Full Text Journal Articles by
Author Ahmed Bahieldin

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Dysbiosis of gut microbiota in inflammatory bowel disease: Current therapies and potential for microbiota-modulating therapeutic approaches.

Dikhnah Alshehri, Omar Saadah, Mahmoud Mosli, Sherif Edris, Rashad Alhindi, Ahmed Bahieldin,

There is a growing body of evidence reinforcing the unique connections between the host microbiome, health and diseases. Due to the extreme importance of the symbiotic relationship between the intestinal microbiome and the host, it is not surprising that any alteration in the gut microbiota would result in various diseases, ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

Cited: 0 times

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Molecular cloning, expression, overproduction and characterization of human TRAIP Leucine zipper protein.

Eijaz Ahmed Bhat, Nasreena Sajjad, Jamal S M Sabir, Majid Rasool Kamli, Khalid Rehman Hakeem, Irfan A Rather, Ahmed Bahieldin,

The TRAIP interacting protein is known as a negative regulator of TNF-induced-nuclear factor, kappa-light-chain-enhancer of activated B cell (NF-κB) by direct interaction with the adaptor protein TRAF2, which inhibits the function of TRAF2 via the RINGCC domain protein. The TRAIP protein is composed of 469 amino acids with an N-terminal ... Read more >>

Saudi J Biol Sci (Saudi journal of biological sciences)
[2020, 27(6):1562-1565]

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Detection of Secondary Metabolites as Biomarkers for the Early Diagnosis and Prevention of Type 2 Diabetes.

Jumana Y Al-Aama, Hadiah B Al Mahdi, Mohammed A Salama, Khadija H Bakur, Amani Alhozali, Hala H Mosli, Suhad M Bahijri, Ahmed Bahieldin, Lothar Willmitzer, Sherif Edris,

Background:Type 2 diabetes, or T2D, is a metabolic disease that results in insulin resistance. In the present study, we hypothesize that metabolomic analysis in blood samples of T2D patients sharing the same ethnic background can recover new metabolic biomarkers and pathways that elucidate early diagnosis and predict the incidence of ... Read more >>

Diabetes Metab Syndr Obes (Diabetes, metabolic syndrome and obesity : targets and therapy)
[2019, 12:2675-2684]

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Molecular evolution of cytochrome C oxidase-I protein of insects living in Saudi Arabia.

Jamal S M Sabir, Samar Rabah, Haitham Yacoub, Nahid H Hajrah, Ahmed Atef, Mohammed Al-Matary, Sherif Edris, Mona G Alharbi, Magdah Ganash, Jazem Mahyoub, Rashad R Al-Hindi, Khalid M Al-Ghamdi, Neil Hall, Ahmed Bahieldin, Majid R Kamli, Irfan A Rather,

The study underpins barcode characterization of insect species collected from Saudi Arabia and explored functional constraints during evolution at the DNA and protein levels to expect the possible mechanisms of protein evolution in insects. Codon structure designated AT-biased insect barcode of the cytochrome C oxidase I (COI). In addition, the ... Read more >>

PLoS One (PloS one)
[2019, 14(11):e0224336]

Cited: 1 time

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Thermopriming reprograms metabolic homeostasis to confer heat tolerance.

Natalia Serrano, Yu Ling, Ahmed Bahieldin, Magdy M Mahfouz,

Heat stress threatens agriculture worldwide. Plants acquire heat stress tolerance through priming, which establishes stress memory during mild or severe transient heat stress. Such induced thermotolerance restructures metabolic networks and helps maintain metabolic homeostasis under heat stress. Here, we used an electrospray ionization mass spectrometry-based platform to explore the composition ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):181]

Cited: 3 times

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Control of β-sitosterol biosynthesis under light and watering in desert plant Calotropis procera.

Ahmed M Ramadan, Ahmed Abdel Azeiz, Saeed Baabad, Sameh Hassanein, Nour O Gadalla, Sabah Hassan, Mardi Algandaby, Salwa Bakr, Thana Khan, Heba H Abouseadaa, Hani Mohammed Ali, Areej Al-Ghamdi, Gamal Osman, Sherif Edris, Hala Eissa, Ahmed Bahieldin,

Most scientific studies on Calotropis procera refer to the plant as an important source of pharmaceutical compounds and its valuable benefits in medicine. One of the most important substances in this plant is the potential immunostimulant β-sitosterol (BS) that acts in improving human health. This study focused on the effects ... Read more >>

Steroids (Steroids)
[2019, 141:1-8]

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Stepwise response of MeJA-induced genes and pathways in leaves of C. roseus.

Ahmed Bahieldin, Ahmed Atef, Sherif Edris, Nour O Gadalla, Mohammed Al-Matary, Magdy A Al-Kordy, Ahmed M Ramadan, Sameera Bafeel, Mona G Alharbi, Diana A H Al-Quwaie, Jamal S M Sabir, Hassan S Al-Zahrani, Mahmoud E Nasr, Fotouh M El-Domyati,

Catharanthus roseus is a perennial herb known for the production of important terpenoid indole alkaloids (TIAs) in addition to a variety of phenolic compounds. The goal of the present work was to detect the prolonged effects of MeJA (6 uM) treatment across time (up to 24 days) in order to ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2018, 341(9-10):411-420]

Cited: 0 times

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Isolation, Molecular Characterization and Probiotic Potential of Lactic Acid Bacteria in Saudi Raw and Fermented Milk.

Maged S Bin Masalam, Ahmed Bahieldin, Mona G Alharbi, Saad Al-Masaudi, Soad K Al-Jaouni, Steve M Harakeh, Rashad R Al-Hindi,

Probiotic bacteria can confer health benefits to the human gastrointestinal tract. Lactic acid bacteria (LAB) are candidate probiotic bacteria that are widely distributed in nature and can be used in the food industry. The objective of this study is to isolate and characterize LAB present in raw and fermented milk ... Read more >>

(Evidence-based complementary and alternative medicine : eCAM)
[2018, 2018:7970463]

Cited: 5 times

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Transcriptomic and metabolic responses of Calotropis procera to salt and drought stress.

Mohammed Z Mutwakil, Nahid H Hajrah, Ahmed Atef, Sherif Edris, Mernan J Sabir, Areej K Al-Ghamdi, Meshaal J S M Sabir, Charlotte Nelson, Rania M Makki, Hani M Ali, Fotouh M El-Domyati, Abdulrahman S M Al-Hajar, Yoann Gloaguen, Hassan S Al-Zahrani, Jamal S M Sabir, Robert K Jansen, Ahmed Bahieldin, Neil Hall,

BACKGROUND:Calotropis procera is a wild plant species in the family Apocynaceae that is able to grow in harsh, arid and heat stressed conditions. Understanding how this highly adapted plant persists in harsh environments should inform future efforts to improve the hardiness of crop and forage plant species. To study the ... Read more >>

BMC Plant Biol. (BMC plant biology)
[2017, 17(1):231]

Cited: 5 times

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Analysis of transcriptional response to heat stress in Rhazya stricta.

Abdullah Y Obaid, Jamal S M Sabir, Ahmed Atef, Xuan Liu, Sherif Edris, Fotouh M El-Domyati, Mohammed Z Mutwakil, Nour O Gadalla, Nahid H Hajrah, Magdy A Al-Kordy, Neil Hall, Ahmed Bahieldin, Robert K Jansen,

Climate change is predicted to be a serious threat to agriculture due to the need for crops to be able to tolerate increased heat stress. Desert plants have already adapted to high levels of heat stress so they make excellent systems for identifying genes involved in thermotolerance. Rhazya stricta is ... Read more >>

BMC Plant Biol. (BMC plant biology)
[2016, 16(1):252]

Cited: 8 times

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Structural identification of putative USPs in Catharanthus roseus.

Ahmed Bahieldin, Ahmed Atef, Ahmed M Shokry, Saleh Al-Karim, Sanaa G Al Attas, Nour O Gadallah, Sherif Edris, Magdy A Al-Kordy, Abdulkader M Shaikh Omer, Jamal S M Sabir, Ahmed M Ramadan, Abdulrahman S M Al-Hajar, Rania M Makki, Sabah M Hassan, Fotouh M El-Domyati,

Nucleotide sequences of the C. roseus SRA database were assembled and translated in order to detect putative universal stress proteins (USPs). Based on the known conserved USPA domain, 24 Pfam putative USPA proteins in C. roseus were detected and arranged in six architectures. The USPA-like domain was detected in all architectures, while the ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2015, 338(10):643-649]

Cited: 2 times

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RNA-Seq analysis of the wild barley (H. spontaneum) leaf transcriptome under salt stress.

Ahmed Bahieldin, Ahmed Atef, Jamal S M Sabir, Nour O Gadalla, Sherif Edris, Ahmed M Alzohairy, Nezar A Radhwan, Mohammed N Baeshen, Ahmed M Ramadan, Hala F Eissa, Sabah M Hassan, Nabih A Baeshen, Osama Abuzinadah, Magdy A Al-Kordy, Fotouh M El-Domyati, Robert K Jansen,

Wild salt-tolerant barley (Hordeum spontaneum) is the ancestor of cultivated barley (Hordeum vulgare or H. vulgare). Although the cultivated barley genome is well studied, little is known about genome structure and function of its wild ancestor. In the present study, RNA-Seq analysis was performed on young leaves of wild barley treated ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2015, 338(5):285-297]

Cited: 12 times

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Corrected sequence of the wheat plastid genome.

Ahmed Bahieldin, Magdy A Al-Kordy, Ahmed M Shokry, Nour O Gadalla, Ahmed M M Al-Hejin, Jamal S M Sabir, Sabah M Hassan, Ahlam A Al-Ahmadi, Erika N Schwarz, Hala F Eissa, Fotouh M El-Domyati, Robert K Jansen,

Wheat is the most important cereal in the world in terms of acreage and productivity. We sequenced and assembled the plastid genome of one Egyptian wheat cultivar using next-generation sequence data. The size of the plastid genome is 133,873 bp, which is 672 bp smaller than the published plastid genome ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2014, 337(9):499-502]

Cited: 2 times

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Retrotransposon-based molecular markers for assessment of genomic diversity.

Ahmed M Alzohairy, G Bor Gyulai, Mohamed F Ramadan, Sherif Edris, Jamal S M Sabir, Robert K Jansen, Hala F Eissa, Ahmed Bahieldin,

Retrotransposons (RTs) are major components of most eukaryotic genomes. They are ubiquitous, dispersed throughout the genome, and their abundance correlates with genome size. Their copy-and-paste lifestyle in the genome consists of three molecular steps involving transcription of an RNA copy from the genomic RT, followed by reverse transcription to generate ... Read more >>

Funct. Plant Biol. (Functional plant biology : FPB)
[2014, 41(8):781-789]

Cited: 0 times

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Whole mitochondrial and plastid genome SNP analysis of nine date palm cultivars reveals plastid heteroplasmy and close phylogenetic relationships among cultivars.

Jamal S M Sabir, Dhivya Arasappan, Ahmed Bahieldin, Salah Abo-Aba, Sameera Bafeel, Talal A Zari, Sherif Edris, Ahmed M Shokry, Nour O Gadalla, Ahmed M Ramadan, Ahmed Atef, Magdy A Al-Kordy, Fotoh M El-Domyati, Robert K Jansen,

Date palm is a very important crop in western Asia and northern Africa, and it is the oldest domesticated fruit tree with archaeological records dating back 5000 years. The huge economic value of this crop has generated considerable interest in breeding programs to enhance production of dates. One of the ... Read more >>

PLoS One (PloS one)
[2014, 9(4):e94158]

Cited: 15 times

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Construction of naïve camelids VHH repertoire in phage display-based library.

Jamal S M Sabir, Ahmed Atef, Fotouh M El-Domyati, Sherif Edris, Nahid Hajrah, Ahmed M Alzohairy, Ahmed Bahieldin,

Camelids have unique antibodies, namely HCAbs (VHH) or commercially named Nanobodies(®) (Nb) that are composed only of a heavy-chain homodimer. As libraries based on immunized camelids are time-consuming, costly and likely redundant for certain antigens, we describe the construction of a naïve camelid VHHs library from blood serum of non-immunized ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2014, 337(4):244-249]

Cited: 5 times

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Environmental stress activation of plant long-terminal repeat retrotransposons

Ahmed M Alzohairy, Jamal S M Sabir, Gábor Gyulai, Rania A A Younis, Robert K Jansen, Ahmed Bahieldin,

Genomic retrotransposons (RTs) are major components of most plant genomes. They spread throughout the genomes by a process termed retrotransposition, which consists of reverse transcription and reinsertion of the copied element into a new genomic location (a copy-and-paste system). Abiotic and biotic stresses activate long-terminal repeat (LTR) RTs in photosynthetic ... Read more >>

Funct. Plant Biol. (Functional plant biology : FPB)
[2014, 41(6):557-567]

Cited: 6 times

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Control of glycerol biosynthesis under high salt stress in Arabidopsis

Ahmed Bahieldin, Jamal S M Sabir, Ahmed Ramadan, Ahmed M Alzohairy, Rania A Younis, Ahmed M Shokry, Nour O Gadalla, Sherif Edris, Sabah M Hassan, Magdy A Al-Kordy, Khalid B H Kamal, Samar Rabah, Osama A Abuzinadah, Fotouh M El-Domyati,

Loss-of-function and gain-of-function approaches were utilised to detect the physiological importance of glycerol biosynthesis during salt stress and the role of glycerol in conferring salt tolerance in Arabidopsis. The salt stress experiment involved wild type (WT) and transgenic Arabidopsis overexpressing the yeast GPD1 gene (analogue of Arabidopsis GLY1 gene). The ... Read more >>

Funct. Plant Biol. (Functional plant biology : FPB)
[2014, 41(1):87-95]

Cited: 4 times

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Environmental stress activation of plant long-terminal repeat retrotransposons.

Ahmed M Alzohairy, Jamal S M Sabir, G Bor Gyulai, Rania A A Younis, Robert K Jansen, Ahmed Bahieldin,

Genomic retrotransposons (RTs) are major components of most plant genomes. They spread throughout the genomes by a process termed retrotransposition, which consists of reverse transcription and reinsertion of the copied element into a new genomic location (a copy-and-paste system). Abiotic and biotic stresses activate long-terminal repeat (LTR) RTs in photosynthetic ... Read more >>

Funct. Plant Biol. (Functional plant biology : FPB)
[2014, 41(6):557-567]

Cited: 0 times

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Thymoquinone causes multiple effects, including cell death, on dividing plant cells.

Sameh E Hassanien, Ahmed M Ramadan, Ahmed Z Abdel Azeiz, Rasha A Mohammed, Sabah M Hassan, Ahmed M Shokry, Ahmed Atef, Khalid B H Kamal, Samar Rabah, Jamal S M Sabir, Osama A Abuzinadah, Fotouh M El-Domyati, Gregory B Martin, Ahmed Bahieldin,

Thymoquinone (TQ) is a major constituent of Nigella sativa oil with reported anti-oxidative activity and anti-inflammatory activity in animal cells. It also inhibits proliferation and induces programmed cell death (apoptosis) in human skin cancer cells. The present study sought to detect the influence of TQ on dividing cells of three ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2013, 336(11-12):546-556]

Cited: 2 times

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Efficient production of lycopene in Saccharomyces cerevisiae by expression of synthetic crt genes from a plasmid harboring the ADH2 promoter.

Ahmed Bahieldin, Nour O Gadalla, Saleh M Al-Garni, Hussein Almehdar, Samah Noor, Sabah M Hassan, Ahmed M Shokry, Jamal S M Sabir, Norio Murata,

Lycopene is an effective antioxidant proposed as a possible treatment for some cancers and other degenerative human conditions. This study aims at generation of a yeast strain (Saccharomyces cerevisiae) of efficient productivity of lycopene by overexpressing synthetic genes derived from crtE, crtB and crtI genes of Erwinia uredovora. These synthetic ... Read more >>

Plasmid (Plasmid)
[2014, 72:18-28]

Cited: 6 times

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Detection of a Usp-like gene in Calotropis procera plant from the de novo assembled genome contigs of the high-throughput sequencing dataset.

Ahmed M Shokry, Saleh Al-Karim, Ahmed Ramadan, Nour Gadallah, Sanaa G Al Attas, Jamal S M Sabir, Sabah M Hassan, Magdy A Madkour, Ray Bressan, Magdy Mahfouz, Ahmed Bahieldin,

The wild plant species Calotropis procera (C. procera) has many potential applications and beneficial uses in medicine, industry and ornamental field. It also represents an excellent source of genes for drought and salt tolerance. Genes encoding proteins that contain the conserved universal stress protein (USP) domain are known to provide organisms ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2014, 337(2):86-94]

Cited: 6 times

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Characterization of ten date palm (Phoenix dactylifera L.) cultivars from Saudi Arabia using AFLP and ISSR markers.

Jamal S M Sabir, Salah Abo-Aba, Sameera Bafeel, Talal A Zari, Sherif Edris, Ahmed M Shokry, Ahmed Atef, Nour O Gadalla, Ahmed M Ramadan, Magdy A Al-Kordy, Fotouh M El-Domyati, Robert K Jansen, Ahmed Bahieldin,

Date palm is the most economically important plant in the Middle East due to its nutritionally valuable fruit. The development of accurate DNA fingerprints to characterize cultivars and the detection of genetic diversity are of great value for breeding programs. The present study explores the usefulness of ISSR and AFLP ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2014, 337(1):6-18]

Cited: 3 times

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Retrotransposon-based molecular markers for assessment of genomic diversity

Ahmed M Alzohairy, Gábor Gyulai, Mohamed F Ramadan, Sherif Edris, Jamal S M Sabir, Robert K Jansen, Hala F Eissa, Ahmed Bahieldin,

Retrotransposons (RTs) are major components of most eukaryotic genomes. They are ubiquitous, dispersed throughout the genome, and their abundance correlates with genome size. Their copy-and-paste lifestyle in the genome consists of three molecular steps involving transcription of an RNA copy from the genomic RT, followed by reverse transcription to generate ... Read more >>

Funct. Plant Biol. (Functional plant biology : FPB)
[2014, 41(8):781-789]

Cited: 0 times

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Detection of phytochrome-like genes from Rhazya stricta (Apocynaceae) using de novo genome assembly.

Jamal S M Sabir, Nabih A Baeshen, Ahmed M Shokry, Nour O Gadalla, Sherif Edris, Mohammed H Mutwakil, Ahmed M Ramadan, Ahmed Atef, Magdy A Al-Kordy, Osama A Abuzinadah, Fotouh M El-Domyati, Robert K Jansen, Ahmed Bahieldin,

Phytochrome-like genes in the wild plant species Rhazya stricta Decne were characterized using a de novo genome assembly of next generation sequence data. Rhazya stricta contains more than 100 alkaloids with multiple pharmacological properties, and leaf extracts have been used to cure chronic rheumatism, to treat tumors, and in the ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2013, 336(11-12):521-529]

Cited: 0 times

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