>Experimental approach</h4>We investigated the role of kinin B(1) and B(2) receptors in ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2012, 167(8):1737-1752]

Cited: 13 times

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