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Outbreak of Enterovirus D68 Among Children in Japan-Worldwide Circulation of Enterovirus D68 Clade B3 in 2018.

Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

<h4>Background</h4>Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred in the United States in 2014. We experienced an accumulation of pediatric cases with asthma-like respiratory illness in Niigata, Japan, in 2018.<h4>Study design</h4>To determine whether EV-D68 was responsible for ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):6-10]

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Pott's puffy tumour: a rare and life-threatening disease.

Nahoko Ikoma, Yuta Aizawa, Takanobu Sasaki, Makoto Oishi, Naka Saito, Hiroshi Yoshida, Akihiko Saitoh,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(12):1482]

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Effect of a vaccine information statement (VIS) on immunization status and parental knowledge, attitudes, and beliefs regarding infant immunization in Japan.

Aya Saitoh, Akihiko Saitoh, Tomohiro Katsuta, Mahito Mine, Hajime Kamiya, Isao Miyairi, Naruhiko Ishiwada, Makoto Oshiro, Ryutaro Kira, Naoki Shimizu, Shigeru Suga, Takeshi Tsugawa, Masashi Fujioka, Chiaki Miyazaki, Ichiro Morioka, Seigo Korematsu, Takashi Nakano, Keiko Tanaka-Taya, Tetsushi Yoshikawa, Satoshi Iwata, Koichi Kusuhara, Hiroshi Azuma, Hiroyuki Moriuchi, Nobuhiko Okabe, Mitsuaki Hosoya, Hiroyuki Tsutsumi, Kenji Okada,

<h4>Background</h4>Because of the overabundance of vaccination information on the internet, in the media, and on social media, providing clear and correct information on immunization is critical for parental decision-making. In 2018, the Japan Pediatric Society created and distributed a Vaccine Information Statement (VIS) to provide appropriate immunization information to caregivers. ... Read more >>

Vaccine (Vaccine)
[2020, 38(50):8049-8054]

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Comparison of immunization systems in Japan and the United States - What can be learned?

Tomohiro Katsuta, Charlotte A Moser, Kristen A Feemster, Akihiko Saitoh, Paul A Offit,

Recently, efforts have been made to fill a so-called "vaccine gap" between Japan and other countries; however, more work remains. Concerns about adverse events following immunization (AEFI) resulted in an historically passive approach to policy making in the National Immunization Program (NIP). For example, reports of AEFI following human papillomavirus ... Read more >>

Vaccine (Vaccine)
[2020, 38(46):7401-7408]

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Fatal Progressive Meningoencephalitis Diagnosed in Two Members of a Family With X-Linked Agammaglobulinemia.

Yasushi Kasahara, Masaru Imamura, Chansu Shin, Hiroshi Shimizu, Jirou Utsumi, Ryosuke Hosokai, Haruko Iwabuchi, Takayuki Takachi, Akiyoshi Kakita, Hirokazu Kanegane, Akihiko Saitoh, Chihaya Imai,

Chronic enteroviral meningoencephalitis is a well-known complication in patients with X-linked agammaglobulinemia (XLA). However, progressive neurodegenerative disorders or chronic neuroinflammatory diseases with no causative microorganisms have been recognized as rare central nervous system (CNS) complications in XLA. We herein report a family in which two of three members with XLA ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:579]

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Development and characterisation of NKp44-based chimeric antigen receptors that confer T cells with NK cell-like specificity.

Yasushi Kasahara, Chansu Shin, Nobuhiro Kubo, Keichiro Mihara, Haruko Iwabuchi, Takayuki Takachi, Masaru Imamura, Akihiko Saitoh, Chihaya Imai,

<h4>Objectives</h4>One of the reasons as to why chimeric antigen receptors (CAR)-T cell therapy for malignancies other than CD19- or BCMA-positive tumors has yet to produce remarkable progress is the paucity of targetable antigens. NKp44 is only expressed by activated natural killer cells and detects a variety of transformed cells, while ... Read more >>

Clin Transl Immunology (Clinical & translational immunology)
[2020, 9(7):e1147]

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Skin thickness in neonates: Implications for intradermal vaccination.

Akihiko Saitoh, Jun Nirei, Takeshi Tanaka, Hisanori Haniu, Takatsugu Sakai, Soichiro Okubo, Harunobu Hirano,

<h4>Introduction</h4>Intradermal (ID) injection is an alternate route that enhances vaccine immunogenicity and decreases vaccine dose. Regular immunization usually starts at age 2 months, and the limited immune capacity of neonates and young infants makes them vulnerable to infection. Successful ID vaccine delivery in this population requires knowledge of skin thickness. Although ... Read more >>

Vaccine (Vaccine)
[2020, 38(35):5659-5664]

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Timing of hyponatremia development in patients with salt-wasting-type 21-hydroxylase deficiency.

Rohi Shima, Kentaro Sawano, Nao Shibata, Hiromi Nyuzuki, Sunao Sasaki, Hidetoshi Sato, Yohei Ogawa, Yuki Abe, Keisuke Nagasaki, Akihiko Saitoh,

Newborn screening (NBS) can detect 21-hydroxylase deficiency (21-OHD), allowing for early treatment initiation. However, many patients present with adrenal crises or hyponatremia at their first visit. Age (in days) of hyponatremia development in infants with salt-wasting (SW)-type 21-OHD remains unclear. Therefore, we determined the earliest age of hyponatremia diagnosis in ... Read more >>

Clin Pediatr Endocrinol (Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology)
[2020, 29(3):105-110]

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STING Mediates Cytosolic Dna-Induced Muc5ac Mrna Expression in Human Bronchial Epithelial Cells

Masaya Ohta, Yutaka Nishida, Hisako Yagi, Aikira Aizawa, Takahito Oyanagi, Akihiko Saitoh, Satoshi Yamada, Takashi Ishige, Yasuko Kobayashi, Hirokzu Arakawa, Takumi Takizawa,

<h4>Background: </h4> : Non-autologous and autologous cytosolic DNA are recognized as danger signals by cytoplasmic sensor molecules that activate signal-transduction pathways. An important molecule in cytosolic DNA sensing is stimulator of interferon genes (STING), an endoplasmic reticulum protein activated by cyclic GMP–AMP (cGAMP) produced in response to cytosolic DNA. STING ... Read more >>

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Innate Immune Responses in Serum and Cerebrospinal Fluid From Neonates and Infants Infected With Parechovirus-A3 or Enteroviruses.

Rie Habuka, Yuta Aizawa, Ryohei Izumita, Hisanori Domon, Yutaka Terao, Hayato Takihara, Shujiro Okuda, Akihiko Saitoh,

BACKGROUND:Parechovirus (PeV)-A3 and enteroviruses (EV) are the most common viruses causing sepsis and meningoencephalitis in neonates and young infants. Clinical manifestations of PeV-A3 infection are more severe than those of EV infection, and no pleocytosis with a positive polymerase chain reaction (PCR) result for PeV-A3 in cerebrospinal fluid (CSF) are ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 222(4):681-689]

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Serostatus following polio-containing vaccination before and after liver transplantation.

Takanori Funaki, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Akihiko Saitoh, Isao Miyairi,

<h4>Background</h4>The strategy to eradicate polio is based on preventing infection by immunizing all children until the world is polio-free. However, data regarding efficacy of polio-containing vaccination in immunocompromised patients such as LT recipients are limited.<h4>Methods</h4>We conducted an observational study at the largest pediatric transplant center in Japan from January 2011 ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, 24(6):e13766]

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Degeneration of dopaminergic neurons and impaired intracellular trafficking in Atp13a2 deficient zebrafish.

Hiromi Nyuzuki, Shinji Ito, Keisuke Nagasaki, Yohei Nitta, Noriko Matsui, Akihiko Saitoh, Hideaki Matsui,

<i>ATP13A2</i> is the autosomal recessive causative gene for juvenile-onset Parkinson's disease (PARK9, Parkinson's disease 9), also known as Kufor-Rakeb syndrome. The disease is characterized by levodopa-responsive Parkinsonism, supranuclear gaze palsy, spasticity, and dementia. Previously, we have reported that Atp13a2 deficient medaka fish showed dopaminergic neurodegeneration and lysosomal dysfunction, indicating that ... Read more >>

IBRO Rep (IBRO reports)
[2020, 9:1-8]

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Changes in laboratory findings in Parechovirus-A infection in nine neonates and infants.

Keiko Nimura, Yuta Maruyama, Yuta Aizawa, Akihiko Saitoh, Yozo Nakazawa,

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, 62(6):755-758]

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Improving Hand Hygiene Adherence in Healthcare Workers Before Patient Contact: A Multimodal Intervention in Four Tertiary Care Hospitals in Japan.

Akihiko Saitoh, Kiyomi Sato, Yoko Magara, Kakuei Osaki, Kiyoko Narita, Kumiko Shioiri, Karen E Fowler, David Ratz, Sanjay Saint,

<h4>Background</h4>Hand hygiene is key to preventing healthcare-associated infection and the spread of respiratory viruses like the novel coronavirus that causes COVID-19. Unfortunately, hand hygiene adherence of healthcare workers (HCWs) in Japan is suboptimal according to previous studies.<h4>Objectives</h4>Our objectives were to evaluate hand hygiene adherence among physicians and nurses before touching ... Read more >>

J Hosp Med (Journal of hospital medicine)
[2020, 15(5):262-267]

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Parechovirus-A3 encephalitis presenting with focal seizure mimicking herpes simplex virus infection.

Sakiko Arai, Takayuki Yamanaka, Masashi Kasai, Tetsuhiro Fukuyama, Yuta Aizawa, Ko Matsui, Masanori Sato, Hiroko Matsui, Akihiko Saitoh,

BACKGROUND:Febrile neonates and young infants presenting with seizure require immediate evaluation and treatment. Herein we experienced two young infants with parechovirus-A3 (PeV-A3) encephalitis, initially presented with focal seizure suspecting herpes simplex virus (HSV) encephalitis. CASES:We have experienced 2 infantile cases, initially presented with focal seizure. At presentation, HSV encephalitis was ... Read more >>

J Infect Chemother (Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy)
[2020, 26(7):736-740]

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Epidemic of influenza A(H1N1)pdm09 analyzed by full genome sequences and the first case of oseltamivir-resistant strain in Myanmar 2017.

Su Mon Kyaw Win, Reiko Saito, Nay Chi Win, Di Ja Lasham, Yadanar Kyaw, Nay Lin, Khin Nyo Thein, Irina Chon, Takashi Odagiri, Win Thein, Latt Latt Kyaw, Ommar Swe Tin, Akihiko Saitoh, Tsutomu Tamura, Chika Hirokawa, Yuko Uchida, Takehiko Saito, Shinji Watanabe, Takato Odagiri, Kazuhiro Kamata, Hidekazu Osada, Clyde Dapat, Hisami Watanabe, Htay Htay Tin,

A community outbreak of human influenza A(H1N1)pdm09 virus strains was observed in Myanmar in 2017. We investigated the circulation patterns, antigenicity, and drug resistance of 2017 influenza A(H1N1)pdm09 viruses from Myanmar and characterized the full genome of influenza virus strains in Myanmar from in-patients and out-patients to assess the pathogenicity ... Read more >>

PLoS One (PloS one)
[2020, 15(3):e0229601]

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Novel scoring system for differentiating parechovirus-A3 and enterovirus infection in neonates and young infants.

Ryohei Izumita, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Nobutaka Kitamura, Kohei Akazawa, Akihiko Saitoh,

BACKGROUND:Parechovirus-A3 (PeV-A3) and the enteroviruses (EVs) are the most common viral pathogens responsible for sepsis and meningoencephalitis in neonates and young infants; however, differences in the clinical presentations of two infections are not well described. OBJECTIVES:To describe the clinical presentations of PeV-A3- and EVs-related diseases and develop a novel scoring ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2020, 124:104256]

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Intrafamilial Transmission of Parechovirus A and Enteroviruses in Neonates and Young Infants.

Ryohei Izumita, Kazuki Deuchi, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

<h4>Background</h4>Parechovirus A (PeV-A) is an important cause of sepsis and meningoencephalitis in neonates and young infants. Thus, identifying the source of PeV-A is essential for prevention; however, little is known regarding the spread of PeV-A among family members of PeV-A-infected neonates and young infants.<h4>Methods</h4>In this prospective study, we evaluated stool ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2019, 8(6):501-506]

Cited: 2 times

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Spontaneous remission of infant acute myeloid leukemia with a novel four-way translocation.

Nobuhiro Kubo, Haruko Iwabuchi, Masaru Imamura, Akihiko Saitoh, Chihaya Imai,

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(2):e28052]

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2635. Outbreak of Enterovirus D68 Among Children in Japan and Simultaneous Circulation of Clade B3 in Europe.

Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

AbstractBackgroundEnterovirus D68 (EV-D68) is a re-emerging, high-morbidity pathogen that causes severe respiratory infection and acute flaccid myelitis in children. EV-D68 is phylogenetically divided into 4 major groups—clade A through D—and each clade has subclades defined by genetic variant. Outbreaks of all strains have been reported in more than 10 countries. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S920-S921]

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2586. Human Breast Milk Inhibits the Replication of Parechovirus-A3.

Ryohei Izumita, Kazuki Kon, Yuta Aizawa, Kanako Watanabe, Akihiko Saitoh,

AbstractBackgroundParechovirus-A3 (PeV-A3) is an emerging pathogen causing sepsis and meningoencephalitis in neonates and young infants. We previously reported that maternal antibodies against PeV-A3 are important to protect neonates and young infants from the infection. Recent studies showed that (1) breastfeeding had a protective effect against enterovirus, which is closely-related virus ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S899-S899]

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2853. Innate Immune Response in Serum and Cerebrospinal Fluid of Neonates and Infants Infected with Parechovirus-A3 and Enteroviruses.

Rie Habuka, Yuta Aizawa, Ryohei Izumita, Hisanori Domon, Yutaka Terao, Akihiko Saitoh,

AbstractBackgroundParechovirus-A3 (PeV-A3) and enteroviruses (EVs) are the most common viral causes of neonatal and infantile sepsis. We previously reported that the clinical manifestations of PeV-A3 infection—e.g., high body temperature, tachycardia, and poor peripheral circulation, but not cerebrospinal fluid (CSF) pleocytosis—tend be more severe than those of EV infection. We tested ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S74-S74]

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2585. Changing Epidemiological Profile of Infantile Parechovirus-A3 Infection in Japan

Yuta Aizawa, Ryohei Izumita, Takayuki Yamanaka, Rie Habuka, Tatsuki Ikuse, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

Abstract <h4>Background</h4> Parechovirus-A3 (PeV-A3) causes severe disease, including sepsis and meningoencephalitis in young infants. The first case of PeV-A3 was reported in Japan in 1999 and, although epidemics have been reported every 2 to 3 years in more than 20 countries, no major epidemic has occurred in Japan since 2014. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S898-S899]

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Clinical Characteristics of Saffold Virus Infection in Children.

Satoko Ugai, Atsushi Iwaya, Hiromichi Taneichi, Chika Hirokawa, Yuta Aizawa, Shuji Hatakeyama, Akihiko Saitoh,

BACKGROUND:Saffold virus (SAFV) is a novel human cardiovirus that was identified in 2007. Recently, SAFV has been isolated from nasal and stool specimens of infants presenting with respiratory and gastrointestinal symptoms and from cerebrospinal fluid (CSF) specimens of children with central nervous system infection. However, little is known regarding clinical ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(8):781-785]

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Persistence of High Neutralizing Antibody Titers After Neonatal and Early Infantile Infection with Parechovirus-A3.

Ryohei Izumita, Yuta Aizawa, Kanako Watanabe, Akihiko Saitoh,

This 3-year follow-up study evaluated neutralizing antibody titers (NATs) against parechovirus-A3 (PeV-A3) in neonates and young infants who developed PeV-A3 infection. All children had low NATs at disease onset and high NATs after infection during infancy. At age 3 years, all 16 patients tested had high NATs (≥1:512) against PeV-A3 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(7):e159-e161]

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