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Author Aiqiang Xu

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Late-onset Hearing Loss From Congenital Cytomegalovirus Infection After Newborn Period in a Highly Immune Population in China.

Chengbin Wang, Xiaolin Liu, Shiwen Wang, Wenqiang Zhang, Haiyan Wang, Wei Ma, Xiangxin Meng, Xingqu Xu, Zhan Li, Qiang Pan, Shuxia Zhang, Ping Wang, Qian Lin, Xiaofang Wang, Minal Amin, Sheila Dollard, Aiqiang Xu, Winnie Chung,

After following 141 children with likely asymptomatic congenital cytomegalovirus infection in a highly immune population in China, four children (2.8%) were found to have late-onset hearing loss. No maternal or childhood factors, except higher saliva cytomegalovirus viral load at birth (P = 0.03), were associated with increased risk of developing ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):70-73]

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Prevalence and Bayesian Phylogenetics of Enteroviruses Derived From Environmental Surveillance Around Polio Vaccine Switch Period in Shandong Province, China.

Chenxu Zhao, Xiaojuan Lin, Feng Ji, Ping Xiong, Yao Liu, Suting Wang, Peng Chen, Qing Xu, Li Zhang, Zexin Tao, Aiqiang Xu,

We present the results of environmental surveillance for poliovirus (PV) and non-poliovirus (NPEV) around the switch from trivalent to bivalent oral polio-vaccine (OPV) which occurred in China in May 2016. Sewage samples were collected in Jinan and Linyi city from 2015 to 2017. Enterovirus (EV) isolation, VP1 amplification, Sanger sequencing, ... Read more >>

Food Environ Virol (Food and environmental virology)
[2020, 12(4):321-332]

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Environmental Surveillance Complements Case-Based Surveillance of Acute Flaccid Paralysis in Polio Endgame Strategy 2019-2023.

Peng Chen, Yao Liu, Haiyan Wang, Guifang Liu, Xiaojuan Lin, Weiyan Zhang, Feng Ji, Qing Xu, Zexin Tao, Aiqiang Xu,

The Polio Endgame Strategy 2019-2023 has been developed. However, more effective and efficient surveillance activities should be conducted with the preparedness of emergence for vaccine-derived poliovirus (VDPV) or wild poliovirus (WPV). We reviewed the impact of the case-based acute flaccid paralysis (AFP) surveillance (1991 to 2018) and environmental surveillance (2011 ... Read more >>

Appl Environ Microbiol (Applied and environmental microbiology)
[2020, 86(15):]

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Associations Between Salt-Restriction Spoons and Long-Term Changes in Urinary Na+/K+ Ratios and Blood Pressure: Findings From a Population-Based Cohort.

Lei Hou, Xiaolei Guo, Jiyu Zhang, Xi Chen, Liuxia Yan, Xiaoning Cai, Junli Tang, Chunxiao Xu, Baohua Wang, Jing Wu, Jixiang Ma, Aiqiang Xu,

Background There have been few studies on the relationship between long-term changes in sodium intake and blood pressure. A method of reducing sodium intake in a population that is known for high-sodium intake based on homemade cooking is also needed. Methods and Results Our study was based on a baseline ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(14):e014897]

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Association of a Province-Wide Intervention With Salt Intake and Hypertension in Shandong Province, China, 2011-2016.

Aiqiang Xu, Jixiang Ma, Xiaolei Guo, Linhong Wang, Jing Wu, Jiyu Zhang, Yamin Bai, Jianwei Xu, Zilong Lu, Zhongji Xu, Xiaochang Zhang, Gangqiang Ding, Yuling Hong, Fengjun Du, Yangfeng Wu, Liuxia Yan, Junli Tang, Xiaoning Cai, Jing Dong, Chunxiao Xu, Jie Ren, Xi Chen, Congcong Gao, Bingyin Zhang, Quanhe Yang, Ronald Moolenaar, Ying Cai, Sandra L Jackson, Gaoqiang Xie, Shicheng Yu, Jing Cui, Zengwu Wang, Liyun Zhao, Lahong Ju, Danyang Shen, Shumei Yun, Xiaofeng Liang, Zhenqiang Bi, Yu Wang,

<h4>Importance</h4>High salt intake is associated with hypertension, which is a leading modifiable risk factor for cardiovascular disease.<h4>Objective</h4>To assess the association of a government-led, multisectoral, and population-based intervention with reduced salt intake and blood pressure in Shandong Province, China.<h4>Design, setting, and participants</h4>This cross-sectional study used data from the Shandong-Ministry of Health ... Read more >>

JAMA Intern Med (JAMA internal medicine)
[2020, 180(6):877-886]

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Detection of enteroviruses in urban sewage by next generation sequencing and its application in environmental surveillance.

Zexin Tao, Peng Chen, Ning Cui, Xiaojuan Lin, Feng Ji, Yao Liu, Ping Xiong, Li Zhang, Qing Xu, Yanyan Song, Aiqiang Xu,

Environmental surveillance has been used successfully in monitoring enterovirus (EV) circulation; however cell culture method may introduce a selective bias in those EV strains that are recovered from the environment. In this study, urban sewage samples were collected monthly in Jinan, China in 2018 and concentrated via membrane adsorption/elution method. ... Read more >>

Sci Total Environ (The Science of the total environment)
[2020, 728:138818]

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Estimating 24-Hour Sodium Excretion from Spot Urine Samples in Chinese Adults: Can Spot Urine Substitute 24-Hour Urine Samples?

Jianwei Xu, Jiyu Zhang, Min Liu, Yamin Bai, Xiaolei Guo, Jing Dong, Aiqiang Xu, Jing Wu,

Several estimating equations for predicting 24-h urinary sodium (24-hUNa) excretion using spot urine (SU) samples have been developed, but have not been readily available to Chinese populations. We aimed to compare and validate the six existing methods at population level and individual level. We extracted 1671 adults eligible for both ... Read more >>

Nutrients (Nutrients)
[2020, 12(3):]

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Association of weather variability with resurging pertussis infections among different age groups: A non-linear approach.

Yuzhou Zhang, Hilary Bambrick, Kerrie Mengersen, Shilu Tong, Lei Feng, Guifang Liu, Aiqiang Xu, Li Zhang, Wenbiao Hu,

Pertussis has resurged in many countries over recent years, especially among adolescents and adults. This study assessed the effect of weather variability on resurging pertussis among different age groups in Jinan, China. Data on weekly pertussis notifications by age group and weather factors (mean temperature (MeanT), mean temperature standard deviation ... Read more >>

Sci Total Environ (The Science of the total environment)
[2020, 719:137510]

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Association of sociodemographic factors and internet query data with pertussis infections in Shandong, China.

Yuzhou Zhang, Hilary Bambrick, Kerrie Mengersen, Shilu Tong, Lei Feng, Li Zhang, Guifang Liu, Aiqiang Xu, Wenbiao Hu,

This study explored how internet queries vary in facilitating monitoring of pertussis, and the effects of sociodemographic characteristics on such variation by city in Shandong province, China. We collected weekly pertussis notifications, Baidu Index (BI) data and yearly sociodemographic data at the city level between 1 January 2009 and 31 ... Read more >>

Epidemiol Infect (Epidemiology and infection)
[2019, 147:e302]

Cited: 1 time

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Reply.

Jiaye Liu, Tao Li, Li Zhang, Aiqiang Xu,

Hepatology (Hepatology (Baltimore, Md.))
[2019, 70(4):1489-1490]

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Using big data to predict pertussis infections in Jinan city, China: a time series analysis.

Yuzhou Zhang, Hilary Bambrick, Kerrie Mengersen, Shilu Tong, Lei Feng, Li Zhang, Guifang Liu, Aiqiang Xu, Wenbiao Hu,

This study aims to use big data (climate data, internet query data and school calendar patterns (SCP)) to improve pertussis surveillance and prediction, and develop an early warning model for pertussis epidemics. We collected weekly pertussis notifications, SCP, climate and internet search query data (Baidu index (BI)) in Jinan, China ... Read more >>

Int J Biometeorol (International journal of biometeorology)
[2020, 64(1):95-104]

Cited: 3 times

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Spatial distribution and clusters of pancreatic cancer mortality in Shandong Province, China.

Fan Jiang, Jie Chu, Xianxian Chen, Jiyu Zhang, Zhentao Fu, Jiandong Sun, Zilong Lu, Xiaolei Guo, Aiqiang Xu,

This study aimed to explore the geographic distribution and risk clusters of pancreatic cancer mortality from 2011 to 2013 in Shandong, China, and to detect the differences between urban and rural areas. Our data were obtained from the Shandong Death Registration System (SDRS) and were adjusted according to the underreporting ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):12917]

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Individual- and Area-Level Socioeconomic Inequalities in Esophageal Cancer Survival in Shandong Province, China: A Multilevel Analysis.

Kou Kou, Peter D Baade, Michelle Gatton, Susanna M Cramb, Jiandong Sun, Zilong Lu, Zhentao Fu, Jie Chu, Aiqiang Xu, Xiaolei Guo,

<h4>Background</h4>China contributes to almost half of the esophageal cancer cases diagnosed globally each year. However, the prognosis information of this disease in this large population is scarce.<h4>Methods</h4>Data on a population-based cohort consisting of residents of Shandong Province, China who were diagnosed with esophageal cancer during the period from 2005 to ... Read more >>

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2019, 28(9):1427-1434]

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Seroprevalence and associated factors of HSV-2 infection among general population in Shandong Province, China.

Pengcheng Huai, Furong Li, Zhen Li, Lele Sun, Xi'an Fu, Qing Pan, Gongqi Yu, Zemin Chai, Tongsheng Chu, Zihao Mi, Fangfang Bao, Honglei Wang, Bingni Zhou, Chuan Wang, Yonghu Sun, Guiye Niu, Yuan Zhang, Fanghui Fu, Xiaoqiao Lang, Xiaoling Wang, Hui Zhao, Daina Liu, Hong Liu, Dianchang Liu, Jian Liu, Aiqiang Xu, Furen Zhang,

<h4>Background</h4>Herpes simplex virus type-2 (HSV-2) infection is the main cause of genital ulcer disease and increases the risk of HIV acquisition. Little information is available regards the epidemiological characteristics of HSV-2 among general population in China. The aim of this study was to explore seroprevalence and associated factors of HSV-2 ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2019, 19(1):382]

Cited: 1 time

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Complete genome characterization of three enterovirus C96 isolates in China.

Qian Wang, Feng Ji, Suting Wang, Xiaojuan Lin, Zexin Tao, Aiqiang Xu,

Enterovirus C96 (EV-C96) is a newer member of the species Enterovirus C. In this study, we determined the complete genome sequences of three EV-C96 isolates, one recovered from domestic sewage in 2013 and the other two isolated during surveillance of acute flaccid paralysis cases in 1991 and 2009, respectively. The ... Read more >>

Arch Virol (Archives of virology)
[2019, 164(8):2183-2186]

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Area socioeconomic status is independently associated with esophageal cancer mortality in Shandong, China.

Kou Kou, Peter David Baade, Xiaolei Guo, Michelle Gatton, Susanna Cramb, Zilong Lu, Zhentao Fu, Jie Chu, Aiqiang Xu, Jiandong Sun,

Esophageal cancer (EC) is a leading cause of cancer death in China. Within Shandong Province, a geographic cluster with high EC mortality has been identified, however little is known about how area-level socioeconomic status (SES) is associated with EC mortality in this province. Multilevel models were applied to EC mortality ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):6388]

Cited: 2 times

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Novel astrovirus types circulating in Shandong Province (Eastern China) during 2016: A clinical and environmental surveillance.

Zexin Tao, Haiyan Wang, Wenqiang Zhang, Aiqiang Xu,

<h4>Background</h4>In recent years, several novel astroviruses have been discovered by molecular assays. Their prevalence in many parts of the world remains unclear.<h4>Objectives</h4>To investigate the existence and genetic diversity of novel astroviruses in China.<h4>Study design</h4>Stool specimens were collected from patients suffering gastroenteritis from two hospitals in Jinan city in 2016, and ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2019, 116:69-73]

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Resurgence of Pertussis Infections in Shandong, China: Space-Time Cluster and Trend Analysis.

Yuzhou Zhang, Hilary Bambrick, Kerrie Mengersen, Shilu Tong, Lei Feng, Li Zhang, Guifang Liu, Aiqiang Xu, Wenbiao Hu,

Although vaccination is effective in preventing infection, pertussis remains endemic worldwide, including China. To lead better targeted prevention strategies, we examined dynamics of spatial and temporal patterns of pertussis transmission in Shandong, China, from 2009 to 2017. We used space-time cluster analysis, logistic regression analysis, and regression tree model to ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2019, 100(6):1342-1354]

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Reply.

Tao Li, Jiaye Liu, Li Zhang, Aiqiang Xu,

Hepatology (Hepatology (Baltimore, Md.))
[2019, 69(4):1844]

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Serogroup-specific meningococcal carriage by age group: a systematic review and meta-analysis.

Meagan E Peterson, You Li, Heather Shanks, Rebecca Mile, Harish Nair, Moe H Kyaw, ,

<h4>Objective</h4><i>Neisseria meningitidis</i> carriage prevalence has known variation across the lifespan, but it is unclear whether carriage varies among meningococcal capsular groups. Therefore, we aimed to characterise group-specific meningococcal carriage by age group and world region from 2007 to 2016.<h4>Design</h4>Systematic review and meta-analysis.<h4>Data sources</h4>MEDLINE, Embase, Global Health Database, WHO Global Health ... Read more >>

BMJ Open (BMJ open)
[2019, 9(4):e024343]

Cited: 3 times

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Cardiovascular Diseases Deaths Attributable to High Sodium Intake in Shandong Province, China.

Jiyu Zhang, Xiaolei Guo, Zilong Lu, Junli Tang, Yichong Li, Aiqiang Xu, Shiwei Liu,

Background High sodium intake elevates blood pressure and thereby raises cardiovascular diseases ( CVD s). Sodium intake is high in northern China, including Shandong province where the SMASH (Shandong-Ministry of Health Action on Sodium and Hypertension) is currently underway. Methods and Results Blood pressure values and sodium intake measurements using ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(1):e010737]

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Spatial Analysis of Esophageal Cancer Mortality in a High-risk Population in China: Consistent Clustering Pattern in 1970-74 and 2011-13

Kou Kou, Xiaolei Guo, Peter Baade, Zilong Lu, Zhentao Fu, Jie Chu, Aiqiang Xu, Jiandong Sun,

Purpose: Almost half of the global esophageal cancer (EC) deaths occurred in China. This study aims to examine the geographic spread of EC mortality in two periods in a large Chinese population. Methods: Age-standardized mortality rates (ASMRs) for 140 county-level units in Shandong Province during the periods 1970-74 and 2011-13 were derived using ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2018, 19(11):3161-3166]

Cited: 2 times

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Prevalence, risk factors, and medical costs of Chlamydia trachomatis infections in Shandong Province, China: a population-based, cross-sectional study.

Pengcheng Huai, Furong Li, Zhen Li, Lele Sun, Xi'an Fu, Qing Pan, Gongqi Yu, Zemin Chai, Tongsheng Chu, Zihao Mi, Fangfang Bao, Honglei Wang, Bingni Zhou, Chuan Wang, Yonghu Sun, Guiye Niu, Yuan Zhang, Fanghui Fu, Xiaoqiao Lang, Xiaoling Wang, Hui Zhao, Daina Liu, Hong Liu, Dianchang Liu, Jian Liu, Aiqiang Xu, Furen Zhang,

<h4>Background</h4>A population-based study of Chlamydia trachomatis (CT) infections is essential in designing a specific control program; however, no large investigation of CT infections among the general population in mainland China has been conducted since 2000. We aimed to determine the prevalence, risk factors, and associated medical costs of CT among ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2018, 18(1):534]

Cited: 4 times

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Viral Loads in Congenital Cytomegalovirus Infection From a Highly Immune Population.

Aiqiang Xu, Shiwen Wang, Wenqiang Zhang, Xiaofang Wang, Tongzhan Wang, Xiaolin Liu, Haiyan Wang, Wei Ma, Minal Amin, Sheila Dollard, Chengbin Wang,

Among newborns with congenital cytomegalovirus (CMV) infection from China, there was no difference in CMV viral load in saliva specimens dried and stored at room temperature compared with those kept wet and stored cold, even after longer storage time for the former than the later (74 vs 58 days, P ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2018, 7(3):e160-e162]

Cited: 1 time

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The gap between cause-of-death statistics and Household Registration reports in Shandong, China during 2011-2013: Evaluation and adjustment for underreporting in the mortality data for 262 subcounty level populations.

Jiandong Sun, Xiaolei Guo, Zilong Lu, Zhentao Fu, Xiujun Li, Jie Chu, Gaohui Zhang, Kou Kou, Fuzhong Xue, Aiqiang Xu,

Underreporting is a quality concern in mortality statistics. The purpose of this study was to assess and adjust underreporting in the population-based cause-of-death statistics. The total population (96 million) in Shandong, China was divided into 262 subcounty level populations geographically and by residence type (urban/rural). For each subpopulation, the total ... Read more >>

PLoS One (PloS one)
[2018, 13(6):e0199133]

Cited: 2 times

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