Full Text Journal Articles by
Author Alaa A A Aljabali

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Circadian rhythm disruption and Alzheimer's disease: The dynamics of a vicious cycle.

Ashish Sharma, Gautam Sethi, Murtaza M Tambuwala, Alaa A A Aljabali, Dinesh Kumar Chellappan, Kamal Dua, Rohit Goyal,

All mammalian cells exhibit circadian rhythm in cellular metabolism and energetics. Autonomous cellular clocks are modulated by various pathways that are essential for robust time keeping. In addition to the canonical transcriptional translational feedback loop, several new pathways of circadian timekeeping - non-transcriptional oscillations, post-translational modifications, epigenetics and cellular signaling ... Read more >>

Curr Neuropharmacol (Current neuropharmacology)
[2020, :]

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Monotherapy of RAAS blockers and mobilization of aldosterone: A mechanistic perspective study in kidney disease.

Gaurav Gupta, Rajiv Dahiya, Yogendra Singh, Anurag Mishra, Aseem Verma, Sunil Kumar Gothwal, Alaa A A Aljabali, Harish Dureja, Parteek Prasher, Poonam Negi, Deepak N Kapoor, Rohit Goyal, Murtaza M Tambuwala, Dinesh K Chellappan, Kamal Dua,

In patients with acute kidney injury progressively converting into chronic kidney disease (CKD), proteinuria and high blood pressure predict progression to end-stage renal disease (ESRD). Although, Renin-angiotensin-aldosterone system (RAAS) regulates blood pressure and kidney disease through both direct and indirect mechanisms. RAAS blockers that act at the level of angiotensin ... Read more >>

Chem. Biol. Interact. (Chemico-biological interactions)
[2020, 317:108975]

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Homologous G776G Variant of Transcobalamin-II Gene is Linked to Vitamin B12 Deficiency.

Khalid M Al-Batayneh, Mazhar Salim Al Zoubi, Bahaa Al-Trad, Emad Hussein, Wesam Al Khateeb, Alaa A A Aljabali, Khaldon Bodoor, Murad Shehab, Mohammad A Al Hamad, Greg J Eaton, Christopher T Cornelison,

Vitamin B12 (Cobalamin) deficiency, due to improper internalization of cobalamin, is a metabolic disorder prevalent in impoverished and elderly populations and is associated with megaloblastic anemia and dementia. It has been suggested that mutations in transcobalamin II (TCN2) or gastric intrinsic factor (GIF) proteins can alter their binding efficiency to ... Read more >>

Int J Vitam Nutr Res (International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition)
[2020, 90(1-2):151-155]

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Evaluation of Vitamin B12, Folate and Ferritin Serum Levels in Jordanian Population.

Mazhar Salim Al Zoubi, Khalid M Al-Batayneh, Bahaa Al-Trad, Yazan Haddad, Emad Hussein, Wesam Al Khateeb, Alaa A A Aljabali, Khaldon Bodoor, Murad Shehab, Mohammad Al Hamad, Riyadh Muhaidat,

Vitamin B12, folate, and ferritin are vital for the development of the nervous system, blood formation, and diverse metabolic functions. The aim of the current study is to evaluate the status of vitamin B12, folate and ferritin in the Jordanian population across distinct geographical locations. In this retrospective study, the ... Read more >>

J. Nutr. Sci. Vitaminol. (Journal of nutritional science and vitaminology)
[2019, 65(4):309-317]

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Association between MTHFR 677C>T Polymorphism and Vitamin B12 Deficiency: A Case-control Study.

Khalid M Al-Batayneh, Mazhar Salim Al Zoubi, Murad Shehab, Bahaa Al-Trad, Khaldon Bodoor, Wesam Al Khateeb, Alaa A A Aljabali, Mohammad Al Hamad, Greg Eaton,

Background:Vitamin B12 (cobalamin) deficiency is a prevalent worldwide health concern. Several factors are associated with vitamin B12 deficiency including lifestyle, genetic predisposition, and malfunctions in the absorption and transport of vitamin B12. In the current case-control study, we aimed at investigating the association between MTHFR polymorphisms and vitamin B12 deficiency ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2018, 37(2):141-147]

Cited: 2 times

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Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients.

Mazhar Salim Al Zoubi, Katia Zavaglia, Chiara Mazanti, Mohammad Al Hamad, Khalid Al Batayneh, Alaa A A Aljabali, Generoso Bevilacqua,

Genotoxic factors, including ionizing radiation and oxidative stress, are associated with genomic instability and development of breast cancer (BC). The homologous recombination DNA repair (HRR) pathway, base excision repair (BER) mechanism, and antioxidative enzymes are required as defense mechanisms against these DNA damaging agents. GSTP1, XRCC1, XRCC3 and RAD51 proteins ... Read more >>

Int. J. Biol. Markers (The International journal of biological markers)
[2017, 32(3):e337-e343]

Cited: 4 times

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Controlled immobilisation of active enzymes on the cowpea mosaic virus capsid.

Alaa A A Aljabali, J Elaine Barclay, Nicole F Steinmetz, George P Lomonossoff, David J Evans,

Immobilisation of horseradish peroxidase (HRP) and glucose oxidase (GOX) via covalent attachment of modified enzyme carbohydrate to the exterior of the cowpea mosaic virus (CPMV) capsid gave high retention of enzymatic activity. The number of enzymes bound per virus was determined to be about eleven for HRP and 2-3 for ... Read more >>

Nanoscale (Nanoscale)
[2012, 4(18):5640-5645]

Cited: 15 times

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Chemically-coupled-peptide-promoted virus nanoparticle templated mineralization.

Alaa A A Aljabali, Sachin N Shah, Richard Evans-Gowing, George P Lomonossoff, David J Evans,

The external surface of the plant virus Cowpea mosaic virus (CPMV) can be chemically modified with peptides that direct specific mineralization processes. Subsequent mineralization of the peptide-CPMV conjugates produces monodisperse nanoparticles of ca. 32 nm diameter coated with, for example, cobalt-platinum, iron-platinum or zinc sulfide, which cannot be readily prepared ... Read more >>

Integr Biol (Camb) (Integrative biology : quantitative biosciences from nano to macro)
[2011, 3(2):119-125]

Cited: 10 times

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Redox-active ferrocene-modified Cowpea mosaic virus nanoparticles.

Alaa A A Aljabali, J Elaine Barclay, Julea N Butt, George P Lomonossoff, David J Evans,

A naturally occurring nanoparticle, the plant virus Cowpea mosaic virus, can be decorated with ferrocene derivatives, of various linker lengths with amine and carboxylate groups, on the external surface using a range of conjugation strategies. The multiple, organometallic, redox-active ferrocene moieties on the outer surface of the virus are electrochemically ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2010, 39(32):7569-7574]

Cited: 12 times

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