Full Text Journal Articles by
Author Alan L Hutchison


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The effect of COVID-19 on liver transplantation: impact, practice patterns, therapeutics, and next steps.

Alan L Hutchison, Anjana Pillai,

<h4>Purpose of review</h4>To assess the impact of coronavirus disease 2019 (COVID-19) and the pandemic on liver transplant candidates, recipients, and donors, and review guidelines and recommendations for integrating COVID-19 therapies into current practice.<h4>Recent findings</h4>COVID-19 has high morbidity and mortality for transplant candidates; interestingly, posttransplant comorbidities play a larger role than ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):339-345]

Cited: 0 times

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Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity.

Fangke Xu, Elzbieta Kula-Eversole, Marta Iwanaszko, Alan L Hutchison, Aaron Dinner, Ravi Allada,

Neurodegenerative diseases commonly involve the disruption of circadian rhythms. Studies indicate that mutant Huntingtin (mHtt), the cause of Huntington's disease (HD), disrupts circadian rhythms often before motor symptoms are evident. Yet little is known about the molecular mechanisms by which mHtt impairs circadian rhythmicity and whether circadian clocks can modulate ... Read more >>

Cell Rep (Cell reports)
[2019, 27(1):59-70.e4]

Cited: 8 times

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Bootstrapping and Empirical Bayes Methods Improve Rhythm Detection in Sparsely Sampled Data.

Alan L Hutchison, Ravi Allada, Aaron R Dinner,

There is much interest in using genome-wide expression time series to identify circadian genes. However, the cost and effort of such measurements often limit data collection. Consequently, it is difficult to assess the experimental uncertainty in the measurements and, in turn, to detect periodic patterns with statistical confidence. We show ... Read more >>

J Biol Rhythms (Journal of biological rhythms)
[2018, 33(4):339-349]

Cited: 9 times

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miR-4728-3p Functions as a Tumor Suppressor in Ulcerative Colitis-associated Colorectal Neoplasia Through Regulation of Focal Adhesion Signaling.

Joel Pekow, Alan L Hutchison, Katherine Meckel, Kymberly Harrington, Zifeng Deng, Nitya Talasila, David T Rubin, Stephen B Hanauer, Roger Hurst, Konstantin Umanskiy, Alessandro Fichera, John Hart, Aaron R Dinner, Marc Bissonnette,

<h4>Background</h4>As mechanisms of neoplasia in patients with ulcerative colitis (UC) remain poorly understood, we sought to identify pathways of carcinogenesis in this high-risk population.<h4>Methods</h4>MicroRNA (miRNA) and mRNA expression was examined in nondysplastic rectosigmoid mucosa from UC patients with (n = 19) or without remote colon neoplasia (n = 23). We ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2017, 23(8):1328-1337]

Cited: 13 times

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An Experimental Survey on the Effect of Using the CTS-6 Tool on the Diagnosis of Carpal Tunnel Syndrome by Hand Surgeons.

Richard L Hutchison, Alan L Hutchison, Maureen A Hirthler,

<h4>Background</h4>This controlled randomized experiment tested the research hypothesis that providing the CTS-6 quantitative diagnostic information to hand surgeons affects the diagnosis of carpal tunnel syndrome.<h4>Methods</h4>Surgeon members of American Association for Hand Surgery participated in an online survey. Demographic and practice pattern information was collected. Few surgeons routinely use diagnostic questionnaires ... Read more >>

J Hand Surg Asian Pac Vol (The journal of hand surgery Asian-Pacific volume)
[2017, 22(1):88-92]

Cited: 0 times

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A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability.

Matthieu Flourakis, Elzbieta Kula-Eversole, Alan L Hutchison, Tae Hee Han, Kimberly Aranda, Devon L Moose, Kevin P White, Aaron R Dinner, Bridget C Lear, Dejian Ren, Casey O Diekman, Indira M Raman, Ravi Allada,

Circadian clocks regulate membrane excitability in master pacemaker neurons to control daily rhythms of sleep and wake. Here, we find that two distinctly timed electrical drives collaborate to impose rhythmicity on Drosophila clock neurons. In the morning, a voltage-independent sodium conductance via the NA/NALCN ion channel depolarizes these neurons. This ... Read more >>

Cell (Cell)
[2015, 162(4):836-848]

Cited: 89 times

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Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.

Mark Perelis, Biliana Marcheva, Kathryn Moynihan Ramsey, Matthew J Schipma, Alan L Hutchison, Akihiko Taguchi, Clara Bien Peek, Heekyung Hong, Wenyu Huang, Chiaki Omura, Amanda L Allred, Christopher A Bradfield, Aaron R Dinner, Grant D Barish, Joseph Bass,

The mammalian transcription factors CLOCK and BMAL1 are essential components of the molecular clock that coordinate behavior and metabolism with the solar cycle. Genetic or environmental perturbation of circadian cycles contributes to metabolic disorders including type 2 diabetes. To study the impact of the cell-autonomous clock on pancreatic β cell ... Read more >>

Science (Science (New York, N.Y.))
[2015, 350(6261):aac4250]

Cited: 150 times

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Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.

Vanessa Leone, Sean M Gibbons, Kristina Martinez, Alan L Hutchison, Edmond Y Huang, Candace M Cham, Joseph F Pierre, Joseph F Pierre, Aaron F Heneghan, Anuradha Nadimpalli, Nathaniel Hubert, Elizabeth Zale, Yunwei Wang, Yong Huang, Betty Theriault, Aaron R Dinner, Mark W Musch, Kenneth A Kudsk, Brian J Prendergast, Jack A Gilbert, Eugene B Chang,

Circadian clocks and metabolism are inextricably intertwined, where central and hepatic circadian clocks coordinate metabolic events in response to light-dark and sleep-wake cycles. We reveal an additional key element involved in maintaining host circadian rhythms, the gut microbiome. Despite persistence of light-dark signals, germ-free mice fed low or high-fat diets ... Read more >>

Cell Host Microbe (Cell host & microbe)
[2015, 17(5):681-689]

Cited: 244 times

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Improved statistical methods enable greater sensitivity in rhythm detection for genome-wide data.

Alan L Hutchison, Mark Maienschein-Cline, Andrew H Chiang, S M Ali Tabei, Herman Gudjonson, Neil Bahroos, Ravi Allada, Aaron R Dinner,

Robust methods for identifying patterns of expression in genome-wide data are important for generating hypotheses regarding gene function. To this end, several analytic methods have been developed for detecting periodic patterns. We improve one such method, JTK_CYCLE, by explicitly calculating the null distribution such that it accounts for multiple hypothesis ... Read more >>

PLoS Comput Biol (PLoS computational biology)
[2015, 11(3):e1004094]

Cited: 21 times

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Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa.

Xin Deng, Haihua Liang, Olesya A Ulanovskaya, Quanjiang Ji, Tianhong Zhou, Fei Sun, Zhike Lu, Alan L Hutchison, Lefu Lan, Min Wu, Benjamin F Cravatt, Chuan He,

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from human pathogens Staphylococcus aureus and Pseudomonas aeruginosa can be readily inhibited by reactive oxygen species (ROS)-mediated direct oxidation of their catalytic active cysteines. Because of the rapid degradation of H2O2 by bacterial catalase, only steady-state but not one-dose treatment with H2O2 rapidly induces glycolysis and the ... Read more >>

J Bacteriol (Journal of bacteriology)
[2014, 196(14):2499-2513]

Cited: 15 times

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Cofilin-linked changes in actin filament flexibility promote severing.

Brannon R McCullough, Elena E Grintsevich, Christine K Chen, Hyeran Kang, Alan L Hutchison, Arnon Henn, Wenxiang Cao, Cristian Suarez, Jean-Louis Martiel, Laurent Blanchoin, Emil Reisler, Enrique M De La Cruz,

The actin regulatory protein, cofilin, increases the bending and twisting elasticity of actin filaments and severs them. It has been proposed that filaments partially decorated with cofilin accumulate stress from thermally driven shape fluctuations at bare (stiff) and decorated (compliant) boundaries, thereby promoting severing. This mechanics-based severing model predicts that ... Read more >>

Biophys J (Biophysical journal)
[2011, 101(1):151-159]

Cited: 86 times

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Impaired consciousness in epilepsy investigated by a prospective responsiveness in epilepsy scale (RES).

Li Yang, Irina Shklyar, Hyang Woon Lee, Celestine C Ezeani, Joseph Anaya, Samantha Balakirsky, Xiao Han, Sheila Enamandram, Clara Men, Joyce Y Cheng, Abigail Nunn, Tanya Mayer, Czestochowa Francois, Molly Albrecht, Alan L Hutchison, Ee-Lynn Yap, Kevin Ing, Gvantsa Didebulidze, Bo Xiao, Hamada Hamid, Pue Farooque, Kamil Detyniecki, Joseph T Giacino, Hal Blumenfeld,

<h4>Purpose</h4>Impaired consciousness in epileptic seizures has a major negative impact on patient quality of life. Prior work on epileptic unconsciousness has mainly used retrospective and nonstandardized methods. Our goal was to validate and to obtain initial data using a standardized prospective testing battery.<h4>Methods</h4>The responsiveness in epilepsy scale (RES) was used ... Read more >>

Epilepsia (Epilepsia)
[2012, 53(3):437-447]

Cited: 22 times

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Fibonacci, littler, and the hand: a brief review.

Alan L Hutchison, Richard L Hutchison,

In a landmark paper published in 1973, the eminent hand surgeon J. William Littler, MD, proposed two mathematical relationships between the anatomic and functional geometry of the hand. His proposal that the motion of the tips of the fingers follow an equiangular spiral has been experimentally supported. Studies have not ... Read more >>

Hand (N Y) (Hand (New York, N.Y.))
[2010, 5(4):364-368]

Cited: 10 times

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César Roux and his original 1893 paper.

Richard L Hutchison, Alan L Hutchison,

The Roux-en-Y type of gastrointestinal anastomosis, originated by the Swiss surgeon César Roux, is a valuable technique used in drainage of the stomach, esophagus, and the pancreatico-biliary tree. It is now frequently used in reconstructing the GI tract after resections for a number of diseases, and known by the general ... Read more >>

Obes Surg (Obesity surgery)
[2010, 20(7):953-956]

Cited: 5 times

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