Full Text Journal Articles by
Author Alberto Briganti

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Survival rates with external beam radiation therapy in newly diagnosed elderly metastatic prostate cancer patients.

Mike Wenzel, Claudia Collà Ruvolo, Christoph Würnschimmel, Luigi Nocera, Zhe Tian, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Andreas Becker, Frederik Roos, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>The survival benefit of primary external beam radiation therapy (EBRT) has never been formally tested in elderly men who were newly diagnosed with metastatic prostate cancer (mPCa). We hypothesized that elderly patients may not benefit of EBRT to the extent as younger newly diagnosed mPCa patients, due to shorter life ... Read more >>

Prostate (The Prostate)
[2021, :]

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Cancer-specific survival after radical prostatectomy versus external beam radiotherapy in high-risk and very high-risk African American prostate cancer patients.

Benedikt Hoeh, Christoph Würnschimmel, Rocco S Flammia, Benedikt Horlemann, Gabriele Sorce, Francesco Chierigo, Zhe Tian, Fred Saad, Markus Graefen, Michele Gallucci, Alberto Briganti, Carlo Terrone, Shahrokh F Shariat, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

To test for differences in cancer-specific mortality (CSM) rates between radical prostatectomy (RP) vs external beam radiotherapy (EBRT) in National Comprehensive Cancer Network (NCCN) high-risk African American patients, as well as Johns Hopkins University (JHU) high-risk and very high-risk patients. Within the Surveillance, Epidemiology, and End Results database (2010-2016), we ... Read more >>

Prostate (The Prostate)
[2021, :]

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Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis.

Nicolò Pernigoni, Elena Zagato, Arianna Calcinotto, Martina Troiani, Ricardo Pereira Mestre, Bianca Calì, Giuseppe Attanasio, Jacopo Troisi, Mirko Minini, Simone Mosole, Ajinkya Revandkar, Emiliano Pasquini, Angela Rita Elia, Daniela Bossi, Andrea Rinaldi, Pasquale Rescigno, Penny Flohr, Joanne Hunt, Antje Neeb, Lorenzo Buroni, Christina Guo, Jonathan Welti, Matteo Ferrari, Matteo Grioni, Josée Gauthier, Raad Z Gharaibeh, Anna Palmisano, Gladys Martinetti Lucchini, Eugenia D'Antonio, Sara Merler, Marco Bolis, Fabio Grassi, Antonio Esposito, Matteo Bellone, Alberto Briganti, Maria Rescigno, Jean-Philippe Theurillat, Christian Jobin, Silke Gillessen, Johann de Bono, Andrea Alimonti,

[Figure: see text]. ... Read more >>

Science (Science (New York, N.Y.))
[2021, 374(6564):216-224]

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Risk factors and survival outcomes for upstaging after inguinal lymph node dissection for cN1 penile squamous cell carcinoma.

Nicholas H Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A Ornellas, Mario Catanzaro, Oliver W Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E Spiess,

<h4>Objectives</h4>To identify incidence and risk factors for upstaging from cN1 to pN2/N3 at inguinal lymphadenectomy (ILND) for penile cancer (pSCC). Our secondary objective is to assess survival outcomes and associations for cN1 patients undergoing ILND.<h4>Subjects/patients and methods</h4>Patients with pT≥1cN1cM0 pSCC who underwent bilateral ILND and had complete data were identified ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Re: Marra et al. 'Transperineal freehand multiparametric MRI fusion targeted biopsies under local anaesthesia for prostate cancer diagnosis: a multicentre prospective study of 1014 cases'.

Francesco Montorsi, Armando Stabile, Giorgio Gandaglia, Nicola Fossati, Federico Deho', Andrea Gallina, Alberto Briganti,

BJU Int (BJU international)
[2021, 128(4):523]

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The Key Role of Patient Involvement in the Development of Core Outcome Sets in Prostate Cancer.

Katharina Beyer, Sara J MacLennan, Lisa Moris, Michael Lardas, Ken Mastris, Gary Hooker, Robert Greene, Erik Briers, Muhammad Imran Omar, Jemma Healey, Sheela Tripathee, Giorgio Gandaglia, Lionne D F Venderbos, Emma J Smith, Josefine Bjorkqvist, Alex Asiimwe, Johannes Huber, Monique J Roobol, Jihong Zong, Anders Bjartell, James N'Dow, Alberto Briganti, Steven MacLennan, Mieke Van Hemelrijck, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

Patients are the stewards of their own care and hence their voice is important when designing and implementing research. Patients should be involved not only as participants in research that impacts their care, as the recipients of that care and any associated harms, but also as research collaborators in prioritising ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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An Algorithm to Personalize Nerve Sparing in Men with Unilateral High-Risk Prostate Cancer.

Alberto Martini, Timo F W Soeterik, Hester Haverdings, Razvan George Rahota, Enrico Checcucci, Sabrina De Cillis, Thomas Hermanns, Christian Daniel Fankhauser, Luca Afferi, Marco Moschini, Agostino Mattei, Claudia Kesch, Isabel Heidegger, Felix Preisser, Fabio Zattoni, Alessandro Marquis, Giancarlo Marra, Paolo Gontero, Alberto Briganti, Francesco Montorsi, Francesco Porpiglia, Jean Paul Van Basten, Roderick C N Van den Bergh, Harm H E Van Melick, Guillaume Ploussard, Giorgio Gandaglia, Massimo Valerio,

<h4>Purpose</h4>Current guidelines do not provide strong recommendations on the preservation of the neurovascular bundles during RP in case of HR PCa and/or suspicious EPE. We aimed to evaluate when, in case of unilateral HR disease, contralateral NS should be considered or not.<h4>Methods</h4>Within a multi-institutional dataset we selected patients with unilateral ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000002205]

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Re: Andrew J. Vickers. Effects of Magnetic Resonance Imaging Targeting on Overdiagnosis and Overtreatment of Prostate Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.06.026.

Francesco Montorsi, Giorgio Gandaglia, Alberto Briganti,

Eur Urol (European urology)
[2021, :]

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Continuing acetylsalicylic acid during Robotic-Assisted Radical Cystectomy with intracorporeal urinary diversion does not increase hemorrhagic complications: results from a large multicentric cohort.

Simone Albisinni, Romain Diamand, Georges Mjaess, Gregoire Assenmacher, Christophe Assenmacher, Shirley Loos, Gregory Verhoest, Serge Holz, Michel Naudin, Guillaume Ploussard, Andrea Mari, Fabrizio Di Maida, Andrea Minervini, Fouad Aoun, Andrea Tay, Rami Issa, Mathieu Roumiguié, Anne Sophie Bajeot, Giuseppe Simone, Umberto Anceschi, Paolo Umari, Ashwin Sridhar, John Kelly, Kees Hendricksen, Sarah Einerhand, Rafael Sanchez-Salas, Anna Colomer, Thierry Quackels, Alexandre Peltier, Francesco Montorsi, Alberto Briganti, Benjamin Pradere, Marco Moschini, Thierry Roumeguère,

<h4>Objectives</h4>To evaluate whether continuing the antiplatelet drug acetylsalicylic acid≤100mg (ASA) during Robotic-assisted radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD) increases the risk of peri-and postoperative hemorrhagic complications and overall morbidity. Indeed, guidelines recommend interrupting antiplatelet therapy before radical cystectomy; however, RARC with ICUD is associated to reduced estimated blood ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Contemporary Outcomes of Patients with Nonmuscle-Invasive Bladder Cancer Treated with bacillus Calmette-Guérin. Letter.

Francesco Montorsi, Marco Moschini, Andrea Necchi, Federico Deho, Giorgio Gandaglia, Alberto Briganti,

J Urol (The Journal of urology)
[2021, :101097JU0000000000002237]

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External beam radiotherapy and radical prostatectomy are associated with better survival in Asian prostate cancer patients.

Christoph Würnschimmel, Mike Wenzel, Francesco Chierigo, Rocco Simone Flammia, Zhe Tian, Fred Saad, Alberto Briganti, Shahrokh F Shariat, Nazareno Suardi, Carlo Terrone, Michele Gallucci, Felix Kh Chun, Derya Tilki, Markus Graefen, Pierre I Karakiewicz,

<h4>Objectives</h4>To test the effect of race/ethnicity on cancer-specific mortality after radical prostatectomy or external beam radiotherapy in localized prostate cancer patients.<h4>Methods</h4>In the Surveillance, Epidemiology and End Results database 2004-2016, we identified intermediate-risk and high-risk white (n = 151 632), Asian (n = 11 189), Hispanic/Latino (n = 20 077) and African American (n = 32 550) localized prostate cancer patients, treated with ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, :]

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Clinical Outcomes and Adverse Events after First-Line Treatment in Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-Analysis.

Luigi Nocera, Pierre I Karakiewicz, Mike Wenzel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Felix K H Chun, Alberto Briganti, Anil Kapoor, Aly-Khan Lalani,

<h4>Purpose</h4>Four recent first-line clinical trials leveraging immune-oncology agents demonstrated an overall survival (OS) benefit relative to sunitinib. We aimed to provide formal comparisons among immune-oncology combinations in terms of OS, progression-free survival (PFS), objective response rates (ORR) and treatment-related adverse events (AEs).<h4>Materials and methods</h4>PubMed® database was searched for studies indexed ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000002252]

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Can Negative Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Avoid the Need for Pelvic Lymph Node Dissection in Newly Diagnosed Prostate Cancer Patients? A Systematic Review and Meta-analysis with Backup Histology as Reference Standard.

Armando Stabile, Antony Pellegrino, Elio Mazzone, Donato Cannoletta, Mario de Angelis, Francesco Barletta, Simone Scuderi, Vito Cucchiara, Giorgio Gandaglia, Daniele Raggi, Andrea Necchi, Pierre Karakiewicz, Francesco Montorsi, Alberto Briganti,

<h4>Context</h4>The role of positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA) in the primary staging for patients with prostate cancer (PCa) is still debated.<h4>Objective</h4>To analyze published studies reporting the accuracy of PSMA PET/CT for detecting lymph node invasion (LNI) at pelvic lymph node dissection (PLND).<h4>Evidence acquisition</h4>A search of ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Association of Negative Followup Biopsy and Reclassification during Active Surveillance of Prostate Cancer: A Systematic Review and Meta-Analysis. Letter.

Francesco Montorsi, Riccardo Leni, Alberto Briganti, Giorgio Gandaglia,

J Urol (The Journal of urology)
[2021, :101097JU0000000000002245]

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Improvement in overall and cancer-specific survival in contemporary, metastatic prostate cancer chemotherapy exposed patients.

Benedikt Hoeh, Christoph Würnschimmel, Rocco S Flammia, Benedikt Horlemann, Gabriele Sorce, Francesco Chierigo, Zhe Tian, Fred Saad, Markus Graefen, Michele Gallucci, Alberto Briganti, Carlo Terrone, Shahrokh F Shariat, Derya Tilki, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Introduction</h4>Over the last decade, multiple clinical trials demonstrated improved survival after chemotherapy for metastatic prostate cancer (mPCa). However, real-world data validating this effect within large-scale epidemiological data sets are scarce. We addressed this void.<h4>Materials and methods</h4>Men with de novo mPCa were identified and systemic chemotherapy status was ascertained within the ... Read more >>

Prostate (The Prostate)
[2021, :]

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Stage and cancer-specific mortality differ within specific Asian ethnic groups for upper tract urothelial carcinoma: North American population-based study.

Claudia Collà Ruvolo, Christoph Würnschimmel, Luigi Nocera, Mike Wenzel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Paolo Verze, Ciro Imbimbo, Alberto Briganti, Vincenzo Mirone, Pierre I Karakiewicz,

<h4>Objectives</h4>To examine the effect of specific Asian ethnic subgroups on stage at presentation and cancer-specific mortality in non-metastatic upper tract urothelial carcinoma among North American upper tract urothelial carcinoma Asian patients treated with radical nephroureterectomy.<h4>Methods</h4>We relied on the Surveillance, Epidemiology and End Results database, from 2004 to 2016. Kaplan-Meier plots ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, :]

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Radical Cystectomy vs. Radiotherapy in Urothelial Bladder Cancer in Elderly and Very Elderly Patients.

Benedikt Horlemann, Christoph Würnschimmel, Benedikt Hoeh, Gabriele Sorce, Francesco Chierigo, Rocco Simone Flammia, Zhe Tian, Fred Saad, Alberto Briganti, Sharokh F Shariat, Michele Galucci, Felix K H Chun, Markus Graefen, Pierre I Karakiewicz,

<h4>Introduction</h4>Controversy regarding cancer-specific mortality (CSM) of elderly and very elderly patients with muscle-invasive, non-metastatic, urothelial carcinoma of the urinary bladder (UCUB) undergoing radical cystectomy (RC) vs radiotherapy (RT) still exists.<h4>Materials and methods</h4>In the 2004-2016 Surveillance, Epidemiology and End Results (SEER) database, we identified 2663 UCUB patients aged 75-79 (1808 RC ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma.

Mike Wenzel, Nicolas Siron, Claudia Collà Ruvolo, Luigi Nocera, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Derya Tilki, Severine Banek, Luis A Kluth, Frederik C Roos, Felix K H Chun, Pierre I Karakiewicz,

<h4>Purpose</h4>To compare Cancer-specific mortality (CSM) in patients with Squamous cell carcinoma (SCC) vs. non-SCC penile cancer, since survival outcomes may differ between histological subtypes.<h4>Methods</h4>Within the Surveillance, Epidemiology and End Results database (2004-2016), penile cancer patients of all stages were identified. Temporal trend analyses, cumulative incidence and Kaplan-Meier plots, multivariable Cox ... Read more >>

Cancer Causes Control (Cancer causes & control : CCC)
[2021, :]

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A mechanistic insight into the anti-metastatic role of the prostate specific antigen.

Francesco Pellegrino, Arianna Coghi, Giovanni Lavorgna, Walter Cazzaniga, Edoardo Guazzoni, Irene Locatelli, Isabella Villa, Simona Bolamperti, Nadia Finocchio, Massimo Alfano, Roberta Lucianò, Alberto Briganti, Francesco Montorsi, Andrea Salonia, Ilaria Cavarretta,

<h4>Aim</h4>Since its discovery Prostate Specific Antigen (PSA), also referred to as kallikrein-3 (KLK3), has been used as standard circulating biomarker for prostate cancer (PCa). However, its specificity remains not adequate and its mechanism of action still elusive. Therefore, deciphering PSA role throughout PCa-pathobiology would be relevant in improving both cancer ... Read more >>

Transl Oncol (Translational oncology)
[2021, 14(11):101211]

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The impact of race/ethnicity on upstaging and/or upgrading rates among intermediate risk prostate cancer patients treated with radical prostatectomy.

Luigi Nocera, Mike Wenzel, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Felix K H Chun, Vincenzo Mirone, Markus Graefen, Fred Saad, Shahrokh F Shariat, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz,

<h4>Background</h4>Race/ethnicity may predispose to less favorable prostate cancer characteristics in intermediate risk prostate cancer (IR PCa) patients. We tested this hypothesis in a subgroup of IR PCa patients treated with radical prostatectomy (RP).<h4>Methods</h4>We relied on the Surveillance, Epidemiology and End Results 2004-2016. The effect of race/ethnicity was tested in univariable ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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The effect of primary urological cancers on survival in men with secondary prostate cancer.

Mike Wenzel, Christoph Würnschimmel, Luigi Nocera, Claudia Collà Ruvolo, Zhe Tian, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Frederik C Roos, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>To test the effect of urological primary cancers (bladder, kidney, testis, upper tract, penile, urethral) on overall mortality (OM) after secondary prostate cancer (PCa).<h4>Methods</h4>Within the Surveillance, Epidemiology and End Results (SEER) database, patients with urological primary cancers and concomitant secondary PCa (diagnosed 2004-2016) were identified and were matched in 1:4 ... Read more >>

Prostate (The Prostate)
[2021, 81(15):1149-1158]

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Median time to progression with TKI-based therapy after failure of immuno-oncology therapy in metastatic kidney cancer: A systematic review and meta-analysis.

Mike Wenzel, Marina Deuker, Luigi Nocera, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Luis A Kluth, Andreas Becker, Frederik C Roos, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>The efficacy of tyrosine kinase inhibitor (TKI)-based therapy after previous immuno-oncology therapy (IO) failure has been addressed before. However, summary efficacy estimates have never been generated in these reports. We addressed this void.<h4>Material and methods</h4>We systematically examined TKI efficacy after IO-failure and generated weighted median progression-free survival (PFS) estimates for ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 155:245-255]

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Survival Outcomes After Immediate Radical Cystectomy Versus Conservative Management with Bacillus Calmette-Guérin Among T1 High-grade Micropapillary Bladder Cancer Patients: Results from a Multicentre Collaboration.

Chiara Lonati, Philipp Baumeister, Luca Afferi, Andrea Mari, Andrea Minervini, Wojciech Krajewski, Sosan Azizi, Kees Hendricksen, Alberto Martini, Andrea Necchi, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Alessandro Tafuri, Alessandro Antonelli, Maria Angela Cerruto, Morgan Rouprêt, Alexandra Masson-Lecomte, Ekaterina Laukhtina, David D'Andrea, Shahrokh F Shariat, Francesco Soria, Giancarlo Marra, Paolo Gontero, Roberto Contieri, Rodolfo Hurle, Anne Sophie Valiquette, M Carmen Mir, Stefania Zamboni, Claudio Simeone, Tobias Klatte, Jeremy Yuen-Chun Teoh, Soichiro Yoshida, Yasuhisa Fujii, Roberto Carando, Gerald B Schulz, Livio Mordasini, Agostino Mattei, Marco Moschini, ,

<h4>Background</h4>Literature lacks clear evidence regarding the optimal treatment for non-muscle-invasive micropapillary bladder cancer (MPBC) due to its rarity and the presence of only small sample size and single-centre studies.<h4>Objective</h4>To assess cancer-specific mortality (CSM) and overall mortality (OM) between immediate radical cystectomy (RC) and conservative management among T1 high-grade (HG) MPBC.<h4>Design, ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Reply by Authors.

Nicholas H Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A Ornellas, Mario Catanzaro, Oliver W Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E Spiess,

J Urol (The Journal of urology)
[2021, 206(4):969]

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Risk Stratification of Patients Candidate to Radical Prostatectomy Based on Clinical and Multiparametric Magnetic Resonance Imaging Parameters: Development and External Validation of Novel Risk Groups.

Elio Mazzone, Giorgio Gandaglia, Guillame Ploussard, Giancarlo Marra, Massimo Valerio, Riccardo Campi, Andrea Mari, Andrea Minervini, Sergio Serni, Marco Moschini, Alessandro Marquis, Jean Baptiste Beauval, Roderick van den Bergh, Razvan-George Rahota, Timo Soeterik, Mathieu Roumiguiè, Luca Afferi, Junlong Zhuang, Hongqian Tuo, Agostino Mattei, Paolo Gontero, Vito Cucchiara, Armando Stabile, Nicola Fossati, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>Despite the key importance of magnetic resonance imaging (MRI) parameters, risk classification systems for biochemical recurrence (BCR) in prostate cancer (PCa) patients treated with radical prostatectomy (RP) are still based on clinical variables alone.<h4>Objective</h4>We aimed at developing and validating a novel classification integrating clinical and radiological parameters.<h4>Design, setting, and participants</h4>A ... Read more >>

Eur Urol (European urology)
[2021, :]

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