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Evaluation of the risk of patella fracture as the result of decreasing tibial plateau angle following tibial plateau leveling osteotomy.

Cindy M Geier, Steven W Frederick, Alan R Cross,

<h4>Objective</h4>To evaluate the effect of postoperative tibial plateau angle (TPA) following tibial plateau leveling osteotomy (TPLO) on the risk of patella fracture during the convalescent period.<h4>Study design</h4>Retrospective study.<h4>Sample population</h4>Fracture group: 20 stifles; reference group: 65 stifles.<h4>Methods</h4>Medical records were reviewed for stifles with patellar fractures after a TPLO procedure (fracture group) ... Read more >>

Vet Surg (Veterinary surgery : VS)
[2021, :]

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A pilot study of an anti-endotoxin Ig-enriched bovine colostrum to prevent experimental sepsis.

Alan S Cross, Steven M Opal, John E Palardy, Surekha Shridhar, Scott M Baliban, Alison J Scott, Abdullah B Chahin, Robert K Ernst,

Despite the dramatic increase in antimicrobial resistance, there is a dearth of antibiotics in development and few pharmaceutical companies working in the field. Further, any new antibiotics are likely to have a short shelf life. Ab-based interventions offer alternatives that are not likely to be circumvented by the widely prevalent ... Read more >>

Innate Immun (Innate immunity)
[2021, 27(3):266-274]

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Mapping origins of variation in neural trajectories of human pluripotent stem cells

Suel-Kee Kim, Seungmae Seo, Genevieve Stein-O’Brien, Amritha Jaishankar, Kazuya Ogawa, Nicola Micali, Yanhong Wang, Thomas Hyde, Joel Kleinman, Ty Voss, Elana Fertig, Joo-Heon Shin, Roland Bürli, Alan Cross, Nicholas Brandon, Daniel Weinberger, Joshua Chenoweth, Daniel Hoeppner, Nenad Sestan, Carlo Colantuoni, Ronald McKay,

<h4>SUMMARY</h4> Variability between human pluripotent stem cell (hPSC) lines remains a challenge and opportunity in biomedicine. We identify differences in the spontaneous self-organization of individual hPSC lines during self-renewal that lie along a fundamental axis of in vivo development. Distinct stable and dynamic transcriptional elements were revealed by decomposition of ... Read more >>

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Hypobaria Exposure Worsens Cardiac Function and Endothelial Injury in an Animal Model of Polytrauma: Implications for Aeromedical Evacuation.

Kerri Lopez, Andrew Suen, Yang Yang, Sheng Wang, Brittney Williams, Jing Zhu, Jiang Hu, Gary Fiskum, Alan Cross, Rosemary Kozar, Catriona Miller, Lin Zou, Wei Chao,

<h4>Background</h4>Aeromedical evacuation can expose traumatically injured patients to low pressure (hypobaria) and hypoxia. Here we sought to assess the impact of hypobaria on inflammation, organ injury, and mortality in a mouse model of polytrauma.<h4>Methods</h4>Eight to 12 week-old male C57BL/6J mice were subjected to sham or polytrauma consisting of bowel ischemia ... Read more >>

Shock (Shock (Augusta, Ga.))
[2020, Publish Ahead of Print:]

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Evaluation of a Fixed-Angle Wedge Osteotomy Guide.

Katherine M Neal, Steven W Frederick, Matthew R Corse, Alan R Cross,

<h4>Objective</h4> The aim of this study was to evaluate a fixed-angle cutting guide designed to aid in the performance of coplanar wedge osteotomies using a proximal tibial cranial closing wedge ostectomy model.<h4>Study design</h4> A 30-degree cranial closing wedge ostectomy was created using canine tibia models with either a standard template (method T) ... Read more >>

Vet Comp Orthop Traumatol (Veterinary and comparative orthopaedics and traumatology : V.C.O.T)
[2021, 34(1):32-36]

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The effect of extracorporeal shockwave on liposomal bupivacaine in a tibial plateau leveling osteotomy model.

Steven W Frederick, Alan R Cross,

<h4>Objective</h4>To determine the effect of extracorporeal shock wave (ESWT) on liposomal bupivacaine in a tibial-plateau-leveling osteotomy model.<h4>Study design</h4>In vitro study.<h4>Sample population</h4>Ten samples per group.<h4>Methods</h4>In addition to a control group (sham treatment), five treatment groups were defined as A, energy (E) 3 (0.22 mJ/mm<sup>2</sup> ), 360 pulses per minute (p/m); B, E6 ... Read more >>

Vet Surg (Veterinary surgery : VS)
[2020, 49(8):1503-1508]

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The Diversity of Lipopolysaccharide (O) and Capsular Polysaccharide (K) Antigens of Invasive Klebsiella pneumoniae in a Multi-Country Collection.

Myeongjin Choi, Nicolas Hegerle, Joseph Nkeze, Shaichi Sen, Sanchita Jamindar, Shamima Nasrin, Sunil Sen, Jasnehta Permala-Booth, James Sinclair, Milagritos D Tapia, J Kristie Johnson, Sylla Mamadou, Joshua T Thaden, Vance G Fowler, Ana Aguilar, Enrique Terán, Dominique Decre, Florence Morel, Karen Angeliki Krogfelt, Annelie Brauner, Efthymia Protonotariou, Eirini Christaki, Yuichiro Shindo, Yi-Tsung Lin, Andrea L Kwa, Sadia Shakoor, Ashika Singh-Moodley, Olga Perovic, Jan Jacobs, Octavie Lunguya, Raphael Simon, Alan S Cross, Sharon M Tennant,

<i>Klebsiella pneumoniae</i> is a common cause of sepsis and is particularly associated with healthcare-associated infections. New strategies are needed to prevent or treat infections due to the emergence of multi-drug resistant <i>K. pneumoniae</i>. The goal of this study was to determine the diversity and distribution of O (lipopolysaccharide) and K ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:1249]

Cited: 3 times

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Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates.

Nicola Micali, Suel-Kee Kim, Marcelo Diaz-Bustamante, Genevieve Stein-O'Brien, Seungmae Seo, Joo-Heon Shin, Brian G Rash, Shaojie Ma, Yanhong Wang, Nicolas A Olivares, Jon I Arellano, Kristen R Maynard, Elana J Fertig, Alan J Cross, Roland W Bürli, Nicholas J Brandon, Daniel R Weinberger, Joshua G Chenoweth, Daniel J Hoeppner, Nenad Sestan, Pasko Rakic, Carlo Colantuoni, Ronald D McKay,

Better understanding of the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here, we use RNA sequencing, cell imaging, and lineage tracing of mouse and human in vitro NSCs and monkey brain sections to model the ... Read more >>

Cell Rep (Cell reports)
[2020, 31(5):107599]

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Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs.

Emily E Burke, Joshua G Chenoweth, Joo Heon Shin, Leonardo Collado-Torres, Suel-Kee Kim, Nicola Micali, Yanhong Wang, Carlo Colantuoni, Richard E Straub, Daniel J Hoeppner, Huei-Ying Chen, Alana Sellers, Kamel Shibbani, Gregory R Hamersky, Marcelo Diaz Bustamante, BaDoi N Phan, William S Ulrich, Cristian Valencia, Amritha Jaishankar, Amanda J Price, Anandita Rajpurohit, Stephen A Semick, Roland W Bürli, James C Barrow, Daniel J Hiler, Stephanie C Page, Keri Martinowich, Thomas M Hyde, Joel E Kleinman, Karen F Berman, Jose A Apud, Alan J Cross, Nicholas J Brandon, Daniel R Weinberger, Brady J Maher, Ronald D G McKay, Andrew E Jaffe,

Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 iPSC donor and 13 subclonal lines across 9 time points over 5 broad conditions: self-renewal, early neuronal differentiation, neural precursor cells (NPCs), assembled rosettes, and ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):462]

Cited: 13 times

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Brucella canis sacroiliitis and discospondylitis in a dog.

Jessica N Forbes, Steven W Frederick, Mason Y Savage, Alan R Cross,

A 1.5-year-old neutered male Labrador retriever dog was presented with a 1-month history of pelvic limb lameness. Physical examination revealed lumbosacral and pelvic pain. Diagnostic imaging findings were consistent with discospondylitis and bilateral sacroiliitis. Brucellosis was definitively diagnosed with rapid slide agglutination (RSAT) and agar gel immunodiffusion (AGID) tests. Brucella ... Read more >>

Can Vet J (The Canadian veterinary journal = La revue veterinaire canadienne)
[2019, 60(12):1301-1304]

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Comprehensive assessment of multiple biases in small RNA sequencing reveals significant differences in the performance of widely used methods.

Carrie Wright, Anandita Rajpurohit, Emily E Burke, Courtney Williams, Leonardo Collado-Torres, Martha Kimos, Nicholas J Brandon, Alan J Cross, Andrew E Jaffe, Daniel R Weinberger, Joo Heon Shin,

<h4>Background</h4>RNA sequencing offers advantages over other quantification methods for microRNA (miRNA), yet numerous biases make reliable quantification challenging. Previous evaluations of these biases have focused on adapter ligation bias with limited evaluation of reverse transcription bias or amplification bias. Furthermore, evaluations of the quantification of isomiRs (miRNA isoforms) or the ... Read more >>

BMC Genomics (BMC genomics)
[2019, 20(1):513]

Cited: 7 times

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Progress towards the development of Klebsiella vaccines.

Myeongjin Choi, Sharon M Tennant, Raphael Simon, Alan S Cross,

Introduction: Klebsiella pneumoniae (KP) are a leading cause of healthcare-associated infections. The dramatic increase in microbial resistance to third-generation cephalosporin and carbapenem 'front line' antimicrobial agents and the paucity of new antimicrobials have left clinicians with few therapeutic options and resulted in increased morbidity and mortality. Vaccines may reduce the ... Read more >>

Expert Rev Vaccines (Expert review of vaccines)
[2019, 18(7):681-691]

Cited: 2 times

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Use of an amikacin-infused collagen sponge concurrent with implant removal for treatment of tibial plateau leveling osteotomy surgical site infection in 31 cases.

Sylvia J Lee, Steven W Frederick, Alan R Cross,

<h4>Objective</h4>To report the use and long-term outcome of dogs with surgical site infection (SSI) after tibial plateau leveling osteotomy (TPO), treated with an amikacin-infused collagen sponge and implant removal.<h4>Study design</h4>Retrospective study.<h4>Animals</h4>Thirty-one client-owned dogs.<h4>Methods</h4>Medical records were reviewed for dogs with SSI after a TPLO that were treated with surgical implant removal ... Read more >>

Vet Surg (Veterinary surgery : VS)
[2019, 48(5):700-706]

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Variation of human neural stem cells generating organizer states in vitro before committing to cortical excitatory or inhibitory neuronal fates

Nicola Micali, Suel-Kee Kim, Marcelo Diaz-Bustamante, Genevieve Stein-O’Brien, Seungmae Seo, Joo-Heon Shin, Brian Rash, Shaojie Ma, Yanhong Wang, Nicolas Olivares, Jon Arellano, Kristen Maynard, Elana Fertig, Alan Cross, Roland Burli, Nicholas Brandon, Daniel Weinberger, Joshua Chenoweth, Daniel Hoeppner, Nenad Sestan, Pasko Rakic, Carlo Colantuoni, Ronald McKay,

<h4>SUMMARY</h4> Better understanding the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here we used RNA-sequencing, cell imaging and lineage tracing of mouse and human in vitro NSCs to model the generation of cortical neuronal ... Read more >>

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The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking.

Nadege Morisot, Anthony L Berger, Khanhky Phamluong, Alan Cross, Dorit Ron,

Fyn is a member of the Src family of protein tyrosine kinases (PTKs) that plays an important role not only in normal synaptic functions but also in brain pathologies including alcohol use disorder. We previously reported that repeated cycles of binge drinking and withdrawal activate Fyn in the dorsomedial striatum ... Read more >>

Addict Biol (Addiction biology)
[2019, 24(6):1227-1234]

Cited: 2 times

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Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19).

Liang Ma, Stephen A Semick, Qiang Chen, Chao Li, Ran Tao, Amanda J Price, Joo Heon Shin, Yankai Jia, , Nicholas J Brandon, Alan J Cross, Thomas M Hyde, Joel E Kleinman, Andrew E Jaffe, Daniel R Weinberger, Richard E Straub,

Genome-wide association studies (GWAS) have identified many genomic loci associated with risk for schizophrenia, but unambiguous identification of the relationship between disease-associated variants and specific genes, and in particular their effect on risk conferring transcripts, has proven difficult. To better understand the specific molecular mechanism(s) at the schizophrenia locus in ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, 25(4):831-843]

Cited: 8 times

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Neuraminidase 1-mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection.

Erik P Lillehoj, Wei Guang, Sang W Hyun, Anguo Liu, Nicolas Hegerle, Raphael Simon, Alan S Cross, Hideharu Ishida, Irina G Luzina, Sergei P Atamas, Simeon E Goldblum,

<i>Pseudomonas aeruginosa</i> (Pa) expresses an adhesin, flagellin, that engages the mucin 1 (MUC1) ectodomain (ED) expressed on airway epithelia, increasing association of MUC1-ED with neuraminidase 1 (NEU1) and MUC1-ED desialylation. The MUC1-ED desialylation unmasks both cryptic binding sites for Pa and a protease recognition site, permitting its proteolytic release as ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2019, 294(2):662-678]

Cited: 3 times

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Modeling the macrophage-anthrax spore interaction: Implications for early host-pathogen interactions.

Buddhi Pantha, Alan Cross, Suzanne Lenhart, Judy Day,

Inhalational anthrax, caused by the gram positive bacteria Bacillus anthracis, is a potentially fatal form of anthrax infection. It is initiated after inhaled spores are deposited in the lung, phagocytosed by immune cells, and subsequently transported to nearby lymph nodes. Intracellular spores that successfully germinate and become vegetative bacteria can ... Read more >>

Math Biosci (Mathematical biosciences)
[2018, 305:18-28]

Cited: 2 times

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Comprehensive assessment of multiple biases in small RNA sequencing reveals significant differences in the performance of widely used methods

Carrie Wright, Anandita Rajpurohit, Emily Burke, Courtney Williams, Leonardo Collado-Torres, Martha Kimos, Nicholas Brandon, Alan Cross, Andrew Jaffe, Daniel Weinberger, Joo Heon Shin,

<h4>ABSTRACT</h4> High-throughput sequencing offers advantages over other quantification methods for microRNA (miRNA), yet numerous biases make reliable quantification challenging. Previous evaluations of the biases associated with small RNA sequencing have focused on adapter ligation bias with limited evaluation of reverse transcription or amplification biases. Furthermore, evaluations of the accuracy of ... Read more >>

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Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin.

Rochelle M Hines, Hans Michael Maric, Dustin J Hines, Amit Modgil, Patrizia Panzanelli, Yasuko Nakamura, Anna J Nathanson, Alan Cross, Tarek Deeb, Nicholas J Brandon, Paul Davies, Jean-Marc Fritschy, Hermann Schindelin, Stephen J Moss,

Fast inhibitory synaptic transmission is mediated by γ-aminobutyric acid type A receptors (GABA<sub>A</sub>Rs) that are enriched at functionally diverse synapses via mechanisms that remain unclear. Using isothermal titration calorimetry and complementary methods we demonstrate an exclusive low micromolar binding of collybistin to the α2-subunit of GABA<sub>A</sub>Rs. To explore the biological ... Read more >>

Nat Commun (Nature communications)
[2018, 9(1):3130]

Cited: 13 times

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Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening.

Roland W Bürli, Huijun Wei, Glen Ernst, Abigail Mariga, Ian M Hardern, Kara Herlihy, Alan J Cross, Steven S Wesolowski, Hongming Chen, Ronald D G McKay, Daniel R Weinberger, Nicholas J Brandon, James C Barrow,

Due to increased interest in As(III) S-adenosylmethionine methyltransferase (AS3MT), a search for chemical probes that can help elucidate function was initiated. A homology model was built based on related enzymes, and virtual screening produced 426 potential hits. Evaluation of these compounds in a functional enzymatic assay revealed several modest inhibitors ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2018, 28(19):3231-3235]

Cited: 1 time

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Development of a broad spectrum glycoconjugate vaccine to prevent wound and disseminated infections with Klebsiella pneumoniae and Pseudomonas aeruginosa.

Nicolas Hegerle, Myeongjin Choi, James Sinclair, Mohammed N Amin, Morgane Ollivault-Shiflett, Brittany Curtis, Rachel S Laufer, Surekha Shridhar, Jerod Brammer, Franklin R Toapanta, Ian Alan Holder, Marcela F Pasetti, Andrew Lees, Sharon M Tennant, Alan S Cross, Raphael Simon,

Klebsiella pneumoniae (KP) and Pseudomonas aeruginosa (PA) are important human pathogens that are associated with a range of infection types, including wound and disseminated infections. Treatment has been complicated by rising rates of antimicrobial resistance. Immunoprophylactic strategies are not constrained by antimicrobial resistance mechanisms. Vaccines against these organisms would be ... Read more >>

PLoS One (PloS one)
[2018, 13(9):e0203143]

Cited: 15 times

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Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis.

Andrew E Jaffe, Richard E Straub, Joo Heon Shin, Ran Tao, Yuan Gao, Leonardo Collado-Torres, Tony Kam-Thong, Hualin S Xi, Jie Quan, Qiang Chen, Carlo Colantuoni, William S Ulrich, Brady J Maher, Amy Deep-Soboslay, , Alan J Cross, Nicholas J Brandon, Jeffrey T Leek, Thomas M Hyde, Joel E Kleinman, Daniel R Weinberger,

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological mechanisms for individual loci are largely unknown. Using developmental, genetic and illness-based RNA sequencing expression analysis in human brain, we characterized the human brain transcriptome around these loci and found enrichment for developmentally regulated genes with novel examples of ... Read more >>

Nat Neurosci (Nature neuroscience)
[2018, 21(8):1117-1125]

Cited: 66 times

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Effect of hypobaria and hyperoxia during sepsis on survival and energy metabolism.

Myeongjin Choi, Pratistha Tamrakar, Patricia F Schuck, Julie L Proctor, Ashley Moore, Katrina Asbury, Gary Fiskum, Turhan Coksaygan, Alan S Cross,

<h4>Background</h4>Injured warfighters air evacuated to tertiary medical care facilities are subjected to many stresses that may promote the development of sepsis. In this study, we tested the hypothesis that exposure to "in-flight" hypobaria and/or hyperoxia within 24 hours after onset of intra-abdominal infection in rats accelerates the development and/or severity ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2018, 85(1S Suppl 2):S68-S76]

Cited: 0 times

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Correction to: Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate.

Benjamin L Oyler, Mohd M Khan, Donald F Smith, Erin M Harberts, David P A Kilgour, Robert K Ernst, Alan S Cross, David R Goodlett,

In the preceding article "Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate" by Oyler et al., an error in the J5 E. coli LPS chemical structure (Figs. 2 and 4) was introduced and propagated into the final revision. ... Read more >>

J Am Soc Mass Spectrom (Journal of the American Society for Mass Spectrometry)
[2018, 29(6):1230]

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