Full Text Journal Articles by
Author Afshan Hussain

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Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease.

John A Spertus, Philip G Jones, David J Maron, Sean M O'Brien, Harmony R Reynolds, Yves Rosenberg, Gregg W Stone, Frank E Harrell, William E Boden, William S Weintraub, Khaula Baloch, Kreton Mavromatis, Ariel Diaz, Gilbert Gosselin, Jonathan D Newman, Stavroula Mavromichalis, Karen P Alexander, David J Cohen, Sripal Bangalore, Judith S Hochman, Daniel B Mark, ,

BACKGROUND:In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. METHODS:We assessed angina-related symptoms, function, and ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 382(15):1408-1419]

Cited: 4 times

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Initial Invasive or Conservative Strategy for Stable Coronary Disease.

David J Maron, Judith S Hochman, Harmony R Reynolds, Sripal Bangalore, Sean M O'Brien, William E Boden, Bernard R Chaitman, Roxy Senior, Jose López-Sendón, Karen P Alexander, Renato D Lopes, Leslee J Shaw, Jeffrey S Berger, Jonathan D Newman, Mandeep S Sidhu, Shaun G Goodman, Witold Ruzyllo, Gilbert Gosselin, Aldo P Maggioni, Harvey D White, Balram Bhargava, James K Min, G B John Mancini, Daniel S Berman, Michael H Picard, Raymond Y Kwong, Ziad A Ali, Daniel B Mark, John A Spertus, Mangalath N Krishnan, Ahmed Elghamaz, Nagaraja Moorthy, Whady A Hueb, Marcin Demkow, Kreton Mavromatis, Olga Bockeria, Jesus Peteiro, Todd D Miller, Hanna Szwed, Rolf Doerr, Matyas Keltai, Joseph B Selvanayagam, P Gabriel Steg, Claes Held, Shun Kohsaka, Stavroula Mavromichalis, Ruth Kirby, Neal O Jeffries, Frank E Harrell, Frank W Rockhold, Samuel Broderick, T Bruce Ferguson, David O Williams, Robert A Harrington, Gregg W Stone, Yves Rosenberg, ,

BACKGROUND:Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS:We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 382(15):1395-1407]

Cited: 10 times

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Ibuprofen and its associated alterations in testicular physiology - Letter to the Editor.

Hafsa Jawaid, Afshan Hussain, Nida Faisal,

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2018, 68(9):1424]

Cited: 0 times

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Vitamin D and its role in sleep physiology: Letter to the Editor.

Hafsa Jawaid, Afshan Hussain, Ateeba Ayesha Khan,

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2018, 68(7):1152]

Cited: 0 times

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Impact of green tea consumption on the risk of Tuberculosis development - Letter to the Editor.

Kiran Shafiq Khan, Afshan Hussain, Hafsa Jawaid, Fauzia Imtiaz,

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2018, 68(9):1421]

Cited: 0 times

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Ruptured Rudimentary Horn Pregnancy Revealed on Emergency Laparotomy: A Case of Primigravida Presenting in a Developing Country.

Afshan Hussain, Hafsa Jawaid, Nida Faisal, Naima Shah, Nusrat S Kamal,

Developmental defects in the Mullerian ducts can result in several uterine anomalies including a unicornuate uterus with a rudimentary horn. Pregnancy in a rudimentary horn is extremely rare occurring in 1:76,000-1:160,000 pregnancies. We present a case of an 18-year-old primigravida with a ruptured rudimentary horn pregnancy (RHP) presenting as acute ... Read more >>

(Cureus)
[2018, 10(5):e2591]

Cited: 0 times

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Differences in symptoms and presentation delay times in myocardial infarction patients with and without diabetes: A cross-sectional study in Pakistan.

Saba Ahmed, Ariba Khan, Syed Ibaad Ali, Mohammad Saad, Hafsa Jawaid, Mahnoor Islam, Hanieya Saiyed, Sarosh Fatima, Aiman Khan, Maleeha A Basham, Syeda Asfia Hussain, Maheen Akhtar, Fatima Kausar, Afshan Hussain, Kaneez Fatima,

OBJECTIVE:A short pre-hospital delay, from the onset of symptoms to rapid initiation of reperfusion therapy, is a crucial factor in determining prognosis of myocardial infarction (MI). The purpose of this study was to evaluate symptoms and presentation delay times in MI patients with and without diabetes. METHODS:This cross-sectional study was ... Read more >>

Indian Heart J (Indian heart journal)
[2018, 70(2):241-245]

Cited: 3 times

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Cardiovascular events associated with proton pump inhibitors.

Hafsa Jawaid, Afshan Hussain, Fauzia Imtiaz,

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2017, 67(9):1466]

Cited: 0 times

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Hospital-based study of epithelial malignancies of endometrial cancer frequency in lahore, pakistan, and common diagnostic pitfalls.

Imrana Tanvir, Sabiha Riaz, Afshan Hussain, Riffat Mehboob, M Usman Shams, Haseeb Ahmad Khan,

The current study was conducted to see the frequency of epithelial malignancies of endometrium with focus on the common diagnostic pitfalls and identify morphological and immunohistochemical markers helpful in the differential diagnosis between different subtypes. It is a retrospective descriptive study carried out on 52 specimens of endometrial tumors received ... Read more >>

(Pathology research international)
[2014, 2014:179384]

Cited: 1 time

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Gβγ-independent recruitment of G-protein coupled receptor kinase 2 drives tumor necrosis factor α-induced cardiac β-adrenergic receptor dysfunction.

Neelakantan T Vasudevan, Maradumane L Mohan, Manveen K Gupta, Elizabeth E Martelli, Afshan K Hussain, Yilu Qin, Unni M Chandrasekharan, David Young, Arthur M Feldman, Subha Sen, Gerald W Dorn, Paul E Dicorleto, Sathyamangla V Naga Prasad,

Proinflammatory cytokine tumor necrosis factor-α (TNFα) induces β-adrenergic receptor (βAR) desensitization, but mechanisms proximal to the receptor in contributing to cardiac dysfunction are not known.Two different proinflammatory transgenic mouse models with cardiac overexpression of myotrophin (a prohypertrophic molecule) or TNFα showed that TNFα alone is sufficient to mediate βAR desensitization ... Read more >>

Circulation (Circulation)
[2013, 128(4):377-387]

Cited: 15 times

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Inhibition of protein phosphatase 2A activity by PI3Kγ regulates β-adrenergic receptor function.

Neelakantan T Vasudevan, Maradumane L Mohan, Manveen K Gupta, Afshan K Hussain, Sathyamangla V Naga Prasad,

Phosphoinositide 3-kinase γ (PI3Kγ) is activated by G protein-coupled receptors (GPCRs). We show here that PI3Kγ inhibits protein phosphatase 2A (PP2A) at the β-adrenergic receptor (βAR, a GPCR) complex altering G protein coupling. PI3Kγ inhibition results in significant increase of βAR-associated phosphatase activity leading to receptor dephosphorylation and resensitization preserving cardiac ... Read more >>

Mol. Cell (Molecular cell)
[2011, 41(6):636-648]

Cited: 50 times

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Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAM dendrimer curcumin conjugate for therapeutic applications.

Wei Shi, Sukanta Dolai, Samar Rizk, Afshan Hussain, Hussnain Tariq, Saadyah Averick, William L'Amoreaux, Abdeslem El ldrissi, Probal Banerjee, Krishnaswami Raja,

Curcumin, the primary active ingredient in the spice turmeric, was converted to reactive monofunctional derivatives (carboxylic acid/azide/alkyne). The derivatives were employed to produce a 3 + 2 azide-alkyne "clicked" curcumin dimer and a poly(amidoamine) (PAMAM) dendrimer-curcumin conjugate. The monofunctional curcumin derivatives retain biological activity and are efficient for labeling and ... Read more >>

Org. Lett. (Organic letters)
[2007, 9(26):5461-5464]

Cited: 41 times

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