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Author Alejandro Granados

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Comparison of Robotic and Manual Implantation of Intracerebral Electrodes: A Single-Centre, Single-Blinded, Randomised Controlled Trial.

Vejay Vakharia, Roman Rodionov, Anna Miserocchi, Andrew McEvoy, Aidan O'Keeffe, Alejandro Granados, Shahrzad Shapoori, Rachel Sparks, Sebastien Ourselin, John Duncan,

There has been a significant rise in robotic trajectory guidance devices that have been utilised for stereotactic neurosurgical procedures. These devices have significant costs and associated learning curves. Previous studies reporting devices usage have not undertaken prospective parallel-group comparisons before their introduction, so the comparative differences are unknown.We study the ... Read more >>

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Imaging cell lineage with a synthetic digital recording system.

Ke-Huan K Chow, Mark W Budde, Alejandro A Granados, Maria Cabrera, Shinae Yoon, Soomin Cho, Ting-Hao Huang, Noushin Koulena, Kirsten L Frieda, Long Cai, Carlos Lois, Michael B Elowitz,

During multicellular development, spatial position and lineage history play powerful roles in controlling cell fate decisions. Using a serine integrase-based recording system, we engineered cells to record lineage information in a format that can be read out in situ<i>.</i> The system, termed integrase-editable memory by engineered mutagenesis with optical in ... Read more >>

Science (Science (New York, N.Y.))
[2021, 372(6538):]

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A generative model of hyperelastic strain energy density functions for multiple tissue brain deformation.

Alejandro Granados, Fernando Perez-Garcia, Martin Schweiger, Vejay Vakharia, Sjoerd B Vos, Anna Miserocchi, Andrew W McEvoy, John S Duncan, Rachel Sparks, Sébastien Ourselin,

<h4>Purpose</h4>Estimation of brain deformation is crucial during neurosurgery. Whilst mechanical characterisation captures stress-strain relationships of tissue, biomechanical models are limited by experimental conditions. This results in variability reported in the literature. The aim of this work was to demonstrate a generative model of strain energy density functions can estimate the ... Read more >>

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2021, 16(1):141-150]

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Refining Planning for Stereoelectroencephalography: A Prospective Validation of Spatial Priors for Computer-Assisted Planning With Application of Dynamic Learning.

Vejay N Vakharia, Rachel E Sparks, Alejandro Granados, Anna Miserocchi, Andrew W McEvoy, Sebastien Ourselin, John S Duncan,

<b>Objective:</b> Stereoelectroencephalography (SEEG) is a procedure in which many electrodes are stereotactically implanted within different regions of the brain to estimate the epileptogenic zone in patients with drug-refractory focal epilepsy. Computer-assisted planning (CAP) improves risk scores, gray matter sampling, orthogonal drilling angles to the skull and intracerebral length in a ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:706]

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Dedicated Poster Abstracts

Forster Bruce B., Bruin Anique de, Arnold Abigail, Hatala Rose, Merrienboer Jeroen van, Darras Kathryn, Spouge Rebecca, Nicolaou Savvas, Moghrabi Kamal, Doroudi Majid, Darras Kathryn, Lee Juvel, Bruin Anique de, Nicolaou Savvas, Forster Bruce, Javadian Farnaz, Jiang Andy, Ng Nicole, Tse Shirley, Doroudi Majid, Ng Nicole, Jiang Andy, Forster Bruce, Nicolaou Savvas, Hu Jeffrey, Spouge Rebecca, Nugent James, Darras Kathryn, Darras Kathryn, Spouge Rebecca, Hatala Rose, Nicolaou Savvas, Hu Jeff, Worthington Anne, Krebs Claudia, Forster Bruce B., Oberoi Vishesh, Hosseini Farshad, Doroudi Majid, Berish Richard, Lehr Josh, Downer Matthew, Duffley Luke, Hillier Phil, Lacey Kieran, Lewis Madison, Turner Brooke, Allison Jill, Vleuten Cees van der, Leppink Jimmie, Barber Cassandra, Chahine Saad, Gipson Meghan, PhD Lisa Richardson MD, Laurin Claudianne, Villeneuve Marie-Ève, Dulude Camille, Chahal Jasmine, Patel Mitesh, Helal Shaimaa, Mohammad Emaad, Islam Omar, Sayal Aarti, Gruber Jackie, Neville Lukas, Rocke Cathy, Elias Brenda, Perlmutter Hartley, Rolfson Darryl, Jeffery Thomas, Daniels Vijay, Hauff Patrick von, Thuswaldner Jessie, Lochnan Heather, Hendry Paul, Parson Robert, Ogilvie Jacqueline, Chen Breanna, Sangha Jill, Ens Andrea, Payne Sarah, Harms Sheila, Snelgrove Natasha, Kwan Ryann, Chafe Roger, Balicki Martha, Darja Barr, Renaud Robert, Sharma Atul, Rodd Celia, Friedman Lauren, Willmott Shannon, Lirette Marie-Pier, Shapka Larissa, Jewitt Natalie, Tse Gabriel, Zipursky Amy, Yorke Lisette, Atkinson Adelle, Weinstein Michael, Punnett Angela, Gunaseelan Senthujan, Walker Danielle, Larocque Natasha, Gibson Michelle, Tang Portia, Boles Ramy, Benedict Leshawn, Lui Joyce, Wright Roxanne, Leung Fok Han, Liederman Zachary, Silver Ivan, Selby Rita, Sandarage Ryan, Tang Brandon, Dutkiewicz Katrina, Saad Stephan, Chai Jocelyn, Dawson Kristin, Kitchin Vanessa, Hatala Rose, McCormick Iain, Kassen Barry, Abbas Aazad, McClennan Sarah, Syed Wasimuddin, Ibrahim Syed, Dergham Ali, Milne Laura, Trier Jessica, Albers Patrick, Ritchie Brodie, Miles Alexander, Crawford Eleanor, Batt Alan, Williams Brett, Brydges Madison, Leyenaar Matthew, Tavares Walter, Marceau Mélanie, Bouchard Denis, McLaughlin Monique, Lee Brian, James Landon, Barber Paul, Halasz Jennifer, Truong Leslie, Raffael Kendra, Phan Christine, Mathura Pam, Kassam Narmin, Hillier Tracey, Croden Jennifer, Wang Shujiao, Wagner Maryam, Dory Valérie, Wade Patricia, Cummings Beth-Ann, Smith Hannah, Sanchez-Ramirez Diana, Waslowski Jasmine, Paton Morag, Freymond Mary, Brownrigg Tristan, Patel Sagar, Olesovsky Shelby, Nyhof-Young Joyce, Zhong Adrina, Quint Elise, Audcent Tobey, Lee Jimin, Guerin Andrea, Lee-Kim Victoria, Grewal Karen, Willmott Shannon, Nowlan-Suart Theresa, Bowden Sylvie, Dimaras Helen, Ali Asim, Taju Sadik, Kletke Stephanie, Bowden Sylvie, Dimaras Helen, Solish Max, Roberts Alanna, Stasiuk Samantha, Maitland Alasdair Nazerali, Frolkis Alex, Michaud Allison, Ruzycki Shannon, Moussa Ahmed, Wassef Evelyne, Pennaforte Thomas, Assaad Michael-Andrew, Ens Andrea, Ogilvie Jacqueline, Chen Breanna, Peebles Erin, Mullowney Tara, Snelgrove Natasha, Westcott Sandra, Harms Sheila, Pardhan Kaif, Pardhan Alim, Brown Michael, Cofie Nicholas, Kwan Benjamin, Mussari Benedetto, Moore Pam, Meilleur Lynne, Islam Omar, Menard Alexandre, Soboleski Don, Dalgarno Nancy, Desanghere Loni, Saxena Anurag, Adams Scott J., Volk Andrew, Lai Hollis, Hillier Tracey, Ma Keon, Ali Jahaan, Deutscher Julianna, Silverman Jason, Novak Chris, Dong Sandy, Chmelicek John, Dance Erica, Goez Helly, Cooke Lara, Groot Janet de, Crowshoe Lynden, Choudhury Parichita, Luhanga Ulemu, Aaron Maria, Webb Adam, Denis-LeBlanc Manon, Pitre Lyne, Mediell Maud, David Adjo, Fotsing Salomon, Dionne Eric, Tan Laura, Tan Laura, Tan Lorraine, Khoo Yihan, Toh Ying Pin, Chin Annelissa, Krishna Lalit, Tan Laura, Tan Lorraine, Khoo Yihan, Toh Ying Pin, Chin Annelissa, Krishna Lalit, Descôteaux Annie, Berkesse Alexandre, Codsi Marie-Pierre, Payot Antoine, Karazivan Philippe, Dumez Vincent, Pont-Thibodeau Amélie Du, Orr-Gaucher Nathalie, Taguemout Melissa, Eymard Anne-Sophie, Jackson Mathieu, Dallaire Clara, Nicaise Louise, Ge Yipeng, Cull Ruth, Séguin Guylaine, Bessette Paul, Gagné Eve-Reine, Houde Sylvie, Mathieu Sylvie, Roulier Sébastien, Petit Geneviève, Pinsonneault Linda, Houde Ghislaine, Séguin Guylaine, Bessette Paul, Trépanier Gabrielle, Gagné Eve-Reine, Mathieu Sylvie, Houde Sylvie, Bélisle Damien, Houde Ghislaine, Truong Judy, Sheng Vanessa, Sandhu Priya, Sadeghi Yasamin, Venus Kevin, Abdullah Nadine, Melvin Lindsay, Lam Wilson, Sibai Hassan, Ralph-Edwards Robin, Ott Michael, VanKoughnett Julie Ann, Michel William Bédard, Castonguay Véronique, Desaulniers Pierre, Piette Éric, Iseppon Massimiliano, Raymer Patrice Chrétien, Leduc Jean-Michel, Bergeron Ariane, Lefebvre Judith, Villeneuve Marie-Ève, Surmanowicz Phillip, Rourke Liam, Damaant Ron, Goldstein Casey, Wright Roxanne, Wang Tianyue, Thibodeau Danielle, Nyhof-Young Joyce, MacNeil Kimberley, Hubinette Maria, Jarvis-Selinger Sandra, Trincao-Batra Sara, Mun Kyung Joon, Pham Tracy, Gondocz Tunde, McDougall Allan, Kosyakovsky Leah, Ruiz Michael, Himelfarb Jonah, Shulman Healey, Bonta Mark, Jiang Stephanie, McQueen Sydney, McParland Aidan, Mobilio Melanie Hammond, Moulton Carol-Anne, Bracken Keyna, Sharma Parth, Allison Emily, Endres Kaitlin, Zheng Katina, Elias Sarah, Deng Mimi, Kobza Alexandra, Li Aimee, Foley Veronique, Foley David, Kearney Grainne, Johnston Jenny, Hart Nigel, Gormley Gerry, Ma Irene, Desy Janeve, Noble Vicki, Liteplo Andrew, Olszynski Paul, Dumoulin Elaine, Arishenkoff Shane, Dversdal Renee, Liu Gigi, Buchanan Brian, Borle Sean, Hillier Tracey, Andrew Susan, Surgin Cody, Lai Hollis, Selim Omar, Dueck Andrew, Walsh Catharine, Brydges Ryan, Kulasegaram Mahan, Okrainec Allan, Lu Amy, Atkinson Adelle, Johnstone Julie, Juster Fern, Dore Kelly, Mawdsley Helen, Rachul Christen, Bernstein Keevin, Ripstein Ira, Hamilton Joanne, Phan Véronique, Ouellet Stéphane, Ramirez Dania, Sabourin Josée, Perreault Isabelle, Fernandez Nicolas, Pietrobon Adam, Chehadé Lucia, Beaudry-Richard Alexandra, Keller Brian, Schlossmacher Michael, Zaki Nicole, Cavett Teresa, Halas Gayle, Caretta-Weyer Holly, Crawford Lindsay, Taylor Sean, Cofie Nicholas, Dagnone Damon, McEwen Laura, Kushneriuk Matt, Andres Deirdre, Symon Andrea, Naidu Di Naidu, LLoyd Joshua, Symon Andrea, Thurgur Lisa, Cortel-LeBlanc Miguel, Landreville Jeffrey, Batt Alan, Tavares Walter, Williams Brett, Wang Wenxuan, Weir Michele, Massey Kyle, Tithecott Gary, Hamadi Cyrus, Ndoja Silvio, Dion Charles, McCarton Alexander, Charron Brynn, LeBel Marie-Eve, Wang Yuding, dore Kelly, Matsumoto Edward, Russle Dana, Wong Nathan, Hoogenes Jen, Shayegan Bobby, Wan Miranda, Spence Stewart, Wan Melissa, Schenker Carly, Herzog Lindsay, Bearss Erin, Forte Milena, Roberts Michael, Waters Ian, Toubassi Diana, Smith Stephanie, Griggs Lauren, Rizzuti Franco, Horton Joan, Kassam Aliya, Brown Allison, Leung Marie, Geen Olivia, Mullett Samantha Woodrow, Li Meirui, Mudachi Naomi, Shah Hely, St-Pierre-Alain Roxanne, Couture Maxime, Désilets Audrey, Kim Valerie S., Chen Allison J., Chen Anna, Beck Lauren A., Berger Ivona, Phung Natalie, Park Caroline, Vi Lisa, Neufeld Adam, Malin Greg, Labine Laurence, Cigna Maude, Deneault-Marchand Ariane, Labelle Karina Salvo, Lavoie Gabriel, Racine-Hamel Sarah-Émilie, Marcoux Sophie, Martel Kendra, Ruzycki Shannon, Seto Anthony, Kennedy William, Margetts Mackenzie, Rohatensky Mitchell, Choo Jian, Crooks Sean, Ertl Nicole, Sharfuddin Nazia, Zondervan Nathan, Streith Lucas, Hufton Louise, Granados Alejandro, Bello Fernando, Wheeler Daniel, Seto Anthony, Kariath Josh, Brownbridge Regan, Persad Amit, Radic Julia, Bicamumpaka-Shema Astrid, Zahabi Sarah, Zahabi Sarah, Tremblay Marie-Frédéric, Rodriguez Rosario, Rozo Laura Rojas, Pusic Luka, Pusic Martin, Baxter Mark, Dubrowski Adam, Weber Tim, Clarke Krystina, Wang Zhujiang, Savaglio Robert, Simpson Ruth, DiGiuseppe Maurice, Kapralos Bill, Frangou Sarah, Edwards Kristen, Garrett Natalie, Frost Joshua, Deck Megan, Rabheru Kiran, Hedlin Peter, Davidson Marla, Frégeau Amélie, Frégeau Amélie, Cournoyer Alexis, Soucy Nathalie, Fortier David, Desaulniers Pierre, Castonguay Véronique, Fleet Richard, Suri Minisha, Kopansky-Giles Deborah, Mior Silvano, Jeffs Lianne, White Kari, Campbell Douglas, Blonde Jackson, Atkins Andrew, Munro Susan, Boulila Cyril, Girouard-Chantal Élise, Lassman Matthew, Gendron Christophe, Dubé Timothy, Girourard-Chantal Elise, D'Eon Marcel, Lombamo Get, Luc Jelyssa, Murdoch Natasha Hubbard, Lowe Poppy, Clarke Krystina, Weber Timothy, Wang Zhujiang, Dubrowski Adam, Quevedo Alvaro, Kapralos Bill, Winstead-Derlega Chris, Sebok-Syer Stefanie, Bach Michelle, Trinh Elizabeth, Trounce Natalia, Boukhman Milana, Vernooy Camille Pelletier, Cohé Clément, Abelsohn Kira, Owen James, Fournier Cathy, Rojas David, Richardson Lisa, Whitehead Cynthia, King Sadie, Maherzi Ahmed, Blain Samuel, Paul Claudie, Petiquay Laurianne, Petiquay Claudia, Yeung Sharon, Bombay Amy, Walker Chad, Denis Jeff, Martin Debbie, Sylvestre Paul, Castleden Heather, Cox Ashton, Lai Hollis, Hillier Tracey, Rodger Joanne, Jeffery Thomas, Stride Devon, Chan Teresa, Hladky Valerie, Lamontagne Amelia, Hladky Valerie, Lamontagne Amelia, Li Qi, Phillips Chantal, Balakrishna Anita, Robinson Lisa, Deng Mimi, Seabrook Christine, Nham Emily (Tu Nhi), Watterson James, Malvea Anahita, Diaz Francis, Ens Anita, Thiem Sasha, Condon Amanda, Wheeler Daniel, Papadopoulos Filippos, Hufton Louise, Portnoy Danielle, Moran Martin, Hillier Tracey, Helal Shaimaa, Guerin Andrea, Faghfoury Hanna, Thivierge-Southidara Maureen, Courchesne Mathieu, Bonneau Steven, Carrier Michel, Henri Margaret, Kasper Graham, Halawa Saly, Jiang Shirley Xue, Masino Caterina, Okrainec Allan, Kobza Alexandra, Endres Kaitlin, Zheng Katina, Elias Sarah, Deng Mimi, Li Aimee, Turcotte Michelle, Thabet Chloé, Phuong Melissa, Rhee Glara, Tsang Phillip, Foley Olwyn, Gotfrit Ryan, Zuccaro Laura, Contreras-Dominguez Vladimir, Bell Robert, Bialy Safaa El, Jay Mohammad, Leddy John, Ramnanan Christopher, Hebert Yamilee, Karol Dalia limor, Manhas Neraj, Correia Rebecca, Klea Lindsay, Campbell Graham, Costa Andrew, Wang Linda, Dizon Stephanie, Arnaout Amel, Kennedy William, Andruchow Daniel, Dowling Shawn, Lonergan Kevin, Rich Tom, Patocka Catherine, Pitre Lyne, D'aoust-Bernard Chantal, Friesen Anne-Marie, Adjo David, Tremblay Marie-Claude, Guichard Anne, Quinty Julien, Rheault Christian, Gravel Chantal, Tremblay Marie-Claude, Préfontaine Cassandra, Lemire Chantal, Corriveau Hélène, April Marie-Josée, Gaboury Isabelle, Bishop Kristen, Hawilo Hasan, Taneja Ravi, Goldszmidt Mark, Genevieve Lemay, Zou Christopher, Leddy John, McConnell Meghan, Antonacci Patrick, Graillon Ann, Poirier Joanie, Ouellet Kathleen, Désilets Valérie, Xhignesse Marianne, St-Onge Christina, Tavares Walter, Kuper Ayelet, Kulasegaram Mahan, Whitehead Cynthia, Hui Jacqueline, Wycliffe-Jones Keith, Lockyer Jocelyn, Lockyer Jocelyn, Campbell Craig, DiMillo Shanna, Sibbald Debra, Sanchez-Ramirez Diana C, Smith Hannah, Rainey Dori, Renaud Jean-Sébastien, Bourget Martine, St-Onge Christina, Eva Kevin, Tavares Walter, Loye Alexis Salvador, Leduc Jean-Michel, Homer Matthew, Henri Margaret, Gagnon Robert, Bourdy Christian, Leduc Jean-Michel, Grégoire Geneviève, Zevin Boris, Barber David, Houlden Robyn, Soleas Eleftherios, Roberts Lynn, Wylick Richard van, Evans Katie, Dalgarno Nancy, Miller Stephen, MacKenzie Diane, Creaser Gail, Sponagle Kim, Condon Amanda, Turcotte Dana, Clendenan Jessica, Rauliuk Margaret, Stewart Wendy A, Friedman Ellen M., Laufman Larry, Friedland Joan, Gill Anne, Shah Vandana, Velez Camila, Friedman Deborah, Shery Nicole-Ann, Maftoul Rebecca, Jobin Vincent, Charlin Bernard, Berkesse Alexandre, Descoteaux Annie, Lebel Caroline, Rouleau Marc, Sénécal Anouck, Ngo-Minh Tin, Brousseau Gilles, Leblanc Michel, Vadnais Fabien, Nutik Melissa, Freeman Risa, Woods Nicole, Moaveni Azadeh, Alvi Ruby, Owen James, Gleberzon Jared, Lee-Poy Michael, Speerstra Sietske, Livy Daniel, Lai Hollis, Hillier Tracey, Dosman Cara, Andrews Debbi, Cervantes Andrea Davila, Guo Qi, Gallagher Sheila, Eliason Sabrina, Hodgson Carol, Cusson Victoria-Marie, Bruyninx Gladys, Laplante Stefan de, Chan Fong, Seet Tony, Yeung Janice, Leung Sharon, MacNeil Kimberley, Li Reanne, Saran Justine, Jarvis-Selinger Sandra, Stalwick Amanda, Taylor-Gjevre Regina, Kulman-Lipsey Shayna, Leo Joanne Leo, Yang Samantha, Javidan Arshia, Levinson Andrea, Nickell Leslie, Brady Colleen, Fischer Michelle, Seet Tony, Ross Shelley, Aquilina Alexandra, Kiddell Rob, Hamza Deena, Goes Theresa van der, Poth Cheryl, Schipper Shirley, Blumer Paige, Claydon Michael, Murray Katey, Krebs Claudia, Schneidewind Sabine, Bintaro Philip, Haft Hadas, Tajani Sarah, Bluman Bob, MacDonell Karen, Lynn Brenna, Young Kathryn, Boicu Bianca, Frenkel Oron, Velez Camila, Shery Nicole-Ann, Friedman Deborah, Pittini Richard, Tu Yuxin, Robinson Lisa, Babcock Glenys, Ruetalo Mariela, Claudio Fernanda, Wade Patricia, Sanchez-Ramirez Diana C, Polimeni Christine, Paton Morag, Rowland Paula, Tavares Walter, Schneeweiss Suzan, Ginsburg Shiphra, Luconi Francesca, Wooster Elizabeth, Paton Morag, Teferra Meron, Quaiattini Andrea, Schneeweiss Suzan, Cook Clare, Kokanie Lisa, Colquhoun Julie, Cauti Susan, Gaunt Heather, Osmar Kari, Goldman Joanne, Wong Brian, Lo Lisha, Kuper Ayelet, Smeraglio Anne, Larsen Takaia, Busche Kevin, Paget Mike, Woloschuk Wayne, Piquette Dominique, Mema Briseida, Lee Christie, Goffi Alberto, Walsh Catharine, Brydges Ryan, Borschel Debaroti Mullick, Najeeb Umberin, Panisko Danny, Sirianni Giovanna, Glover-Takahashi Susan, Cusson Lise, Laurin Suzanne, Peranson Judith, Batty Helen, Jacob Ancy, Ghavam-Rassoul Abbas, Lazor Jana, Bell Jennifer, Innes Lori, Good Eleanor, Tonseth Pete, Sturgeon Anthony, Marinkovic Angelina, Nazerali-Maitland Alasdair, Stasiuk Samantha, Railer Jennifer, Stockley Denise, Flynn Leslie, Hastings-Truelove Amber, Hussain Alicia, Laurin Suzanne, Cuncic Cary, Tessaro James, Nagi Harp, Nakanishi Allison, Nijjar Aman, Myhre Douglas, Malhi Rebecca, Ornstein Jodie, Whalen-Browne Molly, Lee Sonya, Koppula Sudha, Mintsioulis Stephen, Topps Maureen, Jacobs Sarah, Wyman Jennifer, Cohen Ethan, Wideman Anne, David Andrea, Nyhof-Young Joyce, Shuman Mira, Zimcik Heather, Law Marcus, McCabe Jennifer, Murdoch Stuart, Moaveni Azadeh, Freeman Risa, Esliger Mandy, Hazelton Lara, Milliken Heather, Good Kim, Nidumolu Aditya, Kuo Kuo-Hsing, Leo Joyce, Topps David, Lombard Marise, Lombard Marise, Keely King, Kilbertus Frances, Robinson Susan, Cristancho Sayra, Burm Sarah, Ng Stella, Nemoy Lori, Campbell Douglas, Meffe Filomena, Moscovitch Linda, Bishop Catherine, Fella Sabina, Chandrasekaran Nirmala, Brydges Ryan, Grosjean Sylvie, Bonneville Luc, Waldolf Richard, Nahon-Serfaty Isaac, Caon Julianna, Eva Kevin, Miller Stephen, McAdam Stuart, Kulai Tasha, Haroon Babar, Fairbridge Nicholas, Curran Vernon, Deacon Diana, Sauve Karen, Greig Alison, Murphy Sue, Louie Riley, Anthony Joseph, Friedman Ellen M., Harris Toi, Malmberg Erik, Marchington Katie, Lewin Warren, Hazelton Lara, Love Susan, Bonang Lisa, Torti Jacqueline, Inayat Ali, Inayat Hamza, Haddara Wael, Sultan Nabil, Careau Emmanuelle, Bérubé Marie-Claire, Provost Émélie, Poitras Julien, Grosjean Sylvie, Waldolf Richard, Bonneville Luc, Boileau Judith, Nahon-Serfaty Isaac, Cherba Maria, Vesel Tamara, Wang Grace, Blanco Maria, Ernst Emma, Walker Leah, Howse Rebecca, Eatmon Rebekah, Chow Yan, Campbell Kate, Hopkins Claudia, Keesey Andrea, Lynn Brenna, Burnier Isabelle, Fotsing Salomon, Chomienne Marie Hélène, Bouchard-Lamothe Diane, Jackson Mathieu, Descoteaux Annie, Nicaise Louise, Karazivan Philippe, Codsi Marie-Pierre, Dallaire Clara, Davila-Cervantes Andrea, Rashid Marghalara, Goez Helly, Cook Karen, Jalloh Chelsea, Berrington Roger, Condo Nina, Rubayita Felicien, Whetter Ian, Konkin Jill, Lemoine Daniel, Rourke Liam, Nichols Darren, Hauck Ute, Bell Amanda, Stobbe Karl, Chambers Larry W., Basha Vesa, Brazier Jessie, Dragomir Delia, Glibbery Meghan, Kearney Hannah, Knapp Alison, Levin Daniel, Tucker Dyon, Weera Seddiq, Lukings Jorin, Pinder Karen, Ford Jason, Penner Charles, Ouellet Jean, Martel Elise, Turgeon Sébastien, Dubé-Louber Alexandra, Fortin Julie, Thibodeau Raymond, Pelletier Mathieu, Comeau Diane, Parent Claudine, Coderre-Ball Angela, Dalgarno Nancy, Baumhour Jessica, Ko Iris, Zubani Vittoria, Dallaire Clara, Karazivan Philippe, Codsi Marie-Pierre, Descôteaux Annie, Jackson Mathieu, L'Espérance Audrey, Taylor Taryn, Luhanga Ulemu,

Background/Purpose: Virtual dissection is performed with CT scans on near life-size touchscreens, which function like hospital radiology workstations. Students work together to manipulate the data and perform their dissection. The purpose of this study was to develop and qualitatively assess the educational value of virtual dissection laboratories for first year ... Read more >>

Can Med Educ J (Canadian medical education journal)
[2020, 11(2):e155-e274]

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Automated computation and analysis of accuracy metrics in stereoencephalography.

Alejandro Granados, Roman Rodionov, Vejay Vakharia, Andrew W McEvoy, Anna Miserocchi, Aidan G O'Keeffe, John S Duncan, Rachel Sparks, Sébastien Ourselin,

<h4>Background</h4>Implantation accuracy of electrodes during neurosurgical interventions is necessary to ensure safety and efficacy. Typically, metrics are computed by visual inspection which is tedious, prone to inter-/intra-observer variation, and difficult to replicate across sites.<h4>New method</h4>We propose an automated approach for computing implantation metrics and investigate potential sources of error. We ... Read more >>

J Neurosci Methods (Journal of neuroscience methods)
[2020, 340:108710]

Cited: 1 time

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Imaging cell lineage with a synthetic digital recording system

Ke-Huan Chow, Mark Budde, Alejandro Granados, Maria Cabrera, Shinae Yoon, Soomin Cho, Ting-hao Huang, Noushin Koulena, Kirsten Frieda, Long Cai, Carlos Lois, Michael Elowitz,

Multicellular development depends on the differentiation of cells into specific fates with precise spatial organization. Lineage history plays a pivotal role in cell fate decisions, but is inaccessible in most contexts. Engineering cells to actively record lineage information in a format readable in situ would provide a spatially resolved view ... Read more >>

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Taking the Pressure Off the Patient - Understanding Digital Rectal Examinations on a Real Subject.

Alejandro Granados, Seth Cox, Naomi Low-Beer, Jenny Higham, Roger Kneebone, Fernando Bello,

Better understanding of palpation techniques during unsighted physical examinations has mostly been limited to qualitative and quantitative studies of performance of experts whilst conducting examinations on plastic benchtop models. However, little is known about their performance when conducting such examinations on real subjects.<h4>Objective</h4>The aim of this paper is to better ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2020, 67(10):2798-2805]

Cited: 1 time

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Optimizing Trajectories for Cranial Laser Interstitial Thermal Therapy Using Computer-Assisted Planning: A Machine Learning Approach.

Kuo Li, Vejay N Vakharia, Rachel Sparks, Lucas G S França, Alejandro Granados, Andrew W McEvoy, Anna Miserocchi, Maode Wang, Sebastien Ourselin, John S Duncan,

Laser interstitial thermal therapy (LITT) is an alternative to open surgery for drug-resistant focal mesial temporal lobe epilepsy (MTLE). Studies suggest maximal ablation of the mesial hippocampal head and amygdalohippocampal complex (AHC) improves seizure freedom rates while better neuropsychological outcomes are associated with sparing of the parahippocampal gyrus (PHG). Optimal ... Read more >>

Neurotherapeutics (Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics)
[2019, 16(1):182-191]

Cited: 5 times

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Distributed and dynamic intracellular organization of extracellular information.

Alejandro A Granados, Julian M J Pietsch, Sarah A Cepeda-Humerez, Iseabail L Farquhar, Gašper Tkačik, Peter S Swain,

Although cells respond specifically to environments, how environmental identity is encoded intracellularly is not understood. Here, we study this organization of information in budding yeast by estimating the mutual information between environmental transitions and the dynamics of nuclear translocation for 10 transcription factors. Our method of estimation is general, scalable, ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(23):6088-6093]

Cited: 12 times

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Real-time Visualisation and Analysis of Clinicians' Performance during Palpation in Physical Examinations.

Alejandro Granados, Naomi Low-Beer, Jenny Higham, Roger Kneebone, Fernando Bello,

<h4>Objective</h4>Motivated by the fact that palpation skills are challenging to learn and teach, particularly during Digital Rectal Examinations (DRE), and the lack of understanding of what constitutes adequate performance, we present a visualisation and analysis system that uses small position and pressure sensors located on the examining finger, allowing the ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2018, 65(9):2042-2051]

Cited: 0 times

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Standardizing bimanual vaginal examination using cognitive task analysis.

Isabella Plumptre, Omar Mulki, Alejandro Granados, Claudine Gayle, Shahla Ahmed, Naomi Low-Beer, Jenny Higham, Fernando Bello,

<h4>Objective</h4>To create a standardized universal list of procedural steps for bimanual vaginal examination (BVE) for teaching, assessment, and simulator development.<h4>Methods</h4>This observational study, conducted from June-July 2012 and July-December 2014, collected video data of 10 expert clinicians performing BVE in a nonclinical environment. Video data were analyzed to produce a cognitive ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2017, 139(1):114-119]

Cited: 0 times

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Distributed and dynamic intracellular organization of extracellular information

Alejandro Granados, Julian Pietsch, Sarah Cepeda-Humerez, Gašsper Tkačik, Peter Swain,

Although cells respond specifically to environments, how environmental identity is encoded intracellularly is not understood. Here we study this organization of information in budding yeast by estimating the mutual information between environmental transitions and the dynamics of nuclear translocation for ten transcription factors. Our method of estimation is general, scalable, ... Read more >>

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Distributing tasks via multiple input pathways increases cellular survival in stress.

Alejandro A Granados, Matthew M Crane, Luis F Montano-Gutierrez, Reiko J Tanaka, Margaritis Voliotis, Peter S Swain,

Improving in one aspect of a task can undermine performance in another, but how such opposing demands play out in single cells and impact on fitness is mostly unknown. Here we study budding yeast in dynamic environments of hyperosmotic stress and show how the corresponding signalling network increases cellular survival ... Read more >>

Elife (eLife)
[2017, 6:]

Cited: 8 times

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Nucleophilic substitution in ionizable Fischer thiocarbene complexes: steric effect of the alkyl substituent on the heteroatom.

Diego M Andrada, Martin E Zoloff Michoff, Rita H de Rossi, Alejandro M Granados,

A detailed kinetic study has been carried out for the aminolysis of ionizable Fischer thiocarbene complexes (CO)5M[double bond, length as m-dash]C(SR)CH3 (M = Cr, W; R = iPr, nBu, cHex, tBu) with five primary amines and one secondary amine in aqueous acetonitrile solutions (50% MeCN-50% water (v/v)). The observed rate ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2015, 44(12):5520-5534]

Cited: 0 times

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Distinctive interactions of oleic acid covered magnetic nanoparticles with saturated and unsaturated phospholipids in Langmuir monolayers.

Thabo J Matshaya, Anabel E Lanterna, Alejandro M Granados, Rui W M Krause, Bruno Maggio, Raquel V Vico,

The growing number of innovations in nanomedicine and nanobiotechnology are posing new challenges in understanding the full spectrum of interactions between nanomateriales and biomolecules at nano-biointerfaces. Although considerable achievements have been accomplished by in vivo applications, many issues regarding the molecular nature of these interactions are far from being well-understood. ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2014, 30(20):5888-5896]

Cited: 5 times

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Real-time visualisation and analysis of internal examinations--seeing the unseen.

Alejandro Granados, Niels Hald, Aimee Di Marco, Shahla Ahmed, Naomi Low-Beer, Jenny Higham, Roger Kneebone, Fernando Bello,

Internal examinations such as Digital Rectal Examination (DRE) and bimanual Vaginal Examination (BVE) are routinely performed for early diagnosis of cancer and other diseases. Although they are recognised as core skills to be taught on a medical curriculum, they are difficult to learn and teach due to their unsighted nature. ... Read more >>

Med Image Comput Comput Assist Interv (Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention)
[2014, 17(Pt 1):617-625]

Cited: 1 time

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Simulating various levels of clinical challenge in the assessment of clinical procedure competence.

Jimmy Kyaw Tun, Alejandro Granados, Stella Mavroveli, Stuart Nuttall, Ananth Nag Kadiyala, Ruth Brown, Fernando Bello, Roger Lister Kneebone,

<h4>Study objective</h4>Immersive simulation is increasingly used for competency assessment of emergency physicians. This group's concept of hybrid simulation (HS) (combining simulated patients and part-task trainers (a simulator that simulates a limited component of a clinical procedure) to create a multimodal clinical context) requires clinicians to integrate technical and nontechnical skills ... Read more >>

Ann Emerg Med (Annals of emergency medicine)
[2012, 60(1):112-20.e5]

Cited: 8 times

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Role of the hydrophobicity on the thermodynamic and kinetic acidity of Fischer thiocarbene complexes.

Diego M Andrada, Martin E Zoloff Michoff, Rita H de Rossi, Alejandro M Granados,

Rate constants for the reversible deprotonation of (CO)(5)W=C(SR)CH(3) (W-SR) by OH(-), water and a number of primary aliphatic and secondary alicyclic amines, have been determined in 50% MeCN:50% water at 25 degrees C. In addition, solvation energy and proton affinities values for M-SR (M = Cr and W) in the ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2010, 12(25):6616-6624]

Cited: 1 time

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E-Z isomerization and aggregation phenomena of dithiafulvenes in CHCl3.

Alejandro M Fracaroli, Alejandro M Granados, Rita H de Rossi,

The physical-chemical properties of several 1,3-dithiafulvene (DTF) derivatives having a donor and acceptor group in the molecule were studied. The synthesis of these compounds produces selectively the E isomer, but when the compound is dissolved in CHCl(3) isomerization to the Z isomer takes place with a rate that depends on ... Read more >>

J Org Chem (The Journal of organic chemistry)
[2009, 74(5):2114-2119]

Cited: 2 times

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Alkynyl Fischer carbene complex as a traceless directing group for the regioselective cycloaddition of dithiolethiones to arylacetylene: synthesis of E-dithiafulvene thione and dithioesters.

Alejandro M Granados, Alejandro M Fracaroli, Rita H de Rossi, Pedro Fuertes, Tomás Torroba,

A phenylethynyl Fischer carbene complex was used as a traceless directing group for the regioselective cycloaddition of dithiolethiones to arylacetylene, which constitutes the first synthesis of E-dithiafulvene thione or dithioesters. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2008, (4):483-485]

Cited: 3 times

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Kinetics of the reactions of [p-nitrophenoxy(phenyl)carbene]pentacarbonylchromium(0) with aryloxide ions, hydroxide ion, and water in aqueous acetonitrile. Concerted or stepwise?

Claude F Bernasconi, Martin E Zoloff Michoff, Rita H de Rossi, Alejandro M Granados,

The main question addressed in this paper is whether the nucleophilic substitution of the p-nitrophenoxy group in (CO)5Cr=C(OC6H4-4-NO2)Ph (1-NO2) by a series of substituted phenoxide ions is concerted or stepwise. Rate constants, kArO, for these substitution reactions were determined in 50% MeCN-50% water (v/v) at 25 degrees C. A Brønsted ... Read more >>

J Org Chem (The Journal of organic chemistry)
[2007, 72(4):1285-1293]

Cited: 1 time

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Synthesis of 1,3-dithiin dithioortho esters from the reaction of Fischer carbenes and 3H-1,2-dithiole-3-thiones.

Alejandro M Granados, Jeronimo Kreiker, Rita H de Rossi, Pedro Fuertes, Tomás Torroba,

[reaction: see text] Tricyclic 4-ethyl-5-thioxo-3H,5H-bis[1,2]dithiolo[3,4-d][4,3-b]pyrrol-3-one and monocyclic 3H-1,2-dithiole-3-thione derivatives reacted with Fischer carbene complexes, giving 1,3-dithiin dithioortho esters through insertion of the carbenic carbon into the S-S bond next to the thiocarbonyl function of the substrate. ... Read more >>

J Org Chem (The Journal of organic chemistry)
[2006, 71(2):808-810]

Cited: 1 time

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Hydrolysis of Fischer carbene complexes. Steric effects of the pi-donor group.

Martin E Zoloff Michoff, Rita H de Rossi, Alejandro M Granados,

Rate constants for the hydrolysis of Fischer carbenes (CO)5Cr=C(OR)Ph (R = n-propyl, neopentyl, isopropyl, and menthyl) in 50% MeCN-50% water (v/v) at 25 degrees C are reported. The rate constants for the addition of -OH to the carbene carbon are 5.3, 3.7, 0.84, and 0.01 M(-1) s(-1), respectively. These rate ... Read more >>

J Org Chem (The Journal of organic chemistry)
[2006, 71(6):2395-2401]

Cited: 2 times

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