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Author Ahsan Akram

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GB0139, an inhaled small molecule inhibitor of galectin-3, in COVID-19 pneumonitis: a randomised, controlled, open-label, phase 2a experimental medicine trial of safety, pharmacokinetics, and potential therapeutic value

Erin Gaughan, Tariq Sethi, Tom Quinn, Nikhil Hirani, Andrew Mills, Annya Bruce, Alison MacKinnon, Vassilios Aslanis, Feng Li, Richard O’Connor, Richard Parker, John Norrie, James Dear, Ahsan Akram, Oliver Koch, Jie Wang-Jairaj, Robert Slack, Lise Gravelle, Bertil Lindmark, Kevin Dhaliwal,

<h4>Rationale</h4> High galectin-3 levels predict poor outcomes in patients with COVID-19. Galectin-3 activates monocytes and macrophages which are directly implicated in COVID-19 immunopathology and the cytokine storm. GB0139 is a potent thiodigalactoside galectin-3 inhibitor and may reduce the severe effects of the disease. We report safety and pharmacokinetics and pharmacodynamics ... Read more >>

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Evaluation of new or repurposed treatments for COVID-19: protocol for the phase Ib/IIa DEFINE trial platform.

Erin Gaughan, Tom Quinn, Annya Bruce, Jean Antonelli, Vikki Young, Joanne Mair, Ahsan Akram, Nik Hirani, Oliver Koch, Claire Mackintosh, John Norrie, James W Dear, Kevin Dhaliwal,

<h4>Introduction</h4>COVID-19 is a new viral-induced pneumonia caused by infection with a novel coronavirus, SARS-CoV-2. At present, there are few proven effective treatments. This early-phase experimental medicine protocol describes an overarching and adaptive trial designed to provide safety data in patients with COVID-19, pharmacokinetic (PK)/pharmacodynamic (PD) information and exploratory biological surrogates ... Read more >>

BMJ Open (BMJ open)
[2021, 11(12):e054442]

Cited: 1 time

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Full spectrum fluorescence lifetime imaging with 0.5 nm spectral and 50 ps temporal resolution.

Gareth O S Williams, Elvira Williams, Neil Finlayson, Ahmet T Erdogan, Qiang Wang, Susan Fernandes, Ahsan R Akram, Kev Dhaliwal, Robert K Henderson, John M Girkin, Mark Bradley,

The use of optical techniques to interrogate wide ranging samples from semiconductors to biological tissue for rapid analysis and diagnostics has gained wide adoption over the past decades. The desire to collect ever more spatially, spectrally and temporally detailed optical signatures for sample characterization has specifically driven a sharp rise ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):6616]

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Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19.

Clark D Russell, Asta Valanciute, Naomi N Gachanja, Jillian Stephen, Rebekah Penrice-Randal, Stuart D Armstrong, Sara Clohisey, Bo Wang, Wael Al Qsous, William A Wallace, Gabriel C Oniscu, Jo Stevens, David J Harrison, Kevin Dhaliwal, Julian A Hiscox, J Kenneth Baillie, Ahsan R Akram, David A Dorward, Christopher D Lucas,

Immunopathology occurs in the lung and spleen in fatal COVID-19, involving monocytes/macrophages and plasma cells. Anti-inflammatory therapy reduces mortality but additional therapeutic targets are required. We aimed to gain mechanistic insight into COVID-19 immunopathology by targeted proteomic analysis of pulmonary and splenic tissues. Lung parenchymal and splenic tissue was obtained ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2021, :]

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River Tea Tree Oil: Composition, Antimicrobial and Antioxidant Activities, and Potential Applications in Agriculture.

Mursleen Yasin, Adnan Younis, Talha Javed, Ahsan Akram, Muhammad Ahsan, Rubab Shabbir, Muhammad Moaaz Ali, Ayesha Tahir, Enas M El-Ballat, Mohamed S Sheteiwy, Reda Helmy Sammour, Christophe Hano, Fahad A Alhumaydhi, Mohamed A El-Esawi,

Melaleuca is one of the genera of the Myrtaceae family enriched in tea tree oil (TTO). Tea tree oils of <i>Melaleuca bracteata</i> and <i>Melaleuca alternifolia</i> are of prime importance and have antioxidant and antimicrobial properties. Terpinen-4-ol and 1-8 cineole are major constituents of <i>M. alternifolia</i> oil. The percentages of the ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2021, 10(10):]

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Deciphering Mesenchymal Drivers of Human Dupuytren's Disease at Single-Cell Level.

Ross Dobie, Chris C West, Beth E P Henderson, John R Wilson-Kanamori, Dyana Markose, Laura J Kitto, Jordan R Portman, Mariana Beltran, Sadaf Sohrabi, Ahsan R Akram, Prakash Ramachandran, Li Yenn Yong, Dominique Davidson, Neil C Henderson,

Dupuytren's disease (DD) is a common, progressive fibroproliferative disease affecting the palmar fascia of the hands, causing fingers to irreversibly flex toward the palm with significant loss of function. Surgical treatments are limited; therefore, effective new therapies for DD are urgently required. To identify the key cellular and molecular pathways ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2022, 142(1):114-123.e8]

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T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer.

Richard A O'Connor, Vishwani Chauhan, Layla Mathieson, Helen Titmarsh, Lilian Koppensteiner, Irene Young, Guilia Tagliavini, David A Dorward, Sandrine Prost, Kevin Dhaliwal, William A Wallace, Ahsan R Akram,

The success of immune checkpoint therapy shows tumor-reactive T cells can eliminate cancer cells but are restrained by immunosuppression within the tumor micro-environment (TME). Cancer associated fibroblasts (CAFs) are the dominant stromal cell in the TME and co-localize with T cells in non-small cell lung cancer. We demonstrate the bidirectional ... Read more >>

Oncoimmunology (Oncoimmunology)
[2021, 10(1):1940675]

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Sub millimetre flexible fibre probe for background and fluorescence free Raman spectroscopy.

Stephanos Yerolatsitis, András Kufcsák, Katjana Ehrlich, Harry A C Wood, Susan Fernandes, Tom Quinn, Vikki Young, Irene Young, Katie Hamilton, Ahsan R Akram, Robert R Thomson, Keith Finlayson, Kevin Dhaliwal, James M Stone,

Using the shifted-excitation Raman difference spectroscopy technique and an optical fibre featuring a negative curvature excitation core and a coaxial ring of high numerical aperture collection cores, we have developed a portable, background and fluorescence free, endoscopic Raman probe. The probe consists of a single fibre with a diameter of ... Read more >>

J Biophotonics (Journal of biophotonics)
[2021, 14(10):e202000488]

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Mechanisms and Stages of Covid-19 Immunopathology Revealed by Tissue-Specific Proteomes

Clark Donald Russell, Asta Valanciute, Naomi Gachanja, Jillian Stephen, Rebekah Penrice-Randal, Stuart Armstrong, Sara Clohisey, Bo Wang, Wael Al Qsous, William Wallace, Gabriel Oniscu, Jo Stevens, David Harrison, Kevin Dhaliwal, Julian Hiscox, Kenneth Baillie, Ahsan Akram, David Dorward, Christopher Lucas,

Background: Tissue inflammation in fatal COVID-19 is concentrated in the lung and spleen. Anti-inflammatory therapy reduces mortality but knowledge on the host response at the level of inflamed tissues is incomplete. <br><br>Methods: We performed targeted proteomic analysis of pulmonary and splenic tissues from 13 fatal cases of COVID-19 ... Read more >>

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Systematic review of studies investigating ventilator associated pneumonia diagnostics in intensive care.

Basem Al-Omari, Peter McMeekin, A Joy Allen, Ahsan R Akram, Sara Graziadio, Jana Suklan, William S Jones, B Clare Lendrem, Amanda Winter, Milo Cullinan, Joanne Gray, Kevin Dhaliwal, Timothy S Walsh, Thomas H Craven,

<h4>Background</h4>Ventilator-associated pneumonia (VAP) is an important diagnosis in critical care. VAP research is complicated by the lack of agreed diagnostic criteria and reference standard test criteria. Our aim was to review which reference standard tests are used to evaluate novel index tests for suspected VAP.<h4>Methods</h4>We conducted a comprehensive search using ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2021, 21(1):196]

Cited: 1 time

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Solitary pulmonary nodule imaging approaches and the role of optical fibre-based technologies.

Susan Fernandes, Gareth Williams, Elvira Williams, Katjana Ehrlich, James Stone, Neil Finlayson, Mark Bradley, Robert R Thomson, Ahsan R Akram, Kevin Dhaliwal,

Solitary pulmonary nodules (SPNs) are a clinical challenge, given there is no single clinical sign or radiological feature that definitively identifies a benign from a malignant SPN. The early detection of lung cancer has a huge impact on survival outcome. Consequently, there is great interest in the prompt diagnosis, and ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(3):]

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Corrigendum: The Emerging Role of the c-MET-HGF Axis in Non-small Cell Lung Cancer Tumor Immunology and Immunotherapy.

Helen F Titmarsh, Richard O'Connor, Kevin Dhaliwal, Ahsan R Akram,

[This corrects the article DOI: 10.3389/fonc.2020.00054.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1516]

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Molecular detection of Gram-positive bacteria in the human lung through an optical fiber-based endoscope.

Bethany Mills, Alicia Megia-Fernandez, Dominic Norberg, Sheelagh Duncan, Adam Marshall, Ahsan R Akram, Thomas Quinn, Irene Young, Annya M Bruce, Emma Scholefield, Gareth O S Williams, Nikola Krstajić, Tushar R Choudhary, Helen E Parker, Michael G Tanner, Kerrianne Harrington, Harry A C Wood, Timothy A Birks, Jonathan C Knight, Christopher Haslett, Kevin Dhaliwal, Mark Bradley, Muhammed Ucuncu, James M Stone,

<h4>Purpose</h4>The relentless rise in antimicrobial resistance is a major societal challenge and requires, as part of its solution, a better understanding of bacterial colonization and infection. To facilitate this, we developed a highly efficient no-wash red optical molecular imaging agent that enables the rapid, selective, and specific visualization of Gram-positive ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, 48(3):800-807]

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A matrix metalloproteinase activation probe for painting human tumours.

Bethany Mills, Dominic Norberg, Kevin Dhaliwal, Ahsan R Akram, Mark Bradley, Alicia Megia-Fernandez,

A probe that allows specific 'painting' of human tumours is described. Probe activation was mediated by specific matrix metalloproteinases, resulting not only in disruption of a FRET pair, but in the generation of a fragment that "fluorescently paints" human tumours. This probe demonstrated rapid and effective human tumour labelling with ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(69):9962-9965]

Cited: 1 time

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Cadmium Partitioning, Physiological and Oxidative Stress Responses in Marigold (Calendula calypso) Grown on Contaminated Soil: Implications for Phytoremediation.

Amjad Farooq, Muhammad Nadeem, Ghulam Abbas, Arslan Shabbir, Muhammad Shafique Khalid, Hafiz Muhammad Rashad Javeed, Muhammad Farhan Saeed, Ahsan Akram, Adnan Younis, Gulzar Akhtar,

Marigold (Calendula calypso) is a multipurpose ornamental plant, but its cadmium (Cd) tolerance and phytoremediation potential is unknown. The proposed study was carried out to unravel Cd partitioning, physiological and oxidative stress responses of C. calypso grown under Cd stress. Plants were grown for four months in pots having different ... Read more >>

Bull Environ Contam Toxicol (Bulletin of environmental contamination and toxicology)
[2020, 105(2):270-276]

Cited: 1 time

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Deep Learning in ex-vivo Lung Cancer Discrimination using Fluorescence Lifetime Endomicroscopic Images.

Qiang Wang, James R Hopgood, Neil Finlayson, Gareth O S Williams, Susan Fernandes, Elvira Williams, Ahsan Akram, Kevin Dhaliwal, Marta Vallejo,

Fluorescence lifetime is effective in discriminating cancerous tissue from normal tissue, but conventional discrimination methods are primarily based on statistical approaches in collaboration with prior knowledge. This paper investigates the application of deep convolutional neural networks (CNNs) for automatic differentiation of ex-vivo human lung cancer via fluorescence lifetime imaging. Around ... Read more >>

Annu Int Conf IEEE Eng Med Biol Soc (Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference)
[2020, 2020:1891-1894]

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The Emerging Role of the c-MET-HGF Axis in Non-small Cell Lung Cancer Tumor Immunology and Immunotherapy.

Helen F Titmarsh, Richard O'Connor, Kevin Dhaliwal, Ahsan R Akram,

Study of the c-Met-HGF axis in non-small cell lung cancer (NSCLC) has focused on the roles of c-MET signaling in neoplastic epithelial cells and the secretion of its ligand hepatocyte growth factor (HGF) by tumor stromal cells. However, there is increasing evidence that some leukocyte sub-sets also express c-MET raising ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:54]

Cited: 5 times

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Bayesian bacterial detection using irregularly sampled optical endomicroscopy images.

Ahmed Karam Eldaly, Yoann Altmann, Ahsan Akram, Paul McCool, Antonios Perperidis, Kevin Dhaliwal, Stephen McLaughlin,

Pneumonia is a major cause of morbidity and mortality of patients in intensive care. Rapid determination of the presence and gram status of the pathogenic bacteria in the distal lung may enable a more tailored treatment regime. Optical Endomicroscopy (OEM) is an emerging medical imaging platform with preclinical and clinical ... Read more >>

Med Image Anal (Medical image analysis)
[2019, 57:18-31]

Cited: 1 time

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Enhanced avidity from a multivalent fluorescent antimicrobial peptide enables pathogen detection in a human lung model.

Ahsan R Akram, Nicolaos Avlonitis, Emma Scholefield, Marc Vendrell, Neil McDonald, Tashfeen Aslam, Thomas H Craven, Calum Gray, David S Collie, Andrew J Fisher, Paul A Corris, Timothy Walsh, Christopher Haslett, Mark Bradley, Kevin Dhaliwal,

Rapid in situ detection of pathogens coupled with high resolution imaging in the distal human lung has the potential to provide new insights and diagnostic utility in patients in whom pneumonia is suspected. We have previously described an antimicrobial peptide (AMP) Ubiquicidin (fragment UBI<sub>29-41</sub>) labelled with an environmentally sensitive fluorophore ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):8422]

Cited: 4 times

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In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A.

Ahsan R Akram, Sunay V Chankeshwara, Emma Scholefield, Tashfeen Aslam, Neil McDonald, Alicia Megia-Fernandez, Adam Marshall, Bethany Mills, Nicolaos Avlonitis, Thomas H Craven, Annya M Smyth, David S Collie, Calum Gray, Nik Hirani, Adam T Hill, John R Govan, Timothy Walsh, Christopher Haslett, Mark Bradley, Kevin Dhaliwal,

Respiratory infections in mechanically ventilated patients caused by Gram-negative bacteria are a major cause of morbidity. Rapid and unequivocal determination of the presence, localization, and abundance of bacteria is critical for positive resolution of the infections and could be used for patient stratification and for monitoring treatment efficacy. Here, we ... Read more >>

Sci Transl Med (Science translational medicine)
[2018, 10(464):]

Cited: 19 times

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Low-cost high sensitivity pulsed endomicroscopy to visualize tricolor optical signatures.

Nikola Krstajić, Bethany Mills, Ian Murray, Adam Marshall, Dominic Norberg, Thomas H Craven, Philip Emanuel, Tushar R Choudhary, Gareth O S Williams, Emma Scholefield, Ahsan R Akram, Andrew Davie, Nik Hirani, Annya Bruce, Anne Moore, Mark Bradley, Kevin Dhaliwal,

A highly sensitive, modular three-color fluorescence endomicroscopy imaging platform spanning the visible to near-infrared (NIR) range is demonstrated. Light-emitting diodes (LEDs) were sequentially pulsed along with the camera acquisition to provide up to 20 frames per second (fps) three-color imaging performance or 60 fps single color imaging. The system was characterized ... Read more >>

J Biomed Opt (Journal of biomedical optics)
[2018, 23(7):1-12]

Cited: 9 times

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Super-silent FRET Sensor Enables Live Cell Imaging and Flow Cytometric Stratification of Intracellular Serine Protease Activity in Neutrophils.

Thomas H Craven, Nicolaos Avlonitis, Neil McDonald, Tashfeen Walton, Emma Scholefield, Ahsan R Akram, Timothy S Walsh, Chris Haslett, Mark Bradley, Kevin Dhaliwal,

Serine proteases are released by neutrophils to act primarily as antimicrobial proteins but excessive and unbalanced serine protease activity results in serious host tissue damage. Here the synthesis of a novel chemical sensor based on a multi-branched fluorescence quencher is reported. It is super-silent, exhibiting no fluorescence until de-quenched by ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):13490]

Cited: 9 times

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Development of an alveolar transbronchial catheter for concurrent fiber optics based imaging and fluid delivery.

Nathan Knighton, Brian Cottle, Veronique Dentan, Tom Vercauteren, Ahsan Akram, Annya Bruce, Kevin Dhaliwal, Robert Hitchcock,

Optical molecular imaging is an emerging field and high resolution optical imaging of the distal lung parenchyma has been made possible with the advent of clinically approved fiber based imaging modalities. However, currently, there is no single method of allowing the simultaneous imaging and delivery of targeted molecular imaging agents. ... Read more >>

J Med Device (Journal of medical devices)
[2018, 12(3):]

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British Thoracic Society quality standards for the investigation and management of pulmonary nodules.

David Baldwin, Matthew Callister, Ahsan Akram, Paul Cane, Jeanette Draffan, Kevin Franks, Fergus Gleeson, Richard Graham, Puneet Malhotra, Philip Pearson, Manil Subesinghe, David Waller, Ian Woolhouse,

<h4>Introduction</h4>The purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for the investigation and management of pulmonary nodules in the UK, together with measurable markers of good practice.<h4>Methods</h4>Development of British Thoracic Society ... Read more >>

BMJ Open Respir Res (BMJ open respiratory research)
[2018, 5(1):e000273]

Cited: 2 times

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Optical Screening of Novel Bacteria-specific Probes on Ex Vivo Human Lung Tissue by Confocal Laser Endomicroscopy.

Bethany Mills, Ahsan R Akram, Emma Scholefield, Mark Bradley, Kevin Dhaliwal,

Improving the speed and accuracy of bacterial detection is important for patient stratification and to ensure the appropriate use of antimicrobials. To achieve this goal, the development of diagnostic techniques to recognize bacterial presence in real-time at the point-of-care is required. Optical imaging for direct identification of bacteria within the ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2017, (129):]

Cited: 3 times

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