Full Text Journal Articles by
Author Akseli Hemminki

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Second Primary Cancers After Gastric Cancer, and Gastric Cancer as Second Primary Cancer.

Guoqiao Zheng, Kristina Sundquist, Jan Sundquist, Tianhui Chen, Asta Försti, Akseli Hemminki, Kari Hemminki,

<h4>Background</h4>Second primary cancers (SPCs) are increasing, which may negatively influence patient survival. Gastric cancer (GC) has poor survival and when it is diagnosed as SPC it is often the cause of death. We wanted to analyze the risk of SPCs after GC and the risk of GC as SPC after ... Read more >>

Clin Epidemiol (Clinical epidemiology)
[2021, 13:515-525]

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Survival in colon and rectal cancers in Finland and Sweden through 50 years.

Kari Hemminki, Asta Försti, Akseli Hemminki,

<h4>Objectives</h4>Global survival studies have shown favourable development in colon and rectal cancers but few studies have considered extended periods or covered populations for which medical care is essentially free of charge.<h4>Design</h4>We analysed colon and rectal cancer survival in Finland and Sweden over a 50-year period (1967-2016) using data from the ... Read more >>

BMJ Open Gastroenterol (BMJ open gastroenterology)
[2021, 8(1):]

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Progress in survival in renal cell carcinoma through 50 years evaluated in Finland and Sweden.

Kari Hemminki, Asta Försti, Akseli Hemminki, Börje Ljungberg, Otto Hemminki,

Global survival studies have shown favorable development in renal cell carcinoma (RCC) treatment but few studies have considered extended periods or covered populations for which medical care is essentially free of charge. We analyzed RCC survival in Finland and Sweden over a 50-year period (1967-2016) using data from the NORDCAN ... Read more >>

PLoS One (PloS one)
[2021, 16(6):e0253236]

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Incidence trends in lung and bladder cancers in the Nordic Countries before and after the smoking epidemic.

Kari Hemminki, Asta Försti, Akseli Hemminki, Börje Ljungberg, Otto Hemminki,

Cigarette smoking epidemic, which started before the World War II, completely changed the cancer landscape. Reliable incidence data spanning the stepwise spreading epidemic are rare, but the Nordic cancer registries are unique sources in being able to catch the pre-epidemic situation in the female population where smoking became more prevalent ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, :]

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Incidence trends in bladder and lung cancers between Denmark, Finland and Sweden may implicate oral tobacco (snuff/snus) as a possible risk factor.

Kari Hemminki, Asta Försti, Akseli Hemminki, Börje Ljungberg, Otto Hemminki,

<h4>Background</h4>The dominant risk factor for urinary bladder cancer has been cigarette smoking, but, as smoking prevalence is decreasing in many populations, other risk factors may become uncovered. Such new risk factors could be responsible for halting the declining incidence of bladder cancer. We hypothesize that snuff use by Swedish men ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):604]

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Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control.

Dafne C A Quixabeira, Sadia Zafar, Joao M Santos, Victor Cervera-Carrascon, Riikka Havunen, Tatiana V Kudling, Saru Basnet, Marjukka Anttila, Anna Kanerva, Akseli Hemminki,

The notion of developing variants of the classic interleukin 2 (IL-2) cytokine has emerged from the limitations observed with the systemic use of human IL-2 in the clinic: severe adverse events accompanied by low therapeutic response rate in treated patients. Modifications made in the IL-2 receptor-binding structure leads to preferential ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:674400]

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Oncolytic Adenovirus ORCA-010 Activates Proinflammatory Myeloid Cells and Facilitates T Cell Recruitment and Activation by PD-1 Blockade in Melanoma.

Ioanna Milenova, Marta Lopez Gonzalez, Dafne C A Quixabeira, Joao Manuel Santos, Victor Cervera-Carrascon, Wenliang Dong, Akseli Hemminki, Victor W van Beusechem, Rieneke van de Ven, Tanja D de Gruijl,

Immune checkpoint inhibitors have advanced the treatment of melanoma. Nevertheless, a majority of patients are resistant, or develop resistance, to immune checkpoint blockade, which may be related to prevailing immune suppression by myeloid regulatory cells in the tumor microenvironment (TME). ORCA-010 is a novel oncolytic adenovirus that selectively replicates in, ... Read more >>

Hum Gene Ther (Human gene therapy)
[2021, 32(3-4):178-191]

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Oncolytic Adenovirus Type 3 Coding for CD40L Facilitates Dendritic Cell Therapy of Prostate Cancer in Humanized Mice and Patient Samples.

Sadia Zafar, Saru Basnet, Inga-Maria Launonen, Dafne Carolina Alves Quixabeira, Joao Santos, Otto Hemminki, Minna Malmstedt, Victor Cervera-Carrascon, Pasi Aronen, Riikka Kalliokoski, Riikka Havunen, Antti Rannikko, Tuomas Mirtti, Mika Matikainen, Anna Kanerva, Akseli Hemminki,

Dendritic cell (DC)-based vaccines have shown some degree of success for the treatment of prostate cancer (PC). However, the highly immunosuppressive tumor microenvironment leads to DC dysfunction, which has limited the effectiveness of these vaccines. We hypothesized that use of a fully serotype 3 oncolytic adenovirus (Ad3-hTERT-CMV-hCD40L; TILT-234) could stimulate ... Read more >>

Hum Gene Ther (Human gene therapy)
[2021, 32(3-4):192-202]

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Cancer Predisposition Genes in Cancer-Free Families.

Guoqiao Zheng, Calogerina Catalano, Obul Reddy Bandapalli, Nagarajan Paramasivam, Subhayan Chattopadhyay, Matthias Schlesner, Rolf Sijmons, Akseli Hemminki, Dagmara Dymerska, Jan Lubinski, Kari Hemminki, Asta Försti,

Familial clustering, twin concordance, and identification of high- and low-penetrance cancer predisposition variants support the idea that there are families that are at a high to moderate excess risk of cancer. To what extent there may be families that are protected from cancer is unknown. We wanted to test genetically ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(10):]

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Rate differences between first and second primary cancers may outline immune dysfunction as a key risk factor.

Guoqiao Zheng, Kristina Sundquist, Jan Sundquist, Asta Försti, Akseli Hemminki, Kari Hemminki,

<h4>Background</h4>Many cancers are increased in immunosuppressed patients and evidence is accumulating that immune dysfunction may be a contributing risk factor for second primary cancers (SPCs). The aim of this study was to explore the potential influence of immune mechanisms in SPC.<h4>Methods</h4>We used the Swedish Cancer Registry (1990-2015) to select 13 ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(21):8258-8265]

Cited: 1 time

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Incidence Differences Between First Primary Cancers and Second Primary Cancers Following Skin Squamous Cell Carcinoma as Etiological Clues.

Guoqiao Zheng, Kristina Sundquist, Jan Sundquist, Asta Försti, Akseli Hemminki, Kari Hemminki,

<h4>Background</h4>Most literature on second primary cancers (SPCs) focuses on possible factors, which may increase the risk of these cancers, and little attention has been paid for the overall incidence differences between first primary cancers (FPCs) and same SPCs. We wanted to compare the incidence rates for all common cancers when ... Read more >>

Clin Epidemiol (Clinical epidemiology)
[2020, 12:857-864]

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Informing patients about their mutation tests: CDKN2A c.256G>A in melanoma as an example.

Kari Hemminki, Aayushi Srivastava, Sivaramakrishna Rachakonda, Obul Bandapalli, Eduardo Nagore, Akseli Hemminki, Rajiv Kumar,

<h4>Background</h4>When germline mutations are suspected as causal in cancer, patient DNA may be sequenced to detect variants in relevant genes. If a particular mutation has not been reported in reliable family studies, genetic counselors are facing a dilemma of appropriately informing patients. Many sequencing facilities provide an interpretation of the ... Read more >>

Hered Cancer Clin Pract (Hereditary cancer in clinical practice)
[2020, 18:15]

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TNFa and IL2 Encoding Oncolytic Adenovirus Activates Pathogen and Danger-Associated Immunological Signaling.

Camilla Heiniö, Riikka Havunen, Joao Santos, Klaas de Lint, Victor Cervera-Carrascon, Anna Kanerva, Akseli Hemminki,

In order to break tumor resistance towards traditional treatments, we investigate the response of tumor and immune cells to a novel, cytokine-armed oncolytic adenovirus: Ad5/3-d24-E2F-hTNFa-IRES-hIL2 (also known as TILT-123 and OAd.TNFa-IL2). There are several pattern recognition receptors (PRR) that might mediate adenovirus-infection recognition. However, the role and specific effects of ... Read more >>

Cells (Cells)
[2020, 9(4):]

Cited: 8 times

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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.

Lorenzo Galluzzi, Ilio Vitale, Sarah Warren, Sandy Adjemian, Patrizia Agostinis, Aitziber Buqué Martinez, Timothy A Chan, George Coukos, Sandra Demaria, Eric Deutsch, Dobrin Draganov, Richard L Edelson, Silvia C Formenti, Jitka Fucikova, Lucia Gabriele, Udo S Gaipl, Sofia R Gameiro, Abhishek D Garg, Encouse Golden, Jian Han, Kevin J Harrington, Akseli Hemminki, James W Hodge, Dewan Md Sakib Hossain, Tim Illidge, Michael Karin, Howard L Kaufman, Oliver Kepp, Guido Kroemer, Juan Jose Lasarte, Sherene Loi, Michael T Lotze, Gwenola Manic, Taha Merghoub, Alan A Melcher, Karen L Mossman, Felipe Prosper, Øystein Rekdal, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Mark J Smyth, Radek Spisek, John Stagg, Bryan E Strauss, Daolin Tang, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele, Takahiro Yamazaki, Dmitriy Zamarin, Laurence Zitvogel, Alessandra Cesano, Francesco M Marincola,

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(1):]

Cited: 84 times

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Second Primary Cancers in Melanoma Patients Critically Shorten Survival.

Guoqiao Zheng, Subhayan Chattopadhyay, Kristina Sundquist, Jan Sundquist, Asta Försti, Akseli Hemminki, Kari Hemminki,

Background:Survival in malignant cutaneous melanoma has improved but increasing survival will result in an increased likelihood of the occurrence of second primary cancers (SPCs). SPCs may adversely interfere with survival. We quantified survival in patients with different types of SPCs, in comparison to known poor prognostic indicators of metastatic disease. ... Read more >>

Clin Epidemiol (Clinical epidemiology)
[2020, 12:105-112]

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Association between tumor characteristics and second primary cancers with cutaneous melanoma survival: A nationwide cohort study.

Guoqiao Zheng, Subhayan Chattopadhyay, Kristina Sundquist, Jan Sundquist, Asta Försti, Akseli Hemminki, Kari Hemminki,

The increased survival in malignant cutaneous melanoma (melanoma) is probably due to early diagnosis combined with improved treatment most recently. National health campaigns and screening programs for melanoma detection were started in Sweden several decades ago. We want to assess the influence of tumor characteristics, based on the TNM classification, ... Read more >>

Pigment Cell Melanoma Res (Pigment cell & melanoma research)
[2020, 33(4):625-632]

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Randomised Trial of Adjuvant Radiotherapy Following Radical Prostatectomy Versus Radical Prostatectomy Alone in Prostate Cancer Patients with Positive Margins or Extracapsular Extension.

Greetta Hackman, Kimmo Taari, Teuvo L Tammela, Mika Matikainen, Mauri Kouri, Timo Joensuu, Tiina Luukkaala, Arto Salonen, Taina Isotalo, Anssi Pétas, Niilo Hendolin, Peter J Boström, Sirpa Aaltomaa, Kari Lehtoranta, Pekka Hellström, Jarno Riikonen, Merja Korpela, Heikki Minn, Pirkko-Liisa Kellokumpu-Lehtinen, Eero Pukkala, Akseli Hemminki, ,

<h4>Background</h4>It remains unclear whether patients with positive surgical margins or extracapsular extension benefit from adjuvant radiotherapy following radical prostatectomy.<h4>Objective</h4>To compare the effectiveness and tolerability of adjuvant radiotherapy following radical prostatectomy.<h4>Design, setting, and participants</h4>This was a randomised, open-label, parallel-group trial. A total of 250 patients were enrolled between April 2004 and ... Read more >>

Eur Urol (European urology)
[2019, 76(5):586-595]

Cited: 5 times

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Second Primary Cancers in Patients with Invasive and In Situ Squamous Cell Skin Carcinoma, Kaposi Sarcoma, and Merkel Cell Carcinoma: Role for Immune Mechanisms?

Subhayan Chattopadhyay, Akseli Hemminki, Asta Försti, Kristina Sundquist, Jan Sundquist, Kari Hemminki,

Second primary cancers (SPCs) are becoming a common cancer entity, which may interfere with survival in relatively benign first primary cancers. We examined the hypothesis that immune dysfunction may contribute to SPCs by assessing SPCs associated with known immune responsive skin cancers, invasive and in situ squamous cell carcinoma, Kaposi ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2020, 140(1):48-55.e1]

Cited: 3 times

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Modulation of the tumor microenvironment with an oncolytic adenovirus for effective T-cell therapy and checkpoint inhibition.

João Manuel Santos, Riikka Havunen, Akseli Hemminki,

Despite exciting proof-of-concept data mediated by adoptive T-cell transfer and checkpoint blockade, major challenges imposed by the tumor microenvironment restrict clinical benefits to a minority of patients with advanced or metastatic solid malignancies. While employment of toxic pre- and postconditioning regimens to circumvent the inefficacy of T-cell transfer presents a ... Read more >>

Methods Enzymol (Methods in enzymology)
[2020, 635:205-230]

Cited: 4 times

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Second primary cancers in non-Hodgkin lymphoma: Family history and survival.

Subhayan Chattopadhyay, Guoqiao Zheng, Amit Sud, Kristina Sundquist, Jan Sundquist, Asta Försti, Richard Houlston, Akseli Hemminki, Kari Hemminki,

Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses and family history of cancer may be a risk factor for SPCs. Using the Swedish Family-Cancer Database on non-Hodgkin lymphoma (NHL), we assessed the influence of family history on risk of SPCs and of SPCs on survival. ... Read more >>

Int J Cancer (International journal of cancer)
[2020, 146(4):970-976]

Cited: 3 times

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Oncolytic adenoviruses: a game changer approach in the battle between cancer and the immune system.

Victor Cervera-Carrascon, Riikka Havunen, Akseli Hemminki,

<h4>Introduction</h4>Oncolytic adenoviruses are among the most studied oncolytic viruses because of their tumor selectivity, safety, and transgene-delivery capability. With a growing number of different immunotherapies against cancer, the extraordinary immunogenicity of the adenovirus has emerged as a differentiating strength. Enabling T-cell related therapies with oncolytic adenoviruses appears a promising approach ... Read more >>

Expert Opin Biol Ther (Expert opinion on biological therapy)
[2019, 19(5):443-455]

Cited: 7 times

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Types of second primary cancers influence survival in chronic lymphocytic and hairy cell leukemia patients.

Guoqiao Zheng, Subhayan Chattopadhyay, Amit Sud, Kristina Sundquist, Jan Sundquist, Asta Försti, Richard S Houlston, Akseli Hemminki, Kari Hemminki,

Blood Cancer J (Blood cancer journal)
[2019, 9(4):40]

Cited: 1 time

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Effect of Genetic Modifications on Physical and Functional Titers of Adenoviral Cancer Gene Therapy Constructs.

Camilla Heiniö, Suvi Sorsa, Mikko Siurala, Susanna Grönberg-Vähä-Koskela, Riikka Havunen, Elina Haavisto, Anniina Koski, Otto Hemminki, Sadia Zafar, Víctor Cervera-Carrascon, Eleonora Munaro, Anna Kanerva, Akseli Hemminki,

After the discovery and characterization of the adenovirus in the 1950s, this prevalent cause of the common cold and other usually mild diseases has been modified and utilized in biomedicine in several ways. To date, adenoviruses are the most frequently used vectors and therapeutic (<i>e.g.</i>, oncolytic) agents with a number ... Read more >>

Hum Gene Ther (Human gene therapy)
[2019, 30(6):740-752]

Cited: 1 time

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Familial Associations of Colon and Rectal Cancers With Other Cancers.

Hongyao Yu, Akseli Hemminki, Kristina Sundquist, Kari Hemminki,

<h4>Background</h4>Many studies have indicated that colon and rectal cancers differ in etiology and histology.<h4>Objective</h4>The aim of this study was to investigate whether the associations of colon and rectal cancers with any other (discordant) cancer were site specific.<h4>Design</h4>A novel approach was implemented in which cancer risks were analyzed in families with ... Read more >>

Dis Colon Rectum (Diseases of the colon and rectum)
[2019, 62(2):189-195]

Cited: 2 times

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Second primary cancers in patients with acute lymphoblastic, chronic lymphocytic and hairy cell leukaemia.

Guoqiao Zheng, Subhayan Chattopadhyay, Amit Sud, Kristina Sundquist, Jan Sundquist, Asta Försti, Richard Houlston, Akseli Hemminki, Kari Hemminki,

Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy ... Read more >>

Br J Haematol (British journal of haematology)
[2019, 185(2):232-239]

Cited: 6 times

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