Full Text Journal Articles by
Author Alejandro Granados

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Refining Planning for Stereoelectroencephalography: A Prospective Validation of Spatial Priors for Computer-Assisted Planning With Application of Dynamic Learning.

Vejay N Vakharia, Rachel E Sparks, Alejandro Granados, Anna Miserocchi, Andrew W McEvoy, Sebastien Ourselin, John S Duncan,

Objective: Stereoelectroencephalography (SEEG) is a procedure in which many electrodes are stereotactically implanted within different regions of the brain to estimate the epileptogenic zone in patients with drug-refractory focal epilepsy. Computer-assisted planning (CAP) improves risk scores, gray matter sampling, orthogonal drilling angles to the skull and intracerebral length in a ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:706]

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Automated computation and analysis of accuracy metrics in stereoencephalography.

Alejandro Granados, Roman Rodionov, Vejay Vakharia, Andrew W McEvoy, Anna Miserocchi, Aidan G O'Keeffe, John S Duncan, Rachel Sparks, Sébastien Ourselin,

BACKGROUND:Implantation accuracy of electrodes during neurosurgical interventions is necessary to ensure safety and efficacy. Typically, metrics are computed by visual inspection which is tedious, prone to inter-/intra-observer variation, and difficult to replicate across sites. NEW METHOD:We propose an automated approach for computing implantation metrics and investigate potential sources of error. ... Read more >>

J. Neurosci. Methods (Journal of neuroscience methods)
[2020, 340:108710]

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Dedicated Poster Abstracts.

Can Med Educ J (Canadian medical education journal)
[2020, 11(2):e154-e273]

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Imaging cell lineage with a synthetic digital recording system

Ke-Huan Chow, Mark Budde, Alejandro Granados, Maria Cabrera, Shinae Yoon, Soomin Cho, Ting-hao Huang, Noushin Koulena, Kirsten Frieda, Long Cai, Carlos Lois, Michael Elowitz,

Abstract Multicellular development depends on the differentiation of cells into specific fates with precise spatial organization. Lineage history plays a pivotal role in cell fate decisions, but is inaccessible in most contexts. Engineering cells to actively record lineage information in a format readable in situ would provide a spatially resolved ... Read more >>

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Taking the Pressure off the Patient - Understanding Digital Rectal Examinations on a Real Subject.

Alejandro Granados, Seth Cox, Naomi Low-Beer, Jenny Higham, Roger Kneebone, Fernando Bello,

Better understanding of palpation techniques during unsighted physical examinations has mostly been limited to qualitative and quantitative studies of performance of experts whilst conducting examinations on plastic benchtop models. However, little is known about their performance when conducting such examinations on real subjects. OBJECTIVE:The aim of this paper is to ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2020, :]

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Optimizing Trajectories for Cranial Laser Interstitial Thermal Therapy Using Computer-Assisted Planning: A Machine Learning Approach.

Kuo Li, Vejay N Vakharia, Rachel Sparks, Lucas G S França, Alejandro Granados, Andrew W McEvoy, Anna Miserocchi, Maode Wang, Sebastien Ourselin, John S Duncan,

Laser interstitial thermal therapy (LITT) is an alternative to open surgery for drug-resistant focal mesial temporal lobe epilepsy (MTLE). Studies suggest maximal ablation of the mesial hippocampal head and amygdalohippocampal complex (AHC) improves seizure freedom rates while better neuropsychological outcomes are associated with sparing of the parahippocampal gyrus (PHG). Optimal ... Read more >>

Neurotherapeutics (Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics)
[2019, 16(1):182-191]

Cited: 3 times

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Distributed and dynamic intracellular organization of extracellular information.

Alejandro A Granados, Julian M J Pietsch, Sarah A Cepeda-Humerez, Iseabail L Farquhar, Gašper Tkačik, Peter S Swain,

Although cells respond specifically to environments, how environmental identity is encoded intracellularly is not understood. Here, we study this organization of information in budding yeast by estimating the mutual information between environmental transitions and the dynamics of nuclear translocation for 10 transcription factors. Our method of estimation is general, scalable, ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(23):6088-6093]

Cited: 3 times

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Real-time Visualisation and Analysis of Clinicians' Performance during Palpation in Physical Examinations.

Alejandro Granados, Naomi Low-Beer, Jenny Higham, Roger Kneebone, Fernando Bello,

OBJECTIVE:Motivated by the fact that palpation skills are challenging to learn and teach, particularly during Digital Rectal Examinations (DRE), and the lack of understanding of what constitutes adequate performance, we present a visualisation and analysis system that uses small position and pressure sensors located on the examining finger, allowing the ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2018, 65(9):2042-2051]

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Standardizing bimanual vaginal examination using cognitive task analysis.

Isabella Plumptre, Omar Mulki, Alejandro Granados, Claudine Gayle, Shahla Ahmed, Naomi Low-Beer, Jenny Higham, Fernando Bello,

To create a standardized universal list of procedural steps for bimanual vaginal examination (BVE) for teaching, assessment, and simulator development.This observational study, conducted from June-July 2012 and July-December 2014, collected video data of 10 expert clinicians performing BVE in a nonclinical environment. Video data were analyzed to produce a cognitive ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2017, 139(1):114-119]

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Distributed and dynamic intracellular organization of extracellular information

Alejandro Granados, Julian Pietsch, Sarah Cepeda-Humerez, Gašsper Tkačik, Peter Swain,

Abstract Although cells respond specifically to environments, how environmental identity is encoded intracellularly is not understood. Here we study this organization of information in budding yeast by estimating the mutual information between environmental transitions and the dynamics of nuclear translocation for ten transcription factors. Our method of estimation is general, ... Read more >>

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Distributing tasks via multiple input pathways increases cellular survival in stress.

Alejandro A Granados, Matthew M Crane, Luis F Montano-Gutierrez, Reiko J Tanaka, Margaritis Voliotis, Peter S Swain,

Improving in one aspect of a task can undermine performance in another, but how such opposing demands play out in single cells and impact on fitness is mostly unknown. Here we study budding yeast in dynamic environments of hyperosmotic stress and show how the corresponding signalling network increases cellular survival ... Read more >>

Elife (eLife)
[2017, 6:]

Cited: 6 times

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Nucleophilic substitution in ionizable Fischer thiocarbene complexes: steric effect of the alkyl substituent on the heteroatom.

Diego M Andrada, Martin E Zoloff Michoff, Rita H de Rossi, Alejandro M Granados,

A detailed kinetic study has been carried out for the aminolysis of ionizable Fischer thiocarbene complexes (CO)5M[double bond, length as m-dash]C(SR)CH3 (M = Cr, W; R = iPr, nBu, cHex, tBu) with five primary amines and one secondary amine in aqueous acetonitrile solutions (50% MeCN-50% water (v/v)). The observed rate ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2015, 44(12):5520-5534]

Cited: 0 times

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Distinctive interactions of oleic acid covered magnetic nanoparticles with saturated and unsaturated phospholipids in Langmuir monolayers.

Thabo J Matshaya, Anabel E Lanterna, Alejandro M Granados, Rui W M Krause, Bruno Maggio, Raquel V Vico,

The growing number of innovations in nanomedicine and nanobiotechnology are posing new challenges in understanding the full spectrum of interactions between nanomateriales and biomolecules at nano-biointerfaces. Although considerable achievements have been accomplished by in vivo applications, many issues regarding the molecular nature of these interactions are far from being well-understood. ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2014, 30(20):5888-5896]

Cited: 4 times

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Real-time visualisation and analysis of internal examinations--seeing the unseen.

Alejandro Granados, Niels Hald, Aimee Di Marco, Shahla Ahmed, Naomi Low-Beer, Jenny Higham, Roger Kneebone, Fernando Bello,

Internal examinations such as Digital Rectal Examination (DRE) and bimanual Vaginal Examination (BVE) are routinely performed for early diagnosis of cancer and other diseases. Although they are recognised as core skills to be taught on a medical curriculum, they are difficult to learn and teach due to their unsighted nature. ... Read more >>

Med Image Comput Comput Assist Interv (Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention)
[2014, 17(Pt 1):617-625]

Cited: 1 time

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Simulating various levels of clinical challenge in the assessment of clinical procedure competence.

Jimmy Kyaw Tun, Alejandro Granados, Stella Mavroveli, Stuart Nuttall, Ananth Nag Kadiyala, Ruth Brown, Fernando Bello, Roger Lister Kneebone,

STUDY OBJECTIVE: Immersive simulation is increasingly used for competency assessment of emergency physicians. This group's concept of hybrid simulation (HS) (combining simulated patients and part-task trainers (a simulator that simulates a limited component of a clinical procedure) to create a multimodal clinical context) requires clinicians to integrate technical and nontechnical ... Read more >>

Ann Emerg Med (Annals of emergency medicine)
[2012, 60(1):112-20.e5]

Cited: 8 times

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Role of the hydrophobicity on the thermodynamic and kinetic acidity of Fischer thiocarbene complexes.

Diego M Andrada, Martin E Zoloff Michoff, Rita H de Rossi, Alejandro M Granados,

Rate constants for the reversible deprotonation of (CO)(5)W=C(SR)CH(3) (W-SR) by OH(-), water and a number of primary aliphatic and secondary alicyclic amines, have been determined in 50% MeCN:50% water at 25 degrees C. In addition, solvation energy and proton affinities values for M-SR (M = Cr and W) in the ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2010, 12(25):6616-6624]

Cited: 1 time

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E-Z isomerization and aggregation phenomena of dithiafulvenes in CHCl3.

Alejandro M Fracaroli, Alejandro M Granados, Rita H de Rossi,

The physical-chemical properties of several 1,3-dithiafulvene (DTF) derivatives having a donor and acceptor group in the molecule were studied. The synthesis of these compounds produces selectively the E isomer, but when the compound is dissolved in CHCl(3) isomerization to the Z isomer takes place with a rate that depends on ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2009, 74(5):2114-2119]

Cited: 2 times

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Alkynyl Fischer carbene complex as a traceless directing group for the regioselective cycloaddition of dithiolethiones to arylacetylene: synthesis of E-dithiafulvene thione and dithioesters.

Alejandro M Granados, Alejandro M Fracaroli, Rita H de Rossi, Pedro Fuertes, Tomás Torroba,

A phenylethynyl Fischer carbene complex was used as a traceless directing group for the regioselective cycloaddition of dithiolethiones to arylacetylene, which constitutes the first synthesis of E-dithiafulvene thione or dithioesters. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2008, (4):483-485]

Cited: 2 times

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Kinetics of the reactions of [p-nitrophenoxy(phenyl)carbene]pentacarbonylchromium(0) with aryloxide ions, hydroxide ion, and water in aqueous acetonitrile. Concerted or stepwise?

Claude F Bernasconi, Martin E Zoloff Michoff, Rita H de Rossi, Alejandro M Granados,

The main question addressed in this paper is whether the nucleophilic substitution of the p-nitrophenoxy group in (CO)5Cr=C(OC6H4-4-NO2)Ph (1-NO2) by a series of substituted phenoxide ions is concerted or stepwise. Rate constants, kArO, for these substitution reactions were determined in 50% MeCN-50% water (v/v) at 25 degrees C. A Brønsted ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2007, 72(4):1285-1293]

Cited: 1 time

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Synthesis of 1,3-dithiin dithioortho esters from the reaction of Fischer carbenes and 3H-1,2-dithiole-3-thiones.

Alejandro M Granados, Jeronimo Kreiker, Rita H de Rossi, Pedro Fuertes, Tomás Torroba,

[reaction: see text] Tricyclic 4-ethyl-5-thioxo-3H,5H-bis[1,2]dithiolo[3,4-d][4,3-b]pyrrol-3-one and monocyclic 3H-1,2-dithiole-3-thione derivatives reacted with Fischer carbene complexes, giving 1,3-dithiin dithioortho esters through insertion of the carbenic carbon into the S-S bond next to the thiocarbonyl function of the substrate. ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2006, 71(2):808-810]

Cited: 1 time

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Hydrolysis of Fischer carbene complexes. Steric effects of the pi-donor group.

Martin E Zoloff Michoff, Rita H de Rossi, Alejandro M Granados,

Rate constants for the hydrolysis of Fischer carbenes (CO)5Cr=C(OR)Ph (R = n-propyl, neopentyl, isopropyl, and menthyl) in 50% MeCN-50% water (v/v) at 25 degrees C are reported. The rate constants for the addition of -OH to the carbene carbon are 5.3, 3.7, 0.84, and 0.01 M(-1) s(-1), respectively. These rate ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2006, 71(6):2395-2401]

Cited: 2 times

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