Full Text Journal Articles by
Author Agathe Subtil

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Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells.

Benoit Maffei, Marc Laverrière, Yongzheng Wu, Sébastien Triboulet, Stéphanie Perrinet, Magalie Duchateau, Mariette Matondo, Robert L Hollis, Charlie Gourley, Jan Rupp, Jeffrey W Keillor, Agathe Subtil,

Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme with transamidating activity. We report here that both expression and activity of TG2 are enhanced in mammalian epithelial cells infected with the obligate intracellular bacteria Chlamydia trachomatis. Genetic or pharmacological inhibition of TG2 impairs bacterial development. We show that TG2 increases glucose ... Read more >>

EMBO J. (The EMBO journal)
[2020, 39(8):e102166]

Cited: 0 times

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Chlamydia-induced curvature of the host-cell plasma membrane is required for infection.

Sebastian Hänsch, Dominik Spona, Gido Murra, Karl Köhrer, Agathe Subtil, Ana Rita Furtado, Stephan F Lichtenthaler, Bastian Dislich, Katja Mölleken, Johannes H Hegemann,

During invasion of host cells, Chlamydia pneumoniae secretes the effector protein CPn0678, which facilitates internalization of the pathogen by remodeling the target cell's plasma membrane and recruiting sorting nexin 9 (SNX9), a central multifunctional endocytic scaffold protein. We show here that the strongly amphipathic N-terminal helix of CPn0678 mediates binding ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(5):2634-2644]

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Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis

Benoit Maffei, Marc Laverrière, Yongzheng Wu, Sébastien Triboulet, Stéphanie Perrinet, Magalie Duchateau, Mariette Matondo, Robert Hollis, Charlie Gourley, Jan Rupp, Jeffrey Keillor, Agathe Subtil,

ABSTRACT Transglutaminase 2 (TG2) is a ubiquitous enzyme with transamidating activity. We report here that the expression and activity of TG2 are enhanced in cells infected with the obligate intracellular bacteria Chlamydia trachomatis . Genetic or pharmacological inhibition of TG2 activity impair bacterial development. We show that TG2 increases glucose ... Read more >>

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Make It a Sweet Home: Responses of Chlamydia trachomatis to the Challenges of an Intravacuolar Lifestyle.

Sébastien Triboulet, Agathe Subtil,

Intravacuolar development has been adopted by several bacteria that grow inside a host cell. Remaining in a vacuole, as opposed to breaching the cytosol, protects the bacteria from some aspects of the cytosolic innate host defense and allows them to build an environment perfectly adapted to their needs. However, this ... Read more >>

Microbiol Spectr (Microbiology spectrum)
[2019, 7(2):]

Cited: 0 times

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The Loss of Expression of a Single Type 3 Effector (CT622) Strongly Reduces Chlamydia trachomatis Infectivity and Growth.

Mathilde M Cossé, Michael L Barta, Derek J Fisher, Lena K Oesterlin, Béatrice Niragire, Stéphanie Perrinet, Gaël A Millot, P Scott Hefty, Agathe Subtil,

Invasion of epithelial cells by the obligate intracellular bacterium Chlamydia trachomatis results in its enclosure inside a membrane-bound compartment termed an inclusion. The bacterium quickly begins manipulating interactions between host intracellular trafficking and the inclusion interface, diverging from the endocytic pathway and escaping lysosomal fusion. We have identified a previously ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2018, 8:145]

Cited: 2 times

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Biotic Host-Pathogen Interactions As Major Drivers of Plastid Endosymbiosis.

Ugo Cenci, Debashish Bhattacharya, Andreas P M Weber, Christophe Colleoni, Agathe Subtil, Steven G Ball,

The plastid originated 1.5 billion years ago through a primary endosymbiosis involving a heterotrophic eukaryote and an ancient cyanobacterium. Phylogenetic and biochemical evidence suggests that the incipient endosymbiont interacted with an obligate intracellular chlamydial pathogen that housed it in an inclusion. This aspect of the ménage-à-trois hypothesis (MATH) posits that ... Read more >>

Trends Plant Sci. (Trends in plant science)
[2017, 22(4):316-328]

Cited: 8 times

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Biochemical and structural insights into microtubule perturbation by CopN from Chlamydia pneumoniae.

Agata Nawrotek, Beatriz G Guimarães, Christophe Velours, Agathe Subtil, Marcel Knossow, Benoît Gigant,

Although the actin network is commonly hijacked by pathogens, there are few reports of parasites targeting microtubules. The proposed member of the LcrE protein family from some Chlamydia species (e.g. pCopN from C. pneumoniae) binds tubulin and inhibits microtubule assembly in vitro. From the pCopN structure and its similarity with ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2014, 289(36):25199-25210]

Cited: 7 times

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Massive expansion of Ubiquitination-related gene families within the Chlamydiae.

Daryl Domman, Astrid Collingro, Ilias Lagkouvardos, Lena Gehre, Thomas Weinmaier, Thomas Rattei, Agathe Subtil, Matthias Horn,

Gene loss, gain, and transfer play an important role in shaping the genomes of all organisms; however, the interplay of these processes in isolated populations, such as in obligate intracellular bacteria, is less understood. Despite a general trend towards genome reduction in these microbes, our phylogenomic analysis of the phylum ... Read more >>

Mol. Biol. Evol. (Molecular biology and evolution)
[2014, 31(11):2890-2904]

Cited: 18 times

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Editorial overview: Host-microbe interactions: bacteria. War and peace: the fragile equilibrium between bacteria and host.

Olivia Steele-Mortimer, Agathe Subtil,

Curr. Opin. Microbiol. (Current opinion in microbiology)
[2014, 17:v-vii]

Cited: 0 times

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The intracellular bacteria Chlamydia hijack peroxisomes and utilize their enzymatic capacity to produce bacteria-specific phospholipids.

Gaelle Boncompain, Constanze Müller, Vannary Meas-Yedid, Philippe Schmitt-Kopplin, Paul B Lazarow, Agathe Subtil,

Chlamydia trachomatis is an obligate intracellular pathogen responsible for loss of eyesight through trachoma and for millions of cases annually of sexually transmitted diseases. The bacteria develop within a membrane-bounded inclusion. They lack enzymes for several biosynthetic pathways, including those to make some phospholipids, and exploit their host to compensate. ... Read more >>

PLoS ONE (PloS one)
[2014, 9(1):e86196]

Cited: 22 times

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Tracing the primordial Chlamydiae: extinct parasites of plants?

Agathe Subtil, Astrid Collingro, Matthias Horn,

Chlamydiae are obligate intracellular bacteria found as symbionts and pathogens in a wide range of eukaryotes, including protists, invertebrates, and vertebrates. It was recently proposed that an ancient chlamydial symbiont facilitated the establishment of primary plastids in a tripartite symbiosis with cyanobacteria and early eukaryotes. In this review, we summarize ... Read more >>

Trends Plant Sci. (Trends in plant science)
[2014, 19(1):36-43]

Cited: 17 times

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Exploitation of host lipids by bacteria.

François Vromman, Agathe Subtil,

Bacteria that interact with eukaryotic cells have developed a variety of strategies to divert host lipids, or cellular processes driven by lipids, to their benefit. Host lipids serve as building blocks for bacterial membrane formation and as energy source. They promote the formation of specific microdomains, facilitating interactions with the ... Read more >>

Curr. Opin. Microbiol. (Current opinion in microbiology)
[2014, 17:38-45]

Cited: 20 times

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Metabolic effectors secreted by bacterial pathogens: essential facilitators of plastid endosymbiosis?

Steven G Ball, Agathe Subtil, Debashish Bhattacharya, Ahmed Moustafa, Andreas P M Weber, Lena Gehre, Christophe Colleoni, Maria-Cecilia Arias, Ugo Cenci, David Dauvillée,

Under the endosymbiont hypothesis, over a billion years ago a heterotrophic eukaryote entered into a symbiotic relationship with a cyanobacterium (the cyanobiont). This partnership culminated in the plastid that has spread to forms as diverse as plants and diatoms. However, why primary plastid acquisition has not been repeated multiple times ... Read more >>

Plant Cell (The Plant cell)
[2013, 25(1):7-21]

Cited: 47 times

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Chlamydia co-opts the rod shape-determining proteins MreB and Pbp2 for cell division.

Scot P Ouellette, Gouzel Karimova, Agathe Subtil, Daniel Ladant,

Chlamydiae are obligate intracellular bacterial pathogens that have extensively reduced their genome in adapting to the intracellular environment. The chlamydial genome contains only three annotated cell division genes and lacks ftsZ. How this obligate intracellular pathogen divides is uncharacterized. Chlamydiae contain two high-molecular-weight (HMW) penicillin binding proteins (Pbp) implicated in ... Read more >>

Mol. Microbiol. (Molecular microbiology)
[2012, 85(1):164-178]

Cited: 43 times

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Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta.

Hélène Bierne, Laetitia Travier, Tanel Mahlakõiv, Ludovic Tailleux, Agathe Subtil, Alice Lebreton, Anupam Paliwal, Brigitte Gicquel, Peter Staeheli, Marc Lecuit, Pascale Cossart,

Bacterial infections trigger the expression of type I and II interferon genes but little is known about their effect on type III interferon (IFN-λ) genes, whose products play important roles in epithelial innate immunity against viruses. Here, we studied the expression of IFN-λ genes in cultured human epithelial cells infected ... Read more >>

PLoS ONE (PloS one)
[2012, 7(6):e39080]

Cited: 39 times

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Rerouting of host lipids by bacteria: are you CERTain you need a vesicle?

Agathe Subtil,

PLoS Pathog. (PLoS pathogens)
[2011, 7(9):e1002208]

Cited: 3 times

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Identification of a family of effectors secreted by the type III secretion system that are conserved in pathogenic Chlamydiae.

Sandra Muschiol, Gaelle Boncompain, François Vromman, Pierre Dehoux, Staffan Normark, Birgitta Henriques-Normark, Agathe Subtil,

Chlamydiae are Gram-negative, obligate intracellular pathogens that replicate within a membrane-bounded compartment termed an inclusion. Throughout their development, they actively modify the eukaryotic environment. The type III secretion (TTS) system is the main process by which the bacteria translocate effector proteins into the inclusion membrane and the host cell cytoplasm. ... Read more >>

Infect. Immun. (Infection and immunity)
[2011, 79(2):571-580]

Cited: 23 times

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Histone methylation by NUE, a novel nuclear effector of the intracellular pathogen Chlamydia trachomatis.

Meghan E Pennini, Stéphanie Perrinet, Alice Dautry-Varsat, Agathe Subtil,

Sequence analysis of the genome of the strict intracellular pathogen Chlamydia trachomatis revealed the presence of a SET domain containing protein, proteins that primarily function as histone methyltransferases. In these studies, we demonstrated secretion of this protein via a type III secretion mechanism. During infection, the protein is translocated to ... Read more >>

PLoS Pathog. (PLoS pathogens)
[2010, 6(7):e1000995]

Cited: 67 times

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Intracellular bacteria encode inhibitory SNARE-like proteins.

Fabienne Paumet, Jordan Wesolowski, Alejandro Garcia-Diaz, Cedric Delevoye, Nathalie Aulner, Howard A Shuman, Agathe Subtil, James E Rothman,

Pathogens use diverse molecular machines to penetrate host cells and manipulate intracellular vesicular trafficking. Viruses employ glycoproteins, functionally and structurally similar to the SNARE proteins, to induce eukaryotic membrane fusion. Intracellular pathogens, on the other hand, need to block fusion of their infectious phagosomes with various endocytic compartments to escape ... Read more >>

PLoS ONE (PloS one)
[2009, 4(10):e7375]

Cited: 44 times

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Re: Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas.

Patricia de Cremoux, Agathe Subtil, Andrés J M Ferreri, Anne Vincent-Salomon, Maruilio Ponzoni, Driss Chaoui, Philippe Arnaud, Livia Lumbroso-Le Rouic, Federico Sacchetti, Rémi Dendale, Martine Thioux, Marie-Christine Escande, Marc-Henri Stern, Riccardo Dolcetti, Didier Decaudin,

J. Natl. Cancer Inst. (Journal of the National Cancer Institute)
[2006, 98(5):365-366]

Cited: 20 times

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Recent insights into the mechanisms of Chlamydia entry.

Alice Dautry-Varsat, Agathe Subtil, Ted Hackstadt,

Chlamydia are widespread bacteria that grow in human and animal cells. They enter their host cell, establish an intracellular environment favourable for their multiplication and finally exit the host cell. A combination of host cell factors and of bacterial proteins contribute to pathogen entry. Recent advances have shed new light ... Read more >>

Cell. Microbiol. (Cellular microbiology)
[2005, 7(12):1714-1722]

Cited: 69 times

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Development of a real-time PCR for the detection of Chlamydia psittaci.

Armelle Ménard, Maithé Clerc, Agathe Subtil, Francis Mégraud, Christiane Bébéar, Bertille de Barbeyrac,

J. Med. Microbiol. (Journal of medical microbiology)
[2006, 55(Pt 4):471-473]

Cited: 27 times

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Correlation between Chlamydia pneumoniae detection from coronary angioplasty balloons and atherosclerosis severity.

Benjamin Wyplosz, Gilles Montalescot, Agathe Subtil, Annick Dujeancourt, Marie-Laure Tanguy, Rémi Choussat, Loïc Capron, Alice Dautry-Varsat,

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2006, 47(6):1229-1231]

Cited: 4 times

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ARF6 GTPase controls bacterial invasion by actin remodelling.

María Eugenia Balañá, Florence Niedergang, Agathe Subtil, Andrés Alcover, Philippe Chavrier, Alice Dautry-Varsat,

The obligate intracellular bacterium Chlamydia penetrates the host epithelial cell by inducing cytoskeleton and membrane rearrangements reminiscent of phagocytosis. Here we report that Chlamydia induces a sharp and transient activation of the endogenous small GTP-binding protein ARF6, which is required for efficient uptake. We also show that a downstream effector ... Read more >>

J. Cell. Sci. (Journal of cell science)
[2005, 118(Pt 10):2201-2210]

Cited: 52 times

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A directed screen for chlamydial proteins secreted by a type III mechanism identifies a translocated protein and numerous other new candidates.

Agathe Subtil, Cédric Delevoye, María-Eugenia Balañá, Laurence Tastevin, Stéphanie Perrinet, Alice Dautry-Varsat,

Chlamydiae are strict intracellular parasites that induce their internalization upon contact with the host cell and grow inside an intracellular compartment called an inclusion. They possess a type III secretion (TTS) apparatus, which allows for the translocation of specific proteins in the host cell cytosol. In particular, chlamydial proteins of ... Read more >>

Mol. Microbiol. (Molecular microbiology)
[2005, 56(6):1636-1647]

Cited: 81 times

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