Full Text Journal Articles by
Author Ahmad Kaddourah

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Cumulative Application of Creatinine and Urine Output Staging Optimizes the Kidney Disease: Improving Global Outcomes Definition and Identifies Increased Mortality Risk in Hospitalized Patients With Acute Kidney Injury.

Scott M Sutherland, Ahmad Kaddourah, Scott E Gillespie, Danielle E Soranno, Robert P Woroniecki, Rajit K Basu, Michael Zappitelli, ,

<h4>Objectives</h4>Acute kidney injury is diagnosed according to creatinine and urine output criteria. Traditionally, both are applied, and a severity stage (1-3) is conferred based upon the more severe of the two; information from the other criteria is discarded. Physiologically, however, rising creatinine and oliguria represent two distinct types of renal ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1912-1922]

Cited: 0 times

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Prevalence of Depression and Sleep Disorders in Patients on Dialysis: A Cross-Sectional Study in Qatar.

Fadwa Al-Ali, Mostafa Elshirbeny, Abdullah Hamad, Ahmad Kaddourah, Tarek Ghonimi, Rania Ibrahim, Tarek Fouda,

Patients with end-stage renal disease treated with dialysis have poor quality of life (QOL). Improving QOL in these patients with multiple comorbidities is a large challenge. We performed a cross-sectional study to evaluate the prevalence and associated factors of depression and sleep disorders in this population. Our primary aim was ... Read more >>

Int J Nephrol (International journal of nephrology)
[2021, 2021:5533416]

Cited: 0 times

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Weight as a Risk Factor for Mortality in Critically Ill Patients.

Itay Ayalon, Jessica G Woo, Rajit K Basu, Ahmad Kaddourah, Stuart L Goldstein, Jennifer M Kaplan, ,

<h4>Objectives</h4>To explore the hypothesis that obesity is associated with increased mortality and worse outcomes in children who are critically ill.<h4>Methods</h4>Secondary analysis of the Assessment of Worldwide Acute Kidney Injury, Renal Angina, and Epidemiology study, a prospective, multinational observational study. Patients between 3 months and 25 years across Asia, Australia, Europe, ... Read more >>

Pediatrics (Pediatrics)
[2020, 146(2):]

Cited: 0 times

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Oliguria and Acute Kidney Injury in Critically Ill Children: Implications for Diagnosis and Outcomes.

Ahmad Kaddourah, Rajit K Basu, Stuart L Goldstein, Scott M Sutherland, ,

<h4>Objectives</h4>Consensus definitions for acute kidney injury are based on changes in serum creatinine and urine output. Although the creatinine criteria have been widely applied, the contribution of the urine output criteria remains poorly understood. We evaluated these criteria individually and collectively to determine their impact on the diagnosis and outcome ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(4):332-339]

Cited: 13 times

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Assessment of a renal angina index for prediction of severe acute kidney injury in critically ill children: a multicentre, multinational, prospective observational study.

Rajit K Basu, Ahmad Kaddourah, Stuart L Goldstein, ,

<h4>Background</h4>Acute kidney injury (AKI) occurs in one in four children admitted to the intensive care unit (ICU) and AKI severity is independently associated with increased patient morbidity and mortality. Early prediction of AKI has the potential to improve outcomes. In smaller, single center populations, we have previously derived and validated ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2018, 2(2):112-120]

Cited: 19 times

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The epidemiology of acute peritonitis in end-stage renal disease patients on peritoneal dialysis in Qatar: An 8-year follow-up study.

Abdullah Hamad, Hany Ismail, Mohamed Elsayed, Ahmad Kaddourah, Hanaa Ahmed, Rania Ibrahim, Ahlam Ali, Fadwa Alali,

Acute peritonitis (AP) is a common and devastating complication in end-stage renal disease patients on peritoneal dialysis (PD). We are reporting an epidemiologic study of AP in Qatar over 8-year follow-up. We retrospectively reviewed medical records of all PD patients in Qatar from 2007 to 2014. The analysis was conducted ... Read more >>

Saudi J Kidney Dis Transpl (Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia)
[2018, 29(1):88-94]

Cited: 2 times

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Subclinical Kidney Injury in Children Receiving Nonsteroidal Anti-Inflammatory Drugs After Cardiac Surgery.

Edward Nehus, Ahmad Kaddourah, Michael Bennett, Olivia Pyles, Prasad Devarajan,

<h4>Objective</h4>To investigate the association of nonsteroidal anti-inflammatory drug (NSAID) administration with urinary neutrophil gelatinase-associated lipocalin (NGAL) levels in children following cardiopulmonary bypass (CPB) who did not develop acute kidney injury (AKI).<h4>Study design</h4>In this prospective observational study, urinary NGAL levels were investigated in 210 children who underwent cardiothoracic surgery requiring CPB. ... Read more >>

J Pediatr (The Journal of pediatrics)
[2017, 189:175-180]

Cited: 3 times

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Acute Kidney Injury in Critically Ill Children and Young Adults.

Stuart L Goldstein, Rajit K Basu, Ahmad Kaddourah,

N Engl J Med (The New England journal of medicine)
[2017, 376(13):1295-1296]

Cited: 0 times

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Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults.

Ahmad Kaddourah, Rajit K Basu, Sean M Bagshaw, Stuart L Goldstein, ,

<h4>Background</h4>The epidemiologic characteristics of children and young adults with acute kidney injury have been described in single-center and retrospective studies. We conducted a multinational, prospective study involving patients admitted to pediatric intensive care units to define the incremental risk of death and complications associated with severe acute kidney injury.<h4>Methods</h4>We used ... Read more >>

N Engl J Med (The New England journal of medicine)
[2017, 376(1):11-20]

Cited: 233 times

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Identifying evidence of cardio-renal syndrome in patients with Duchenne muscular dystrophy using cystatin C.

Chet R Villa, Ahmad Kaddourah, Jacob Mathew, Thomas D Ryan, Brenda L Wong, Stuart L Goldstein, John L Jefferies,

Patients with Duchenne muscular dystrophy (DMD) develop dilated cardiomyopathy and are at risk for kidney injury. Creatinine based estimated glomerular filtration rate (eGFR) is limited by low muscle mass with low serum creatinine levels in DMD. We assessed the relationship between cardiac function, modified Schwartz eGFR and cystatin C eGFR ... Read more >>

Neuromuscul Disord (Neuromuscular disorders : NMD)
[2016, 26(10):637-642]

Cited: 5 times

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Urinary biomarker incorporation into the renal angina index early in intensive care unit admission optimizes acute kidney injury prediction in critically ill children: a prospective cohort study.

Shina Menon, Stuart L Goldstein, Theresa Mottes, Lin Fei, Ahmad Kaddourah, Tara Terrell, Patricia Arnold, Michael R Bennett, Rajit K Basu,

<h4>Background</h4>The inconsistent ability of novel biomarkers to predict acute kidney injury (AKI) across heterogeneous patients and illnesses limits integration into routine practice. We previously retrospectively validated the ability of the renal angina index (RAI) to risk-stratify patients and provide context for confirmatory serum biomarker testing for the prediction of severe ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2016, 31(4):586-594]

Cited: 30 times

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Novel urinary tubular injury markers reveal an evidence of underlying kidney injury in children with reduced left ventricular systolic function: a pilot study.

Ahmad Kaddourah, Stuart L Goldstein, Rajit Basu, Edwards J Nehus, Tara C Terrell, Lori Brunner, Michael R Bennett, Christopher Haffner, John L Jefferies,

<h4>Background</h4>Evolving data suggest tubular injury markers (TIM) to be diagnostic and prognostic biomarkers of kidney injury in adults with chronic cardiac dysfunction. Such data are not well delineated in asymptomatic children with cardiomyopathy. This study sought to evaluate kidney involvement in children with left ventricular (LV) systolic dysfunction.<h4>Methods</h4>We conducted a ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2016, 31(10):1637-1645]

Cited: 4 times

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Thrombocytopenia-associated multi-organ failure caused by diabetic ketoacidosis.

Tarek Alsaied, Stuart L Goldstein, Ahmad Kaddourah, Sue E Poynter,

Thrombocytopenia-associated multi-organ failure (TAMOF) is an increasingly reported entity in the pediatric intensive care unit. The clinical presentation is similar to thrombotic thrombocytopenic purpura, but with no evidence of hemolysis and no schistocytes on peripheral smear. We report a case of TAMOF induced by diabetic ketoacidosis and treated with therapeutic ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2016, 58(3):232-234]

Cited: 3 times

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Assessment of Worldwide Acute Kidney Injury, Renal Angina and Epidemiology in critically ill children (AWARE): study protocol for a prospective observational study.

Rajit K Basu, Ahmad Kaddourah, Tara Terrell, Theresa Mottes, Patricia Arnold, Judd Jacobs, Jennifer Andringa, Stuart L Goldstein, ,

<h4>Background</h4>Acute kidney injury (AKI) is associated with poor outcome in critically ill children. While data extracted from retrospective study of pediatric populations demonstrate a high incidence of AKI, the literature lacks focused and comprehensive multicenter studies describing AKI risk factors, epidemiology, and outcome. Additionally, very few pediatric studies have examined ... Read more >>

BMC Nephrol (BMC nephrology)
[2015, 16:24]

Cited: 37 times

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Prevalence, predictors, and outcomes of cardiorenal syndrome in children with dilated cardiomyopathy: a report from the Pediatric Cardiomyopathy Registry.

Ahmad Kaddourah, Stuart L Goldstein, Steven E Lipshultz, James D Wilkinson, Lynn A Sleeper, Minmin Lu, Steven D Colan, Jeffrey A Towbin, Scott I Aydin, Joseph Rossano, Melanie D Everitt, Jeffrey G Gossett, Paolo Rusconi, Paul F Kantor, Paul F Kantor, Rakesh K Singh, John L Jefferies,

<h4>Background</h4>The association of cardiorenal syndrome (CRS) with mortality in children with dilated cardiomyopathy (DCM) is unknown.<h4>Methods</h4>With a modified Schwartz formula, we estimated glomerular filtration rates (eGFR) for children ≥1 year of age with DCM enrolled in the Pediatric Cardiomyopathy Registry at the time of DCM diagnosis and annually thereafter. CRS ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2015, 30(12):2177-2188]

Cited: 4 times

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Prevalence and predictors of aortic dilation as a novel cardiovascular complication in children with end-stage renal disease.

Ahmad Kaddourah, Susan Uthup, Peace Madueme, Matthew O'Rourke, David K Hooper, Michael D Taylor, Steven D Colan, John L Jefferies, Marepalli B Rao, Jens Goebel,

<h4>Background</h4>Cardiovascular disease is the leading cause of death in children with end-stage renal disease (ESRD). Isolated aortic dilation (AD) is rare in children. We aimed to determine the prevalence and the risk factors for AD in children with ESRD.<h4>Methods and study design</h4>We reviewed records of all ESRD patients followed mat ... Read more >>

Clin Nephrol (Clinical nephrology)
[2015, 83(5):262-271]

Cited: 9 times

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Assessment of Worldwide Acute Kidney Injury, Renal Angina and Epidemiology in Critically Ill Children (AWARE): A Prospective Study to Improve Diagnostic Precision.

Rajit K Basu, Ahmad Kaddourah, Tara Terrell, Theresa Mottes, Patricia Arnold, Judd Jacobs, Jennifer Andringa, Melissa Armor, Lauren Hayden, Stuart L Goldstein,

<h4>Background</h4>Acute kidney injury (AKI) is associated with poor outcomes in critically ill children. Recent international consensus panels recommend standardized classification systems to improve the precision of AKI diagnosis, but there is a paucity of data to enable this refinement, particularly in pediatric critical care.<h4>Methods/design</h4>This is a prospective observational study. We ... Read more >>

J Clin Trials (Journal of clinical trials)
[2015, 5(3):]

Cited: 6 times

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Renal replacement therapy in neonates.

Ahmad Kaddourah, Stuart L Goldstein,

The incidence of acute kidney injury (AKI) has steadily increased in the last decade in neonates and infants. Despite the extensive proposed pharmacologic approaches to treat or prevent AKI, renal replacement therapy is the only available therapeutic approach to manage the consequences of significant AKI and maintain electrolyte homeostasis and ... Read more >>

Clin Perinatol (Clinics in perinatology)
[2014, 41(3):517-527]

Cited: 5 times

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