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Author Alberto Briganti

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68Ga-PSMA and 68Ga-DOTA-RM2 PET/MRI in Staging of High-risk Prostate Cancer Patients: a Prospective Pilot Trial

Paola Mapelli, Samuele Ghezzo, Ana Maria Samanes Gajate, Erik Preza, Giorgio Brembilla, Vito Cucchiara, Carolina Bezzi, Luca Presotto, Valentino Bettinardi, Annarita Savi, Patrizia Magnani, Raffaele Menichini, Angela Coliva, Ilaria Neri, Ettore Di Gaeta, Luigi Gianolli, Alberto Briganti, Francesco De Cobelli, Paola Scifo, Maria Picchio,

<h4>Purpose: </h4> The aim of the present study is to investigate the synergic role of 68Ga-PSMA PET/MRI and 68Ga-DOTA-RM2 PET/MRI in PCa staging. <h4>Methods: </h4>: Fifteen patients with biopsy-proven PCa underwent both 68Ga-PSMA PET/MRI and 68Ga-DOTA-RM2 PET/MRI within one month. TNM classification based on image findings was performed and semi-quantitative ... Read more >>

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Comparison between 1973 and 2004/2016 World Health Organization grading in upper tract urothelial carcinoma treated with radical nephroureterectomy.

Claudia Collà Ruvolo, Christoph Würnschimmel, Mike Wenzel, Luigi Nocera, Giuseppe Celentano, Francesco Mangiapia, Zhe Tian, Shahrokh F Shariat, Fred Saad, Felix H C Chun, Alberto Briganti, Nicola Longo, Vincenzo Mirone, Pierre I Karakiewicz,

<h4>Aims</h4>The European Association of Urology guideline for upper tract urothelial carcinoma (UTUC) relies on two grading system: 1973 World Health Organization (WHO) and 2004/2016 WHO. No consensus has been made which classification should supersede the other and both are recommended in clinical practice. We hypothesized that one may be superior ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, :]

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Salvage Robot-assisted Renal Surgery for Local Recurrence After Surgical Resection or Renal Mass Ablation: Classification, Techniques, and Clinical Outcomes.

Alberto Martini, Filippo Turri, Ravi Barod, Bernardo Rocco, Umberto Capitanio, Alberto Briganti, Francesco Montorsi, Alexandre Mottrie, Ben Challacombe, Brunolf W Lagerveld, Karim Bensalah, Ronney Abaza, Ketan K Badani, Reza Mehrazin, Maurizio Buscarini, Alessandro Larcher, ,

<h4>Background</h4>Salvage treatment for local recurrence after prior partial nephrectomy (PN) or local tumor ablation (LTA) for kidney cancer is, as of yet, poorly investigated.<h4>Objective</h4>To classify the treatments and standardize the nomenclature of salvage robot-assisted renal surgery, to describe the surgical technique for each scenario, and to investigate complications, renal function, ... Read more >>

Eur Urol (European urology)
[2021, :]

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Re: Histological comparison between predictive value of preoperative 3-T multiparametric MRI and 68 Ga-PSMA PET/CT scan for pathological outcomes at radical prostatectomy and pelvic lymph node dissection for prostate cancer.

Francesco Montorsi, Giorgio Gandaglia, Nicola Fossati, Federico Dehò, Alberto Briganti,

BJU Int (BJU international)
[2021, 127(6):746]

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Contemporary analysis of the effect of marital status on survival in upper tract urothelial carcinoma patients treated with radical nephroureterectomy: A population-based study.

Claudia Collà Ruvolo, Luigi Nocera, Franziska L Stolzenbach, Mike Wenzel, Christoph Würnschimmel, Ferdinando Fusco, Alessandro Palmieri, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Ciro Imbimbo, Vincenzo Mirone, Pierre I Karakiewicz,

<h4>Purpose</h4>Unmarried status is an established risk factor for worse cancer control outcomes in various malignancies. Moreover, several investigators observed worse outcomes in unmarried males, but not in females. This concept has not been tested in upper tract urothelial carcinoma and represents the topic of the study.<h4>Methods</h4>Within Surveillance, Epidemiology and End ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer.

Fahad Quhal, Pawel Rajwa, Keiichiro Mori, Ekaterina Laukhtina, Nico C Grossmann, Victor M Schuettfort, Frederik König, Abdulmajeed Aydh, Reza S Motlagh, Satoshi Katayama, Hadi Mostafai, Benjamin Pradere, Giancarlo Marra, Paolo Gontero, Romain Mathieu, Pierre I Karakiewicz, Alberto Briganti, Shahrokh F Shariat, Axel Heidenreich,

<h4>Purpose</h4>To examine the effect of lymph node dissection on the outcomes of patients who underwent salvage radical prostatectomy (SRP).<h4>Material and methods</h4>We retrospectively reviewed data from radiation-recurrent patients with prostate cancer (PCa) who underwent SRP from 2000-2016. None of the patients had clinical lymph node involvement before SRP. The effect of ... Read more >>

Prostate (The Prostate)
[2021, :]

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Correction to: Renal histology across the stages of chronic kidney disease.

Francesco Trevisani, Federico Di Marco, Umberto Capitanio, Giacomo Dell'Antonio, Alessandra Cinque, Alessandro Larcher, Roberta Lucianò, Arianna Bettiga, Riccardo Vago, Alberto Briganti, Andrea Salonia, Francesco Montorsi, Esteban Porrini,

J Nephrol (Journal of nephrology)
[2021, 34(3):961]

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Radical prostatectomy improves survival in selected metastatic prostate cancer patients: A North American population-based study.

Lara Franziska Stolzenbach, Marina Deuker, Claudia Collà-Ruvolo, Luigi Nocera, Zhe Tian, Tobias Maurer, Thomas Steuber, Derya Tilki, Alberto Briganti, Fred Saad, Felix Kh Chun, Markus Graefen, Pierre I Karakiewicz,

<h4>Objective</h4>To test whether radical prostatectomy might result in better survival than external beam radiation therapy in metastatic prostate cancer patients.<h4>Methods</h4>Newly diagnosed metastatic prostate cancer patients with M1a/b substages, treated with radical prostatectomy or external beam radiation therapy were abstracted from the Surveillance, Epidemiology and End Results database (2004-2016). Temporal trend ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, :]

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Research Protocol for an Observational Health Data Analysis to Assess the Long-term Outcomes of Prostate Cancer Patients Undergoing Non-Interventional Management (i.e., Watchful Waiting) and the Impact of Comorbidities and Life Expectancy – PIONEER IMI’s “Big Data for Better Outcomes” program

Giorgio Gandaglia, Kees van Bochove, Anders Bjartell, Alberto Briganti, Phil Conford, Susan Evans Axelsson, Asieh Golozar, Mieke Van Hemelrijck, Katharina Beyer, Peter-Paul Willemse, Muhammad Imran Omar, James N’Dow, Alex Asiimwe, Monique Roobol, Robert Snijder, Carl Steinbeisser, Roderick Van Den Bergh, Samuel Fatoba, Ariel Achtman, Thamir Alshammari, Nicolas Thurin, Adam Kinnaird, Sebastian Remmers, Emma Jane Smith, Riccardo Campi, Isabella Greco,

This is a study protocol for an observational health data analysis, submitted as a preprint to facilitate transparency and open science. Watchful waiting (WW) represents a deferred treatment option for prostate cancer (PCa) patients when curative treatment seems overtreatment right from the outset. Patients are ‘watched’ for the development of ... Read more >>

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Oncologic impact of delaying radical prostatectomy in men with intermediate- and high-risk prostate cancer: a systematic review.

Ekaterina Laukhtina, Reza Sari Motlagh, Keiichiro Mori, Fahad Quhal, Victor M Schuettfort, Hadi Mostafaei, Satoshi Katayama, Nico C Grossmann, Guillaume Ploussard, Pierre I Karakiewicz, Alberto Briganti, Mohammad Abufaraj, Dmitry Enikeev, Benjamin Pradere, Shahrokh F Shariat,

<h4>Purpose</h4>To summarize the available evidence on the survival and pathologic outcomes after deferred radical prostatectomy (RP) in men with intermediate- and high-risk prostate cancer (PCa).<h4>Methods</h4>The PubMed database and Web of Science were searched in November 2020 according to the PRISMA statement. Studies were deemed eligible if they reported the survival ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Reply to Nicolas Mottet, Olivier Rouviere, and Theodorus H. van der Kwast. Incidental Prostate Cancer: A Real Need for Expansion in Guidelines? Eur Urol Oncol. In press: Incidental Prostate Cancer: An Example of How Important Guidelines Are, Especially When Evidence Is Limited.

Umberto Capitanio, Riccardo Autorino, Marco Bandini, Alberto Briganti, Liang Cheng, Matthew R Cooperberg, Federico Dehò, Andrea Gallina, Laurence Klotz, Brian R Lane, Rodolfo Montironi, Andrea Salonia, Christian Stief, Bertrand Tombal, Francesco Montorsi,

Eur Urol Oncol (European urology oncology)
[2021, :]

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Is There a Detrimental Effect of Antibiotic Therapy in Patients with Muscle-invasive Bladder Cancer Treated with Neoadjuvant Pembrolizumab?

Filippo Pederzoli, Marco Bandini, Daniele Raggi, Laura Marandino, Giuseppe Basile, Massimo Alfano, Renzo Colombo, Andrea Salonia, Alberto Briganti, Andrea Gallina, Francesco Montorsi, Andrea Necchi,

In locally advanced and metastatic malignancies, antibiotic (ATB) therapy has a negative effect on immunotherapy efficacy. Therefore, we aimed to evaluate whether ATB therapy and use of specific ATB classes with concomitant neoadjuvant pembrolizumab affected pathologic complete response (ypT0N0) and relapse-free survival (RFS) for patients with clinical T2-4N0M0 bladder cancer ... Read more >>

Eur Urol (European urology)
[2021, :]

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Overall survival and adverse events after treatment with darolutamide vs. apalutamide vs. enzalutamide for high-risk non-metastatic castration-resistant prostate cancer: a systematic review and network meta-analysis.

Mike Wenzel, Luigi Nocera, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Derya Tilki, Markus Graefen, Luis A Kluth, Alberto Briganti, Philipp Mandel, Francesco Montorsi, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>The most recent overall survival (OS) and adverse event (AE) data have not been compared for the three guideline-recommended high-risk non-metastatic castration-resistant prostate cancer (nmCRPC) treatment alternatives.<h4>Methods</h4>We performed a systematic review and network meta-analysis focusing on OS and AE according to the most recent apalutamide, enzalutamide, and darolutamide reports. We ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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Multiparametric MRI of the prostate underestimates tumor volume of small visible lesions.

Gabriele Sorce, Armando Stabile, Roberta Lucianò, Giovanni Motterle, Simone Scuderi, Francesco Barletta, Francesco Pellegrino, Vito Cucchiara, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Ilaria Guccini, Alberto Briganti,

<h4>Objective</h4>To assess the relationship between the volume of the index lesion (IL) measured at mpMRI (MRIvol) and at radical prostatectomy (RPvol), stratifying it according to PI-RADS score.<h4>Materials and methods</h4>We identified 332 men with a positive mpMRI (single lesion with PI-RADS≥3) who underwent systematic plus targeted biopsy and subsequent RP at ... Read more >>

BJU Int (BJU international)
[2021, :]

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Re: Paolo Dell'Oglio, Elio Mazzone, Edward Lambert, et al. The Effect of Surgical Experience on Perioperative and Oncological Outcomes After Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion: Evidence from a Referral Centre with Extensive Experience in Robotic Surgery. Eur Urol Focus 2021;7:352-8.

Francesco Montorsi, Giorgio Gandaglia, Federico Dehò, Andrea Gallina, Marco Moschini, Andrea Salonia, Alberto Briganti,

Eur Urol Focus (European urology focus)
[2021, :]

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Presence of biopsy Gleason pattern 5 + 3 is associated with higher mortality after radical prostatectomy but not after external beam radiotherapy compared to other Gleason Grade Group IV patterns.

Christoph Würnschimmel, Mike Wenzel, Francesco Chierigo, Rocco S Flammia, Keiichiro Mori, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Nazareno Suardi, Carlo Terrone, Michele Gallucci, Felix K H Chun, Derya Tilki, Markus Graefen, Pierre I Karakiewicz,

<h4>Background</h4>We hypothesized that Gleason Grade Group (GGG) IV patients treated with radical prostatectomy (RP) or external beam radiotherapy (EBRT) exhibit different cancer-specific mortality (CSM) rates according to underlying Gleason patterns (GP): 4 + 4 versus 3 + 5 versus 5 + 3.<h4>Materials and methods</h4>We identified all GGG IV patients treated with either RP or EBRT within ... Read more >>

Prostate (The Prostate)
[2021, :]

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Patterns of Recurrence Following Inguinal Lymph Node Dissection for Penile Cancer: Optimizing Surveillance Strategies.

Nicholas H Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A Ornellas, Mario Catanzaro, Oliver W Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E Spiess,

<h4>Purpose</h4>Our primary objective is to detail the incidence, site, and timing of pSCC recurrence after ILND.<h4>Methods</h4>Retrospective analysis of 551 patients who underwent ILND for pSCC, from 2000 to 2017. The primary outcome was pSCC recurrence after ILND. Recurrences were identified and stratified by site. Timing of recurrence was determined. Multivariable ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001790]

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A novel expressed prostatic secretion (EPS)-urine metabolomic signature for the diagnosis of clinically significant prostate cancer.

Denise Drago, Annapaola Andolfo, Ettore Mosca, Alessandro Orro, Luigi Nocera, Vito Cucchiara, Matteo Bellone, Francesco Montorsi, Alberto Briganti,

<h4>Objective</h4>Significant efforts are currently being made to identify novel biomarkers for the diagnosis and risk stratification of prostate cancer (PCa). Metabolomics can be a very useful approach in biomarker discovery because metabolites are an important read-out of the disease when characterized in biological samples. We aimed to determine a metabolomic ... Read more >>

Cancer Biol Med (Cancer biology & medicine)
[2021, :]

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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor VH BCa at radical cystectomy. We aimed to create a personalized follow-up scheme that dynamically weighs OCM versus the risk of recurrence for VH BCa, and to compare it with a similar one for pUC.<h4>Methods</h4>Within ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001886]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, :]

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Life expectancy in metastatic prostate cancer patients according to racial/ethnic groups.

Christoph Würnschimmel, Mike Wenzel, Claudia Collà Ruvolo, Luigi Nocera, Zhe Tian, Fred Saad, Alberto Briganti, Shahrokh F Shariat, Vincenzo Mirone, Felix Kh Chun, Derya Tilki, Markus Graefen, Pierre I Karakiewicz,

<h4>Objectives</h4>To quantify the magnitude of differences between observed overall survival and respective, age-adjusted Social Security Administration life tables-derived life expectancy in Caucasian, African American, Hispanic/Latino and Asian metastatic prostate cancer patients. Furthermore, to test for differences in cancer-specific mortality and other-cause mortality according to race/ethnicity.<h4>Methods</h4>We relied on the 2004-2006 Surveillance, ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, :]

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The effect of race/ethnicity on active treatment rates among septuagenarian or older low risk prostate cancer patients.

Luigi Nocera, Mike Wenzel, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Felix K H Chun, Vincenzo Mirone, Markus Graefen, Shahrokh F Shariat, Fred Saad, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz,

<h4>Background</h4>Race/ethnicity may predispose to higher active treatment rates in septuagenarian or older low risk prostate cancer (CaP) patients. We tested this hypothesis within a contemporary North American cohort.<h4>Material and methods</h4>We relied on the Surveillance, Epidemiology and End Results (SEER) database 2010-2016. The effect of race/ethnicity was tested in univariable and ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Survival advantage of Asian metastatic prostate cancer patients treated with external beam radiotherapy over other races/ethnicities.

Christoph Würnschimmel, Mike Wenzel, Claudia Collà Ruvolo, Luigi Nocera, Zhe Tian, Fred Saad, Alberto Briganti, Shahrokh F Shariat, Philipp Mandel, Felix K H Chun, Derya Tilki, Markus Graefen, Pierre I Karakiewicz,

<h4>Purpose</h4>To assess the effect of race/ethnicity in cancer-specific mortality (CSM) adjusted for other-cause mortality (OCM) in metastatic prostate cancer patients (mPCa) treated with external beam radiotherapy (EBRT) to the prostate.<h4>Methods</h4>We relied on the Surveillance, Epidemiology, and End Results (SEER) database to identify Caucasian, African-American, Hispanic/Latino and Asian mPCa patients treated ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Optimizing prostate-targeted biopsy schemes in men with multiple mpMRI visible lesions: should we target all suspicious areas? Results of a two institution series.

Armando Stabile, Francesco Barletta, Giovanni Motterle, Francesco Pellegrino, Gabriele Sorce, Elio Mazzone, Simone Scuderi, Giuseppe Ottone Cirulli, Vito Cucchiara, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Alberto Briganti,

<h4>Background</h4>To assess the diagnostic added value of sampling secondary lesions at prostate mpMRI (SL) in addition to index lesion (IL) in detecting significant prostate cancer (csPCa) when also systematic biopsy (SBx) is performed.<h4>Methods</h4>We relied on a cohort of 312 men with two suspicious lesions at prostate mpMRI who underwent subsequent ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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Sex- and age-related differences in the distribution of bladder cancer metastases.

Giuseppe Rosiello, Carlotta Palumbo, Marina Deuker, Lara Franziska Stolzenbach, Thomas Martin, Zhe Tian, Andrea Gallina, Francesco Montorsi, Peter Black, Wassim Kassouf, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Pierre I Karakiewicz,

<h4>Objective</h4>Our objective was to investigate age- and sex-related differences in the distribution of metastases in patients with metastatic bladder cancer.<h4>Methods</h4>Within the National Inpatient Sample database (2008-2015), we identified 7040 patients with metastatic bladder cancer. Trend test and Chi-square test analyses were used to evaluate the relationship between age and site ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(6):976-983]

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