Full Text Journal Articles by
Author Alaa Abou Daher

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Translational Aspects of the Mammalian Target of Rapamycin Complexes in Diabetic Nephropathy.

Alaa Abou Daher, Sahar Alkhansa, William S Azar, Rim Rafeh, Hilda E Ghadieh, Assaad Antoine Eid,

<h4>Significance</h4>Despite the many efforts put into understanding diabetic nephropathy (DN), direct treatments for DN have yet to be discovered. Understanding the mechanisms behind DN is an essential step in the development of novel therapeutic regimens. The mTOR pathway has emerged as an important candidate in the quest for drug discovery ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, :]

Cited: 0 times

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Crosstalk Between SMPDL3b and NADPH Oxidases Mediates Radiation-Induced Damage of Renal Podocytes.

Patrick Azzam, Marina Francis, Tarek Youssef, Manal Mroueh, Alaa Abou Daher, Assaad A Eid, Alessia Fornoni, Brian Marples, Youssef H Zeidan,

Patients undergoing radiotherapy (RT) for various tumors localized in the abdomen or pelvis often suffer from radiation nephrotoxicity as collateral damage. Renal podocytes are vulnerable targets for ionizing radiation and contribute to radiation-induced nephropathies. Our prior work previously highlighted the importance of the lipid-modifying enzyme sphingomyelinase acid phosphodiesterase like 3b ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:732528]

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Abdominal apoplexy: A rare case of spontaneous middle colic artery rupture with transverse colectomy.

Taha M Qaraqe, Alaa Abou Daher, Ramzi S Alami,

<h4>Introduction and importance</h4>Idiopathic spontaneous intraperitoneal hemorrhage (ISIH) is a rare but potentially fatal entity. The majority of the reported cases of ISIH due to middle colic artery rupture are associated with pseudoaneurysm. Our case is unique in that no pathology could be identified. To our knowledge, this is the third ... Read more >>

Int J Surg Case Rep (International journal of surgery case reports)
[2021, 81:105835]

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Crosstalk Between SMPDL3b and NADPH Oxidases Mediates Radiation-Induced Damage of Renal Podocytes

Patrick Azzam, Marina Francis, Tarek Youssef, Manal Mroueh, Alaa Abou Daher, Assaad A. Eid, Alessia Fornoni, Brian Marples, Youssef H. Zeidan,

Patients undergoing radiotherapy (RT) for various tumors localized in the abdomen or pelvis often suffer from radiation nephrotoxicity as collateral damage. Renal podocytes are vulnerable targets for ionizing radiation and contribute to radiation-induced nephropathies. Our prior work previously highlighted the importance of the lipid-modifying enzyme sphingomyelinase acid phosphodiesterase like 3b ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:]

Cited: 0 times

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Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities.

Patrick Azzam, Manal Mroueh, Marina Francis, Alaa Abou Daher, Youssef H Zeidan,

Head and neck cancer (HNC) is the sixth most common human malignancy with a global incidence of 650,000 cases per year. Radiotherapy (RT) is commonly used as an effective therapy to treat tumours as a definitive or adjuvant treatment. Despite the substantial advances in RT contouring and dosage delivery, patients ... Read more >>

Ecancermedicalscience (Ecancermedicalscience)
[2020, 14:1133]

Cited: 2 times

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Modulation of radiation-induced damage of human glomerular endothelial cells by SMPDL3B.

Alaa Abou Daher, Marina Francis, Patrick Azzam, Anis Ahmad, Assaad A Eid, Alessia Fornoni, Brian Marples, Youssef H Zeidan,

The intracellular molecular pathways involved in radiation-induced nephropathy are still poorly understood. Glomerular endothelial cells are key components of the structure and function of the glomerular filtration barrier but little is known about the mechanisms implicated in their injury and repair. The current study establishes the response of immortalized human ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(6):7915-7926]

Cited: 4 times

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Translational Aspects of Sphingolipid Metabolism in Renal Disorders.

Alaa Abou Daher, Tatiana El Jalkh, Assaad A Eid, Alessia Fornoni, Brian Marples, Youssef H Zeidan,

Sphingolipids, long thought to be passive components of biological membranes with merely a structural role, have proved throughout the past decade to be major players in the pathogenesis of many human diseases. The study and characterization of several genetic disorders like Fabry's and Tay Sachs, where sphingolipid metabolism is disrupted, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(12):]

Cited: 6 times

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