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Author Aikou Okamoto

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FIGO staging for carcinoma of the vulva: 2021 revision.

Alexander B Olawaiye, Joseph Cotler, Mauricio A Cuello, Neerja Bhatla, Aikou Okamoto, Sarikapan Wilailak, Chittaranjan N Purandare, Gerhard Lindeque, Jonathan S Berek, Sean Kehoe,

To revise the FIGO staging for carcinoma of the vulva using a new approach that involves analyses of prospectively collected data. The FIGO Committee for Gynecologic Oncology reviewed the recent literature to gain an insight into the impact of the 2009 vulvar cancer staging revision. The Committee resolved to revise ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):43-47]

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Nivolumab Versus Gemcitabine or Pegylated Liposomal Doxorubicin for Patients With Platinum-Resistant Ovarian Cancer: Open-Label, Randomized Trial in Japan (NINJA).

Junzo Hamanishi, Nobuhiro Takeshima, Noriyuki Katsumata, Kimio Ushijima, Tadashi Kimura, Satoshi Takeuchi, Koji Matsumoto, Kimihiko Ito, Masaki Mandai, Hidekatsu Nakai, Noriaki Sakuragi, Hidemichi Watari, Nobutaka Takahashi, Hidenori Kato, Kosei Hasegawa, Kan Yonemori, Mika Mizuno, Kazuhiro Takehara, Hitoshi Niikura, Takashi Sawasaki, Sari Nakao, Toshiaki Saito, Takayuki Enomoto, Satoru Nagase, Nao Suzuki, Takashi Matsumoto, Eiji Kondo, Kenzo Sonoda, Satomi Aihara, Yoichi Aoki, Aikou Okamoto, Hirokuni Takano, Hiroshi Kobayashi, Hisamori Kato, Yoshito Terai, Akira Takazawa, Yusuke Takahashi, Yoshinobu Namba, Daisuke Aoki, Keiichi Fujiwara, Toru Sugiyama, Ikuo Konishi,

[Figure: see text]. ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, :JCO2100334]

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Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cells.

Akiko Tanuma-Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Ryo Takagi, Ayumi Yamaguchi, Osamu Samura, Hidenori Akutsu, Haruhiko Sago, Tohru Kiyono, Aikou Okamoto, Akihiro Umezawa,

<h4>Background</h4>An extra copy of chromosome 21 in humans can alter cellular phenotypes as well as immune and metabolic systems. Down syndrome is associated with many health-related problems and age-related disorders including dermatological abnormalities. However, few studies have focused on the impact of trisomy 21 (T21) on epidermal stem cells and ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2021, 12(1):476]

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A multi-ethnic analysis of immune-related gene expression signatures in patients with ovarian clear cell carcinoma.

Valerie Heong, Tuan Z Tan, Maiko Miwa, Jieru Ye, Diana Lim, C Simon Herrington, Yasushi Iida, Mitsutake Yano, Masanori Yasuda, Natalie Yl Ngoi, Sb Justin Wong, Aikou Okamoto, Charlie Gourley, Kosei Hasegawa, David Sp Tan, Ruby Yj Huang,

Little is known about the immune environment of ovarian clear cell carcinoma (OCCC) and its impact on various ethnic backgrounds. The aim of this OCCC immune-related gene expression signatures (irGES) study was to address the interaction between tumour and immune environment of ethnically-diverse Asian and Caucasian populations and to identify ... Read more >>

J Pathol (The Journal of pathology)
[2021, :]

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Isolation and characterization of fetal nucleated red blood cells from maternal blood as a target for single cell sequencing-based non-invasive genetic testing.

Noriko Ito, Kazuhiro Tsukamoto, Kosuke Taniguchi, Ken Takahashi, Aikou Okamoto, Hiroaki Aoki, Yuka Otera-Takahashi, Michihiro Kitagawa, Hiroko Ogata-Kawata, Hideaki Morita, Kenichiro Hata, Kazuhiko Nakabayashi,

<h4>Purpose</h4>Although non-invasive prenatal testing (NIPT) based on cell-free DNA (cfDNA) in maternal plasma has been prevailing worldwide, low levels of fetal DNA fraction may lead to false-negative results. Since fetal cells in maternal blood provide a pure source of fetal genomic DNA, we aimed to establish a workflow to isolate ... Read more >>

Reprod Med Biol (Reproductive medicine and biology)
[2021, 20(3):352-360]

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A rare case of heterotopic pregnancy after a single embryo transfer: A case report and literature review.

Satoshi Hosoya, Yuta Kasahara, Hiromi Komazaki, Hiroshi Kishi, Hirokuni Takano, Aikou Okamoto,

Heterotopic pregnancy (HP) is a rare but life-threatening disease. We report a rare case of HP that occurred after single embryo transfer (SET) with spontaneous natural pregnancy possibly due to sexual intercourse (SI) during assisted reproductive technology treatment and reviewed previous reports. A 39-year-old woman at 7 weeks 5 days' gestation with ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, :]

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Alteration of circulating cell-free DNA level by external cephalic version: A potential biomarker for direct evaluation of placental damage.

Keiko Yabuzaki, Taizan Kamide, Ruriko Ejima, Yuto Tsuruoka, Mariko Sato, Ibuki Kondo, Akihiro Hasegawa, Taisuke Sato, Osamu Samura, Aikou Okamoto,

<h4>Aim</h4>To confirm that variations in cell-free fetal DNA (cffDNA) are indicators of external placental damage, we quantitatively investigated cffDNA alterations in maternal peripheral blood during external cephalic version (ECV).<h4>Methods</h4>We recruited 48 singleton pregnant women who underwent ECV in our hospital. Before and immediately after ECV, we harvested 10 ml of maternal ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, 47(9):3144-3150]

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Prenatal enzyme replacement therapy for Akp2 -/- mice with lethal hypophosphatasia.

Akihiro Hasegawa, Aki Nakamura-Takahashi, Masataka Kasahara, Nana Saso, Sonoko Narisawa, José Luis Millán, Osamu Samura, Haruhiko Sago, Aikou Okamoto, Akihiro Umezawa,

Hypophosphatasia (HPP) is a congenital skeletal disease. Impairment of bone mineralization and seizures are due to a deficiency of tissue-nonspecific alkaline phosphatase (TNAP). Enzyme replacement therapy (ERT) is available as a highly successful treatment for pediatric-onset HPP. However, the potential for prenatal ERT has not been fully investigated to date. ... Read more >>

Regen Ther (Regenerative therapy)
[2021, 18:168-175]

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Total parietal peritonectomy in primary debulking surgery for advanced ovarian cancer.

Kota Yokosu, Hiroshi Tanabe, Shogo Nomura, Hirokazu Ozone, Motoaki Saito, Hirokuni Takano, Aikou Okamoto,

The object of this study is to evaluate the clinical safety and efficacy of total parietal peritonectomy (TPP) in primary debulking surgery (PDS) for advanced ovarian cancer. This retrospective single-center study analyzed 16 patients with FIGO stages IIIC-IVB epithelial ovarian cancer who underwent TPP in PDS and achieved macroscopically complete ... Read more >>

Gynecol Oncol Rep (Gynecologic oncology reports)
[2021, 37:100805]

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Progression-free survival by investigator versus blinded independent central review in newly diagnosed patients with high-grade serous ovarian cancer: Analysis of the VELIA/GOG-3005 trial.

Carol Aghajanian, Michael A Bookman, Gini F Fleming, Elizabeth M Swisher, Karina D Steffensen, Michael Friedlander, Aikou Okamoto, Camille Gunderson Jackson, Danielle Sullivan, Christine K Ratajczak, Robert L Coleman,

<h4>Objective</h4>In the phase 3 VELIA/GOG-3005 trial, veliparib added to carboplatin-paclitaxel and continued as maintenance improved progression-free survival (PFS) compared to carboplatin-paclitaxel alone in patients with newly diagnosed ovarian carcinoma. Primary analysis of PFS was by investigator (INV) assessment, with a supplemental analysis of PFS by blinded independent central review (BICR).<h4>Methods</h4>Patients ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 162(2):375-381]

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Treatment Strategies for ARID1A-Deficient Ovarian Clear Cell Carcinoma.

Kazuaki Takahashi, Masataka Takenaka, Aikou Okamoto, David D L Bowtell, Takashi Kohno,

Ovarian clear cell carcinoma (OCCC) is a histological subtype of ovarian cancer that is more frequent in Asian countries (~25% of ovarian cancers) than in US/European countries (less than 10%). OCCC is refractory to conventional platinum-based chemotherapy, which is effective against high-grade serous carcinoma (HGSC), a major histological subtype of ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(8):]

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Initiatives and achievements of the Japanese Society of Obstetrics and Gynecology, Obstetrics and Gynecology MIRAI Committee 2020.

Hiroaki Komatsu, Hidemichi Watari, Yohei Onodera, Tokumasa Suemitsu, Satoshi Nakagawa, Tae Kusabiraki, Yusuke Matoba, Kei Ihira, Nozomu Yanaihara, Kouji Banno, Aikou Okamoto, Makio Shozu, Tadashi Kimura, ,

<h4>Backgrounds</h4>In 2013, the total number of obstetrician-gynecologists decreased. The Japanese Society of Obstetrics and Gynecology established the Obstetrics and Gynecology MIRAI Committee in 2015. Within the MIRAI Committee, Japanese Trainees in Obstetrics and Gynecology (JTOG) was established; it was comprised of 20 promising young obstetrician-gynecologists recommended from regions across Japan. ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, 47(6):1973-1977]

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Analysis of Surgical Procedure of Four Cases of Ovarian Pregnancies Treated with Laparoscopic Surgery.

Yuta Kasahara, Ryo Yokomizo, Kazu Ueda, Rei Makishima, Hiroshi Kishi, Aikou Okamoto,

Ovarian pregnancy is a rare disease, accounting for 0.5%-3% of ectopic pregnancies. Ovarian pregnancy risk factors and preoperative diagnosis have been extensively reported. However, its histopathology and surgical findings have been poorly studied. To examine appropriate surgical procedures, we investigated the clinical features, surgical findings, and histopathological examinations of four ... Read more >>

Gynecol Minim Invasive Ther (Gynecology and minimally invasive therapy)
[2021, 10(2):117-120]

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Follicular development during hormone replacement therapy in patients with premature ovarian insufficiency.

Takuma Sato, Atsuko Kusuhara, Yuta Kasahara, Takayuki Haino, Hiroshi Kishi, Aikou Okamoto,

<h4>Purpose</h4>To provide information about the relationship between follow-up period and follicular development in patients with infertility due to premature ovarian insufficiency (POI) who are undergoing hormone replacement therapy (HRT). It is necessary to detect follicle development for artificial insemination or in vitro fertilization.<h4>Methods</h4>This retrospective cohort study was conducted at a ... Read more >>

Reprod Med Biol (Reproductive medicine and biology)
[2021, 20(2):234-240]

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Atezolizumab, Bevacizumab, and Chemotherapy for Newly Diagnosed Stage III or IV Ovarian Cancer: Placebo-Controlled Randomized Phase III Trial (IMagyn050/GOG 3015/ENGOT-OV39).

Kathleen N Moore, Michael Bookman, Jalid Sehouli, Austin Miller, Charles Anderson, Giovanni Scambia, Tashanna Myers, Cagatay Taskiran, Katina Robison, Johanna Mäenpää, Lyndsay Willmott, Nicoletta Colombo, Jessica Thomes-Pepin, Michalis Liontos, Michael A Gold, Yolanda Garcia, Sudarshan K Sharma, Christopher J Darus, Carol Aghajanian, Aikou Okamoto, Xiaohua Wu, Rustem Safin, Fan Wu, Luciana Molinero, Vidya Maiya, Victor K Khor, Yvonne G Lin, Sandro Pignata,

<h4>Purpose</h4>To evaluate the addition of the humanized monoclonal antiprogrammed death ligand-1 (PD-L1) antibody, atezolizumab, to platinum-based chemotherapy and bevacizumab in newly diagnosed stage III or IV ovarian cancer (OC).<h4>Methods</h4>This multicenter placebo-controlled double-blind randomized phase III trial (ClinicalTrials.gov identifier: NCT03038100) enrolled patients with newly diagnosed untreated International Federation of Gynecology and ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, 39(17):1842-1855]

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Interleukin-6 as an enhancer of anti-angiogenic therapy for ovarian clear cell carcinoma.

Toshiyuki Seki, Nozomu Yanaihara, Jason Solomon Shapiro, Misato Saito, Junya Tabata, Ryo Yokomizo, Daito Noguchi, Takafumi Kuroda, Ayako Kawabata, Jiro Suzuki, Kazuaki Takahashi, Haruka Matsuzawa, Misayo Miyake, Masataka Takenaka, Yasushi Iida, Satoshi Yanagida, Aikou Okamoto,

Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer (EOC) that is associated with elevated interleukin-6 (IL-6) expression, resistance to chemotherapy, and increased mortality. Although bevacizumab (Bev) is a widely used anti-angiogenic agent for EOC, the efficacy of Bev and the role of IL-6 in modulating angiogenesis ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):7689]

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Neoadjuvant Chemotherapy for Patients With Diaphragmatic Lesions: A Prognostic Postoperative Analysis.

Motoaki Saito, Suguru Odajima, Masahiro Ezawa, Yasushi Iida, Kazu Ueda, Nozomu Yanaihara, Hiroshi Tanabe, Hirokuni Takano, Kyosuke Yamada, Aikou Okamoto,

<h4>Background/aim</h4>We aimed to analyse the prognosis of patients who underwent primary debulking surgery (PDS) and those who underwent interval debulking surgery (IDS) following four courses of paclitaxel+ carboplatin as preoperative chemotherapy to examine the usefulness of preoperative chemotherapy.<h4>Patients and methods</h4>We included 45 patients with epithelial ovarian and peritoneal cancers accompanied ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2020, 34(3):1277-1281]

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The Scenario of Adoption and Foster Care in Relation to the Reproductive Medicine Practice in Asia.

Eriko Shiraishi, Seido Takae, Ahmad Mohd Faizal, Kohei Sugimoto, Aikou Okamoto, Nao Suzuki,

In vitro fertilization (IVF) is a hallmark of reproductive medicine. However, the inconclusive outcome leads to marital disharmonies; thus, the choices of gamete donation and surrogacy (GD/S) are often offered. In restricted countries, the child-rearing choice through foster/adoption care is promising, but the uptake remains low. We explore the current ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(7):]

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Safety assessment of the prophylactic use of silicone gel sheets (Lady Care®) for the prevention of hypertrophic scars following caesarean section.

Yuki Ito, Akiko Konishi, Miki Okubo, Takuma Sato, Akihiro Hasegawa, Keiko Yabuzaki, Tomona Matsuoka, Michihiro Yamamura, Momoko Inoue, Haruhiko Udagawa, Kazuhiro Kajiwara, Taizan Kamide, Hiroaki Aoki, Osamu Samura, Aikou Okamoto,

This study aimed to investigate the side effects of silicone gel sheet (Lady Care<sup>®</sup>) and evaluate its prophylactic efficacy in preventing abnormal scarring. Sixty women who underwent caesarean section were recruited from September 2016 to September 2017 in this prospective study. Lady Care<sup>®</sup> was applied from the 2nd to the ... Read more >>

J Obstet Gynaecol (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology)
[2021, 41(3):380-384]

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Follicular development during hormone replacement therapy in patients with premature ovarian insufficiency

Takuma Sato, Atsuko Kusuhara, Yuta Kasahara, Takayuki Haino, Hiroshi Kishi, Aikou Okamoto,

Abstract <h4>Purpose</h4> To provide information about the relationship between follow‐up period and follicular development in patients with infertility due to premature ovarian insufficiency (POI) who are undergoing hormone replacement therapy (HRT). It is necessary to detect follicle development for artificial insemination or in vitro fertilization. <h4>Methods</h4> This retrospective cohort study ... Read more >>

Reprod Med Biol (Reproductive medicine and biology)
[2021, 20(2):234-240]

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Risk factors and outcomes of abnormal bleeding after external cephalic version.

Hitoshi Matsui, Kohei Ogawa, Aikou Okamoto, Haruhiko Sago,

<h4>Objectives</h4>To present the consequences of and risk factors for abnormal bleeding after ECV (external cephalic version).<h4>Methods</h4>We conducted a retrospective chart review at a single center in Japan. Abnormal bleeding was defined as vaginal bleeding and/or intrauterine hemorrhage. We descriptively assessed birth outcomes among women with abnormal bleeding, and investigated the ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2021, 49(6):733-739]

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E2F5 Promotes the Malignancy of Ovarian Cancer Via the Regulation of Hippo and Wnt Pathways.

Shika Hanif Malgundkar, Ikram Burney, Mansour Al Moundhri, Moza Al Kalbani, Ritu Lakhtakia, Aikou Okamoto, Yahya Tamimi,

<b><i>Background:</i></b> <i>E2F5</i> is a transcription factor that is overexpressed in the early stages of ovarian cancer and has been suggested as a potential biomarker for early detection. In this study, we aimed to examine the role of <i>E2F5</i> in invasion and proliferation of ovarian cancer cells. <b><i>Materials and Methods:</i></b> We ... Read more >>

Genet Test Mol Biomarkers (Genetic testing and molecular biomarkers)
[2021, 25(3):179-186]

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Endometrial regeneration with endometrial epithelium: homologous orchestration with endometrial stroma as a feeder.

Ryo Yokomizo, Yukiko Fujiki, Harue Kishigami, Hiroshi Kishi, Tohru Kiyono, Sanae Nakayama, Haruhiko Sago, Aikou Okamoto, Akihiro Umezawa,

<h4>Background</h4>Thin endometrium adversely affects reproductive success rates with fertility treatment. Autologous transplantation of exogenously prepared endometrium can be a promising therapeutic option for thin endometrium; however, endometrial epithelial cells have limited expansion potential, which needs to be overcome in order to make regenerative medicine a therapeutic strategy for refractory thin ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2021, 12(1):130]

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Re-thinking the prognostic significance of positive peritoneal cytology in endometrial cancer.

Masataka Takenaka, Misato Kamii, Yasushi Iida, Nozomu Yanaihara, Jiro Suzuki, Kazuaki Takahashi, Satoshi Yanagida, Motoaki Saito, Hirokuni Takano, Kyosuke Yamada, Aikou Okamoto,

<h4>Background</h4>Whether abnormal peritoneal cytology (PC) is an independent prognostic factor in endometrial cancer (EC) remains controversial. This study aimed to re-think the prognostic significance of PC in not only all EC patients but also in various subgroups with similar clinicopathological and biological characteristics.<h4>Methods</h4>EC patients who underwent primary surgery of at ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 161(1):135-142]

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First Biomedical Science Conference in Oman: 26-27 February 2020.

Sultan Qaboos Univ Med J (Sultan Qaboos University medical journal)
[2021, 21(1):e146-e159]

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