Full Text Journal Articles by
Author Aisha Iskakova

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Association of polymorphisms in TP53 and the promoter region of IL10 with gastric cancer in a Kazakh population.

Gulmira Kulmambetova, Ivan Shtefanov, Akbota Aitkulova, Meruyert Imanbekova, Aisha Iskakova, Abay Makishev, Yerlan Ramankulov,

The emerging evidence indicates that single nucleotide polymorphisms (SNPs) of the tumor necrosis factor (TNF), interleukin 10 (IL10), tumor protein p53 (TP53), and cluster of differentiation 14 (CD14) genes may determine individual susceptibility to gastric cancer (GC). We aimed to investigate the associations for polymorphisms of the TNF, IL10, TP53, ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):539-546]

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Genetic Risk Factors for Intracranial Aneurysm in the Kazakh Population.

Elena V Zholdybayeva, Yerkin Z Medetov, Akbota M Aitkulova, Yerbol T Makhambetov, Serik K Akshulakov, Assylbek B Kaliyev, Yerkebulan A Talzhanov, Gulmira N Kulmambetova, Aisha N Iskakova, Yerlan M Ramankulov,

An intracranial aneurysm (IA) is a weak or thin area on a blood vessel in the brain that balloons as it fills with blood. Genetic factors can influence the risk of developing an aneurism. The purpose of this study was to explore the relationship between single nucleotide polymorphisms (SNPs) and ... Read more >>

J. Mol. Neurosci. (Journal of molecular neuroscience : MN)
[2018, 66(1):135-145]

Cited: 3 times

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Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population.

Nurgul Sikhayeva, Yerkebulan Talzhanov, Aisha Iskakova, Jarkyn Dzharmukhanov, Raushan Nugmanova, Elena Zholdybaeva, Erlan Ramanculov,

Ethnic differences exist in the frequencies of genetic variations that contribute to the risk of common disease. This study aimed to analyse the distribution of several genes, previously associated with susceptibility to type 2 diabetes and obesity-related phenotypes, in a Kazakh population.A total of 966 individuals belonging to the Kazakh ... Read more >>

Clin Interv Aging (Clinical interventions in aging)
[2018, 13:377-388]

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Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.

Nurgul Sikhayeva, Aisha Iskakova, Nuria Saigi-Morgui, Elena Zholdybaeva, Chin-Bin Eap, Erlan Ramanculov,

BACKGROUND:We evaluated the associations between single nucleotide polymorphisms and different clinical parameters related to type 2 diabetes mellitus (T2DM), obesity risk, and metabolic syndrome (MS) in a Kazakh cohort. METHODS:A total of 1336 subjects, including 408 T2DM patients and 928 control subjects, were recruited from an outpatient clinic and genotyped ... Read more >>

BMC Med. Genet. (BMC medical genetics)
[2017, 18(1):76]

Cited: 5 times

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Genetic risk factors for restenosis after percutaneous coronary intervention in Kazakh population.

Elena V Zholdybayeva, Yerkebulan A Talzhanov, Akbota M Aitkulova, Pavel V Tarlykov, Gulmira N Kulmambetova, Aisha N Iskakova, Aliya U Dzholdasbekova, Olga A Visternichan, Dana Zh Taizhanova, Yerlan M Ramanculov,

After coronary stenting, the risk of developing restenosis is from 20 to 35 %. The aim of the present study is to investigate the association of genetic variation in candidate genes in patients diagnosed with restenosis in the Kazakh population.Four hundred fifty-nine patients were recruited to the study; 91 patients were ... Read more >>

Hum. Genomics (Human genomics)
[2016, 10(1):15]

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Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan.

Aisha N Iskakova, Aliya A Romanova, Akbota M Aitkulova, Nurgul S Sikhayeva, Elena V Zholdybayeva, Erlan M Ramanculov,

Studies of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are crucial to the development of therapeutics in clinical medicine. Such data provide information that may improve our understanding of individual differences in sensitivity or resistance to certain drugs, thereby helping to avoid adverse drug reactions ... Read more >>

BMC Genet. (BMC genetics)
[2016, 17:23]

Cited: 3 times

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Polymorphisms of HLA-DRB1, -DQA1 and -DQB1 in inhabitants of Astana, the capital city of Kazakhstan.

Alexandr B Kuranov, Mikhail N Vavilov, Gulshara Zh Abildinova, Ainur R Akilzhanova, Aisha N Iskakova, Elena V Zholdybayeva, Margarita N Boldyreva, Claudia A Müller, Kuvat T Momynaliev,

BACKGROUND: Kazakhstan has been inhabited by different populations, such as the Kazakh, Kyrgyz, Uzbek and others. Here we investigate allelic and haplotypic polymorphisms of human leukocyte antigen (HLA) genes at DRB1, DQA1 and DQB1 loci in the Kazakh ethnic group, and their genetic relationship between world populations. METHODOLOGY/PRINCIPAL FINDINGS: A ... Read more >>

PLoS ONE (PloS one)
[2014, 9(12):e115265]

Cited: 4 times

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Frequency of NAT2 and GSTP1 polymorphisms in the Kazakh population.

Aisha Iskakova, Aliya Romanova, Elena Zholdybayeva, Erlan Ramanculov, Kuvat Momynaliev,

Introduction:Phase II xenobiotic biotransformation enzymes perform detoxification of hydrophilic and often toxic Phase I products through glutathionetransferase (GST), UDP-glucuronosyltransferase (UDF), N-acetyltransferase (NAT) families and other enzymes. GST protein families metabolize a large number of electrophilic xenobiotics, by conjugating fusing them with glutathione. Arylamine-N-acetyltransferase (NAT) catalyzes the acetylation of the aromatic ... Read more >>

(Central Asian journal of global health)
[2013, 2(Suppl):83]

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Pharmacogenetic research in Kazakhstan.

Elena Zholdybayeva, Aisha Iskakova, Aliya Romanova, Erlan Ramanculov, Kuvat Momynaliev,

Introduction:Pharmacogenomics is an emerging field of medicine that combines genetics and pharmacology. Pharmacogenomic research is relatively new in Kazahkstan, but, in recent years, significant progress has been made in this field. The National Scientific Laboratory for Biotechnology has launched several government-funded research projects focused on finding genetic markers that determine ... Read more >>

(Central Asian journal of global health)
[2013, 2(Suppl):87]

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