Full Text Journal Articles by
Author Ahmed Al Khafaji

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In Vitro Macrophage Nitric Oxide and Interleukin-1 Beta Suppression by Moringa peregrina Seed.

Shaymaa Fadhel Abbas Albaayit, Ahmed Salim Kadhim Al-Khafaji, Hiba Sarmed Alnaimy,

Objectives:Moringa peregrina has long been used in folk medicine to treat diseases including fever, headache, burns, constipation, gut pains, and inflammation. Nitric oxide (NO) and interleukin-1β (IL-1β) play an important role in the pathophysiology of inflammation. The objectives of this study were to determine the effect of M. peregrina seed ... Read more >>

Turk J Pharm Sci (Turkish journal of pharmaceutical sciences)
[2019, 16(3):362-365]

Cited: 1 time

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Overexpression of HURP mRNA in head and neck carcinoma and association with in vitro response to vinorelbine.

Ahmed S K Al-Khafaji, Paschalia Pantazi, Amelia Acha-Sagredo, Andrew Schache, Janet M Risk, Richard J Shaw, Triantafillos Liloglou,

HURP gene encodes the hepatoma upregulated protein (HURP), a microtubule associated protein regulating mitotic spindle dynamics, which promotes chromosomal congression and alignment during mitosis, with a potential role in tumorigenesis. In the present study, HURP mRNA expression was investigated by reverse transcription-quantitative PCR in oropharyngeal squamous cell carcinoma (OPSCC). Primary ... Read more >>

Oncol Lett (Oncology letters)
[2020, 19(3):2502-2507]

Cited: 0 times

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Use of low-power He-Ne laser therapy to accelerate regeneration processes of injured sciatic nerve in rabbit.

Ahmed Majeed Al-Shammari, Yahya Syhood, Ahmed S Al-Khafaji,

Background:Photostimulation using low-power laser had been used for nervous repair with interesting results. This study aimed to evaluate the influence of 20 mW low-power He-Ne laser on the regeneration of a peripheral sciatic nerve after trauma using the Albino rabbit as an animal model for experimental treatment. Methods:Six adult male rabbits ... Read more >>

Egypt J Neurol Psychiatr Neurosurg (The Egyptian journal of neurology, psychiatry and neurosurgery)
[2019, 55(1):1]

Cited: 1 time

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Aurora B expression modulates paclitaxel response in non-small cell lung cancer.

Ahmed Sk Al-Khafaji, Michael Pa Davies, Janet M Risk, Michael W Marcus, Maria Koffa, John R Gosney, Richard J Shaw, John K Field, Triantafillos Liloglou,

<h4>Background</h4>Taxanes are mitotic poisons widely used in the treatment of non-small cell lung cancer (NSCLC), however, little is known about potential molecular modulators of response to these compounds. Aurora B (AURKB) is a critical regulator of the mitotic spindle assembly, previously shown overexpressed in NSCLC. Here we investigated the hypothesis ... Read more >>

Br J Cancer (British journal of cancer)
[2017, 116(5):592-599]

Cited: 13 times

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AURKA mRNA expression is an independent predictor of poor prognosis in patients with non-small cell lung cancer.

Ahmed S K Al-Khafaji, Michael W Marcus, Michael P A Davies, Janet M Risk, Richard J Shaw, John K Field, Triantafillos Liloglou,

Deregulation of mitotic spindle genes has been reported to contribute to the development and progression of malignant tumours. The aim of the present study was to explore the association between the expression profiles of Aurora kinases (<i>AURKA</i>, <i>AURKB</i> and <i>AURKC</i>), cytoskeleton-associated protein 5 (<i>CKAP5</i>), discs large-associated protein 5 (<i>DLGAP5</i>), kinesin-like ... Read more >>

Oncol Lett (Oncology letters)
[2017, 13(6):4463-4468]

Cited: 9 times

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Superoxide induces Neutrophil Extracellular Trap Formation in a TLR-4 and NOX-dependent mechanism.

Ahmed B Al-Khafaji, Samer Tohme, Hamza Obaid Yazdani, David Miller, Hai Huang, Allan Tsung,

Neutrophils constitute the early innate immune response to perceived infectious and sterile threats. Neutrophil Extracellular Traps (NETs) are a novel mechanism to counter pathogenic invasion and sequelae of ischemia including cell death and oxidative stress. Superoxide is a radical intermediate of oxygen metabolism produced by parenchymal and non-parenchymal hepatic cells, ... Read more >>

Mol Med (Molecular medicine (Cambridge, Mass.))
[2016, 22:621-631]

Cited: 19 times

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Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress.

Samer Tohme, Hamza O Yazdani, Ahmed B Al-Khafaji, Alexis P Chidi, Patricia Loughran, Kerri Mowen, Yanming Wang, Richard L Simmons, Hai Huang, Allan Tsung,

Risks of tumor recurrence after surgical resection have been known for decades, but the mechanisms underlying treatment failures remain poorly understood. Neutrophils, first-line responders after surgical stress, may play an important role in linking inflammation to cancer progression. In response to stress, neutrophils can expel their protein-studded chromatin to form ... Read more >>

Cancer Res (Cancer research)
[2016, 76(6):1367-1380]

Cited: 169 times

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Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury.

Hai Huang, Samer Tohme, Ahmed B Al-Khafaji, Sheng Tai, Patricia Loughran, Li Chen, Shu Wang, Jiyun Kim, Timothy Billiar, Yanming Wang, Allan Tsung,

<h4>Unlabelled</h4>Innate immunity plays a crucial role in the response to sterile inflammation such as liver ischemia/reperfusion (I/R) injury. The initiation of liver I/R injury results in the release of damage-associated molecular patterns, which trigger an innate immune and inflammatory cascade through pattern recognition receptors. Neutrophils are recruited to the liver ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2015, 62(2):600-614]

Cited: 158 times

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Precaution (ihtiyāt): do not proceed.

Ahmed B Al-Khafaji, Ali Moughania, Mohammed Al-Saadi,

Am J Bioeth (The American journal of bioethics : AJOB)
[2015, 15(1):23-25]

Cited: 1 time

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In vivo misfolding of proinsulin below the threshold of frank diabetes.

Israel Hodish, Afaf Absood, Leanza Liu, Ming Liu, Leena Haataja, Dennis Larkin, Ahmed Al-Khafaji, Anthony Zaki, Peter Arvan,

<h4>Objective</h4>Endoplasmic reticulum (ER) stress has been described in pancreatic β-cells after onset of diabetes-a situation in which failing β-cells have exhausted available compensatory mechanisms. Herein we have compared two mouse models expressing equally small amounts of transgenic proinsulin in pancreatic β-cells.<h4>Research design and methods</h4>In hProCpepGFP mice, human proinsulin (tagged with ... Read more >>

Diabetes (Diabetes)
[2011, 60(8):2092-2101]

Cited: 27 times

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