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Author Aimee Jaramillo Lambert

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Endogenous localization of TOP-2 in C. elegans using a C-terminal GFP-tag.

Christine K Rourke, Darline Murat, Tyler J Hansen, Aimee Jaramillo-Lambert,

To investigate the dynamic localization of Topoisomerase II in live <i>C. elegans</i> we have generated a C-terminally GFP-tagged version of TOP-2 at the endogenous locus. We found that TOP-2::GFP localizes in a similar pattern to the previously published TOP-2::3XFLAG strain and does not disrupt the meiotic chromosome segregation functions of ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 0 times

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Identification of Suppressors of top-2 Embryonic Lethality in Caenorhabditis elegans.

Nirajan Bhandari, Christine Rourke, Thomas Wilmoth, Alekya Bheemreddy, David Schulman, Dina Collins, Harold E Smith, Andy Golden, Aimee Jaramillo-Lambert,

Topoisomerase II is an enzyme with important roles in chromosome biology. This enzyme relieves supercoiling and DNA and RNA entanglements generated during mitosis. Recent studies have demonstrated that Topoisomerase II is also involved in the segregation of homologous chromosomes during the first meiotic division. However, the function and regulation of ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2020, 10(4):1183-1191]

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The Identification of a Novel Mutant Allele of topoisomerase II in Caenorhabditis elegans Reveals a Unique Role in Chromosome Segregation During Spermatogenesis.

Aimee Jaramillo-Lambert, Amy S Fabritius, Tyler J Hansen, Harold E Smith, Andy Golden,

Topoisomerase II alleviates DNA entanglements that are generated during mitotic DNA replication, transcription, and sister chromatid separation. In contrast to mitosis, meiosis has two rounds of chromosome segregation following one round of DNA replication. In meiosis II, sister chromatids segregate from each other, similar to mitosis. Meiosis I, on the ... Read more >>

Genetics (Genetics)
[2016, 204(4):1407-1422]

Cited: 13 times

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Mapping challenging mutations by whole-genome sequencing

Harold Smith, Amy Fabritius, Aimee Jaramillo-Lambert, Andy Golden,

<h4>ABSTRACT</h4> Whole-genome sequencing provides a rapid and powerful method for identifying mutations on a global scale, and has spurred a renewed enthusiasm for classical genetic screens in model organisms. The most commonly characterized category of mutation consists of monogenic, recessive traits, due to their genetic tractability. Therefore, most of the ... Read more >>

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Mapping Challenging Mutations by Whole-Genome Sequencing.

Harold E Smith, Amy S Fabritius, Aimee Jaramillo-Lambert, Andy Golden,

Whole-genome sequencing provides a rapid and powerful method for identifying mutations on a global scale, and has spurred a renewed enthusiasm for classical genetic screens in model organisms. The most commonly characterized category of mutation consists of monogenic, recessive traits, due to their genetic tractability. Therefore, most of the mapping ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2016, 6(5):1297-1304]

Cited: 9 times

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Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing.

Aimee Jaramillo-Lambert, Abigail S Fuchsman, Amy S Fabritius, Harold E Smith, Andy Golden,

The production of viable embryos requires the coordination of many cellular processes, including protein synthesis, cytoskeletal reorganization, establishment of polarity, cell migration, cell division, and in Caenorhabditis elegans, eggshell formation. Defects in any of these processes can lead to embryonic lethality. We examined six temperature-sensitive mutants as well as one ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2015, 5(5):1007-1019]

Cited: 14 times

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Acidic nucleoplasmic DNA-binding protein (And-1) controls chromosome congression by regulating the assembly of centromere protein A (CENP-A) at centromeres.

Aimee Jaramillo-Lambert, Jing Hao, Haijie Xiao, Yongming Li, Zhiyong Han, Wenge Zhu,

The centromere is an epigenetically designated chromatin domain that is essential for the accurate segregation of chromosomes during mitosis. The incorporation of centromere protein A (CENP-A) into chromatin is fundamental in defining the centromeric loci. Newly synthesized CENP-A is loaded at centromeres in early G(1) phase by the CENP-A-specific histone ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2013, 288(3):1480-1488]

Cited: 9 times

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The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase.

Yongming Li, Aimee Jaramillo-Lambert, Jing Hao, Yi Yang, Wenge Zhu,

Histone acetyltransferases play important roles in the regulation of chromatin structure and gene transcription. As one of the most important histone acetyltransferases, general control non-derepressible (Gcn) 5 has been linked to diverse cellular processes and tumorigenesis as well. We have recently identified a functional link between Gcn5 and acidic nucleoplasmic ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2011, 286(48):41344-41352]

Cited: 13 times

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Meiotic errors activate checkpoints that improve gamete quality without triggering apoptosis in male germ cells.

Aimee Jaramillo-Lambert, Yuriko Harigaya, Jeffrey Vitt, Anne Villeneuve, JoAnne Engebrecht,

<h4>Background</h4>Meiotic checkpoints ensure the production of gametes with the correct complement and integrity of DNA; in metazoans, these pathways sense errors and transduce signals to trigger apoptosis to eliminate damaged germ cells. The extent to which checkpoints monitor and safeguard the genome differs between sexes and may contribute to the ... Read more >>

Curr Biol (Current biology : CB)
[2010, 20(23):2078-2089]

Cited: 32 times

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A single unpaired and transcriptionally silenced X chromosome locally precludes checkpoint signaling in the Caenorhabditis elegans germ line.

Aimee Jaramillo-Lambert, JoAnne Engebrecht,

In many organisms, female and male meiosis display extensive sexual dimorphism in the temporal meiotic program, the number and location of recombination events, sex chromosome segregation, and checkpoint function. We show here that both meiotic prophase timing and germ-line apoptosis, one output of checkpoint signaling, are dictated by the sex ... Read more >>

Genetics (Genetics)
[2010, 184(3):613-628]

Cited: 22 times

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Differential timing of S phases, X chromosome replication, and meiotic prophase in the C. elegans germ line.

Aimee Jaramillo-Lambert, Marina Ellefson, Anne M Villeneuve, JoAnne Engebrecht,

The replication of chromosomes in meiosis is an important first step for subsequent chromosomal interactions that promote accurate disjunction in the first of two segregation events to generate haploid gametes. We have developed an assay to monitor DNA replication in vivo in mitotic and meiotic germline nuclei of the nematode ... Read more >>

Dev Biol (Developmental biology)
[2007, 308(1):206-221]

Cited: 123 times

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