Perihan A Elzahhar, Rana A Alaaeddine, Rasha Nassra, Azza Ismail, Hala F Labib, Mohamed G Temraz, Ahmed S F Belal, Ahmed F El-Yazbi,
The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds possessed COX-2 inhibitory activities comparable to celecoxib (IC<sub>50</sub> values of 0.09-0.14 µM) with significant 15-LOX inhibitory activities (IC<sub>50</sub>s ... Read more >>
J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):669-684]
Cited: 0 times
Haneen S Dwaib, Ibrahim AlZaim, Ghina Ajouz, Ali H Eid, Ahmed F El-Yazbi,
The Evolving view of gut microbiota has shifted towards describing the colonic flora as a dynamic organ in continuous interaction with systemic physiological processes. Alterations of the normal gut bacterial profile, known as dysbiosis, has been linked to a wide array of pathologies. Of particular interest is the cardiovascular-metabolic disease ... Read more >>
Mol Pharmacol (Molecular pharmacology)
[2021, :]
Cited: 0 times
Safaa H Hammoud, Ibrahim AlZaim, Yusra Al-Dhaheri, Ali H Eid, Ahmed F El-Yazbi,
A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it contributes to energy homeostasis and provides insulation for internal organs. Adipocytes were previously thought to be a passive store of excess calories, however this view evolved to include an endocrine role. Adipose tissue was shown to ... Read more >>
Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:707126]
Cited: 0 times
Ibrahim Chaaban, Haidy Hafez, Ibrahim AlZaim, Cynthia Tannous, Hanan Ragab, Aly Hazzaa, Salma Ketat, Asser Ghoneim, Mohamed Katary, Mohammad M Abd-Alhaseeb, Fouad A Zouein, Amgad Albohy, Ahmed Noby Amer, Ahmed F El-Yazbi, Ahmed S F Belal,
We managed to repurpose the old drug iodoquinol to a series of novel anticancer 7-iodo-quinoline-5,8-diones. Twelve compounds were identified as inhibitors of moderate to high potency on an inhouse MCF-7 cell line, of which 2 compounds (5 and 6) were capable of reducing NAD level in MCF-7 cells in concentrations ... Read more >>
Bioorg Chem (Bioorganic chemistry)
[2021, 113:105035]
Cited: 0 times
Nour-Mounira Z Bakkar, Ahmed F El-Yazbi, Fouad A Zouein, Souha A Fares,
Blood pressure (BP) varies on the long, short and very-short term. Owing to the hidden physiological and pathological information present in BP time-series, increasing interest has been given to the study of continuous, beat-to-beat BP variability (BPV) using invasive and noninvasive methods. Different linear and nonlinear parameters of variability are ... Read more >>
J Hypertens (Journal of hypertension)
[2021, 39(5):830-845]
Cited: 0 times
Rana A Alaaeddine, Ibrahim AlZaim, Safaa H Hammoud, Aya Arakji, Ali H Eid, Khaled S Abd-Elrahman, Ahmed F El-Yazbi,
Antithrombotic drugs are widely used for primary and secondary prevention, as well as treatment of many cardiovascular disorders. Over the past few decades, major advances in the pharmacology of these agents have been made with the introduction of new drug classes as novel therapeutic options. Accumulating evidence indicates that the ... Read more >>
Clin Sci (Lond) (Clinical science (London, England : 1979))
[2021, 135(8):1015-1051]
Cited: 0 times
Safaa H Hammoud, Ibrahim AlZaim, Nahed Mougharbil, Sahar Koubar, Ali H Eid, Assaad A Eid, Ahmed F El-Yazbi,
Diabetic nephropathy is a major health challenge with considerable economic burden and significant impact on patients' quality of life. Despite recent advances in diabetic patient care, current clinical practice guidelines fall short of halting the progression of diabetic nephropathy to end-stage renal disease. Moreover, prior literature reported manifestations of renal ... Read more >>
Biochem Pharmacol (Biochemical pharmacology)
[2021, 186:114491]
Cited: 2 times
Ali Dakroub, Suzanne A Nasser, Firas Kobeissy, Hadi M Yassine, Alexander Orekhov, Javad Sharifi-Rad, Rabah Iratni, Ahmed F El-Yazbi, Ali H Eid,
Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular inflammation, and atherosclerosis, all of which pose increased risks of cardiovascular events. In this context, increased levels of visfatin have been correlated with several upregulated pro-inflammatory ... Read more >>
J Cell Physiol (Journal of cellular physiology)
[2021, 236(9):6282-6296]
Cited: 1 time
Rana A Alaaeddine, Perihan A Elzahhar, Ibrahim AlZaim, Wassim Abou-Kheir, Ahmed S F Belal, Ahmed F El-Yazbi,
Emerging evidence supports an intertwining framework for the involvement of different inflammatory pathways in a common pathological background for a number of disorders. Of importance are pathways involving arachidonic acid metabolism by cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX). Both enzyme activities and their products are implicated in a range of pathophysiological ... Read more >>
Curr Med Chem (Current medicinal chemistry)
[2021, 28(11):2260-2300]
Cited: 2 times
Adnan Badran, Suzanne A Nasser, Joelle Mesmar, Ahmed F El-Yazbi, Alessandra Bitto, Manal M Fardoun, Elias Baydoun, Ali H Eid,
Reactive oxygen species (ROS) are natural byproducts of oxygen metabolism in the cell. At physiological levels, they play a vital role in cell signaling. However, high ROS levels cause oxidative stress, which is implicated in cardiovascular diseases (CVD) such as atherosclerosis, hypertension, and restenosis after angioplasty. Despite the great amount ... Read more >>
Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]
Cited: 2 times
Nour-Mounira Z Bakkar, Haneen S Dwaib, Souha Fares, Ali H Eid, Yusra Al-Dhaheri, Ahmed F El-Yazbi,
Cardiac autonomic neuropathy (CAN) is one of the earliest complications of type 2 diabetes (T2D), presenting a silent cause of cardiovascular morbidity and mortality. Recent research relates the pathogenesis of cardiovascular disease in T2D to an ensuing chronic, low-grade proinflammatory and pro-oxidative environment, being the hallmark of the metabolic syndrome. ... Read more >>
Int J Mol Sci (International journal of molecular sciences)
[2020, 21(23):]
Cited: 4 times
Safaa H Hammoud, Zena Wehbe, Samar Abdelhady, Firas Kobeissy, Ali H Eid, Ahmed F El-Yazbi,
ACE2 has emerged as a double agent in the COVID-19 ordeal, as it is both physiologically protective and virally conducive. The identification of ACE2 in as many as 72 tissues suggests that extrapulmonary invasion and damage is likely, which indeed has already been demonstrated by cardiovascular and gastrointestinal symptoms. On ... Read more >>
Mol Pharmacol (Molecular pharmacology)
[2021, 99(1):17-28]
Cited: 7 times
Ibrahim AlZaim, Safaa H Hammoud, Houssam Al-Koussa, Alaa Ghazi, Ali H Eid, Ahmed F El-Yazbi,
Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As the main storage pool of lipids, subcutaneous and visceral adipose tissues undergo marked hypertrophy and hyperplasia in response to nutritional excess leading to hypoxia, adipokine ... Read more >>
Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2020, 7:602088]
Cited: 7 times
Ali Dakroub, Suzanne A Nasser, Nour Younis, Humna Bhagani, Yusra Al-Dhaheri, Gianfranco Pintus, Assaad A Eid, Ahmed F El-Yazbi, Ali H Eid,
Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions in nicotinamide adenine dinucleotide biosynthesis, with ubiquitous expression in skeletal muscles, liver, cardiomyocytes, and brain cells. Visfatin exists in an intracellular (iNAMPT) and extracellular (eNAMPT) ... Read more >>
Cells (Cells)
[2020, 9(11):]
Cited: 3 times
Nour-Mounira Z Bakkar, Nahed Mougharbil, Ali Mroueh, Abdullah Kaplan, Ali H Eid, Souha Fares, Fouad A Zouein, Ahmed F El-Yazbi,
Cardiac autonomic neuropathy (CAN) is an early cardiovascular manifestation of type 2 diabetes (T2D) that constitutes an independent risk factor for cardiovascular mortality and morbidity. Nevertheless, its underlying pathophysiology remains poorly understood. We recently showed that localized perivascular adipose tissue (PVAT) inflammation underlies the incidence of parasympathetic CAN in prediabetes. ... Read more >>
Am J Physiol Endocrinol Metab (American journal of physiology. Endocrinology and metabolism)
[2020, 319(5):E835-E851]
Cited: 2 times
Nadine Wehbe, Suzanne Awni Nasser, Yusra Al-Dhaheri, Rabah Iratni, Alessandra Bitto, Ahmed F El-Yazbi, Adnan Badran, Firas Kobeissy, Elias Baydoun, Ali H Eid,
Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over-proliferate and ... Read more >>
Int J Mol Sci (International journal of molecular sciences)
[2020, 21(14):]
Cited: 3 times
Humna Bhagani, Suzanne A Nasser, Ali Dakroub, Ahmed F El-Yazbi, Assaad A Eid, Firas Kobeissy, Gianfranco Pintus, Ali H Eid,
Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; however, several processes involving the mitochondria, such as lipid and glucose metabolism, reactive oxygen species (ROS) production, apoptosis, autophagy ... Read more >>
Int J Mol Sci (International journal of molecular sciences)
[2020, 21(14):]
Cited: 4 times
Perihan A Elzahhar, Shrouk M Abd El Wahab, Mohamed Elagawany, Hoda Daabees, Ahmed S F Belal, Ahmed F El-Yazbi, Ali H Eid, Rana Alaaeddine, Rehab R Hegazy, Rasha M Allam, Maged W Helmy, Bahaa Elgendy, Andrea Angeli, Soad A El-Hawash, Claudiu T Supuran,
Cancer is a multifactorial disorder involving multiplicity of interrelated signaling pathways and molecular targets. To that end, a multi-target design strategy was adopted to develop some 1,2,3-triazoles hybridized with some pharmacophoric anticancer fragments, as first-in-class simultaneous inhibitors of COX-2, 15-LOX and tumor associated carbonic anhydrase enzymes. Results revealed that compounds ... Read more >>
Eur J Med Chem (European journal of medicinal chemistry)
[2020, 200:112439]
Cited: 3 times
Ahmed F El-Yazbi, Gavin Y Oudit,
Adipose biology research has grown rapidly offering new insights into the physiological and pathophysiological roles of different body fat depots. This Thematic Collection of Clinical Science brings a well-rounded timely view of the recent development in this field. We highlight the state of the art on adipose tissue function/dysfunction in ... Read more >>
Clin Sci (Lond) (Clinical science (London, England : 1979))
[2020, 134(12):1473-1474]
Cited: 0 times
Walaa Fakih, Ali Mroueh, Houssein Salah, Ali H Eid, Makram Obeid, Firas Kobeissy, Hala Darwish, Ahmed F El-Yazbi,
Prediabetes is a highly prevalent stage of early metabolic dysfunction that poses a high risk for cardiovascular and cognitive impairment without a clear pathological mechanism. Here, we used a non-obese prediabetic rat model previously developed in our laboratory to examine this mechanism. These rats were subjected to a mild metabolic ... Read more >>
Biochem Pharmacol (Biochemical pharmacology)
[2020, 178:114041]
Cited: 3 times
Rim Rafeh, Anissa Viveiros, Gavin Y Oudit, Ahmed F El-Yazbi,
Major shifts in human lifestyle and dietary habits toward sedentary behavior and refined food intake triggered steep increase in the incidence of metabolic disorders including obesity and Type 2 diabetes. Patients with metabolic disease are at a high risk of cardiovascular complications ranging from microvascular dysfunction to cardiometabolic syndromes including ... Read more >>
Clin Sci (Lond) (Clinical science (London, England : 1979))
[2020, 134(7):827-851]
Cited: 8 times
Mohammed A W Elkhatib, Ali Mroueh, Rim W Rafeh, Fatima Sleiman, Hosny Fouad, Evan I Saad, Mohamed A Fouda, Ola Elgaddar, Khodr Issa, Ali H Eid, Assaad A Eid, Khaled S Abd-Elrahman, Ahmed F El-Yazbi,
The onset of vascular impairment precedes that of diagnostic hyperglycemia in diabetic patients suggesting a vascular insult early in the course of metabolic dysfunction without a well-defined mechanism. Mounting evidence implicates adipose inflammation in the pathogenesis of insulin resistance and diabetes. It is not certain whether amelioration of adipose inflammation ... Read more >>
Transl Res (Translational research : the journal of laboratory and clinical medicine)
[2019, 214:121-143]
Cited: 4 times
Rana Alaaeddine, Mohammed A W Elkhatib, Ali Mroueh, Hosny Fouad, Evan I Saad, Marwan E El-Sabban, Frances Plane, Ahmed F El-Yazbi,
Endothelial dysfunction is a hallmark of diabetic vasculopathies. Although hyperglycemia is believed to be the culprit causing endothelial damage, the mechanism underlying early endothelial insult in prediabetes remains obscure. We used a nonobese high-calorie (HC)-fed rat model with hyperinsulinemia, hypercholesterolemia, and delayed development of hyperglycemia to unravel this mechanism. Compared ... Read more >>
J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2019, 371(3):567-582]
Cited: 4 times
Rana A Alaaeddine, Ali Mroueh, Stephen Gust, Ali H Eid, Frances Plane, Ahmed F El-Yazbi,
Over the past three decades, our view of the endothelium rapidly evolved from a static lining of the blood vessels to a dynamic determinant and regulator of vascular tone and homeostasis. It is now widely accepted that endothelial dysfunction is a hallmark of almost every vascular pathology, either as a ... Read more >>
Curr Opin Pharmacol (Current opinion in pharmacology)
[2019, 45:33-41]
Cited: 4 times
Perihan A Elzahhar, Rana Alaaeddine, Tamer M Ibrahim, Rasha Nassra, Azza Ismail, Benjamin S K Chua, Rebecca L Frkic, John B Bruning, Nadja Wallner, Tilo Knape, Andreas von Knethen, Hala Labib, Ahmed F El-Yazbi, Ahmed S F Belal,
In search for effective multi-targeting drug ligands (MTDLs) to address low-grade inflammatory changes of metabolic disorders, we rationally designed some novel glitazones-like compounds. This was achieved by incorporating prominent pharmacophoric motifs from previously reported COX-2, 15-LOX and PPARγ ligands. Challenging our design with pre-synthetic docking experiments on PPARγ showed encouraging ... Read more >>
Eur J Med Chem (European journal of medicinal chemistry)
[2019, 167:562-582]
Cited: 6 times