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Author Aleksandra Mineyko

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Population Based Birth Prevalence of Disease-Specific Perinatal Stroke.

Mary Dunbar, Aleksandra Mineyko, Michael Hill, Jacquie Hodge, Amalia Floer, Adam Kirton,

BACKGROUND:Perinatal stroke encompasses multiple disease-specific cerebrovascular syndromes that cause lifelong neurodevelopmental morbidity for millions worldwide. Acute presentations include neonatal arterial ischemic stroke (NAIS), neonatal cerebral sinovenous thrombosis, and neonatal hemorrhagic stroke (NHS). Delayed presentations include arterial presumed perinatal ischemic stroke, periventricular venous infarction, and presumed perinatal hemorrhagic stroke. Our objective ... Read more >>

Pediatrics (Pediatrics)
[2020, 146(5):]

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Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study.

Carmen Yea, Ari Bitnun, Helen M Branson, Beyza Ciftci-Kavaklioglu, Mubeen F Rafay, Olivier Fortin, Paola Moresoli, Guillaume Sébire, Myriam Srour, Hélène Decaluwe, Louis Marois, Félixe Pelletier, Michelle Barton, Maryam Nabavi Nouri, Jason Brophy, Sunita Venkateswaran, Daniela Pohl, Kathryn Selby, Kevin Jones, Joan Robinson, Aleksandra Mineyko, Christoph Licht, Birgit Ertl-Wagner, E Ann Yeh,

BACKGROUND:Acute flaccid myelitis (AFM) is characterised by rapid onset of limb weakness with spinal cord grey-matter abnormalities on MRI scan. We aimed to assess whether detection of enterovirus in respiratory or other specimens can help predict prognosis in children with AFM. METHODS:In this nationwide, longitudinal study, we evaluated the significance ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):828-836]

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Association of neonatal inflammatory markers and perinatal stroke subtypes.

Aleksandra Mineyko, Alberto Nettel-Aguirre, Pauline de Jesus, Susanne Benseler, Kamran Yusuf, Aru Narendran, Adam Kirton,

OBJECTIVE:To examine the relationship between neonatal inflammatory cytokines and perinatal stroke using a systems biology approach analyzing serum and blood-spot cytokines from 47 patients. METHODS:This was a population-based, controlled cohort study with prospective and retrospective case ascertainment. Participants were recruited through the Alberta Perinatal Stroke Project. Stroke was classified as ... Read more >>

Neurology (Neurology)
[2020, 95(9):e1163-e1173]

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Seizures and Outcome One Year After Neonatal and Childhood Cerebral Sinovenous Thrombosis.

Aleksandra Mineyko, Adam Kirton, Lori Billinghurst, Nana Nino Tatishvili, Max Wintermark, Gabrielle deVeber, Christine Fox, ,

BACKGROUND:Pediatric cerebral sinovenous thrombosis is a treatable cause of brain injury, acute symptomatic seizures, and remote epilepsy. Our objective was to prospectively study epilepsy and outcomes in neonates and children one year after cerebral sinovenous thrombosis diagnosis. METHODS:Patients with cerebral sinovenous thrombosis were enrolled prospectively from 21 international sites through ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2020, 105:21-26]

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Long-Term Outcome After Bilateral Perinatal Arterial Ischemic Stroke.

Aleksandra Mineyko, Adam Kirton,

AIM:We aimed to characterize the phenotype and outcome of children with bilateral, large vessel perinatal arterial ischemic stroke. METHODS:Patients with bilateral, large vessel perinatal arterial ischemic stroke were identified from a large, population-based cohort (Alberta Perinatal Stroke Project). Subjects were included if stroke involving a major cerebral artery territory was ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2019, 101:39-42]

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Bihemispheric alterations in myelination in children following unilateral perinatal stroke.

Sabrina Yu, Helen L Carlson, Aleksandra Mineyko, Brian L Brooks, Andrea Kuczynski, Jacquie Hodge, Sean Dukelow, Adam Kirton,

Background:Stroke is a leading cause of perinatal brain injury with variable outcomes including cerebral palsy and epilepsy. The biological processes that underlie these heterogeneous outcomes are poorly understood. Alterations in developmental myelination are recognized as a major determinant of outcome in preterm brain injury but have not been explored in ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2018, 20:7-15]

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Neuropsychological Outcome in Perinatal Stroke Associated With Epileptiform Discharges in Sleep.

Aleksandra Mineyko, Wei Qi, Helen L Carlson, Luis Bello-Espinosa, Brian L Brooks, Adam Kirton,

Patients with arterial perinatal stroke often suffer long-term motor sequelae, difficulties in language, social development, and behaviour as well as epilepsy. Despite homogeneous lesions, long-term behavioural and cognitive outcomes are variable and unpredictable. Sleep-related epileptic encephalopathies can occur after early brain injury and are associated with global developmental delays. We ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2017, 44(4):358-365]

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Neonatal arterial ischemic stroke: evidence required for future guidelines.

Aleksandra Mineyko, Adam Kirton,

Dev Med Child Neurol (Developmental medicine and child neurology)
[2017, 59(9):892-893]

Cited: 0 times

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Transcranial direct current stimulation for children with perinatal stroke and hemiparesis.

Adam Kirton, Patrick Ciechanski, Ephrem Zewdie, John Andersen, Alberto Nettel-Aguirre, Helen Carlson, Lisa Carsolio, Mia Herrero, Jillian Quigley, Aleksandra Mineyko, Jacquie Hodge, Michael Hill,

OBJECTIVE:To determine whether the addition of transcranial direct current stimulation (tDCS) to intensive therapy increases motor function in children with perinatal stroke and hemiparetic cerebral palsy. METHODS:This was a randomized, controlled, double-blind clinical trial. Participants were recruited from a population-based cohort with MRI-classified unilateral perinatal stroke, age of 6 to ... Read more >>

Neurology (Neurology)
[2017, 88(3):259-267]

Cited: 20 times

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Longitudinal Outcomes in the 2014 Acute Flaccid Paralysis Cluster in Canada.

Carmen Yea, Ari Bitnun, Joan Robinson, Aleksandra Mineyko, Michelle Barton, Jean K Mah, Jiri Vajsar, Susan Richardson, Christoph Licht, Jason Brophy, Megan Crone, Shalini Desai, Juliette Hukin, Kevin Jones, Katherine Muir, Jeffrey M Pernica, Robert Pless, Daniela Pohl, Mubeen F Rafay, Kathryn Selby, Sunita Venkateswaran, Geneviève Bernard, E Ann Yeh,

We describe the presenting features and long-term outcome of an unusual cluster of pediatric acute flaccid paralysis cases that occurred in Canada during the 2014 enterovirus D68 outbreak. Children (n = 25; median age 7.8 years) presenting to Canadian centers between July 1 and October 31, 2014, and who met ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2017, 32(3):301-307]

Cited: 13 times

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Thrombophilia risk is not increased in children after perinatal stroke.

Colleen Curtis, Aleksandra Mineyko, Patricia Massicotte, Michael Leaker, Xiu Yan Jiang, Amalia Floer, Adam Kirton,

Perinatal stroke causes cerebral palsy and lifelong disability. Specific diseases are definable, but mechanisms are poorly understood. Evidence suggests possible associations between arterial perinatal stroke and prothrombotic disorders, but population-based, controlled, disease-specific studies are limited. Understanding thrombophilia in perinatal stroke informs pathogenesis models and clinical management. We conducted a population-based, ... Read more >>

Blood (Blood)
[2017, 129(20):2793-2800]

Cited: 6 times

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Biomarkers of Inflammation in Pediatric Arterial Ischemic Stroke.

Mary Dunbar, Aleksandra Mineyko,

Investigators from Switzerland studied inflammatory markers in children and neonates with acute arterial ischemic stroke (AIS). ... Read more >>

(Pediatric neurology briefs)
[2016, 30(11):41]

Cited: 1 time

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Treatment of dysphasia with rTMS and language therapy after childhood stroke: Multimodal imaging of plastic change.

Helen L Carlson, Zeanna Jadavji, Aleksandra Mineyko, Omar Damji, Jacquie Hodge, Jenny Saunders, Mia Hererro, Michele Nowak, Rebecca Patzelt, Anya Mazur-Mosiewicz, Frank P MacMaster, Adam Kirton,

Expressive dysphasia accompanies left inferior frontal gyrus (IFG/Broca) injury. Recovery may relate to interhemispheric balance with homologous, contralesional IFG but is unexplored in children. We evaluated effects of inhibitory rTMS to contralesional IFG combined with intensive speech therapy (SLT). A 15year-old, right-handed male incurred a left middle cerebral artery stroke. ... Read more >>

Brain Lang (Brain and language)
[2016, 159:23-34]

Cited: 3 times

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Brain stimulation and constraint for perinatal stroke hemiparesis: The PLASTIC CHAMPS Trial.

Adam Kirton, John Andersen, Mia Herrero, Alberto Nettel-Aguirre, Lisa Carsolio, Omar Damji, Jamie Keess, Aleksandra Mineyko, Jacquie Hodge, Michael D Hill,

To determine whether the addition of repetitive transcranial magnetic stimulation (rTMS) and/or constraint-induced movement therapy (CIMT) to intensive therapy increases motor function in children with perinatal stroke and hemiparesis.A factorial-design, blinded, randomized controlled trial (clinicaltrials.gov/NCT01189058) assessed rTMS and CIMT effects in hemiparetic children (aged 6-19 years) with MRI-confirmed perinatal stroke. ... Read more >>

Neurology (Neurology)
[2016, 86(18):1659-1667]

Cited: 30 times

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Polio-Like Illness Associated With Outbreak of Upper Respiratory Tract Infection in Children.

Megan Crone, Raymond Tellier, Xing-Chang Wei, Susan Kuhn, Otto G Vanderkooi, Jong Kim, Jean K Mah, Aleksandra Mineyko,

Poliomyelitis is a historically devastating neurological complication of poliovirus infection. Poliovirus vaccines have decreased the incidence of poliomyelitis to 209 global cases in 2014, with new cases of acute flaccid myelitis primarily associated with nonpolio enteroviruses. Recently, during outbreaks of enterovirus D68 throughout North America and Europe, cases of acute ... Read more >>

J Child Neurol (Journal of child neurology)
[2016, 31(4):409-414]

Cited: 12 times

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Baroreflex failure, sympathetic storm, and cerebral vasospasm in fibulin-4 cutis laxa.

Thilinie Rajapakse, Aleksandra Mineyko, Caroline Chee, Suresh Subramaniam, Frank Dicke, Francois P Bernier, Adam Kirton,

Sudden, severe, and life-threatening, the crises associated with baroreflex failure are diagnostically challenging, particularly in children, a population in which it has rarely been described. The baroreflex failure syndrome results from impaired afferent baroreceptive input and manifests with autonomic stimulation-induced surges in blood pressure and heart rate accompanied by distinct ... Read more >>

Pediatrics (Pediatrics)
[2014, 133(5):e1396-400]

Cited: 0 times

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Postictal subcortical restricted diffusion in a child with focal symptomatic epilepsy.

Kenneth A Myers, Mehmet S Albayram, Aleksandra Mineyko,

BACKGROUND: Diffusion abnormalities on MRI are well described after prolonged seizures. However, isolated, focal, subcortical restricted diffusion is uncommon. PATIENT: A girl of Kurdish descent experienced focal-onset epilepsy secondary to a left thalamic infarction at age 3 years. At age 6 years, she developed status epilepticus in the context of ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2014, 50(6):652-654]

Cited: 1 time

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Normal intracranial periarterial enhancement on pediatric brain MR imaging.

Aleksandra Mineyko, Adam Kirton, Danny Ng, Xing-Chang Wei,

Large/medium vessel vasculitis is an important etiology of childhood stroke. Early research suggests vessel wall enhancement on postcontrast MRI may be a marker of intracranial vasculitis yet no systematic descriptions of normal periarterial enhancement exist in the literature. The aim was to describe normal periarterial enhancement in the pediatric population.We ... Read more >>

Neuroradiology (Neuroradiology)
[2013, 55(9):1161-1169]

Cited: 9 times

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Fibromuscular dysplasia and childhood stroke.

Adam Kirton, Megan Crone, Susanne Benseler, Aleksandra Mineyko, Derek Armstrong, Andrew Wade, Guillaume Sebire, Ana-Maria Crous-Tsanaclis, Gabrielle deVeber,

Arteriopathies are the leading cause of childhood stroke but mechanisms are poorly understood. Fibromuscular dysplasias are non-inflammatory arteriopathies classically described in adults with a cerebral-renal distribution and distinct 'string-of-beads' angiographic appearance. Diagnostic characteristics of paediatric fibromuscular dysplasia are uncharacterized. We aimed to compare pathologically proven versus clinically suspected paediatric fibromuscular ... Read more >>

Brain (Brain : a journal of neurology)
[2013, 136(Pt 6):1846-1856]

Cited: 23 times

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Mechanisms of pediatric cerebral arteriopathy: an inflammatory debate.

Aleksandra Mineyko, Adam Kirton,

Arteriopathy is the leading cause of childhood arterial ischemic stroke, but its mechanisms are poorly understood. This review explores the possible role of inflammatory mechanisms and evidence for inflammatory pathophysiology in specific pediatric cerebral arteriopathies. Pathologically proven small-vessel central nervous system vasculitis provides a definitive inflammatory model where available treatments ... Read more >>

Pediatr. Neurol. (Pediatric neurology)
[2013, 48(1):14-23]

Cited: 14 times

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Inflammatory biomarkers of pediatric focal cerebral arteriopathy.

Aleksandra Mineyko, Aru Narendran, Mark L Fritzler, Xing-Chang Wei, Heinrike Schmeling, Adam Kirton,

Neurology (Neurology)
[2012, 79(13):1406-1408]

Cited: 13 times

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Hyperekplexia: treatment of a severe phenotype and review of the literature.

Aleksandra Mineyko, Sharon Whiting, Gail E Graham,

Hyperekplexia is a rare disorder caused by autosomal dominant or recessive modes of inheritance and characterized by episodes of exaggerated startle. Five causative genes have been identified to date. The syndrome has been recognized for decades and due to its rarity, the literature contains mostly descriptive reports, many early studies ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2011, 38(3):411-416]

Cited: 2 times

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The black box of perinatal ischemic stroke pathogenesis.

Aleksandra Mineyko, Adam Kirton,

An improved understanding of perinatal stroke epidemiology, classification, neuroimaging, and outcomes has emerged in recent years. Despite this, little is known regarding the pathophysiological mechanisms responsible for most cases. A multitude of possible associations and putative risk factors have been reported, but most lack definitive empirical evidence supporting primary causation. ... Read more >>

J Child Neurol (Journal of child neurology)
[2011, 26(9):1154-1162]

Cited: 23 times

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A novel missense mutation in LIS1 in a child with subcortical band heterotopia and pachygyria inherited from his mildly affected mother with somatic mosaicism.

Aleksandra Mineyko, Asif Doja, Julie Hurteau, William B Dobyns, Soma Das, Kym M Boycott,

Mutations in the LIS1 gene result in isolated lissencephaly or subcortical band heterotopia. We report a 5-year-old male who presented with seizures and global developmental delay. Magnetic resonance imaging (MRI) demonstrated posteriorly predominant pachygyria and subcortical band heterotopia. His mother had a history of epilepsy, with onset in her teenage ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2010, 25(6):738-741]

Cited: 8 times

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Case 2: Long-standing neuropathy with acute onset of weakness.

Aleksandra Mineyko, Pierre Jacob,

(Paediatrics & child health)
[2008, 13(2):121-123]

Cited: 0 times

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