Full Text Journal Articles by
Author Ahmed E I Hamouda

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Efficacy of CD40 agonists is mediated by distinct cDC subsets and subverted by suppressive macrophages.

Aleksandar Murgaski, Máté Kiss, Helena Van Damme, Daliya Kancheva, Isaure Vanmeerbeek, Jiri Keirsse, Eva Hadadi, Jan Brughmans, Sana M Arnouk, Ahmed E I Hamouda, Ayla Debraekeleer, Victor Bosteels, Yvon Elkrim, Louis Boon, Sabine Hoves, Niels Vandamme, Sofie Deschoemaeker, Sophie Janssens, Abhishek D Garg, Greetje Vande Velde, Martina Schmittnaegel, Carola H Ries, Damya Laoui,

Agonistic αCD40 therapy has been shown to inhibit cancer progression in only a fraction of patients. Understanding the cancer cell-intrinsic and microenvironmental determinants of αCD40 therapy response is therefore crucial to identify responsive patient populations and design efficient combinatorial treatments. Here, we show that the therapeutic efficacy of αCD40 in ... Read more >>

Cancer Res (Cancer research)
[2022, :CAN-22-0094]

Cited: 0 times

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Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis.

Marcelo A S Toledo, Malrun Gatz, Stephanie Sontag, Karoline V Gleixner, Gregor Eisenwort, Kristina Feldberg, Ahmed E I Hamouda, Frederick Kluge, Riccardo Guareschi, Giulia Rossetti, Antonio S Sechi, Olli M J Dufva, Satu M Mustjoki, Angela Maurer, Herdit M Schüler, Roman Goetzke, Till Braunschweig, Anne Kaiser, Jens Panse, Mohamad Jawhar, Andreas Reiter, Frank Hilberg, Peter Ettmayer, Wolfgang Wagner, Steffen Koschmieder, Tim H Brümmendorf, Peter Valent, Nicolas Chatain, Martin Zenke,

The KIT D816V mutation is found in >80% of patients with systemic mastocytosis (SM) and is key to neoplastic mast cell (MC) expansion and accumulation in affected organs. Therefore, KIT D816V represents a prime therapeutic target for SM. Here, we generated a panel of patient-specific KIT D816V induced pluripotent stem ... Read more >>

Blood (Blood)
[2021, 137(15):2070-2084]

Cited: 3 times

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