Full Text Journal Articles by
Author Akram Zamani

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Diffusion Imaging Reveals Sex Differences in the White Matter Following Sports-Related Concussion.

David K Wright, Georgia F Symons, William T O'Brien, Stuart J McDonald, Akram Zamani, Brendan Major, Zhibin Chen, Daniel Costello, Rhys D Brady, Mujun Sun, Meng Law, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz,

Sports-related concussion (SRC) is a serious health concern. However, the temporal profile of neuropathophysiological changes after SRC and how these relate to biological sex are still poorly understood. This preliminary study investigated whether diffusion-weighted magnetic resonance imaging (dMRI) was sensitive to neuropathophysiological changes following SRC; whether these changes were sex-specific; ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, 31(10):4411-4419]

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Corrigendum to "Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury" [Experimental Neurology 339 (2021): 113652].

Jessica L Fletcher, Larissa K Dill, Rhiannon J Wood, Sharon Wang, Kate Robertson, Simon S Murray, Akram Zamani, Bridgette D Semple,

Exp Neurol (Experimental neurology)
[2021, 343:113790]

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A systemic immune challenge to model hospital-acquired infections independently regulates immune responses after pediatric traumatic brain injury.

Rishabh Sharma, Akram Zamani, Larissa K Dill, Mujun Sun, Erskine Chu, Marcus J Robinson, Terence J O'Brien, Sandy R Shultz, Bridgette D Semple,

<h4>Background</h4>Traumatic brain injury (TBI) is a major cause of disability in young children, yet the factors contributing to poor outcomes in this population are not well understood. TBI patients are highly susceptible to nosocomial infections, which are mostly acquired within the first week of hospitalization, and such infections may modify ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2021, 18(1):72]

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The promiscuous potential of cellulase in degradation of polylactic acid and its jute composite.

Mina Karimi-Avargani, Faranak Bazooyar, Davoud Biria, Akram Zamani, Mikael Skrifvars,

It has been suggested that cellulolytic enzymes can be effective on the degradation of PLA samples. The idea was investigated by examining the impact of cellulase on degradation of PLA and PLA-jute (64/36) composite in an aqueous medium. The obtained results demonstrated 55% and 61% thickness reduction in PLA and ... Read more >>

Chemosphere (Chemosphere)
[2021, 278:130443]

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Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury.

Jessica L Fletcher, Larissa K Dill, Rhiannon J Wood, Sharon Wang, Kate Robertson, Simon S Murray, Akram Zamani, Bridgette D Semple,

Young children have a high risk of sustaining a traumatic brain injury (TBI), which can have debilitating life-long consequences. Importantly, the young brain shows particular vulnerability to injury, likely attributed to ongoing maturation of the myelinating nervous system at the time of insult. Here, we examined the effect of acute ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 339:113652]

Cited: 2 times

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White matter changes following experimental pediatric traumatic brain injury: an advanced diffusion-weighted imaging investigation.

Akram Zamani, Terence J O'Brien, Jeff Kershaw, Leigh A Johnston, Bridgette D Semple, David K Wright,

Pediatric traumatic brain injury (pTBI) is a major community health concern. Due to ongoing maturation, injury to the brain at a young age can have devastating consequences in later life. However, how pTBI affects brain development, including white matter maturation, is still poorly understood. Here, we used advanced diffusion weighted ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2021, :]

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Synthesis of Lactic Acid-Based Thermosetting Resins and Their Ageing and Biodegradability.

Lara Lopes Gomes Hastenreiter, Sunil Kumar Ramamoorthy, Rajiv K Srivastava, Anilkumar Yadav, Akram Zamani, Dan Åkesson,

The present work is focused on the synthesis of bio-based thermoset polymers and their thermo-oxidative ageing and biodegradability. Toward this aim, bio-based thermoset resins with different chemical architectures were synthesized from lactic acid by direct condensation with ethylene glycol, glycerol and pentaerythritol. The resulting branched molecules with chain lengths (n) ... Read more >>

Polymers (Basel) (Polymers)
[2020, 12(12):]

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Extraction and characterization of fungal chitin nanofibers from Mucor indicus cultured in optimized medium conditions.

Fatemeh Salehinik, Tayebeh Behzad, Akram Zamani, Bahador Bahrami,

Chitin nanofibers (ChNFs) were extracted from Mucor indicus by a purification method followed by a mechanical treatment, cultivated under obtained optimum culture medium conditions to improve fungal chitin production rate. A semi synthetic media containing 50 g/l glucose was used for cultivation of the fungus in shake flasks. The cell wall ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 167:1126-1134]

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Characterization of a novel model of global forebrain ischaemia-reperfusion injury in mice and comparison with focal ischaemic and haemorrhagic stroke.

Natasha Ting Lee, Carly Selan, Joanne S J Chia, Sharelle A Sturgeon, David K Wright, Akram Zamani, Melrine Pereira, Harshal H Nandurkar, Maithili Sashindranath,

Stroke is caused by obstructed blood flow (ischaemia) or unrestricted bleeding in the brain (haemorrhage). Global brain ischaemia occurs after restricted cerebral blood flow e.g. during cardiac arrest. Following ischaemic injury, restoration of blood flow causes ischaemia-reperfusion (I/R) injury which worsens outcome. Secondary injury mechanisms after any stroke are similar, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):18170]

Cited: 1 time

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Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury

Jessica Fletcher, Larissa Dill, Rhiannon Wood, Sharon Wang, Kate Robertson, Simon Murray, Akram Zamani, Bridgette Semple,

<h4>ABSTRACT</h4> Young children have a high risk of sustaining a traumatic brain injury (TBI), which can have debilitating life-long consequences. Importantly, the young brain shows particular vulnerability to injury, likely attributed to ongoing maturation of the myelinating nervous system at the time of insult. Here, we examined the effect of ... Read more >>

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The Impact of Traumatic Injury to the Immature Human Brain: A Scoping Review with Insights from Advanced Structural Neuroimaging.

Akram Zamani, Nicholas P Ryan, David K Wright, Karen Caeyenberghs, Bridgette D Semple,

Traumatic brain injury (TBI) during critical periods of early-life brain development can affect the normal formation of brain networks responsible for a range of complex social behaviors. Because of the protracted nature of brain and behavioral development, deficits in cognitive and socioaffective behaviors may not become evident until late adolescence ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, 37(5):724-738]

Cited: 4 times

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Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model.

Akram Zamani, Kim L Powell, Ashleigh May, Bridgette D Semple,

Quantitative polymerase chain reaction (qPCR) is the gold standard method in targeted analysis of messenger RNA (mRNA) levels in a tissue. To minimize methodological errors, a reference gene (or a combination of reference genes) is routinely used for normalization to account for technical variables such as RNA quality and sample ... Read more >>

Brain Res Bull (Brain research bulletin)
[2020, 156:43-49]

Cited: 3 times

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Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets.

Rishabh Sharma, Wai Lam Leung, Akram Zamani, Terence J O'Brien, Pablo M Casillas Espinosa, Bridgette D Semple,

Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to increased morbidity and mortality for survivors. As post-traumatic epilepsy (PTE) is drug-resistant in at least one-third of patients, there is a clear need for novel therapeutic strategies to prevent epilepsy from developing after TBI, or to mitigate ... Read more >>

Brain Sci (Brain sciences)
[2019, 9(11):]

Cited: 7 times

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Determinants of social behavior deficits and recovery after pediatric traumatic brain injury.

Akram Zamani, Richelle Mychasiuk, Bridgette D Semple,

Traumatic brain injury (TBI) during early childhood is associated with a particularly high risk of developing social behavior impairments, including deficits in social cognition that manifest as reduced social interactions, with profound consequences for the individuals' quality of life. A number of pre-injury, post-injury, and injury-related factors have been identified ... Read more >>

Exp Neurol (Experimental neurology)
[2019, 314:34-45]

Cited: 2 times

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Clinical Relevance of Behavior Testing in Animal Models of Traumatic Brain Injury.

Sandy R Shultz, Stuart J McDonald, Frances Corrigan, Bridgette D Semple, Sabrina Salberg, Akram Zamani, Nigel C Jones, Richelle Mychasiuk,

Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, with patients often suffering from consequences such as cognitive deficits, social abnormalities, anxiety, depression, pain, and motor dysfunction. Given that these impairments often have a significant impact on the patient's quality of life, a key aim of therapeutic intervention ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, 37(22):2381-2400]

Cited: 0 times

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Anaerobic degradation of bioplastics: A review.

Veronika Bátori, Dan Åkesson, Akram Zamani, Mohammad J Taherzadeh, Ilona Sárvári Horváth,

Anaerobic digestion (AD) of the organic fraction of municipal solid waste (OFMSW), leading to renewable energy production in the form of methane, is a preferable method for dealing with the increasing amount of waste. Food waste is separated at the source in many countries for anaerobic digestion. However, the presence ... Read more >>

Waste Manag (Waste management (New York, N.Y.))
[2018, 80:406-413]

Cited: 7 times

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Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy.

Bridgette D Semple, Akram Zamani, Genevieve Rayner, Sandy R Shultz, Nigel C Jones,

Survivors of traumatic brain injury (TBI) often develop chronic neurological, neurocognitive, psychological, and psychosocial deficits that can have a profound impact on an individual's wellbeing and quality of life. TBI is also a common cause of acquired epilepsy, which is itself associated with significant behavioral morbidity. This review considers the ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2019, 123:27-41]

Cited: 13 times

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Tropomyosin-Related Kinase B (TrkB) Regulates Neurite Outgrowth via a Novel Interaction with Suppressor of Cytokine Signalling 2 (SOCS2).

Akram Zamani, Junhua Xiao, Ann M Turnley, Simon S Murray,

Brain-derived neurotrophic factor (BDNF) is highly expressed in the hippocampus, where it can initiate signalling pathways leading to neurite outgrowth, neuron survival, spine maturation and increased synapse strength. Although suppressor of cytokine signalling 2 (SOCS2) is primarily known to negatively regulate cytokine signalling, it is also highly expressed in the ... Read more >>

Mol Neurobiol (Molecular neurobiology)
[2019, 56(2):1262-1275]

Cited: 2 times

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Preparation of Nanocellulose Reinforced Chitosan Films, Cross-Linked by Adipic Acid.

Pouria Falamarzpour, Tayebeh Behzad, Akram Zamani,

Adipic acid, an abundant and nontoxic compound, was used to dissolve and cross-link chitosan. After the preparation of chitosan films through casting technique, the in situ amidation reaction was performed at 80-100 °C as verified by Fourier transform infrared (FT-IR). The reaction was accompanied by the release of water which ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(2):]

Cited: 5 times

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Impact of Phosphate, Potassium, Yeast Extract, and Trace Metals on Chitosan and Metabolite Production by Mucor indicus.

Zahra Safaei, Keikhosro Karimi, Akram Zamani,

In this study the effects of phosphate, potassium, yeast extract, and trace metals on the growth of Mucor indicus and chitosan, chitin, and metabolite production by the fungus were investigated. Maximum yield of chitosan (0.32 g/g cell wall) was obtained in a phosphate-free medium. Reversely, cell growth and ethanol formation ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2016, 17(9):]

Cited: 3 times

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Co-Production of Fungal Biomass Derived Constituents and Ethanol from Citrus Wastes Free Sugars without Auxiliary Nutrients in Airlift Bioreactor.

Behzad Satari, Keikhosro Karimi, Mohammad J Taherzadeh, Akram Zamani,

The potential of two zygomycetes fungi, Mucor indicus and Rhizopus oryzae, in assimilating citrus waste free sugars (CWFS) and producing fungal chitosan, oil, and protein as well as ethanol was investigated. Extraction of free sugars from citrus waste can reduce its environmental impact by decreasing the possibility of wild microorganisms ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2016, 17(3):302]

Cited: 8 times

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Optimizing growth and post treatment of diamond for high capacitance neural interfaces.

Wei Tong, Kate Fox, Akram Zamani, Ann M Turnley, Kumaravelu Ganesan, Arman Ahnood, Rosemary Cicione, Hamish Meffin, Steven Prawer, Alastair Stacey, David J Garrett,

Electrochemical and biological properties are two crucial criteria in the selection of the materials to be used as electrodes for neural interfaces. For neural stimulation, materials are required to exhibit high capacitance and to form intimate contact with neurons for eliciting effective neural responses at acceptably low voltages. Here we ... Read more >>

Biomaterials (Biomaterials)
[2016, 104:32-42]

Cited: 4 times

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Effects of Plant Growth Hormones on Mucor indicus Growth and Chitosan and Ethanol Production.

Zahra Safaei, Keikhosro Karimi, Poorandokht Golkar, Akram Zamani,

The objective of this study was to investigate the effects of indole-3-acetic acid (IAA) and kinetin (KIN) on Mucor indicus growth, cell wall composition, and ethanol production. A semi-synthetic medium, supplemented with 0-5 mg/L hormones, was used for the cultivations (at 32 °C for 48 h). By addition of 1 ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2015, 16(7):16683-16694]

Cited: 5 times

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VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes.

Stephanie L Taylor, Dustin Trudeau, Brendan Arnold, Joshua Wang, Kim Gerrow, Kieran Summerfeldt, Andrew Holmes, Akram Zamani, Patricia S Brocardo, Craig E Brown,

Clinical and experimental studies have shown a clear link between diabetes, vascular dysfunction and cognitive impairment. However, the molecular underpinnings of this association remain unclear. Since vascular endothelial growth factor (VEGF) signaling is important for maintaining vascular integrity and function, we hypothesized that vascular and cognitive impairment in the diabetic ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2015, 78:1-11]

Cited: 14 times

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Characterization of Nizimuddinia zanardini macroalgae biomass composition and its potential for biofuel production.

Parviz Yazdani, Akram Zamani, Keikhosro Karimi, Mohammad J Taherzadeh,

Nizimuddinia zanardini macroalgae, harvested from Persian Gulf, was chemically characterized and employed for the production of ethanol, seaweed extract, alginic acid, and biogas. In order to improve the products yields, the biomass was pretreated with dilute sulfuric acid and hot water. The pretreated and untreated biomasses were subjected to enzymatic ... Read more >>

Bioresour Technol (Bioresource technology)
[2015, 176:196-202]

Cited: 3 times

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