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Author Alena Skalova

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High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.

Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H W Simpson, Göran Stenman, Vincent Vander Poorten, Justin A Bishop, Alessandro Franchi, Juan C Hernandez-Prera, David Slouka, Stefan M Willems, Kerry D Olsen, Alfio Ferlito,

High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):107-118]

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A Comparison of 18F-FDG-PET/MRI and 18F-FDG-PET/CT in the Cancer Staging of Locoregional Lymph Nodes.

David Slouka, Jiri Krcal, Tomas Kostlivy, Petr Hrabacka, Alena Skalova, Hynek Mirka, Ondrej Topolcan, Radek Kucera,

<h4>Aim</h4>The aim of the study was to evaluate the yields of 2-deoxy-2-[<sup>18</sup>F]-fluoro-D-glucose positron-emission tomography/magnetic resonance imaging (<sup>18</sup>F-FDG-PET/MRI) and <sup>18</sup>F-FDG-PET/computed tomography (CT) for the detection of metastatic involvement of locoregional neck nodes in patients with head and neck malignancy.<h4>Patients and methods</h4>A total of 90 patients (66 men and 24 women) met ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2020, 34(4):2029-2032]

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Risk of Postoperative Bleeding in Tonsillectomy for Peritonsillar Abscess, as Opposed to in Recurrent and Chronic Tonsillitis-A Retrospective Study.

David Slouka, Štěpánka Čejková, Jana Hanáková, Petr Hrabačka, Stanislav Kormunda, David Kalfeřt, Alena Skálová, Václav Šimánek, Radek Kucera,

Tonsillectomy is a routine surgery in otorhinolaryngology and the occurrence of postoperative bleeding is not a rare complication. The aim of this retrospective, observational, analytic, cohort study is to compare the incidence of this complication for the most common indications. A group of patients indicated for tonsillectomies for peritonsillar abscess ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(4):]

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MAML2-Rearranged Tumors of the Breast: A Diagnostic Dilemma.

Martina Baněčková, Dmitry V Kazakov, Alena Skálová, Michal Michal,

Int J Surg Pathol (International journal of surgical pathology)
[2020, :1066896920981634]

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Molecular Profiling of Clear Cell Myoepithelial Carcinoma of Salivary Glands With EWSR1 Rearrangement Identifies Frequent PLAG1 Gene Fusions But No EWSR1 Fusion Transcripts.

Alena Skálová, Abbas Agaimy, Tomas Vanecek, Martina Baněčková, Jan Laco, Nikola Ptáková, Petr Šteiner, Hanna Majewska, Wojciech Biernat, Luigi Corcione, Václav Eis, Olena Koshyk, Jan Vondrák, Michal Michal, Ilmo Leivo,

Myoepithelial carcinoma of salivary glands is an underrecognized and challenging entity with a broad morphologic spectrum, including an EWSR1-rearranged clear cell variant. Myoepithelial carcinoma is generally aggressive with largely unknown genetic features. A retrospective review of Salivary Gland Tumor Registry in Pilsen searching for the key words "clear cell myoepithelial ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(1):1-13]

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Pleomorphic Adenoma: The Great Mimicker of Malignancy.

Juan C Hernandez-Prera, Alena Skálová, Alessandro Franchi, Alessandra Rinaldo, Vincent Vander Poorten, Peter Zbären, Alfio Ferlito, Bruce M Wenig,

Pleomorphic adenoma is the most common salivary gland neoplasm and its diagnosis is straightforward in majority of cases. However; not infrequently PA exhibits unusual and uncommon histological findings that can erroneously be confused with malignancy. The diagnostic difficulties of PA arise from its ability of mimic invasion, show atypical or ... Read more >>

Histopathology (Histopathology)
[2020, :]

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Molecular Profiling of Salivary Oncocytic Mucoepidermoid Carcinomas Helps to Resolve Differential Diagnostic Dilemma With Low-grade Oncocytic Lesions.

Alena Skálová, Abbas Agaimy, Olga Stanowska, Martina Baneckova, Nikola Ptáková, Laura Ardighieri, Piero Nicolai, Davide Lombardi, Monika Durzynska, Luigi Corcione, Jan Laco, Olena Koshyk, Radim Žalud, Michal Michal, Tomáš Vanecek, Ilmo Leivo,

Oncocytic mucoepidermoid carcinoma (OMEC) is a rare but diagnostically challenging variant of mucoepidermoid carcinoma (MEC). OMEC is notable for differential diagnostic considerations that are raised as a result of overlap with other benign and low-grade oncocytic salivary gland tumors. Diffuse and strong immunoreactivity of p63 protein may be useful in ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(12):1612-1622]

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Cervical lymphocele: A rare complication following salvage surgery for ocular adnexal apocrine adenocarcinoma. A case report and review of the literature.

Lukas Hauer, Jiri Gencur, Petr Posta, Zdenek Kasl, Stepan Rusnak, Alena Skalova, Miroslava Chalupova, Jan Liska, Vlasta Merglova,

<h4>Background</h4>An ocular adnexal apocrine adenocarcinoma (OAAA) is an extremely rare, but potentially aggressive and life-threatening tumor with ill-defined management based only on recommendations from a limited number of reported cases. The development of cervical lymphocele following neck dissection is a very rare complication, but one with well established methods for ... Read more >>

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub (Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia)
[2020, :]

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Heterotopic acinic cell carcinoma and its clinical implications.

Ivo Starek, Richard Salzman, Alena Skalova,

This is a review of the clinical and histopathological published data on very rare heterotopic acinic cell carcinomas (AcCCs) with suggested optimal management. Extrasalivary AcCCs originate primarily in parotid lymph nodes. They present at low clinical stage, show mostly low-grade histopathology and are circumscribed with a complete nodal capsule. Extracapsular ... Read more >>

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub (Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia)
[2021, 165(1):13-18]

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FNA diagnostics of secondary malignancies in the salivary gland: Bi-institutional experience of 36 cases.

Markéta Horáková, Sinikka Porre, Satu Tommola, Martina Baněčková, Alena Skálová, Ivana Kholová,

<h4>Objective</h4>Fine-needle aspiration (FNA) is a key diagnostic method in the evaluation of salivary gland lesions. Secondary tumors of salivary glands represent only 5% of all malignancies of major salivary glands. The goal of our study was to examine the cytological and clinical features of secondary tumors sampled by FNA.<h4>Materials and ... Read more >>

Diagn Cytopathol (Diagnostic cytopathology)
[2021, 49(2):241-251]

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Expanding the Molecular Spectrum of Secretory Carcinoma of Salivary Glands With a Novel VIM-RET Fusion.

Alena Skálová, Martina Banečkova, Lester D R Thompson, Nikola Ptáková, Todd M Stevens, Luka Brcic, Martin Hyrcza, Michael Michal, Roderick H W Simpson, Thalita Santana, Michal Michal, Tomas Vaněček, Ilmo Leivo,

<h4>Background</h4>Secretory carcinoma (SC), originally described as mammary analogue SC, is a predominantly low-grade salivary gland neoplasm characterized by a recurrent t(12;15)(p13;q25) translocation, resulting in ETV6-NTRK3 gene fusion. Recently, alternative ETV6-RET, ETV6-MAML3, and ETV6-MET fusions have been found in a subset of SCs lacking the classic ETV6-NTRK3 fusion transcript, but still ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(10):1295-1307]

Cited: 2 times

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MUC4 is a valuable marker for distinguishing secretory carcinoma of the salivary glands from its mimics.

Cecilia Taverna, Martina Baněčková, Monica Lorenzon, Annarita Palomba, Alessandro Franchi, Alena Skalova, Abbas Agaimy,

<h4>Aims</h4>Secretory carcinoma (SC) (synonym: mammary analogue secretory carcinoma) is a low-grade salivary gland tumour that occurs in both major and minor salivary glands. SC is known for its wide morphological, architectural and immunohistochemical spectrum, which overlaps with those of several salivary gland neoplasms, including acinic cell carcinoma (AciCC) and intercalated ... Read more >>

Histopathology (Histopathology)
[2020, :]

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What is hiding behind S100 protein and SOX10 positive oncocytomas? Oncocytic pleomorphic adenoma and myoepithelioma with novel gene fusions in a subset of cases.

Martina Baněčková, Emmanuelle Uro-Coste, Nikola Ptáková, Petr Šteiner, Olga Stanowska, Giulio Benincasa, Giuseppe Colella, Jan Vondrák, Michal Michal, Ilmo Leivo, Alena Skálová,

Oncocytomas (OCs) in salivary glands are rare benign tumors composed of mitochondria-rich epithelial cells (oncocytes), mostly localized in the parotid gland. The treatment of choice is simple excision. Extensive oncocytic metaplasia of pleomorphic adenoma (PA) and myoepithelioma (ME) can be diagnostically challenging and may camouflage the correct diagnosis. These tumors ... Read more >>

Hum Pathol (Human pathology)
[2020, 103:52-62]

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Salivary Gland Mucinous Adenocarcinoma With Minor (Mammary Analogue) Secretory and Low-Grade In Situ Carcinoma Components Sharing the Same ETV6-RET Translocation and With No Other Molecular Genetic Aberrations Detected on NGS Analysis.

Fredrik Petersson, Michael Michal, Nikola Ptáková, Alena Skalova, Michal Michal,

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2020, 28(6):e53]

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Ameloblastic fibrosarcoma: clinicopathological and molecular analysis of seven cases highlighting frequent BRAF and occasional NRAS mutations.

Abbas Agaimy, Alena Skalova, Alessandro Franchi, Rana Alshagroud, Anthony J Gill, Robert Stoehr, Daniel Baumhoer, Sebastian Bauer,

<h4>Aims</h4>Ameloblastic fibrosarcoma (AFS) is an aggressive odontogenic neoplasm featuring malignant mesenchymal stroma in addition to an ameloblastic epithelial component, and is hence considered to be the malignant counterpart of ameloblastic fibroma (AF). AFS is exceedingly rare, with <110 cases having been reported so far. Although BRAF mutations are recognised driver ... Read more >>

Histopathology (Histopathology)
[2020, 76(6):814-821]

Cited: 2 times

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Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG): An International Interobserver Study.

Bin Xu, Andrea L Barbieri, Justin A Bishop, Simon I Chiosea, Snjezana Dogan, Silvana Di Palma, William C Faquin, Ronald Ghossein, Martin Hyrcza, Vickie Y Jo, James S Lewis, John R Lozada, Michal Michal, Fresia G Pareja, Bayardo Perez-Ordonez, Manju L Prasad, Bibianna Purgina, Jorge S Reis-Filho, Theresa Scognamiglio, Ana P M Sebastiao, Raja R Seethala, Alena Skálová, Stephen M Smith, Merva S Tekkeşin, Lester D R Thompson, Jason K Wasseman, Bruce M Wenig, Ilan Weinreb, Nora Katabi,

Polymorphous adenocarcinoma (PAC) shows histologic diversity with streaming and targetoid features whereas cribriform adenocarcinoma of salivary gland (CASG) demonstrates predominantly cribriform and solid patterns with glomeruloid structures and optically clear nuclei. Opinions diverge on whether CASG represents a separate entity or a variant of PAC. We aimed to assess the ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(4):545-552]

Cited: 2 times

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Solitary fibrous tumors of the head and neck region revisited: a single-institution study of 20 cases and review of the literature.

Martina Baněčková, Petr Martínek, Alena Skálová, Roman Mezencev, Ladislav Hadravský, Michal Michal, Marián Švajdler,

A solitary fibrous tumor (SFT) is a rare, NAB2-STAT6 fusion gene-associated mesenchymal neoplasm. It most commonly arises in the pleural site, but it can occur at many other sites, and rarely also in the head and neck (H&N) region. STFs may show many growth patterns and therefore can be easily ... Read more >>

Hum Pathol (Human pathology)
[2020, 99:1-12]

Cited: 1 time

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Sinonasal Undifferentiated Carcinoma (SNUC): From an Entity to Morphologic Pattern and Back Again-A Historical Perspective.

Abbas Agaimy, Alessandro Franchi, Valerie J Lund, Alena Skálová, Justin A Bishop, Asterios Triantafyllou, Simon Andreasen, Douglas R Gnepp, Henrik Hellquist, Lester D R Thompson, Alessandra Rinaldo, Alfio Ferlito,

Since the first description of sinonasal undifferentiated carcinoma (SNUC) as a distinctive highly aggressive sinonasal neoplasm with probable origin from the sinonasal mucosa (Schneiderian epithelium), SNUC has been the subject of ongoing study and controversy. In particular, the SNUC category gradually became a "wastebasket" for any undifferentiated or unclassifiable sinonasal ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(2):51-60]

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Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands.

Florian Haller, Alena Skálová, Stephan Ihrler, Bruno Märkl, Matthias Bieg, Evgeny A Moskalev, Ramona Erber, Susanne Blank, Christa Winkelmann, Simone Hebele, Martina Baněčková, Stefan Wiemann, Sarina Müller, Johannes Zenk, Roland Eils, Heinrich Iro, Arndt Hartmann, Abbas Agaimy,

Recently, we discovered the recurrent genomic rearrangement [t(4;9)(q13;q31)] enabling upregulation of the transcription factor Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) through enhancer hijacking as the oncogenic driver event in acinic cell carcinoma (AciCC) of the salivary glands. In the current study, we evaluated the usefulness of NR4A3 ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(9):1264-1272]

Cited: 5 times

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Immunohistochemical and genetic analysis of respiratory epithelial adenomatoid hamartomas and seromucinous hamartomas: are they precursor lesions to sinonasal low-grade tubulopapillary adenocarcinomas?

Martina Baněčková, Michael Michal, Jan Laco, Ilmo Leivo, Nikola Ptáková, Markéta Horáková, Michal Michal, Alena Skálová,

Respiratory epithelial adenomatoid hamartoma (REAH) and seromucinous hamartoma (SH) are rare tumor-like lesions of the nasal cavity, paranasal sinuses, and nasopharynx. The pathogenesis of REAH/SH is still unclear. Neoplastic proliferation, chronic mechanical irritation, inflammation, or possible embryological tissue misplacement are speculated as possible mechanisms of their development. Low-grade tubulopapillary adenocarcinoma ... Read more >>

Hum Pathol (Human pathology)
[2020, 97:94-102]

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STRN-NTRK3-rearranged Mesenchymal Tumor of the Uterus: Expanding the Morphologic Spectrum of Tumors With NTRK Fusions.

Michael Michal, Veronika Hájková, Alena Skálová, Michal Michal,

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(8):1152-1154]

Cited: 3 times

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Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome.

David Slouka, Radek Kucera, Bretislav Gal, Jaroslav Betka, Alena Skalova,

OBJECTIVES:Sleep apnea syndrome affects approximately 4% of adult males and 2% of adult females. It is associated with significant cardio-, cerebrovascular, metabolic and hormonal comorbidities and ranks among the more expensive medical specialties due to the requirement of high-quality technical diagnostic and therapeutic equipment as well as well-educated and experienced ... Read more >>

Neuro Endocrinol Lett (Neuro endocrinology letters)
[2019, 40(2):85-92]

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NCOA4-RET and TRIM27-RET Are Characteristic Gene Fusions in Salivary Intraductal Carcinoma, Including Invasive and Metastatic Tumors: Is "Intraductal" Correct?

Alena Skálová, Nikola Ptáková, Thalita Santana, Abbas Agaimy, Stephan Ihrler, Emmanuelle Uro-Coste, Lester D R Thompson, Justin A Bishop, Martina Baněčkova, Niels J Rupp, Patrizia Morbini, Stefano de Sanctis, Marco Schiavo-Lena, Tomas Vanecek, Michal Michal, Ilmo Leivo,

Intraductal carcinoma (IC) is the new WHO designation for tumors previously encompassed by "low-grade cribriform cystadenocarcinoma" and "low-grade salivary duct carcinoma." The relationship of IC to salivary duct carcinoma (SDC) is controversial, even though they are considered to be distinct entities. IC is a rare low-grade malignant salivary gland neoplasm ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(10):1303-1313]

Cited: 6 times

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New Insights into Tumor Heterogeneity: A Case of Solid-Oncocytic Epithelial-Myoepithelial Carcinoma of the Parotid Gland Harboring a HRAS and Heterogeneous Terminating ARID1A Mutation.

Niels J Rupp, Muriel Brada, Alena Skálová, Beata Bode, Martina A Broglie, Grégoire B Morand, Markus Rechsteiner, Sandra N Freiberger,

Epithelial-myoepithelial carcinoma (EMC) can be a challenging diagnosis due to a lack of obvious invasion and bland cytology. We report an unusual case of a low-grade EMC with prominent fibrous stroma, an extensive solid-oncocytic differentiation and limited areas of morphological clearly identifiable characteristic biphasic (tubular) differentiation, clear cells and PAS-positive ... Read more >>

Head Neck Pathol (Head and neck pathology)
[2020, 14(2):554-558]

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Don't stop the champions of research now: a brief history of head and neck pathology developments.

Lester D R Thompson, James S Lewis, Alena Skálová, Justin A Bishop,

The field of head and neck pathology was just developing 50 years ago but has certainly come a long way in a relatively short time. Thousands of developments in diagnostic criteria, tumor classification, malignancy staging, immunohistochemistry application, and molecular testing have been made during this time, with an exponential increase in ... Read more >>

Hum Pathol (Human pathology)
[2020, 95:1-23]

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