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Author Akira Yokoyama

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Impacts of interactions between ADH1B and ALDH2 genotypes on alcohol flushing, alcohol reeking on the day after drinking, and age distribution in Japanese alcohol-dependent men.

Akira Yokoyama, Tetsuji Yokoyama, Toshifumi Matsui, Takeshi Mizukami, Mitsuru Kimura, Sachio Matsushita, Susumu Higuchi, Katsuya Maruyama,

OBJECTIVE:This study sought to evaluate the impacts of interactions between the alcohol dehydrogenase-1B (rs1229984) genotype and the aldehyde dehydrogenase-2 (rs671) genotype on alcohol flushing, alcohol reeking on the day after drinking, and the age distribution in alcohol-dependent patients. METHODS:The study subjects were 4107 Japanese alcohol-dependent men who underwent alcohol dehydrogenase-1B ... Read more >>

Pharmacogenet. Genomics (Pharmacogenetics and genomics)
[2020, 30(3):54-60]

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Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions.

Chikatoshi Katada, Tetsuji Yokoyama, Tomonori Yano, Ichiro Oda, Yuichi Shimizu, Kenichi Takemura, Tomoyuki Koike, Kohei Takizawa, Motohiro Hirao, Hiroyuki Okada, Norisuke Nakayama, Yutaro Kubota, Yasumasa Matsuo, Hirofumi Kawakubo, Hideki Ishikawa, Akira Yokoyama, Manabu Muto,

This study was designed to evaluate the relation between dysplastic squamous epithelium in the esophageal mucosa and the development of metachronous secondary primary malignancies (mSPM) other than esophagus after endoscopic resection (ER) in patients with early esophageal squamous cell carcinoma (SCC). We studied 330 patients with early esophageal SCC who ... Read more >>

Dis. Esophagus (Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus)
[2020, :]

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The Alcohol Use Disorders Identification Test and the risk of metachronous cancer after endoscopic resection of esophageal cancer.

Akira Yokoyama, Chikatoshi Katada, Tetsuji Yokoyama, Kohei Takizawa, Tomonori Yano, Ichiro Oda, Yuichi Shimizu, Hiroyoshi Nakanishi, Tomoyuki Koike, Motohiro Hirao, Hiroyuki Okada, Takako Yoshii, Atsushi Katagiri, Takenori Yamanouchi, Yasumasa Matsuo, Hirofumi Kawakubo, Nozomu Kobayashi, Hideki Ishikawa, Manabu Muto,

Follow-up studies of Japanese patients who had undergone endoscopic resection (ER) for early esophageal squamous cell carcinoma (ESCC) have reported a high prevalence of metachronous SCC in the upper aerodigestive tract (UAT). This prospective multicenter cohort study followed up 330 Japanese patients after ER of ESCC for a median of ... Read more >>

Carcinogenesis (Carcinogenesis)
[2020, :]

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Qualitative and Quantitative Analysis of Posttreatment Strategy After Endoscopic Resection for Patients with T1 Colorectal Cancer at High Risk of Lymph Node Metastasis.

Yoshitaka Nishikawa, Takahiro Horimatsu, Daisuke Nishizaki, Ayako Kohno, Akira Yokoyama, Masahiro Yoshioka, Koya Hida, Katsuyuki Sakanaka, Sachiko Minamiguchi, Hiroshi Seno, Yoshiharu Sakai, Takeo Nakayama,

BACKGROUND:Although endoscopic resection is increasingly performed to treat submucosal invasive colorectal cancer (T1CRC), approximately 10% are at risk of lymph node metastasis. The Japanese Society for Cancer of the Colon and Rectum guideline indicates that the following risk factors should be considered when deciding whether to perform additional surgical resection ... Read more >>

J Gastrointest Cancer (Journal of gastrointestinal cancer)
[2020, 51(1):242-249]

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Changing trends in cancer incidence of upper aerodigestive tract and stomach in Japanese alcohol-dependent men (1993-2018).

Akira Yokoyama, Tai Omori, Tetsuji Yokoyama,

BACKGROUND:Esophageal squamous cell carcinoma (ESCC), head and neck SCC (HNSCC), and gastric adenocarcinoma (GA) are frequently detected at an early stage using endoscopic screening in Japanese alcohol-dependent men. METHODS:We performed endoscopic screening with esophageal iodine staining and oropharyngolaryngeal inspection in 7582 Japanese alcohol-dependent men (40-79 years) during 1993-2018, and retrospectively investigated ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(2):837-846]

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Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.

Nobuyuki Kakiuchi, Kenichi Yoshida, Motoi Uchino, Takako Kihara, Kotaro Akaki, Yoshikage Inoue, Kenji Kawada, Satoshi Nagayama, Akira Yokoyama, Shuji Yamamoto, Minoru Matsuura, Takahiro Horimatsu, Tomonori Hirano, Norihiro Goto, Yasuhide Takeuchi, Yotaro Ochi, Yusuke Shiozawa, Yasunori Kogure, Yosaku Watatani, Yoichi Fujii, Soo Ki Kim, Ayana Kon, Keisuke Kataoka, Tetsuichi Yoshizato, Masahiro M Nakagawa, Akinori Yoda, Yasuhito Nanya, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Eiji Sugihara, Taka-Aki Sato, Takashi Maruyama, Hiroyuki Miyoshi, Makoto Mark Taketo, Jun Oishi, Ryosaku Inagaki, Yutaka Ueda, Shinya Okamoto, Hideaki Okajima, Yoshiharu Sakai, Takaki Sakurai, Hironori Haga, Seiichi Hirota, Hiroki Ikeuchi, Hiroshi Nakase, Hiroyuki Marusawa, Tsutomu Chiba, Osamu Takeuchi, Satoru Miyano, Hiroshi Seno, Seishi Ogawa,

Chronic inflammation is accompanied by recurring cycles of tissue destruction and repair and is associated with an increased risk of cancer1-3. However, how such cycles affect the clonal composition of tissues, particularly in terms of cancer development, remains unknown. Here we show that in patients with ulcerative colitis, the inflamed ... Read more >>

Nature (Nature)
[2020, 577(7789):260-265]

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Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese men with alcohol dependence.

Akira Yokoyama, Nobuhito Taniki, Nobuhiro Nakamoto, Kengo Tomita, Sachiko Hara, Takeshi Mizukami, Katsuya Maruyama, Tetsuji Yokoyama,

AIM:To elucidate associations among liver disease, lipid profile, body mass index (BMI), ketonuria, and meal skipping under the influence of alcohol dehydrogenase-1B (ADH1B; rs1229984) and aldehyde dehydrogenase-2 (ALDH2; rs671) genotypes in men with alcohol dependence. METHODS:We investigated the associations among these variables in 1768 Japanese men with alcohol dependence. Serum ... Read more >>

Hepatol. Res. (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(5):565-577]

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Aldehyde dehydrogenase-2 as a therapeutic target.

Mitsuru Kimura, Akira Yokoyama, Susumu Higuchi,

Introduction: Aldehyde dehydrogenase-2 (ALDH2) is a main contributor of the alcohol elimination process. Functional polymorphism in the ALDH2 gene and its inactive form causes unpleasant flushing responses after alcohol consumption and prevents excessive alcohol intake. ALDH2 plays a key role in removing endogenous aldehydes like 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA) ... Read more >>

Expert Opin. Ther. Targets (Expert opinion on therapeutic targets)
[2019, 23(11):955-966]

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Telomere shortening in the oral epithelium in relation to alcohol intake, alcohol dehydrogenase (ADH-1B), and acetaldehyde dehydrogenase (ALDH-2) genotypes and clinicopathologic features.

Junko Aida, Akira Yokoyama, Sachiko Hara, Tatsuro Ishizaki, Mutsunori Fujiwara, Tomio Arai, Toshiyuki Ishiwata, Kaiyo Takubo,

BACKGROUND:Progressive telomere shortening with age or chronic inflammation may lead to genomic instability that characterizes the early stage of carcinogenesis. Certain risk factors, such as drinking alcoholic beverages or smoking, predispose the oral mucosa to squamous cell carcinoma. The ADH1B and ALDH2 genotypes can influence the risk of cancer due ... Read more >>

J. Oral Pathol. Med. (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology)
[2020, 49(1):82-90]

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Association between macrocytosis and metachronous squamous cell carcinoma of the esophagus after endoscopic resection in men with early esophageal squamous cell carcinoma.

Chikatoshi Katada, Tetsuji Yokoyama, Tomonori Yano, Ichiro Oda, Yuichi Shimizu, Hisashi Doyama, Tomoyuki Koike, Kohei Takizawa, Motohiro Hirao, Hiroyuki Okada, Takako Yoshii, Yutaro Kubota, Takenori Yamanouchi, Takashi Tsuda, Tai Omori, Nozomu Kobayashi, Haruhisa Suzuki, Satoshi Tanabe, Keisuke Hori, Norisuke Nakayama, Hirofumi Kawakubo, Naomi Kakushima, Yasumasa Matsuo, Hideki Ishikawa, Akira Yokoyama, Manabu Muto,

BACKGROUND:Macrocytosis is associated with an increased risk of squamous cell carcinoma (SCC) arising in the esophagus in men. The aim of this study was to evaluate the association between macrocytosis and metachronous SCC of the esophagus after endoscopic resection (ER) of early esophageal SCC in men. METHODS:The study group comprised ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2020, 17(2):149-158]

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Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.

Soo Ki Kim, Haruhiko Takeda, Atsushi Takai, Tomonori Matsumoto, Nobuyuki Kakiuchi, Akira Yokoyama, Kenichi Yoshida, Toshimi Kaido, Shinji Uemoto, Sachiko Minamiguchi, Hironori Haga, Yuichi Shiraishi, Satoru Miyano, Hiroshi Seno, Seishi Ogawa, Hiroyuki Marusawa,

BACKGROUND:Hepatocellular carcinoma (HCC) recurrently develops in cirrhotic liver containing a number of regenerative nodules (RNs). However, the biological tumorigenic potential of RNs is still unclear. To uncover the molecular bases of tumorigenesis in liver cirrhosis, we investigated the genetic aberrations in RNs of cirrhotic tissues using next-generation sequencing. METHODS:We isolated ... Read more >>

J. Gastroenterol. (Journal of gastroenterology)
[2019, 54(7):628-640]

Cited: 1 time

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Endoscopic screening using esophageal iodine staining and genotypes of ADH1B and ALDH2 in Japanese alcohol-dependent women.

Akira Yokoyama, Tetsuji Yokoyama, Tai Omori, Hitoshi Maesato, Tsuyoshi Takimura, Chie Iwahara, Mitsuru Kimura, Toshifumi Matsui, Takeshi Mizukami, Katsuya Maruyama,

BACKGROUND:The presence of large or multiple esophageal distinct iodine-unstained lesions (DIULs) is a strong predictor of field cancerization in the upper aerodigestive tract. Several risk factors for DIULs, including genetic polymorphisms of alcohol and aldehyde dehydrogenases (ADH1B, rs1229984; ALDH2, rs671), have been demonstrated in Japanese alcohol-dependent men. However, few evaluations ... Read more >>

PLoS ONE (PloS one)
[2019, 14(1):e0210546]

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Age-related remodelling of oesophageal epithelia by mutated cancer drivers.

Akira Yokoyama, Nobuyuki Kakiuchi, Tetsuichi Yoshizato, Yasuhito Nannya, Hiromichi Suzuki, Yasuhide Takeuchi, Yusuke Shiozawa, Yusuke Sato, Kosuke Aoki, Soo Ki Kim, Yoichi Fujii, Kenichi Yoshida, Keisuke Kataoka, Masahiro M Nakagawa, Yoshikage Inoue, Tomonori Hirano, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Yoshitaka Nishikawa, Yusuke Amanuma, Shinya Ohashi, Ikuo Aoyama, Takahiro Horimatsu, Shin'ichi Miyamoto, Shigeru Tsunoda, Yoshiharu Sakai, Maiko Narahara, J B Brown, Yoshitaka Sato, Genta Sawada, Koshi Mimori, Sachiko Minamiguchi, Hironori Haga, Hiroshi Seno, Satoru Miyano, Hideki Makishima, Manabu Muto, Seishi Ogawa,

Clonal expansion in aged normal tissues has been implicated in the development of cancer. However, the chronology and risk dependence of the expansion are poorly understood. Here we intensively sequence 682 micro-scale oesophageal samples and show, in physiologically normal oesophageal epithelia, the progressive age-related expansion of clones that carry mutations ... Read more >>

Nature (Nature)
[2019, 565(7739):312-317]

Cited: 28 times

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Abnormal Amino Acid Profiles of Blood and Cerebrospinal Fluid from Cystathionine β-Synthase-Deficient Mice, an Animal Model of Homocystinuria.

Noriyuki Akahoshi, Akira Yokoyama, Tomoko Nagata, Asumi Miura, Shotaro Kamata, Isao Ishii,

Mental retardation is the most common feature among inborn errors of amino acid metabolism. Patients with homocystinuria/homocysteinemia caused by cystathionine β-synthase (CBS) deficiency suffer from thromboembolism and mental retardation from early ages; therefore, detection by newborn screening is performed. Furthermore, elevated levels of serum homocysteine during pregnancy are associated with ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2019, 42(6):1054-1057]

Cited: 1 time

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Genetic analysis of a case of Helicobacter pylori-uninfected intramucosal gastric cancer in a family with hereditary diffuse gastric cancer.

Taro Funakoshi, Shin'ichi Miyamoto, Nobuyuki Kakiuchi, Mitsuhiro Nikaido, Takeshi Setoyama, Akira Yokoyama, Takahiro Horimatsu, Atsushi Yamada, Masako Torishima, Shinji Kosugi, Hidetaka Yamada, Haruhiko Sugimura, Hironori Haga, Yoshiharu Sakai, Seishi Ogawa, Hiroshi Seno, Manabu Muto, Tsutomu Chiba,

Germline mutations in CDH1, encoding E-cadherin, are known to be the causative mechanism of hereditary diffuse gastric cancer (HDGC). We encountered two cases of gastric cancer in a Japanese family with HDGC. A 28-year-old man (Case 1) died of advanced gastric cancer. His younger sister aged 27 (Case 2) was ... Read more >>

Gastric Cancer (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association)
[2019, 22(4):892-898]

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Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde.

Naruhisa Yamaki, Sachio Matsushita, Sachiko Hara, Akira Yokoyama, Akitoyo Hishimoto, Susumu Higuchi,

Heavy drinking leads to premature aging and precipitates the onset of age-related diseases. Acetaldehyde (AcH), a toxic metabolite of ethanol, has been implicated in various types of cancer. However, whether alcohol accelerates biological aging at a cellular level is controversial and the mechanism involved is unclear. We addressed these questions ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2019, 109:27-32]

Cited: 1 time

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Prognostic value ​of Lung Cancer Subscale in older patients with advanced non-small cell lung cancer: An integrated analysis of JCOG0207 and JCOG0803/WJOG4307L (JCOG1414A).

Tomonori Mizutani, Masahiko Ando, Junki Mizusawa, Kenichi Nakamura, Haruhiko Fukuda, Hiroko Tsukada, Tetsuya Abe, Koji Takeda, Akira Yokoyama, Shinichiro Nakamura, Kazuhiko Nakagawa, Noboru Yamamoto, Yuichiro Ohe,

OBJECTIVE:The Lung Cancer Subscale (LCS) of the Functional Assessment of Cancer Therapy-Lung (FACT-L) questionnaire is commonly used for evaluating lung cancer-specific symptoms. The objective of this study was to elucidate the prognostic value of the LCS in older patients with advanced non-small cell lung cancer (NSCLC). MATERIAL AND METHODS:We conducted ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2018, 9(6):583-588]

Cited: 1 time

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Pulmonary Adenocarcinoma, Harboring Both an EGFR Mutation and ALK Rearrangement, Presenting a Stable Disease to Erlotinib and a Partial Response to Alectinib.

Akira Yokoyama, Atsuhisa Tamura, Kazuko Miyakawa, Kei Kusaka, Masahiro Shimada, Takashi Hirose, Hirotoshi Matsui, Masashi Kitani, Akira Hebisawa, Ken Ohta,

A 63-year-old woman with pulmonary adenocarcinoma (stage IIIB) that was positive for an epidermal growth factor receptor (EGFR) mutation and an anaplastic lymphoma kinase (ALK) rearrangement was treated with erlotinib as the first-line treatment, resulting in a stable disease. Due to skin rashes, fatigue and anorexia, erlotinib was suspended on ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2018, 57(16):2377-2382]

Cited: 2 times

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Mycobacterium heckeshornense lung infection diagnosed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).

Akira Yokoyama, Hidenori Kage, Yuki Ohama, Tomoaki Sato, Naoya Miyashita, Satoshi Noguchi, Shu Okugawa, Yasuhiro Yamauchi, Kyoji Moriya, Takahide Nagase,

Identification of microorganisms by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been widely accepted. However, the significance of MALDI-TOF MS for identifying mycobacteria, particularly rare nontuberculous mycobacteria, has not been established. M. heckeshornense is one such bacteria, and distinguishing it from M. xenopi is difficult. The patient was ... Read more >>

J. Infect. Chemother. (Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy)
[2018, 24(9):763-765]

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[Risk factors and field cancerization of esophageal squamous cell carcinoma in Japan].

Akira Yokoyama,

Nihon Shokakibyo Gakkai Zasshi (Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology)
[2018, 115(10):868-880]

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Integrated Molecular Characterization of the Lethal Pediatric Cancer Pancreatoblastoma.

Tomoya Isobe, Masafumi Seki, Kenichi Yoshida, Masahiro Sekiguchi, Yusuke Shiozawa, Yuichi Shiraishi, Shunsuke Kimura, Misa Yoshida, Yoshikage Inoue, Akira Yokoyama, Nobuyuki Kakiuchi, Hiromichi Suzuki, Keisuke Kataoka, Yusuke Sato, Tomoko Kawai, Kenichi Chiba, Hiroko Tanaka, Teppei Shimamura, Motohiro Kato, Akihiro Iguchi, Asahito Hama, Tomoaki Taguchi, Masaharu Akiyama, Junya Fujimura, Akiko Inoue, Tsuyoshi Ito, Takao Deguchi, Chikako Kiyotani, Tomoko Iehara, Hajime Hosoi, Akira Oka, Masashi Sanada, Yukichi Tanaka, Kenichiro Hata, Satoru Miyano, Seishi Ogawa, Junko Takita,

Pancreatoblastoma is a rare pediatric pancreatic malignancy for which the molecular pathogenesis is not understood. In this study, we report the findings of an integrated multiomics study of whole-exome and RNA sequencing as well as genome-wide copy number and methylation analyses of ten pancreatoblastoma cases. The pancreatoblastoma genome was characterized ... Read more >>

Cancer Res. (Cancer research)
[2018, 78(4):865-876]

Cited: 1 time

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Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men.

Akira Yokoyama, Kenro Hirata, Rieko Nakamura, Tai Omori, Takeshi Mizukami, Junko Aida, Katsuya Maruyama, Tetsuji Yokoyama,

To determine whether the presence of columnar-lined esophagus (CLE) is associated with the presence of esophageal varices (EVs) in male Japanese alcoholics.The subjects were 1614 Japanese alcohol-dependent men (≥ 40 years of age) who had undergone upper gastrointestinal endoscopic screening. Digitalized records of high-quality endoscopic images that included the squamocolumnar ... Read more >>

World J. Gastroenterol. (World journal of gastroenterology)
[2017, 23(39):7150-7159]

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Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence.

Akira Yokoyama, Nobuhito Taniki, Sachiko Hara, Emiko Haysashi, Nobuhiro Nakamoto, Takeshi Mizukami, Katsuya Maruyama, Tetsuji Yokoyama,

BACKGROUND:Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver. METHODS:We evaluated associations between ... Read more >>

J. Gastroenterol. (Journal of gastroenterology)
[2018, 53(5):660-669]

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Psychotic Symptoms Associated With Varenicline in a Patient With Alcohol and Nicotine Dependence: A Case Report.

Fumihiko Ueno, Hiroyuki Uchida, Takefumi Suzuki, Akira Yokoyama, Sachio Matsushita, Masaru Mimura, Susumu Higuchi,

J Clin Psychopharmacol (Journal of clinical psychopharmacology)
[2017, 37(5):627-628]

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Recovery from anemia and leukocytopenia after abstinence in Japanese alcoholic men and their genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2.

Akira Yokoyama, Philip J Brooks, Tetsuji Yokoyama, Takeshi Mizukami, Shunsuke Shiba, Nobuhiro Nakamoto, Katsuya Maruyama,

Background:The combination of the fast-metabolizing alcohol dehydrogenase-1B (ADH1B*2 allele) and inactive heterozygous aldehyde dehydrogenase-2 (ALDH2*1/*2) increases susceptibility to macrocytic anemia and leukocytopenia in alcoholics due to severe acetaldehydemia. More than half of Japanese drinkers with esophageal cancer have this genotype combination. Methods:To assess the recovery of hematologic abnormalities after drinking ... Read more >>

Jpn. J. Clin. Oncol. (Japanese journal of clinical oncology)
[2017, 47(4):306-312]

Cited: 1 time

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