Full Text Journal Articles by
Author Alan Landay

Advertisement

Find full text journal articles






Brief Report: Differences in Types of Myocardial Infarctions Among People Aging With HIV.

Heidi M Crane, Robin M Nance, Bridget M Whitney, Susan R Heckbert, Matthew Budoff, Kevin High, Alan Landay, Matthew Feinstein, Richard D Moore, William Christopher Mathews, Katerina Christopoulos, Michael S Saag, Amanda Willig, Joseph J Eron, Mari M Kitahata, Joseph A C Delaney, ,

<h4>Background</h4>Type 1 myocardial infarctions (T1MIs) result from atherosclerotic plaque instability, rupture, and/or erosion. Type 2 MIs (T2MIs) are secondary to causes such as sepsis and cocaine-induced vasospasm resulting in an oxygen demand-supply mismatch and are associated with higher mortality than T1MIs. T2MIs account for a higher proportion of MIs among ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):208-212]

Cited: 0 times

View full text PDF listing >>



Non-Invasive Plasma Glycomic and Metabolic Biomarkers of Post-treatment Control of HIV

Leila Giron, Clovis Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas, Mohammad Damra, Aaron Goldman, Hsin-Yao Tang, Rowena Johnston, Karam Mounzer Mounzer, Jay Kostman, Pablo Tebas, Alan Landay, Luis Montaner, Jeffrey Jacobson, Jonathan Li, Mohamed Abdel-Mohsen,

Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety of analytic treatment interruption (ATI) and provide mechanistic insights into the pathways involved in post-ART HIV control. We identified plasma glycomic and metabolic signatures of time-to-viral-rebound and probability-of-viral-rebound using samples ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

COVID-19 Severity Is Associated with Differential Antibody Fc-mediated Innate Immune Functions

Opeyemi Adeniji, Leila Giron, Netanel Zilberstein, Maliha Shaikh, Robert Balk, James Moy, Christopher Forsyth, Ali Keshavarzian, Alan Landay, Mohamed Abdel-Mohsen,

<h4>ABSTRACT</h4> Beyond neutralization, antibodies elicit several innate immune functions including complement deposition (ADCD), phagocytosis (ADCP), and cytotoxicity (ADCC). These functions can be both beneficial (by clearing pathogens) and/or detrimental (by inducing inflammation). We tested the possibility that qualitative differences in SARS-CoV-2 specific antibody-mediated innate immune functions contribute to Coronavirus disease ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Phospholipid Metabolism Is Associated with HIV Rebound Upon Treatment Interruption

Leila Giron, Emmanouil Papasavvas, Xiangfan Yin, Aaron Goldman, Hsin-Yao Tang, Clovis Palmer, Alan Landay, Jonathan Li, John Koethe, Karam Mounzer, Jay Kostman, Qin Liu, Luis Montaner, Mohamed Abdel-Mohsen,

<h4>ABSTRACT</h4> Lipids are biologically active molecules involved in a variety of cellular processes and immunological functions, including inflammation. It was recently shown that phospholipids and their derivatives, lysophospholipids, can reactivate latent (dormant) tumor cells, causing cancer recurrence. However, the potential link between lipids and HIV latency, persistence, and viral rebound ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy.

Brandilyn A Peters, Lila A Sheira, David B Hanna, Qibin Qi, Anjali Sharma, Adebola Adedimeji, Tracey Wilson, Daniel Merenstein, Phyllis C Tien, Mardge Cohen, Eryka L Wentz, Jennifer Kinslow, Alan L Landay, Sheri D Weiser,

<h4>Background</h4>Food insecurity is associated with increased morbidity and mortality in people living with HIV on antiretroviral therapy, but its relationship with immune dysregulation, a hallmark of HIV infection and comorbidity, is unknown.<h4>Methods</h4>In 241 women participating in the Women's Interagency HIV Study, peripheral blood mononuclear cells were characterized by flow cytometry ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Altered Gut Microbiota and Host Metabolite Profiles in Women With Human Immunodeficiency Virus.

Zheng Wang, Mykhaylo Usyk, Christopher C Sollecito, Yunping Qiu, Jessica Williams-Nguyen, Simin Hua, Ana Gradissimo, Tao Wang, Xiaonan Xue, Irwin J Kurland, Klaus Ley, Alan L Landay, Kathryn Anastos, Rob Knight, Robert C Kaplan, Robert D Burk, Qibin Qi,

<h4>Background</h4>Alterations in gut microbiota (GMB) and host metabolites have been noted in individuals with HIV. However, it remains unclear whether alterations in GMB and related functional groups contribute to disrupted host metabolite profiles in these individuals.<h4>Methods</h4>This study included 185 women (128 with longstanding HIV infection, 88% under antiretroviral therapy; and ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(9):2345-2353]

Cited: 1 time

View full text PDF listing >>



Non-Invasive Plasma Glycomic and Metabolic Biomarkers of Post-treatment Control of HIV

Leila Giron, Clovis Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas, Mohammad Damra, Aaron Goldman, Hsin-Yao Tang, Rowena Johnston, Karam Mounzer Mounzer, Jay Kostman, Pablo Tebas, Alan Landay, Luis Montaner, Jeffrey Jacobson, Jonathan Li, Mohamed Abdel-Mohsen,

Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety of analytic treatment interruption (ATI) and provide mechanistic insights into the pathways involved in post-ART HIV control. We identified plasma glycomic and metabolic signatures of time-to-viral-rebound and probability-of-viral-rebound using samples ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Non-Invasive Plasma Glycomic and Metabolic Biomarkers of Post-treatment Control of HIV

Leila Giron, Clovis Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas, Mohammad Damra, Aaron Goldman, Hsin-Yao Tang, Rowena Johnston, Karam Mounzer, Jay Kostman, Pablo Tebas, Alan Landay, Luis Montaner, Jeffrey Jacobson, Jonathan Li, Mohamed Abdel-Mohsen,

<h4>ABSTRACT</h4> Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety of analytic treatment interruption (ATI) and provide mechanistic insights into the pathways involved in post-ART HIV control. We identified plasma glycomic and metabolic signatures of time-to-viral-rebound and probability-of-viral-rebound using ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Maintenance of Viral Suppression in Human Immunodeficiency Virus Controllers Despite Waning T-Cell Responses During Antiretroviral Therapy.

Nikolaus Jilg, Pilar Garcia-Broncano, Michael Peluso, Florencia P Segal, Ronald J Bosch, Carla Roberts-Toler, Samantha M Y Chen, Cornelius N Van Dam, Michael C Keefer, Daniel R Kuritzkes, Alan L Landay, Steven Deeks, Xu G Yu, Paul E Sax, Jonathan Z Li, ,

AIDS Clinical Trials Group study A5308 found reduced T-cell activation and exhaustion in human immunodeficiency virus (HIV) controllers start antiretroviral therapy (ART). We further assessed HIV-specific T-cell responses and post-ART viral loads. Before ART, the 31% of participants with persistently undetectable viremia had more robust HIV-specific T-cell responses. During ART, ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 222(11):1837-1842]

Cited: 1 time

View full text PDF listing >>



Association of monocyte migration marker CD11b with pulmonary function in people living with HIV.

Mark H Kuniholm, Mariam Bramah-Lawani, Meghan Fitzpatrick, Mehdi Nouraie, Shulin Qin, Laurence Huang, Abbe N Vallejo, Alan L Landay, Alison Morris,

<h4>Background</h4>Maladaptive immune responses contribute to the pathogenesis of many chronic lung diseases. Here, we tested hypotheses that CD4 and CD8 T cell and monocyte phenotypes are associated with lung function in people living with HIV (PLWH) and those without HIV.<h4>Methods</h4>Markers of T cell differentiation, activation, exhaustion and senescence, and markers ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, :]

Cited: 0 times

View full text PDF listing >>



A Summary of the Fifth Annual Virology Education HIV Microbiome Workshop.

Scott Sherrill-Mix, Kaleigh Connors, Grace M Aldrovandi, Jason M Brenchley, Charles Boucher, Frederic D Bushman, Ronald G Collman, Satya Dandekar, Nichole R Klatt, Laurel A Lagenaur, Roger Paredes, Gilda Tachedjian, Jim A Turpin, Alan L Landay, Mimi Ghosh,

In October of 2019, researchers and community members from around the world met at the NIH for the fifth annual International Workshop on Microbiome in HIV. New research was presented on the role of the microbiome on chronic inflammation and vaccine design, interactions of genetics, environment, sexual practice and HIV ... Read more >>

AIDS Res Hum Retroviruses (AIDS research and human retroviruses)
[2020, 36(11):886-895]

Cited: 0 times

View full text PDF listing >>



Combined protein and transcript single cell RNA sequencing reveals cardiovascular disease and HIV signatures

Jenifer Vallejo, Ryosuke Saigusa, Rishab Gulati, Yanal Ghosheh, Christopher Durant, Payel Roy, Erik Ehinger, Tanyaporn Pattarabanjird, Lindsey Padgett, Claire Olingy, David Hanna, Alan Landay, Russell Tracy, Jason Lazar, Wendy Mack, Kathleen Weber, Adaora Adimora, Howard Hodis, Phyllis Tien, Igho Ofotokun, Sonya Heath, Huy Dinh, Avishai Shemesh, Coleen McNamara, Lewis Lanier, Catherine Hedrick, Robert Kaplan, Klaus Ley,

<h4>Background</h4> HIV-infected people have an increased risk of atherosclerosis-based cardiovascular disease (CVD), even when the HIV virus is fully controlled. Both chronic HIV infection and CVD are chronic inflammatory diseases. The interaction between these two diseases is not well understood. <h4>Methods</h4> The Women’s Interagency HIV Study (WIHS) collected peripheral blood ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Host Genetic Factors Associated with Vaginal Microbiome Composition in Kenyan Women.

Supriya D Mehta, Drew R Nannini, Fredrick Otieno, Stefan J Green, Walter Agingu, Alan Landay, Yinan Zheng, Lifang Hou,

Bacterial vaginosis (BV) affects 20% of women worldwide and is associated with adverse reproductive health outcomes and increased risk for HIV. Typically, BV represents a shift in the vaginal microbiome from one that is dominated by <i>Lactobacillus</i> to one that is diverse. Persistent racial differences in BV and diverse vaginal ... Read more >>

mSystems (mSystems)
[2020, 5(4):]

Cited: 0 times

View full text PDF listing >>



Classical Monocyte Transcriptomes Reveal Significant Anti-Inflammatory Statin Effect in Women with Chronic HIV.

Erik Ehinger, Yanal Ghosheh, Akula Bala Pramod, Juan Lin, David B Hanna, Karin Mueller, Christopher P Durant, Livia Baas, Qibin Qi, Tao Wang, Konrad Buscher, Kathryn Anastos, Jason M Lazar, Wendy J Mack, Phyllis C Tien, Mardge H Cohen, Igho Ofotokun, Stephen Gange, Sonya L Heath, Howard N Hodis, Russell P Tracy, Alan L Landay, Robert C Kaplan, Klaus Ley,

<h4>Aims</h4>During virally-suppressed chronic HIV infection, persistent inflammation contributes to the development of cardiovascular disease (CVD), a major comorbidity in people living with HIV (LWH). Classical blood monocytes (CMs) remain activated during antiretroviral therapy and are a major source of pro-inflammatory and pro-thrombotic factors that contribute to atherosclerotic plaque development and ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Sleep Health Should be Included as a Therapeutic Target in the Treatment of HIV.

Helen J Burgess, Brett Williams, Alan Landay, Phillip Engen, Shohreh Raeisi, Ankur Naqib, Louis L Fogg, Ali Keshavarzian, Heather E Rasmussen, Xiaowei Zhang, Bruce Hamaker, Stefan J Green,

AIDS Res Hum Retroviruses (AIDS research and human retroviruses)
[2020, 36(8):631]

Cited: 0 times

View full text PDF listing >>



T Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus.

Samuel S Bailin, Kathleen A McGinnis, Wyatt J McDonnell, Kaku So-Armah, Melissa Wellons, Russell P Tracy, Margaret F Doyle, Simon Mallal, Amy C Justice, Matthew S Freiberg, Alan L Landay, Celestine Wanjalla, John R Koethe,

BACKGROUND:A higher proportion of circulating memory CD4+ T cells is associated with prevalent diabetes mellitus in the general population. Given the broad changes in adaptive immunity, including memory T-cell expansion, and rising prevalence of diabetes in the human immunodeficiency virus (HIV) population, we assessed whether similar relationships were present in ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 222(2):252-262]

Cited: 1 time

View full text PDF listing >>



Plasma acylcarnitines and progression of carotid artery atherosclerosis in HIV infection.

Simin Hua, Justin M Scott, David B Hanna, Sabina A Haberlen, Sanjiv J Shah, Howard N Hodis, Alan L Landay, Jason M Lazar, Jorge R Kizer, Bing Yu, Wendy S Post, Kathryn Anastos, Robert C Kaplan, Clary B Clish, Qibin Qi,

<h4>Objective</h4>To evaluate plasma acylcarnitine profiles and their relationships with progression of carotid artery atherosclerosis among individuals with and without HIV infection.<h4>Design</h4>Prospective cohort studies of 499 HIV-positive and 206 HIV-negative individuals from the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study.<h4>Methods</h4>Twenty-four acylcarnitine species were measured in plasma samples of ... Read more >>

AIDS (AIDS (London, England))
[2019, 33(6):1043-1052]

Cited: 1 time

View full text PDF listing >>



Antiretroviral Therapy Reduces T-cell Activation and Immune Exhaustion Markers in Human Immunodeficiency Virus Controllers.

Jonathan Z Li, Florencia P Segal, Ronald J Bosch, Christina M Lalama, Carla Roberts-Toler, Heloise Delagreverie, Rachel Getz, Pilar Garcia-Broncano, Jennifer Kinslow, Randall Tressler, Cornelius N Van Dam, Michael Keefer, Mary Carrington, Mathias Lichterfeld, Daniel Kuritzkes, Xu G Yu, Alan Landay, Paul E Sax, ,

<h4>Background</h4>Despite low plasma human immunodeficiency virus (HIV) RNA, HIV controllers have evidence of viral replication and elevated inflammation. We assessed the effect of antiretroviral therapy (ART) on HIV suppression, immune activation, and quality of life (QoL).<h4>Methods</h4>A5308 was a prospective, open-label study of rilpivirine/emtricitabine/tenofovir disoproxil fumarate in ART-naive HIV controllers (N ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(8):1636-1642]

Cited: 2 times

View full text PDF listing >>



Presence of asymptomatic cytomegalovirus and Epstein--Barr virus DNA in blood of persons with HIV starting antiretroviral therapy is associated with non-AIDS clinical events.

Sara Gianella, Carlee Moser, Andrej Vitomirov, Ashley McKhann, Laura Layman, Brianna Scott, Gemma Caballero, Steven Lada, Ronald J Bosch, Martin Hoenigl, Nell Lurain, Alan Landay, Michael M Lederman, Peter W Hunt, Davey Smith,

BACKGROUND:Even with antiretroviral therapy (ART), persons with HIV (PWH) experience increased morbidity and mortality. Cytomegalovirus (CMV) and Epstein--Barr virus (EBV) co-infections likely exacerbate inflammatory-related diseases. OBJECTIVE:To determine if presence of detectable CMV or EBV DNA in peripheral blood mononuclear cells (PBMC) is associated with non-AIDS events among PWH receiving modern ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(6):849-857]

Cited: 0 times

View full text PDF listing >>



Innate and adaptive immune cell subsets as risk factors for coronary heart disease in two population-based cohorts.

Nels C Olson, Colleen M Sitlani, Margaret F Doyle, Sally A Huber, Alan L Landay, Russell P Tracy, Bruce M Psaty, Joseph A Delaney,

<h4>Background and aims</h4>Cell-mediated immunity is implicated in atherosclerosis. We evaluated whether innate and adaptive immune cell subsets in peripheral blood are risk factors for coronary heart disease.<h4>Methods</h4>A nested case-cohort study (n = 2155) was performed within the Multi-Ethnic Study of Atherosclerosis (MESA) and the Cardiovascular Health Study (CHS). Cases of incident myocardial ... Read more >>

Atherosclerosis (Atherosclerosis)
[2020, 300:47-53]

Cited: 1 time

View full text PDF listing >>



Dysfunctional Immunometabolism in HIV Infection: Contributing Factors and Implications for Age-Related Comorbid Diseases.

Tiffany R Butterfield, Alan L Landay, Joshua J Anzinger,

<b>Purpose of review:</b>An increasing body of evidence indicates that persons living with HIV (PLWH) display dysfunctional immunometabolism. Here, we provide an updated review of this topic and its relationship to HIV-associated immune stimuli and age-related disease.<br><br><b>Recent findings:</b>HIV infection alters immunometabolism by increasing reliance on aerobic glycolysis for energy and productive ... Read more >>

Curr HIV/AIDS Rep (Current HIV/AIDS reports)
[2020, 17(2):125-137]

Cited: 1 time

View full text PDF listing >>



Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection.

Leila B Giron, Ceylan E Tanes, Mariane H Schleimann, Phillip A Engen, Lisa M Mattei, Alitzel Anzurez, Mohammad Damra, Huanjia Zhang, Kyle Bittinger, Frederic Bushman, Andrew Kossenkov, Paul W Denton, Hiroaki Tateno, Ali Keshavarzian, Alan L Landay, Mohamed Abdel-Mohsen,

An emerging paradigm suggests that gut glycosylation is a key force in maintaining the homeostatic relationship between the gut and its microbiota. Nevertheless, it is unclear how gut glycosylation contributes to the HIV-associated microbial translocation and inflammation that persist despite viral suppression and contribute to the development of several comorbidities. ... Read more >>

Mucosal Immunol (Mucosal immunology)
[2020, 13(5):753-766]

Cited: 2 times

View full text PDF listing >>



Associations of Innate and Adaptive Immune Cell Subsets With Incident Type 2 Diabetes Risk: The MESA Study.

Nels C Olson, Margaret F Doyle, Colleen M Sitlani, Ian H de Boer, Stephen S Rich, Sally A Huber, Alan L Landay, Russell P Tracy, Bruce M Psaty, Joseph A Delaney,

<b>Objective: </b>Cell-mediated immunity is implicated in glucose homeostasis and insulin resistance. Whether the levels of innate and adaptive immune cells in peripheral blood are risk factors for incident type 2 diabetes (T2D) remains unknown. We hypothesized that the proportions of naive, memory, CD28-, Th17, and T regulatory CD4+ cells would ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, 105(3):]

Cited: 0 times

View full text PDF listing >>



A Summary of the Fourth Annual Virology Education HIV Microbiome Workshop.

Brett Williams, Mimi Ghosh, Charles Boucher, Frederic Bushman, Stacy Carrington-Lawrence, Ronald G Collman, Satya Dandekar, Que Dang, Angela Malaspina, Roger Paredes, Cara Wilson, Sandra Pinto Cardoso, Laurel Lagenaur, Jessica Santos, Christopher Joy, Alan Landay,

Each year, a growing international collection of researchers meets at the NIH to share and discuss developments in the microbiome HIV story. This past year has seen continued progress toward a detailed understanding of host-microbe interactions both within and outside the field of HIV. Commensal microbes are being linked to ... Read more >>

AIDS Res Hum Retroviruses (AIDS research and human retroviruses)
[2020, 36(5):349-356]

Cited: 0 times

View full text PDF listing >>



Host Genetic Determinants of the Vaginal Microbiome in Kenyan Women

Supriya Mehta, Drew Nannini, Fredrick Otieno, Stefan Green, Walter Agingu, Alan Landay, Yinan Zheng, Lifang Hou,

<h4>Background: </h4> Women with vaginal microbial community state types (CST) with high diversity and a paucity of Lactobacillus crispatus have increased risk of HIV acquisition. Identifying host genetic factors associated with the vaginal microbial composition may aid in elucidating the biological mechanisms regulating these microbial traits and inter-individual variations in ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.3017 s