Full Text Journal Articles by
Author Afaf Absood

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Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding.

Afaf Absood, Benjamin Gandomani, Anthony Zaki, Vlad Nasta, Andrew Michail, Peter M W Habib, Israel Hodish,

Insulin therapy improves β-cell function in early stages of diabetes by mechanisms that may exceed alleviation of glucotoxicity. In advance type 2 diabetes, hyperglycemia causes β-cell damage and ultimately β-cell loss. At such an advanced stage, therapeutic modalities are often inadequate. Growing evidence indicates that in early stages of type-2 ... Read more >>

PLoS One (PloS one)
[2013, 8(2):e54351]

Cited: 7 times

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In vivo misfolding of proinsulin below the threshold of frank diabetes.

Israel Hodish, Afaf Absood, Leanza Liu, Ming Liu, Leena Haataja, Dennis Larkin, Ahmed Al-Khafaji, Anthony Zaki, Peter Arvan,

<h4>Objective</h4>Endoplasmic reticulum (ER) stress has been described in pancreatic β-cells after onset of diabetes-a situation in which failing β-cells have exhausted available compensatory mechanisms. Herein we have compared two mouse models expressing equally small amounts of transgenic proinsulin in pancreatic β-cells.<h4>Research design and methods</h4>In hProCpepGFP mice, human proinsulin (tagged with ... Read more >>

Diabetes (Diabetes)
[2011, 60(8):2092-2101]

Cited: 27 times

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VIP inhibits human HepG2 cell proliferation in vitro.

Afaf Absood, Bin Hu, Nermine Bassily, Lisa Colletti,

Hepatocellular carcinoma (HCC) is an aggressive and often fatal neoplasm. HepG2 cells are a cell line derived from HCC. This investigation shows that vasoactive intestinal peptide (VIP) inhibits HepG2 cell proliferation in vitro. In addition, VIP decreases the expression of signal transducers and activators of transcription-3 (STAT-3) and phosphorylated STAT-3 ... Read more >>

Regul Pept (Regulatory peptides)
[2008, 146(1-3):285-292]

Cited: 6 times

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A comparison of oxidized LDL-induced collagen secretion by graft and aortic SMCs: role of PDGF.

Afaf Absood, Akira Furutani, Tsutomu Kawamura, Linda M Graham,

Smooth muscle cells (SMCs) from prosthetic vascular grafts constitutively secrete higher levels of collagen than aortic SMCs. Lipid oxidation products accumulate in grafts, and we postulated that they stimulate SMC production of collagen. The effect of oxidized low-density lipoprotein (oxLDL) on type I collagen secretion by aortic and graft SMCs ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2004, 287(3):H1200-6]

Cited: 12 times

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Magnetic bead isolation of neutrophil plasma membranes and quantification of membrane-associated guanine nucleotide binding proteins.

Peter S Chang, Afaf Absood, Jennifer J Linderman, Geneva M Omann,

A protocol for isolation of neutrophil plasma membranes utilizing a plasma membrane marker antibody, anti-CD15, attached to superparamagnetic beads was developed. Cells were initially disrupted by nitrogen cavitation and then incubated with anti-CD15 antibody-conjugated superparamagnetic beads. The beads were then washed to remove unbound cellular debris and cytosol. Recovered plasma ... Read more >>

Anal Biochem (Analytical biochemistry)
[2004, 325(2):175-184]

Cited: 16 times

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Receptor binding kinetics and cellular responses of six N-formyl peptide agonists in human neutrophils.

Anna Waller, Karyn L Sutton, Tamara L Kinzer-Ursem, Afaf Absood, John R Traynor, Jennifer J Linderman, Geneva M Omann,

The goal of this study was to elucidate the relationships between early ligand binding/receptor processing events and cellular responses for the N-formyl peptide receptor system on human neutrophils as a model of a GPCR system in a physiologically relevant context. Binding kinetics of N-formyl-methionyl-leucyl-phenylalanyl-phenylalanyl-lysine-fluorescein and N-formyl-valyl-leucyl-phenylalanyl-lysine-fluorescein to the N-formyl peptide ... Read more >>

Biochemistry (Biochemistry)
[2004, 43(25):8204-8216]

Cited: 14 times

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Differential PDGF secretion by graft and aortic SMC in response to oxidized LDL.

Afaf Absood, Akira Furutani, Tsutomu Kawamura, Linda M Graham,

Smooth muscle cells (SMC) from prosthetic vascular grafts constitutively secrete higher levels of platelet-derived growth factor-AA (PDGF-AA) than aortic SMC. Lipid oxidation products accumulate in grafts and may stimulate PDGF production. The effect of oxidized low-density lipoprotein (oxLDL) on PDGF-AA secretion by aortic and graft SMC was compared. SMC isolated ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2002, 283(2):H725-32]

Cited: 8 times

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Vasoactive intestinal peptide inhibits human small-cell lung cancer proliferation in vitro and in vivo.

K Maruno, A Absood, S I Said,

Small-cell lung carcinoma (SCLC) is an aggressive, rapidly growing and metastasizing, and highly fatal neoplasm. We report that vasoactive intestinal peptide inhibits the proliferation of SCLC cells in culture and dramatically suppresses the growth of SCLC tumor-cell implants in athymic nude mice. In both cases, the inhibition was mediated apparently ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[1998, 95(24):14373-14378]

Cited: 20 times

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