Full Text Journal Articles by
Author Alana Christie

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Molecular Genetic Determinants of Shorter Time on Active Surveillance in a Prospective Phase 2 Clinical Trial in Metastatic Renal Cell Carcinoma.

Oscar Reig Torras, Akhilesh Mishra, Alana Christie, Tiffani McKenzie, Oreoluwa Onabolu, Nirmish Singla, Elizabeth R Plimack, Cristina Suárez, Moshe C Ornstein, R Katherine Alpaugh, Roy Elias, I Alex Bowman, Renee M McKay, Christopher Przybycin, Payal Kapur, James Brugarolas, Brian Rini,

Active surveillance (AS) may be used in the management of metastatic renal cell carcinoma (mRCC), but consensus regarding its application is lacking. We report an exploratory analysis of prospectively collected specimens prespecified in the only modern clinical trial evaluating AS in mRCC. Whole-exome and RNA sequencing were performed for patients ... Read more >>

Eur Urol (European urology)
[2021, :]

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No Correlation Between Presenting Symptoms Prior to Suburethral Sling Removal and Explanted Pathology Findings Suggests No Need for Routine Microscopic Pathology Evaluation.

Rahul S Patel, Alana L Christie, Philippe E Zimmern,

<h4>Objectives</h4>We compared explanted midurethral sling (MUS) standard clinical pathology report findings with presenting symptoms before synthetic sling removal (SSR).<h4>Methods</h4>An institutional review board-approved, prospectively maintained database of women who underwent a single SSR for MUS-related complication(s) was retrospectively reviewed for demographics, time interval between MUS placement and SSR, MUS type, and ... Read more >>

Female Pelvic Med Reconstr Surg (Female pelvic medicine & reconstructive surgery)
[2022, 28(1):49-53]

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Phase II Trial of Stereotactic Ablative Radiation for Oligoprogressive Metastatic Kidney Cancer.

Raquibul Hannan, Michael Christensen, Hans Hammers, Alana Christie, Brendan Paulman, Dandan Lin, Aurelie Garant, Waddah Arafat, Kevin Courtney, Isaac Bowman, Suzanne Cole, David Sher, Chul Ahn, Hak Choy, Robert Timmerman, James Brugarolas,

<h4>Background</h4>Patients with metastatic renal cell carcinoma (mRCC) treated with systemic therapy sometimes progress at limited sites.The best treatment approach for patients with oligoprogression remains unclear.<h4>Objective</h4>To determine the ability of stereotactic ablative radiation (SAbR) to extend ongoing systemic therapy in mRCC patients with oligoprogression.<h4>Design, setting, and participants</h4>A single-arm phase II clinical ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Stress Urinary Incontinence After Urethral Diverticulum Repair Without Concomitant Anti-Incontinence Procedure.

Jacqueline A Chavez, Jorge L Fuentes, Alana L Christie, Feras Alhalabi, Maude E Carmel, Gary E Lemack, Philippe E Zimmern,

Urology (Urology)
[2021, :]

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Outcome and Immune Correlates of a Phase II Trial of High-Dose Interleukin-2 and Stereotactic Ablative Radiotherapy for Metastatic Renal Cell Carcinoma.

Raquibul Hannan, Osama Mohamad, Alberto Diaz de Leon, Subrata Manna, Laurentiu M Pop, Ze Zhang, Samantha Mannala, Alana Christie, Scott Christley, Nancy Monson, Dan Ishihara, Eric J Hsu, Chul Ahn, Payal Kapur, Mingyi Chen, Yull Arriaga, Kevin Courtney, Brandi Cantarel, Edward K Wakeland, Yang-Xin Fu, Ivan Pedrosa, Lindsay Cowell, Tao Wang, Vitaly Margulis, Hak Choy, Robert D Timmerman, James Brugarolas,

<h4>Purpose</h4>This phase II clinical trial evaluated whether the addition of stereotactic ablative radiotherapy (SAbR), which may promote tumor antigen presentation, improves the overall response rate (ORR) to high-dose IL2 (HD IL2) in metastatic renal cell carcinoma (mRCC).<h4>Patients and methods</h4>Patients with pathologic evidence of clear cell renal cell carcinoma (RCC) and ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2021, 27(24):6716-6725]

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Determinants of renal cell carcinoma invasion and metastatic competence.

Kangsan Kim, Qinbo Zhou, Alana Christie, Christina Stevens, Yuanqing Ma, Oreoluwa Onabolu, Suneetha Chintalapati, Tiffani Mckenzie, Vanina Toffessi Tcheuyap, Layton Woolford, He Zhang, Nirmish Singla, Pravat Kumar Parida, Mauricio Marquez-Palencia, Ivan Pedrosa, Vitaly Margulis, Arthur Sagalowsky, Zhiqun Xie, Tao Wang, Steffen Durinck, Zora Modrusan, Somasekar Seshagiri, Payal Kapur, James Brugarolas, Srinivas Malladi,

Metastasis is the principal cause of cancer related deaths. Tumor invasion is essential for metastatic spread. However, determinants of invasion are poorly understood. We addressed this knowledge gap by leveraging a unique attribute of kidney cancer. Renal tumors invade into large vessels forming tumor thrombi (TT) that migrate extending sometimes ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):5760]

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Deciphering Intratumoral Molecular Heterogeneity in Clear Cell Renal Cell Carcinoma with a Radiogenomics Platform.

Durga Udayakumar, Ze Zhang, Yin Xi, Durgesh K Dwivedi, Michael Fulkerson, Sydney Haldeman, Tiffani McKenzie, Qurratulain Yousuf, Allison Joyce, Asghar Hajibeigi, Hollis Notgrass, Alberto Diaz de Leon, Qing Yuan, Matthew A Lewis, Ananth J Madhuranthakam, Robert C Sibley, Roy Elias, Junyu Guo, Alana Christie, Renée M McKay, Jeffrey A Cadeddu, Aditya Bagrodia, Vitaly Margulis, James Brugarolas, Tao Wang, Payal Kapur, Ivan Pedrosa,

<h4>Purpose</h4>Intratumoral heterogeneity (ITH) challenges the molecular characterization of clear cell renal cell carcinoma (ccRCC) and is a confounding factor for therapy selection. Most approaches to evaluate ITH are limited by two-dimensional <i>ex vivo</i> tissue analyses. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can noninvasively assess the spatial landscape of entire tumors ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2021, 27(17):4794-4806]

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Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma.

Jonathan E Schoenhals, Osama Mohamad, Alana Christie, Yuanyuan Zhang, Daniel Li, Nirmish Singla, Isaac Bowman, Waddah Arafat, Hans Hammers, Kevin Courtney, Suzanne Cole, Aditya Bagrodia, Vitaly Margulis, Neil Desai, Aurelie Garant, Hak Choy, Robert Timmerman, James Brugarolas, Raquibul Hannan,

<h4>Purpose</h4>Oligoprogression, defined as limited sites of progression on systemic therapy, in patients with metastatic renal cell carcinoma (mRCC) is not uncommon, possibly because of inter- and intratumoral heterogeneity. We evaluated the effect of stereotactic ablative radiation therapy (SAbR) for longitudinal control of oligoprogressive mRCC.<h4>Methods and materials</h4>Patients with extracranial mRCC were ... Read more >>

Adv Radiat Oncol (Advances in radiation oncology)
[2021, 6(5):100692]

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Stress Urinary Incontinence After Urethral Diverticulum Repair Without Concomitant Anti-Incontinence Procedure.

Jacqueline A Chavez, Jorge L Fuentes, Alana L Christie, Feras Alhalabi, Maude E Carmel, Gary E Lemack, Philippe E Zimmern,

<h4>Objective</h4>To review the rates of persistent and de novo stress urinary incontinence (SUI) following urethral diverticulum (UD) repairs performed without concomitant SUI surgical procedures.<h4>Methods</h4>Following IRB approval, charts of women who underwent UD excision by three FPMRS surgeons were reviewed. Data collected from the electronic medical record included demographic information, preoperative ... Read more >>

Urology (Urology)
[2021, 154:103-108]

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A standardized telephone interview with validated questionnaires for very long-term evaluation of women lost to follow-up after a stress urinary incontinence procedure.

Amy Kuprasertkul, Alana L Christie, Philippe Zimmern,

<h4>Objectives</h4>Telephone interviews including questionnaires have been used to obtain very long-term (>10-year) follow-up after stress urinary incontinence (SUI) procedures in women otherwise lost to follow-up (LTF). For questionnaires validated for office use, our goal was to evaluate recent telephone vs last clinic scores in a long-term study.<h4>Methods</h4>For women with >10 years ... Read more >>

Low Urin Tract Symptoms (Lower urinary tract symptoms)
[2021, 13(3):366-371]

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Improving Renal Tumor Biopsy Prognostication With BAP1 Analyses.

Payal Kapur, Sasan Setoodeh, Ellen Araj, Jingsheng Yan, Venkat S Malladi, Jeffrey A Cadeddu, Alana Christie, James Brugarolas,

<h4>Context.—</h4>Active surveillance of small renal masses highlights the need for accurate prognostication of biopsies.<h4>Objective.—</h4>To comprehensively evaluate the accuracy of biopsies in assessing known prognostic parameters including histologic subtype by comparison with subsequent nephrectomy samples.<h4>Design.—</h4>We retrospectively identified patients at University of Texas Southwestern Medical Center, Dallas, Texas, who had a biopsy ... Read more >>

Arch Pathol Lab Med (Archives of pathology & laboratory medicine)
[2021, :]

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Mesh Sling Arm Removal for Persistent Pain After an Initial Vaginal Suburethral Mesh Sling Removal Procedure.

Jorge L Fuentes, Carlos Finsterbusch, Alana L Christie, Philippe E Zimmern,

<h4>Objectives</h4>Pain is a recognized complication of mid-urethral slings (MUS), which may lead to suburethral sling removal (SSR) alone, or to a more extensive removal approach. We report on the outcomes of women who required an SSR or an additional secondary MUS arm removal for pain only.<h4>Methods</h4>After Institutional Review Board (IRB) ... Read more >>

Female Pelvic Med Reconstr Surg (Female pelvic medicine & reconstructive surgery)
[2021, 27(5):e522-e527]

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An operator-independent artificial finger can differentiate anterior vaginal wall indentation parameters between control and prolapse patients.

Connie N Wang, Michael R Abraham, Christopher E Abrego, Panos S Shiakolas, Alana Christie, Philippe E Zimmern,

In this study, the reproducibility and validity of an automated artificial finger for evaluating properties of vaginal wall tissue was assessed. The effect of angle and rate of indentation on displacing the anterior vaginal wall (AVW) was studied in control and prolapse patients. Following IRB approval, an automated artificial finger ... Read more >>

J Biomech (Journal of biomechanics)
[2021, 120:110378]

Cited: 1 time

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Prospective Evaluation of Daily and Weekly Urine pH Variations Along With Diet Intake in Postmenopausal Women With Recurrent Urinary Tract Infections.

Jacqueline A Chavez, Juliann M Chavez, Amy Kuprasertkul, Timothy F Carroll, Jorge L Fuentes, Alana L Christie, Feras Alhalabi, Philippe E Zimmern,

<h4>Objectives</h4>Acidic urine pH may be protective against recurrent urinary tract infections (RUTIs). After reviewing the literature, we primarily analyzed urine pH fluctuations and secondarily compared them with diet in older women with RUTIs.<h4>Methods</h4>After IRB approval, postmenopausal women with documented RUTIs were enrolled. Participants were given preformatted charts to record urinalysis ... Read more >>

Female Pelvic Med Reconstr Surg (Female pelvic medicine & reconstructive surgery)
[2021, 27(2):e352-e359]

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Very long-term follow-up of autologous pubovaginal fascia slings in women with stress urinary incontinence.

Sandy Kim, Daniel G Wong, Dominic Lee, Alana L Christie, Philippe E Zimmern,

<h4>Introduction and hypothesis</h4>The objective was to report on the very long-term outcome of a published series of autologous pubovaginal slings (PVS) in women with stress urinary incontinence (SUI).<h4>Methods</h4>Following institutional review board approval, a cohort of well characterized, non-neurogenic women who underwent an autologous PVS (primary [PVS1] and secondary [PVS2]) for ... Read more >>

Int Urogynecol J (International urogynecology journal)
[2021, :]

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Durability of Macroplastique volume and configuration in women with stress urinary incontinence secondary to intrinsic sphincter deficiency: A retrospective review.

Timothy F Carroll, Alana Christie, Melissa Foreman, Amy Kuprasertkul, Gaurav Khatri, Philippe E Zimmern,

<h4>Objectives</h4>To evaluate the durability of Macroplastique® (MPQ) volume and configuration in women with stress urinary incontinence (SUI) secondary to intrinsic sphincter deficiency (ISD) using serial three-dimensional ultrasound (3DUS) measurements.<h4>Methods</h4>Following Institutional Review Board approval, charts of women with SUI and ISD (defined based on leak point pressure; lateral imaging of urethral ... Read more >>

Low Urin Tract Symptoms (Lower urinary tract symptoms)
[2021, 13(3):335-340]

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Neoadjuvant SABR for Renal Cell Carcinoma Inferior Vena Cava Tumor Thrombus-Safety Lead-in Results of a Phase 2 Trial.

Vitaly Margulis, Yuval Freifeld, Laurentiu M Pop, Subrata Manna, Payal Kapur, Ivan Pedrosa, Alana Christie, Osama Mohamad, Samantha Mannala, Nirmish Singla, Michael Wait, Aditya Bagrodia, Solomon L Woldu, Jeffrey Gahan, James Brugarolas, Robert Timmerman, Raquibul Hannan,

<h4>Purpose</h4>To evaluate the feasibility, safety, oncologic outcomes, and immune effect of neoadjuvant stereotactic radiation (Neo-SAbR) followed by radical nephrectomy and thrombectomy (RN-IVCT).<h4>Methods and materials</h4>These are results from the safety lead-in portion of a single-arm phase 1 and 2 trial. Patients with kidney cancer (renal cell carcinoma [RCC]) and inferior vena ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2021, 110(4):1135-1142]

Cited: 2 times

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Complement as Prognostic Biomarker and Potential Therapeutic Target in Renal Cell Carcinoma.

Britney Reese, Ashok Silwal, Elizabeth Daugherity, Michael Daugherity, Mahshid Arabi, Pierce Daly, Yvonne Paterson, Layton Woolford, Alana Christie, Roy Elias, James Brugarolas, Tao Wang, Magdalena Karbowniczek, Maciej M Markiewski,

Preclinical studies demonstrated that complement promotes tumor growth. Therefore, we sought to determine the best target for complement-based therapy among common human malignancies. High expression of 11 complement genes was linked to unfavorable prognosis in renal cell carcinoma. Complement protein expression or deposition was observed mainly in stroma, leukocytes, and ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2020, 205(11):3218-3229]

Cited: 5 times

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The Evolution of Angiogenic and Inflamed Tumors: The Renal Cancer Paradigm.

James Brugarolas, Satwik Rajaram, Alana Christie, Payal Kapur,

Gene expression analyses have identified subtypes of conventional renal cell carcinoma broadly distributed into angiogenic and proliferative/ immunogenic clades. Integration with genomic and functional experiments in animal models yields an evolutionary model. Evolutionary trajectories illustrate remarkable plasticity, particularly for a tumor that typically begins with inactivation of a single gene. ... Read more >>

Cancer Cell (Cancer cell)
[2020, 38(6):771-773]

Cited: 5 times

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Sensitivity to Change of Subdomain Question 6 of the Urogenital Distress Inventory Short Form After Sling Removal for Pain.

Connie N Wang, Alana L Christie, Philippe E Zimmern,

<h4>Objective</h4>To determine the sensitivity to change of question 6 (Q6) of the modified short form version of the Urogenital Distress Inventory (UDI-6) before and after synthetic sling removal (SSR).<h4>Methods</h4>Following IRB approval, a prospectively maintained database of mid-urethral sling (MUS) complications identified women with UDI-6 Q6 data before and after SSR. ... Read more >>

Urology (Urology)
[2021, 147:104-108]

Cited: 0 times

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Acute interstitial nephritis, a potential predictor of response to immune checkpoint inhibitors in renal cell carcinoma.

Viral Patel, Roy Elias, Joseph Formella, William Schwartzman, Alana Christie, Qi Cai, Venkat Malladi, Payal Kapur, Miguel Vazquez, Renee McKay, Ivan Pedrosa, Raquibul Hannan, Hans Hammers, James Brugarolas,

Immune checkpoint inhibitors (ICIs) such as nivolumab and ipilimumab have improved outcomes in metastatic renal cell carcinoma (mRCC) patients, but they are also associated with immune-related adverse events (irAEs). As observed in melanoma, we hypothesized that patients experiencing an autoimmune reaction directed against the tissue of origin may be more ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(2):]

Cited: 6 times

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What morphology can teach us about renal cell carcinoma clonal evolution.

Payal Kapur, Alana Christie, Satwik Rajaram, James Brugarolas,

While cancer is a clonal process, cumulative evidence suggest that tumors are rather heterogenous and are composed of multiple genetically-distinct subclones that arise at different times and either persist and co-exist, expand and evolve, or are eliminated. A paradigm of tumor heterogeneity is renal cell carcinoma (RCC). By exploiting morphological ... Read more >>

Kidney Cancer J (Kidney cancer journal : official journal of the Kidney Cancer Association)
[2020, 18(3):68-76]

Cited: 0 times

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Adverse effects of chronic nitrofurantoin therapy in women with recurrent urinary tract infections in an outpatient setting.

Navin N Maredia, Michael J Fanning, Alana L Christie, Bonnie C Prokesch, Philippe E Zimmern,

<h4>Purpose</h4>To review the frequency of adverse events reported with nitrofurantoin (NF) in perimenopausal and menopausal women on prolonged daily prophylaxis in an outpatient setting.<h4>Methods</h4>Electronic medical records of women aged 50-95 prescribed NF by 2 primary urology providers for at least 3 consecutive months from 2006 to 2018 were retrospectively reviewed. ... Read more >>

World J Urol (World journal of urology)
[2021, 39(7):2597-2603]

Cited: 0 times

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Favorable Outcomes of Repeat Electrofulguration Procedures in Women With Antibiotic-refractory Recurrent Urinary Tract Infections.

Jacqueline A Chavez, Alana L Christie, Philippe E Zimmern,

<h4>Objective</h4>To evaluate the efficacy of repeat endoscopic electrofulguration in women with antibiotic-refractory, recurrent urinary tract infections (RUTIs) with persistent symptoms after 1 electrofulguration.<h4>Methods</h4>An institutional review board-approved, prospectively maintained database of non-neurogenic women with RUTIs, persistent symptoms and endoscopic findings of bladder wall inflammation after 1 electrofulguration, and minimum 6 months ... Read more >>

Urology (Urology)
[2020, 146:83-89]

Cited: 1 time

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Pancreatic tropism of metastatic renal cell carcinoma.

Nirmish Singla, Zhiqun Xie, Ze Zhang, Ming Gao, Qurratulain Yousuf, Oreoluwa Onabolu, Tiffani McKenzie, Vanina Toffessi Tcheuyap, Yuanqing Ma, Jacob Choi, Renee McKay, Alana Christie, Oscar Reig Torras, Isaac A Bowman, Vitaly Margulis, Ivan Pedrosa, Christopher Przybycin, Tao Wang, Payal Kapur, Brian Rini, James Brugarolas,

Renal cell carcinoma (RCC) is characterized by a particularly broad metastatic swath, and, enigmatically, when the pancreas is a destination, the disease is associated with improved survival. Intrigued by this observation, we sought to characterize the clinical behavior, therapeutic implications, and underlying biology. While pancreatic metastases (PM) are infrequent, we ... Read more >>

JCI Insight (JCI insight)
[2020, 5(7):]

Cited: 15 times

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