Full Text Journal Articles by
Author Akhtar Rasul

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Lipospheres for Simultaneous Controlled Release and Improved Pharmacokinetic Profiles of Saxagliptin-Enalapril: Formulation, Optimization, and Comparative In Vitro-In Vivo Evaluation.

Safirah Maheen, Akhtar Rasul, Muhammad Hanif, Hafeez Ullah Khan,

The current study aims at formulating and optimizing lipospheres (LS) by the Box-Behnken design (BBD) from safe biodegradable carnauba wax (CW) to co-administer saxagliptin (SG) and enalapril (EP) for co-existing chronic hypertensive diabetes in order to overcome inadequacies of conventional modes of drug administration. Optimized liposphere formulation (OLF) was selected ... Read more >>

AAPS PharmSciTech (AAPS PharmSciTech)
[2020, 21(5):188]

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Development, characterization and evaluation of anti-fungal activity of miconazole based nanogel prepared from biodegradable polymer.

Umar Farooq, Akhtar Rasul, Muhammed Sher, Muhammad Imran Qadir, Imran Nazir, Yasir Mehmood, Humayun Riaz, Pervaiz Akhtar Shah, Qazi Adnan Jamil, Barkat A Khan,

Topical candidiasis is a known skin fungal infection which is usually treated by conventional dosage forms such as cream, gel, emulgel which are having numerous adverse effects on skin. To overcome such disadvantages, different novel drug delivery systems have been considered. Polymer based nano-particulate systems have shown good skin penetration ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(1(Special)):449-457]

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Progress and prospects in the management of bacterial infections and developments in Phytotherapeutic modalities.

Muhammad Akram, Muhammad Riaz, Naveed Munir, Akhtar Rasul, Muhammad Daniyal, Muhammad Daniyal, Syed Muhammad Ali Shah, Mohammad Ali Shariati, Ghazala Shaheen, Naheed Akhtar, Farzana Parveen, Naheed Akhter, Aymen Owais Ghauri, Abdul Wadood Chishti, Muhammad Usman Sarwar, Fahad Said Khan,

The advent of antibiotics revolutionized medical care resulting in significantly reduced mortality and morbidity caused by infectious diseases. However, excessive use of antibiotics has led to the development of antibiotic resistance and indeed, the incidence of multidrug-resistant pathogens is considered as a major disadvantage in medication strategy, which has led ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, 47(7):1107-1119]

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REVIEW- Contemporary evidence on the dynamic role of probiotics in liver diseases.

Bilal Ahmed, Akhtar Rasul, Kanwal Zia Tareen, Muhammad Sajid Hamid Akash, Syed Aun Muhammad, Muhammad Irfan, Khizar Abbas, Muhammad Imran Qadir,

Currently probiotics are considered as an emerging therapeutic strategy in the treatment of many liver disorders. The use of probiotics beyond infection of intestinal flora is a very helpful approach. The optimistic effect of probiotics has been observed in treating the hepatic cirrhosis, hepatic encephalopathy, viral hepatitis, irritable bowel syndrome, ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(6):2765-2770]

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Development, characterization and evaluation of ginger extract loaded microemulsion: In vitro and Ex vivo release studies.

Ayesha Akram, Naveed Akhtar, Muhammad Khurram Waqas, Akhtar Rasul, Kashif Ur Rehman, Jahangir Khan, Muhammad Iqbal, Barkat Ali Khan,

Zingeber officinale (ginger) has been used for a long time in conventional medicine for the management of many diseases most important of which is inflammatory diseases. The aim of this study was formulation of topical microemulsion system to enhance the solubility, stability and release profile of ginger extract, as it ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(4(Supplementary)):1873-1877]

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Development, characterization and evaluation of in-vitro anti-inflammatory activity of ginger extract based micro emulsion.

Ayesha Akram, Akhtar Rasul, Muhammad Khurram Waqas, Muhammad Irfan, Syed Haroon Khalid, Muhammad Naeem Aamir, Ghulam Murtaza, Kashif Ur Rehman, Muhammad Iqbal, Barkat Ali Khan,

Zingeber officinale is a commonly used plant which has been shown to possess anti-inflammatory activity. The active compounds present in ginger are gingerols, shagaols and paradol. The aim of this study was formulation of topical microemulsion system to enhance the solubility and stability of ginger extract, as it is unstable ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(3 Special):1327-1332]

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Development and in vitro characterization of niosomal formulations of immunosuppressant model drug.

Mujeebur Rehman, Akhtar Rasul, Muhammad Khurram Waqas, Muhammad Imran Khan, Muhammad Sher,

Among immunosuppressive agents cyclosporine A is drug of unique importance. This drug has a low therapeutic index, and it has many toxic effects. After oral administration its absolute bioavailability is variable due to poor absorption. Niosomes are new and versatile carriers to deliver drug. The bioavailability of immunosuppressant drug cyclosporine ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(6 (Supplementary):2623-2628]

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Mini Review: Chronic obstructive pulmonary disease, its new drug treatments and strategies: A review.

Muhammad Hanif, Junaid Qureshi, Hira Ijaz, Muhammad Iqbal Mustafa, Akhtar Rasul, Naeem Amir, Basma Aftab, Ahad Fayyaz,

COPD is a complicated disease. Current available treatments are just for symptomatic relief and they cannot reverse the damages to lungs tissues due to alveolar destruction in COPD. Research is being conducted to evaluate new treatments and strategies to find specific treatments to minimize the symptoms of COPD. A new ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(3):967-971]

Cited: 1 time

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Optimizing the Role of Polymer Blend in the Preparation of Acyclovir Controlled-Release Tablets: An Approach for Better Patient Compliance

Barkat Khan, Faheem Haider, Kifayat Shah, Bushra Uzair, Kaijian Hou, Muhammad Waqas, Akhtar Rasul,

This study was carried out to formulate and evaluate controlled release (CR) matrix tablets of Acyclovir using combination of hydrophilic and hydrophobic polymers. Acyclovir is a guanine derivative and is its half-life is short hence administered five times a day using immediate release tablets. Six formulations (F1-F6) were developed using ... Read more >>

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Fabrication of Tamarindus indica seeds extract loaded-cream for photo-aged skin: Visioscan® studies.

Muhammad Khurram Waqas, Barkat Ali Khan, Naveed Akhtar, Farzana Chowdhry, Haroon Khan, Sattar Bakhsh, Shahzeb Khan, Akhtar Rasul,

INTRODUCTION:Intracellular and extracellular oxidative stress triggered by free radicals promotes skin aging, which is designated by atypical pigmentation and wrinkles. The consumption of antioxidants is an efficacious measure to avert symptoms involved in skin aging. AIM:The current research was commenced to explore the anti-aging potential of antioxidants present in Tamarindus ... Read more >>

(Postepy dermatologii i alergologii)
[2017, 34(4):339-345]

Cited: 1 time

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Triple-component nanocomposite films prepared using a casting method: Its potential in drug delivery.

Sadia Gilani, Sadullah Mir, Momina Masood, Abida Kalsoom Khan, Rehana Rashid, Saira Azhar, Akhtar Rasul, Muhammad Nadeem Ashraf, Muhammad Khurram Waqas, Ghulam Murtaza,

The purpose of this study was to fabricate a triple-component nanocomposite system consisting of chitosan, polyethylene glycol (PEG), and drug for assessing the application of chitosan-PEG nanocomposites in drug delivery and also to assess the effect of different molecular weights of PEG on nanocomposite characteristics. The casting/solvent evaporation method was ... Read more >>

J Food Drug Anal (Journal of food and drug analysis)
[2018, 26(2):887-902]

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PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION.

Muhammad Hanif, Akhtar Rasul, Muhammad Harris Shoaib, Ghulam Abbas, Huma Ali, Sajid Mahmood Khan,

Single centered crossover, two cycles volunteer study was performed on 12 healthy male volunteers. Both reference and test, immediate release nimesulide formulation was given in a randomized manner with a washout period of 15 days and 5 mL of blood samples were drawn at 0.5, 1, 1.5, 2, 4, 8, ... Read more >>

Acta Pol Pharm (Acta poloniae pharmaceutica)
[2017, 74(2):489-495]

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Role of Interleukin-6 in Development of Insulin Resistance and Type 2 Diabetes Mellitus.

Kanwal Rehman, Muhammad Sajid Hamid Akash, Aamira Liaqat, Shagufta Kamal, Muhammad Imran Qadir, Akhtar Rasul,

Interleukin-6 (IL-6) is a proinflammatory cytokine that decisively induces the development of insulin resistance and pathogenesis of type 2 diabetes mellitus (T2DM) through the generation of inflammation by controlling differentiation, migration, proliferation, and cell apoptosis. The presence of IL-6 in tissues is a normal consequence, but its irregular production and ... Read more >>

Crit. Rev. Eukaryot. Gene Expr. (Critical reviews in eukaryotic gene expression)
[2017, 27(3):229-236]

Cited: 20 times

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Dengue fever: natural management.

Muhammad Imran Qadir, Khizar Abbas, Madeha Tahir, Muhammad Irfan, Syeda Fiza Raza Bukhari, Bilal Ahmed, Muhammad Hanif, Akhtar Rasul, Muhammad Ali,

Dengue fever is caused by the mosquito-borne dengue virus (DENV) serotypes 1-4, and is the most common arboviral infection of humans in subtropical and tropical regions of the world. Dengue virus infections can present with a spacious range of clinical signs, from a mild feverish illness to a life-threatening shock ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2015, 28(2):647-655]

Cited: 2 times

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Whitening efficacy of plant extracts including Hippophae rhamnoides and Cassia fistula extracts on the skin of Asian patients with melasma.

Barkat Ali Khan, Naveed Akhtar, Irshad Hussain, Khwaja Asad Abbas, Akhtar Rasul,

INTRODUCTION:Melasma/hyperpigmentation and solar damage of the skin remains a difficult problem to treat. Various types of whitening agents are used to treat hyperpigmentation. A change has been observed recently to use plant extracts as skin whitening agents. AIM:To compare the effectiveness of emulsion formulations containing plant extracts that include catechins/polyphenols ... Read more >>

(Postepy dermatologii i alergologii)
[2013, 30(4):226-232]

Cited: 4 times

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Design, development and in-vitro evaluation of metoprolol tartrate tablets containing xanthan-tragacanth.

Akhtar Rasul, Muhammad Iqbal, Ghulam Murtaza, Muhammad K Waqas, Muhammad Hanif, Shujaat A Khan, Naveed S Bhatti,

The present study was undertaken to develop oral sustained release tablets of metoprolol tartrate using natural hydrophilic matrix formers (xanthan gum and tragacanth). Sustained release matrix tablets of metoprolol tartrate were prepared by using different ratios of drug, xanthan gum and tragacanth. Microcrystalline cellulose (MCC) was used as diluent. The ... Read more >>

Acta Pol Pharm (Acta poloniae pharmaceutica)
[2010, 67(5):517-522]

Cited: 2 times

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Formulation and characterization of a cream containing extract of fenugreek seeds.

Muhammad K Waqas, Naveed Akhtar, Mahmood Ahmad, Ghulam Murtaza, Haji M S Khan, Muhammad Iqbal, Akhtar Rasul, Naveed S Bhatti,

Fenugreek seeds possess antioxidant effects and contain a mucilage which has emollient properties. It can also produce skin healing, whitening, moisturizing, skin soothening and antiwrinkle effects. The purpose of study was to formulate a stable W/O emulsion containing fenugreek seeds extract using liquid paraffin oil. Fenugreek seeds extract, which was ... Read more >>

Acta Pol Pharm (Acta poloniae pharmaceutica)
[2010, 67(2):173-178]

Cited: 0 times

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