Full Text Journal Articles by
Author Alberto Berardi

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Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand.

Alberto Berardi, Diego R Perinelli, Hamid A Merchant, Lorina Bisharat, Iman A Basheti, Giulia Bonacucina, Marco Cespi, Giovanni F Palmieri,

The world is facing a medical crisis amid the CoViD-19 pandemic and the role of adequate hygiene and hand sanitisers is inevitable in controlling the spread of infection in public places and healthcare institutions. There has been a great surge in demand for hand sanitisation products leading to shortages in ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 584:119431]

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Viral nanoparticles can elude protein barriers: exploiting rather than imitating nature.

Alberto Berardi, Francesca Baldelli Bombelli, Eva C Thuenemann, George P Lomonossoff,

Protein-corona formation in body fluids and/or entrapment of nanoparticles in protein matrices (e.g. food and mucus) can hinder the delivery of nanoparticles, irrespective of the route of administration. Here we demonstrate that certain viral nanoparticles (VNPs) can evade the adhesion of a broad panel of macromolecules from several biological milieus. ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(5):2306-2316]

Cited: 1 time

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Serial clinical observation for management of newborns at risk of early-onset sepsis.

Alberto Berardi, Luca Bedetti, Caterina Spada, Laura Lucaccioni, Adam Frymoyer,

PURPOSE OF REVIEW:Current management approaches for asymptomatic neonates at risk of early onset sepsis remain controversial. Strategies based entirely on clinical observation (SCO, serial clinical observation) have gained consensus. RECENT FINDINGS:We briefly compare different strategies for managing asymptomatic newborns suggested in four high-income countries. Then this review details the existing ... Read more >>

Curr. Opin. Pediatr. (Current opinion in pediatrics)
[2020, 32(2):245-251]

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Different Audiologic Outcomes in Twins with Congenital Cytomegalovirus Infection.

Cecilia Botti, Silvia Palma, Maria Federica Roversi, Daniele Monzani, Alberto Berardi, Elisabetta Genovese,

Congenital cytomegalovirus (cCMV) infection is a major cause of hearing loss in children. A few cases of cCMV twin pregnancies are reported in the literature. Twins can react differently to maternal infection, but hearing loss is rarely evaluated. Two couples of twins with cCMV infection and different audiologic outcomes are ... Read more >>

J Int Adv Otol (The journal of international advanced otology)
[2020, 16(1):130-133]

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Endocrine-Disrupting Chemicals and Their Effects during Female Puberty: A Review of Current Evidence.

Laura Lucaccioni, Viola Trevisani, Lucia Marrozzini, Natascia Bertoncelli, Barbara Predieri, Licia Lugli, Alberto Berardi, Lorenzo Iughetti,

Puberty is the process of physical changes between childhood and adulthood during which adolescents reach sexual maturity and become capable of reproduction. It is considered one of the main temporal windows of susceptibility for the influence of the endocrine-disrupting chemicals (EDCs). EDCs may act as single chemical agents or as ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(6):]

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Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region.

Licia Lugli, Marisa Pugliese, Carlotta Plessi, Alberto Berardi, Isotta Guidotti, Gina Ancora, Sara Grandi, Giancarlo Gargano, Silvia Braibanti, Fabrizio Sandri, Silvia Soffritti, Elisa Ballardini, Vittoria Arena, Marcello Stella, Serafina Perrone, Sabrina Moretti, Vittoria Rizzo, Fabrizio Ferrari, , Odoardo Picciolini, Roberto Bellù, Daniela Turoli, Luigi Tommaso Corvaglia, Gianpaolo Garani, Vittoria Paoletti, Giacomo Biasucci, Augusto Biasini, Belinda Benenati, Paolo Stagi, Cristina Magnani, Sara Dallaglio, Elisa DellaCasa Muttini, Maria Federica Roversi, Luca Bedetti, Laura Lucaccioni, Natascia Bertoncelli, Alessandra Boncompagni,

INTRODUCTION:The survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals. The early identification of children at risk of neuro-developmental disabilities may increase access to intervention, potentially influencing the outcome. AIMS:Neuroprem is an area-based prospective ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):26]

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Intrapartum beta-lactam antibiotics for preventing group B streptococcal early-onset disease: can we abandon the concept of 'inadequate' intrapartum antibiotic prophylaxis?

Alberto Berardi, Caterina Spada, Eleonora Vaccina, Alessandra Boncompagni, Luca Bedetti, Laura Lucaccioni,

Introduction: Neonatal sepsis remains a serious and potentially fatal illness. Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcal (GBS) early-onset sepsis. The optimal duration of IAP (adequate IAP) to reduce vertical transmission of GBS has been debated. Understanding the mechanism of action of IAP may help in minimizing neonatal evaluation ... Read more >>

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2020, 18(1):37-46]

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Epidemiology and complications of late-onset sepsis: an Italian area-based study.

Alberto Berardi, Francesca Sforza, Lorenza Baroni, Caterina Spada, Simone Ambretti, Giacomo Biasucci, Serenella Bolognesi, Mariagrazia Capretti, Edoardo Carretto, Matilde Ciccia, Marcello Lanari, Maria Federica Pedna, Vittoria Rizzo, Claudia Venturelli, Crisoula Tzialla, Laura Lucaccioni, Maria Letizia Bacchi Reggiani,

BACKGROUND:Most studies regarding late-onset sepsis (LOS) address selected populations (i.e., neonates with low birth weight or extremely preterm neonates). Studying all age groups is more suitable to assess the burden of single pathogens and their clinical relevance. METHODS:This is a retrospective regional study involving paediatric departments and NICUs in Emilia-Romagna ... Read more >>

PLoS ONE (PloS one)
[2019, 14(11):e0225407]

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Hospital clusters of invasive Group B Streptococcal disease: A systematic review.

Simon M Collin, Peter Lamb, Elita Jauneikaite, Kirsty Le Doare, Roberta Creti, Alberto Berardi, Paul T Heath, Shiranee Sriskandan, Theresa Lamagni,

OBJECTIVES:To characterize outbreaks of invasive Group B Streptococcal (iGBS) disease in hospitals. METHODS:Systematic review using electronic databases to identify studies describing iGBS outbreaks/clusters or cross-infection/acquisition in healthcare settings where 'cluster' was defined as ≥2 linked cases. PROSPERO CRD42018096297. RESULTS:Twenty-five references were included describing 30 hospital clusters (26 neonatal, 4 adult) ... Read more >>

J. Infect. (The Journal of infection)
[2019, 79(6):521-527]

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Heart failure caused by VGAM: a lesson for diagnosis and treatment from a case and literature review.

Caterina Spada, Elisa Pietrella, Elisa Caramaschi, Patrizia Bergonzini, Alberto Berardi, Laura Lucaccioni, Lorenzo Iughetti,

We describe the case of a neonate with signs of heart failure. Echocardiography showed a structural normal heart shape with left ventricular dysfunction. At 2 months of age, a vein of Galen arteriovenous malformation was diagnosed through a brain magnetic resonance imaging. Embolization therapy was accomplished and a clinical and ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, :1-7]

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Further Delineation of Pyridoxine-Responsive Pyridoxine Phosphate Oxidase Deficiency Epilepsy: Report of a New Case and Review of the Literature With Genotype-Phenotype Correlation.

Licia Lugli, Maria Carolina Bariola, Luca Ori, Laura Lucaccioni, Alberto Berardi, Fabrizio Ferrari,

In recent years, the clinical spectrum of pyridoxine phosphate oxidase (PNPO) deficiency has broadened. There are a growing number of patients with a transient or lasting response to pyridoxine in addition to cases that respond more traditionally to pyridoxal-phosphate. However, among pyridoxine-responsive patients with PNPO gene mutation, there are only ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2019, 34(14):937-943]

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Motor and Postural Patterns Concomitant with General Movements Are Associated with Cerebral Palsy at Term and Fidgety Age in Preterm Infants.

Fabrizio Ferrari, Carlotta Plessi, Laura Lucaccioni, Natascia Bertoncelli, Luca Bedetti, Luca Ori, Alberto Berardi, Elisa Della Casa, Lorenzo Iughetti, Roberto D'Amico,

General movements (GMs) in combination with neurological examination and magnetic resonance imaging at term age can accurately determine the risk of cerebral palsy. The present study aimed to assess whether 11 motor and postural patterns concomitant with GMs were associated with cerebral palsy. Video recordings performed after birth in 79 ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(8):]

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Clinical characterization of neonatal and pediatric enteroviral infections: an Italian single center study.

Alberto Berardi, Marcello Sandoni, Carlotta Toffoli, Alessandra Boncompagni, William Gennari, Maria Barbara Bergamini, Laura Lucaccioni, Lorenzo Iughetti,

BACKGROUND:Enteroviruses (EVs) are an important cause of illness, especially in neonates and young infants. Clinical and laboratory findings at different ages, brain imaging, and outcomes have been inadequately investigated. METHODS:We retrospectively investigated EV infections occurring at an Italian tertiary care center during 2006-2017. Cases were confirmed with a positive polymerase ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2019, 45(1):94]

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Evaluation of the Disintegration Action of Soy Polysaccharide by Image Analysis.

Rana Amayreh, Lorina Bisharat, Marco Cespi, Giovanni Filippo Palimieri, Alberto Berardi,

Here we investigated the disintegration action of the natural superdisintegrant soy polysaccharide (SP) and benchmarked it against sodium starch glycolate (SSG) and crospovidone (XPVP). Kinetics and mechanism of disintegration of various tablet formulations were monitored using a USB microscope connected to a computer, followed by image analysis. SP acts mainly ... Read more >>

AAPS PharmSciTech (AAPS PharmSciTech)
[2019, 20(7):265]

Cited: 1 time

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Risk factors for group B streptococcus early-onset disease: an Italian, area-based, case-control study.

Alberto Berardi, Caterina Spada, Roberta Creti, Simone Ambretti, Rossana Chiarabini, Agostino Barozzi, Rossella Pagano, Mario Sarti, Maria Federica Pedna, Sara Fornaciari, Milena Azzalli, Icilio Dodi, Maria Letizia Bacchi Reggiani, Angela Lanzoni, Eleonora Vaccina, Lorenzo Iughetti, Laura Lucaccioni,

Purpose: Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcus (GBS) early-onset disease (EOD). No European study evaluates the relative impact of risk factors (RFs) for EOD after a screening-based strategy and widespread IAP use We aimed to evaluate the risks of EOD in an Italian region where a screening-based strategy ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, 33(14):2480-2486]

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Worse global intellectual and worse neuropsychological functioning in preterm-born children at preschool age: a meta-analysis.

Elena Arpi, Roberto D'Amico, Laura Lucaccioni, Luca Bedetti, Alberto Berardi, Fabrizio Ferrari,

AIM:Preterm births (<32 weeks of gestational age) are associated with cognitive problems that are difficult to diagnose in infancy but potentially detectable at preschool age. This review aimed to evaluate the extent to which total intelligence quotient (IQ) and neuropsychological functions at ages three to five years differ between children born ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2019, 108(9):1567-1579]

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Severe metabolic alkalosis due to diuretic treatment in a patient with distal renal tubular acidosis: a rare association.

Laura Lucaccioni, Elena Coccolini, Alessandra Dozza, Sante Lucio Cantatore, Alberto Berardi, Barbara Predieri, Lorenzo Iughetti,

INTRODUCTION:Distal renal tubular acidosis is a rare genetic disease, characterised by deficit in renal tubular transport. Clinical features are metabolic acidosis with hypercloraemia and hypokalemia, and inability in urine acidification. Hypercalciuria may also be present, often treated with the use of a diuretic therapy with thiazides. CASE PRESENTATION:We present a ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(2):348-352]

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The influence of core tablets rheology on the mechanical properties of press-coated tablets.

Samantha Ascani, Alberto Berardi, Lorina Bisharat, Giulia Bonacucina, Marco Cespi, Giovanni Filippo Palmieri,

Press-coating (also called compression coating or dry coating) consists of a second compression of an outer layer of material over a preformed tablet core. Despite being old, this technology has returned to popularity due to its widespread use in preparation of chronotherapeutic dosage forms. The literature available on press-coated tablets ... Read more >>

Eur J Pharm Sci (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences)
[2019, 135:68-76]

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Unusual meningitis caused by non-typhoid Salmonella in an Italian infant: a case report.

Monica Ficara, Valentina Cenciarelli, Lisa Montanari, Beatrice Righi, Simone Fontjin, Greta Cingolani, Barbara Predieri, Alberto Berardi, Laura Lucaccioni, Lorenzo Iughetti,

BACKGROUND:Non-typhoid Salmonella (NTS) is an important cause of bacterial meningitis in newborn and infants in developing countries, but rarely in industrialized ones. We describe an unusual presentation of bacterial meningitis in an infant, focusing on his diagnostic and therapeutic management. CASE REPORT:An Italian two-month old male presented high fever and ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(2):333-338]

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Oral delivery of nanoparticles - let's not forget about the protein corona.

Alberto Berardi, Francesca Baldelli Bombelli,

Expert Opin Drug Deliv (Expert opinion on drug delivery)
[2019, 16(6):563-566]

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Group B Streptococcus early-onset disease and observation of well-appearing newborns.

Alberto Berardi, Caterina Spada, Maria Letizia Bacchi Reggiani, Roberta Creti, Lorenza Baroni, Maria Grazia Capretti, Matilde Ciccia, Valentina Fiorini, Lucia Gambini, Giancarlo Gargano, Irene Papa, Giancarlo Piccinini, Vittoria Rizzo, Fabrizio Sandri, Laura Lucaccioni, ,

BACKGROUND:International guidelines lack a substantial consensus regarding management of asymptomatic full-term and late preterm neonates at risk for early-onset disease (EOS). Large cohorts of newborns are suitable to increase the understanding of the safety and efficacy of a given strategy. METHODS:This is a prospective, area-based, cohort study involving regional birth ... Read more >>

PLoS ONE (PloS one)
[2019, 14(3):e0212784]

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The influence of ethanol on superdisintegrants and on tablets disintegration.

Lorina Bisharat, Hatim S AlKhatib, Suha Muhaissen, Julian Quodbach, Anaheed Blaibleh, Marco Cespi, Alberto Berardi,

Disintegration of immediate release tablets originates from the volume expansion of disintegrants within the formulation. Here, we study the impact of ethanol on the disintegrant expansion and on tablets disintegration. The three most commonly used superdisintegrants, namely sodium starch glycolate (SSG), crospovidone (PVPP) and croscarmellose sodium (CCS) were investigated alone ... Read more >>

Eur J Pharm Sci (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences)
[2019, 129:140-147]

Cited: 1 time

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Two Overlapping Clusters of Group B Streptococcus Late-onset Disease in a Neonatal Intensive Care Unit.

Alberto Berardi, Isotta Guidotti, Roberta Creti, Giovanna Alfarone, Antonella Grottola, Claudia Venturelli, Giulia Fregni Serpini, Elisa Della Casa, Elena Vecchi, Alessandra Boncompagni, Carlotta Toffoli, Fabrizio Ferrari,

OBJECTIVES:Current predominant routes of group B Streptococcus (GBS) transmission in preterm neonates admitted to neonatal intensive care unit (NICU) are poorly defined. We report 2 overlapping clusters of GBS late-onset disease (LOD) from June to September 2015 in an Italian NICU. METHODS:During the outbreak, possible sources of transmission (equipment, feeding ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2018, 37(11):1160-1164]

Cited: 1 time

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Brain-derived neurotrophic factor and epilepsy: a systematic review.

Lorenzo Iughetti, Laura Lucaccioni, Francesco Fugetto, Barbara Predieri, Alberto Berardi, Fabrizio Ferrari,

Several in vitro, ex vivo and in vivo studies imply brain-derived neurotrophic factor (BDNF) in the pathophysiology of epilepsy. Aim of our work is to report the most important findings regarding BDNF and its potential role in epilepsy. We targeted those publications addressing both in vitro and in vivo evidences ... Read more >>

Neuropeptides (Neuropeptides)
[2018, 72:23-29]

Cited: 6 times

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Changes of intestinal microbiota in early life.

Monica Ficara, Elisa Pietrella, Caterina Spada, Elisa Della Casa Muttini, Laura Lucaccioni, Lorenzo Iughetti, Alberto Berardi,

There is an increasing evidence that the intestinal microbiota plays a pivotal role in the maturation of the immune system and in the prevention of diseases occurring during the neonatal period, childhood, and adulthood. A number of nonphysiological conditions during the perinatal period (i.e. caesarean section, prolonged hospitalization, formula feeding, ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, 33(6):1036-1043]

Cited: 2 times

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