Full Text Journal Articles by
Author Agatha Schwarz

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Controllers of cutaneous regulatory T cells: ultraviolet radiation and the skin microbiome.

Thomas Schwarz, Agatha Schwarz,

For the maintenance of homeostasis termination of immune reactions is as equally important as their induction. In this scenario regulatory T cells (Treg) play an important role. Accordingly a variety of inflammatory diseases are caused by an impairment of Treg. Hence, it is important to identify triggers by which Treg can ... Read more >>

Biol Chem (Biological chemistry)
[2021, 402(12):1575-1581]

Cited: 0 times

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Elevated NK-cell transcriptional signature and dysbalance of resting and activated NK cells in atopic dermatitis.

Lena Möbus, Elke Rodriguez, Inken Harder, Agatha Schwarz, Ulrike Wehkamp, Dora Stölzl, Nicole Boraczynski, Sascha Gerdes, Thomas Litman, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Jochen Schmitt, Thomas Werfel, Stephan Weidinger, ,

<h4>Background</h4>Altered quantities, activity, and composition of natural killer (NK) cells in blood as well as expression changes of genes involved in NK-cell function in skin lesions of patients with atopic dermatitis (AD) were recently reported.<h4>Objectives</h4>We sought to comprehensively analyze cutaneous NK-cell transcriptomic signatures in AD, and to examine changes under ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, 147(5):1959-1965.e2]

Cited: 1 time

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Induction of Regulatory T Cells and Correction of Cytokine Disbalance by Short-Chain Fatty Acids: Implications for Psoriasis Therapy.

Agatha Schwarz, Rebecca Philippsen, Thomas Schwarz,

Commensal microbes modulate the immune system in the colon through short-chain fatty acids, which induce regulatory T cells (Treg). Accordingly, the short-chain fatty acid sodium butyrate (SB) suppressed allergic contact dermatitis in mice through the activation of Treg. There is evidence that Treg exert the capacity to control inflammation in ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2021, 141(1):95-104.e2]

Cited: 8 times

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Reevaluation of Lung Injury in TNF-Induced Shock: The Role of the Acid Sphingomyelinase.

Lucy K Reiss, Ute Raffetseder, Lydia Gibbert, Hannah K Drescher, Konrad L Streetz, Agatha Schwarz, Christian Martin, Stefan Uhlig, Dieter Adam,

Tumor necrosis factor (TNF) is a well-known mediator of sepsis. In many cases, sepsis results in multiple organ injury including the lung with acute respiratory distress syndrome (ARDS). More than 20-year-old studies have suggested that TNF may be directly responsible for organ injury during sepsis. However, these old studies are ... Read more >>

Mediators Inflamm (Mediators of inflammation)
[2020, 2020:3650508]

Cited: 4 times

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Correction to: The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis.

Marius Pollet, Siraz Shaik, Melina Mescher, Katrin Frauenstein, Julia Tigges, Stephan A Braun, Kevin Sondenheimer, Mana Kaveh, Anika Bruhs, Stephan Meller, Bernhard Homey, Agatha Schwarz, Charlotte Esser, Thierry Douki, Christoph F A Vogel, Jean Krutmann, Thomas Haarmann-Stemmann,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Cell Death Differ (Cell death and differentiation)
[2020, 27(1):403]

Cited: 0 times

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Decreased expression of G-protein-coupled receptors GPR43 and GPR109a in psoriatic skin can be restored by topical application of sodium butyrate.

Alicja Krejner, Anika Bruhs, Ulrich Mrowietz, Ulrike Wehkamp, Thomas Schwarz, Agatha Schwarz,

The G-protein-coupled receptors GPR43 and GPR109a are known to play an important role in mediating anti-inflammatory and anti-cancer functions in the gut. Short-chain fatty acids, such as sodium butyrate (SB), are activators of GPR43 and GPR109a and thereby promote anti-inflammatory effects. The present study aimed to examine the expression of ... Read more >>

Arch Dermatol Res (Archives of dermatological research)
[2018, 310(9):751-758]

Cited: 7 times

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The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis.

Marius Pollet, Siraz Shaik, Melina Mescher, Katrin Frauenstein, Julia Tigges, Stephan A Braun, Kevin Sondenheimer, Mana Kaveh, Anika Bruhs, Stephan Meller, Bernhard Homey, Agatha Schwarz, Charlotte Esser, Thierry Douki, Christoph F A Vogel, Jean Krutmann, Thomas Haarmann-Stemmann,

Ultraviolet B (UVB) radiation induces mutagenic DNA photoproducts, in particular cyclobutane pyrimidine dimers (CPDs), in epidermal keratinocytes (KC). To prevent skin carcinogenesis, these DNA photoproducts must be removed by nucleotide excision repair (NER) or apoptosis. Here we report that the UVB-sensitive transcription factor aryl hydrocarbon receptor (AHR) attenuates the clearance ... Read more >>

Cell Death Differ (Cell death and differentiation)
[2018, 25(10):1823-1836]

Cited: 21 times

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Ultraviolet radiation induces Melan-A-expressing cells in interfollicular epidermis in wild-type mice.

David A De Luca, Barbara Sterniczky, Susanne Kimeswenger, Dagmar Födinger, Agatha Schwarz, Thomas Schwarz, Christian Jantschitsch,

Adult wild-type mice are not supposed to be proper models for ultraviolet radiation (UVR)-induced melanoma since melanocytes are confined to hair follicles and cannot be sufficiently reached by UVR. On the other hand, in mutated mouse models used for melanoma research limitations, including an altered immune system and selection of ... Read more >>

Arch Dermatol Res (Archives of dermatological research)
[2018, 310(6):529-532]

Cited: 1 time

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Disruption of the Epidermal Barrier Induces Regulatory T Cells via IL-33 in Mice.

Anika Bruhs, Ehrhardt Proksch, Thomas Schwarz, Agatha Schwarz,

Disturbance of the epidermal barrier by UVR is associated with the release of antimicrobial peptides and inflammatory cytokines for the purpose of a danger response. On the other hand, UVR causes immunosuppression via regulatory T cells (Treg) that limit the inflammatory reaction. The concurrent induction of antimicrobial peptides and Treg ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2018, 138(3):570-579]

Cited: 11 times

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The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System.

Agatha Schwarz, Anika Bruhs, Thomas Schwarz,

There is evidence that gut commensal microbes affect the mucosal immune system via expansion of regulatory T cells (Tregs) in the colon. This is mediated via short-chain fatty acids, bacterial metabolites generated during fiber fermentation, which include butyrate, propionate, and acetate. We postulated that short-chain fatty acids produced by commensal ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2017, 137(4):855-864]

Cited: 40 times

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Targeted Resequencing and Functional Testing Identifies Low-Frequency Missense Variants in the Gene Encoding GARP as Significant Contributors to Atopic Dermatitis Risk.

Judith Manz, Elke Rodríguez, Abdou ElSharawy, Eva-Maria Oesau, Britt-Sabina Petersen, Hansjörg Baurecht, Gabriele Mayr, Susanne Weber, Jürgen Harder, Eva Reischl, Agatha Schwarz, Natalija Novak, Andre Franke, Stephan Weidinger,

Gene-mapping studies have consistently identified a susceptibility locus for atopic dermatitis and other inflammatory diseases on chromosome band 11q13.5, with the strongest association observed for a common variant located in an intergenic region between the two annotated genes C11orf30 and LRRC32. Using a targeted resequencing approach we identified low-frequency and ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2016, 136(12):2380-2386]

Cited: 14 times

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Infrared A radiation promotes survival of human melanocytes carrying ultraviolet radiation-induced DNA damage.

Susanne Kimeswenger, Agatha Schwarz, Dagmar Födinger, Susanne Müller, Hubert Pehamberger, Thomas Schwarz, Christian Jantschitsch,

The link between solar radiation and melanoma is still elusive. Although infrared radiation (IR) accounts for over 50% of terrestrial solar energy, its influence on human skin is not well explored. There is increasing evidence that IR influences the expression patterns of several molecules independently of heat. A previous in vivo ... Read more >>

Exp Dermatol (Experimental dermatology)
[2016, 25(6):447-452]

Cited: 4 times

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Urocanic Acid: An Endogenous Regulator of Langerhans Cells.

Anika Bruhs, Leopold Eckhart, Erwin Tschachler, Thomas Schwarz, Agatha Schwarz,

J Invest Dermatol (The Journal of investigative dermatology)
[2016, 136(8):1735-1737]

Cited: 2 times

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Prevention and Mitigation of Experimental Autoimmune Encephalomyelitis by Murine β-Defensins via Induction of Regulatory T Cells.

Anika Bruhs, Thomas Schwarz, Agatha Schwarz,

The antimicrobial peptide murine β-defensin-14 (mBD14) was found to exert, in addition to its antimicrobial activity, the capacity to induce regulatory T cells as demonstrated in the model of contact hypersensitivity. Because it is induced by ultraviolet radiation, mBD14 may contribute to the antigen-specific immunosuppression by ultraviolet radiation. To prove ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2016, 136(1):173-181]

Cited: 7 times

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Activation of the arylhydrocarbon receptor causes immunosuppression primarily by modulating dendritic cells.

Anika Bruhs, Thomas Haarmann-Stemmann, Katrin Frauenstein, Jean Krutmann, Thomas Schwarz, Agatha Schwarz,

UVR suppresses the immune system in an antigen-specific manner via induction of regulatory T cells (Tregs). The specific immunosuppression by UVR harbors therapeutic potential but is associated with UVR-induced DNA damage, requiring the identification of other triggers inducing the same immunosuppressive effects without DNA damage. The aryl hydrocarbon receptor (AhR) ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2015, 135(2):435-444]

Cited: 13 times

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The Aryl hydrocarbon receptor is involved in UVR-induced immunosuppression.

Fatemeh Navid, Anika Bruhs, Winfried Schuller, Ellen Fritsche, Jean Krutmann, Thomas Schwarz, Agatha Schwarz,

UVR suppresses the immune system through the induction of regulatory T cells (Tregs). UVR-induced DNA damage has been recognized as the major molecular trigger involved, as reduction of DNA damage by enhanced repair prevents the compromise to the immune system by UVR. Nevertheless, other signaling events may also be involved. ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2013, 133(12):2763-2770]

Cited: 16 times

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Role of fibroblasts in the pathogenesis of atopic dermatitis.

Andreas Berroth, Jochen Kühnl, Nina Kurschat, Agatha Schwarz, Franz Stäb, Thomas Schwarz, Horst Wenck, Regina Fölster-Holst, Gitta Neufang,

<h4>Background</h4>Atopic dermatitis (AD) is a common dermatosis that highly impairs a patient's quality of life. The recent discovery that epidermal barrier defects caused by an aberrant differentiation process of keratinocytes are comparably important to the well-characterized changes in immune response patterns attributed a crucial role to the keratinocytes. Fibroblasts are ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2013, 131(6):1547-1554]

Cited: 23 times

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Ultraviolet radiation-induced upregulation of antimicrobial proteins in health and disease.

Sarah Felton, Fatemeh Navid, Agatha Schwarz, Thomas Schwarz, Regine Gläser, Lesley E Rhodes,

This article reviews recent data on the expression, regulation and activation of antimicrobial peptides (AMP) in human skin, and considers their potential protective and pro-inflammatory roles following upregulation by ultraviolet radiation (UVR). Antimicrobial peptides are small peptides that are key components of the innate immune system, originally identified by their ... Read more >>

Photochem Photobiol Sci (Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology)
[2013, 12(1):29-36]

Cited: 19 times

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1,25-dihydroxyvitamin D exerts similar immunosuppressive effects as UVR but is dispensable for local UVR-induced immunosuppression.

Agatha Schwarz, Fatemeh Navid, Tim Sparwasser, Björn E Clausen, Thomas Schwarz,

Low-dose UV radiation (UVR) inhibits the induction of contact hypersensitivity and induces regulatory T cells (Tregs), which because of their antigen specificity harbor therapeutic potential. Topical application of 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is known to induce Tregs as well, which implies that 1,25(OH)(2)D(3) might be involved in UVR-induced immunosuppression. It was ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2012, 132(12):2762-2769]

Cited: 30 times

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IL-12 and IL-23 affect photocarcinogenesis differently.

Christian Jantschitsch, Michael Weichenthal, Ehrhardt Proksch, Thomas Schwarz, Agatha Schwarz,

Induction of DNA damage by UVR is the key event in photocarcinogenesis. IL-12 and IL-23 are related heterodimeric cytokines consisting of a common p40 unit and a p35/IL-12 and a p19/IL-23 chain, respectively. Both exert immunomodulatory activities but are also found to reduce UVR-induced DNA damage presumably via induction of ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2012, 132(5):1479-1486]

Cited: 14 times

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Induction of regulatory T cells by a murine β-defensin.

Fatemeh Navid, Michele Boniotto, Catherine Walker, Kerstin Ahrens, Ehrhardt Proksch, Tim Sparwasser, Werner Müller, Thomas Schwarz, Agatha Schwarz,

β-Defensins are antimicrobial peptides of the innate immune system produced in the skin by various stimuli, including proinflammatory cytokines, bacterial infection, and exposure to UV radiation (UVR). In this study we demonstrate that the UVR-inducible antimicrobial peptide murine β-defensin-14 (mBD-14) switches CD4(+)CD25(-) T cells into a regulatory phenotype by inducing ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2012, 188(2):735-743]

Cited: 22 times

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In vivo reprogramming of UV radiation-induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity.

Agatha Schwarz, Fatemeh Navid, Tim Sparwasser, Björn E Clausen, Thomas Schwarz,

<h4>Background</h4>Regulatory T (Treg) cells induced by UV radiation (UVR) inhibit only the induction and not the elicitation of contact hypersensitivity (CHS) because they migrate into the lymph nodes but not the skin. The tissue-homing receptor expression and migratory behavior of Treg cells can be altered by means of in vitro coincubation ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2011, 128(4):826-833]

Cited: 36 times

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Infrared radiation does not enhance the frequency of ultraviolet radiation-induced skin tumors, but their growth behaviour in mice.

Christian Jantschitsch, Michael Weichenthal, Akira Maeda, Ehrhardt Proksch, Thomas Schwarz, Agatha Schwarz,

There is increasing concern about the interaction between infrared radiation (IR) and ultraviolet radiation (UVR) with regard to carcinogenesis because prolonged solar exposure is associated with an increased cumulative load not only of UVR but also of IR. We recently demonstrated that IR-pretreatment reduces UVR-induced apoptosis. As this might support ... Read more >>

Exp Dermatol (Experimental dermatology)
[2011, 20(4):346-350]

Cited: 14 times

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Molecular mechanisms of ultraviolet radiation-induced immunosuppression.

Thomas Schwarz, Agatha Schwarz,

Solar ultraviolet radiation (UVR) is well known for its immunosuppressive properties. UVR can suppress immune reactions both in a local and a systemic fashion. One of the major molecular mediators of photoimmunosuppression is UVR-induced DNA damage. In contrast to immunosuppressive drugs, UVR does not act in a general but antigen-specific ... Read more >>

Eur J Cell Biol (European journal of cell biology)
[2011, 90(6-7):560-564]

Cited: 49 times

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UVR-induced regulatory T cells switch antigen-presenting cells from a stimulatory to a regulatory phenotype.

Agatha Schwarz, Thomas Schwarz,

UVR-induced regulatory T cells (UVR-Treg) inhibit sensitization in an antigen-specific manner. The migratory behavior of UVR-Treg can be reprogrammed by antigen-presenting cells (APCs), indicating a cross-talk between these cells. Hence, we sought to investigate whether in turn UVR-Treg can influence APCs. Bone marrow-derived dendritic cells (DCs) were co-incubated with DNFB-specific ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2010, 130(7):1914-1921]

Cited: 24 times

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