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Author Adrie Bekker

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Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study.

Samantha Budhram, Valerie Vannevel, Tanita Botha, Lawrence Chauke, Shastra Bhoora, Gaynor M Balie, Natalie Odell, Hennie Lombaard, Amy Wise, Chrysanthi Georgiou, Nondumiso Ngxola, Emma Wynne, Unati Mbewu, Mfundo Mabenge, Sibusiso Phinzi, Nontsikelelo Gubu-Ntaba, Gareth Goldman, Kay Tunkyi, Sudhir Prithipal, Keshree Naidoo, Santhi Venkatachalam, Terence Moodley, Sean Mould, Mzuvele Hlabisa, Logie Govender, Charlene Maistry, John P Habineza, Priya Israel, Serantha Foolchand, Nomandla V Tsibiyane, Mala Panday, Priya Soma-Pillay, Sumaiya Adam, Felicia Molokoane, Matthew S Mojela, Elizabeth J van Rensburg, Tshililo Mashamba, Mushi Matjila, Sue Fawcus, Ayesha Osman, Mareli Venter, Gregory Petro, Ahminah Fakier, Eduard Langenegger, Catherine A Cluver, Adrie Bekker, Liesl de Waard, Chantal Stewart, Nnabuike C Ngene, Ongombe Lunda, Sylvia N Cebekhulu, Siva Moodley, Mama-Asu Koranteng-Peprah, Emmanuel M C Ati, Salome Maswime, Laura M Yates,

<h4>Objective</h4>To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities.<h4>Methods</h4>A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed.<h4>Results</h4>A total ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

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Epidemiology of clinically suspected and laboratory-confirmed bloodstream infections at a South African neonatal unit.

Angela Dramowski, Adrie Bekker, Mark Frederic Cotton, Andrew Christopher Whitelaw, Susan Coffin,

<h4>Introduction</h4>Data from Africa reporting the epidemiology of infection in hospitalised neonates are limited.<h4>Methodology</h4>A prospective study with convenience sampling was conducted to characterise neonates investigated with blood culture/s for suspected infection at a 132-bed neonatal unit in Cape Town, South Africa (1 February-31 October 2018). Enrolled neonates were classified as having ... Read more >>

J Infect Dev Ctries (Journal of infection in developing countries)
[2021, 15(7):943-952]

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Impact of 1% chlorhexidine gluconate bathing and emollient application on bacterial pathogen colonization dynamics in hospitalized preterm neonates - A pilot clinical trial.

Angela Dramowski, Sheylyn Pillay, Adrie Bekker, Ilhaam Abrahams, Mark F Cotton, Susan E Coffin, Andrew C Whitelaw,

<h4>Background</h4>Chlorhexidine gluconate (CHG) body washes and emollient application may modulate bacterial pathogen colonization and prevent neonatal hospital-acquired infections.<h4>Methods</h4>This pilot, non-randomized, open-label trial, enrolled preterm neonates (1000-1500g; day 1-3 of life) at a tertiary hospital in Cape Town, South Africa. Participants were sequentially allocated to 4 trial arms (n=20 each): 1% ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2021, 37:100946]

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Single Dose Abacavir Pharmacokinetics and Safety in Neonates Exposed to Human Immunodeficiency Virus (HIV).

Adrie Bekker, Eric H Decloedt, Gretchen Slade, Mark F Cotton, Helena Rabie, Tim R Cressey,

Abacavir is a potential option for prophylaxis and early treatment of human immunodeficiency virus (HIV), but no data are available in neonates. Ten neonates administered a single abacavir dose of 8 mg/kg before 15 days of life had substantially higher exposures than those reported in infants and children, with no ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 72(11):2032-2034]

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The Pharmacokinetics of Crushed Levetiracetam Tablets Administered to Neonates.

Veshni Pillay-Fuentes Lorente, Adrie Bekker, Gugu T J Kali, Lizel G Lloyd, Alma W Van der Merwe, Ahmed A Abulfathi, Eric H Decloedt,

<h4>Background</h4>Intravenous phenobarbital remains the first-line therapy in the management of neonatal seizures. Shortages of intravenous phenobarbital in South Africa necessitated the addition of oral levetiracetam as part of management of neonatal seizures.<h4>Objective</h4>We evaluated the pharmacokinetics of crushed immediate-release levetiracetam tablets administered to neonates to terminate seizures.<h4>Methods</h4>A prospective, observational study of ... Read more >>

J Trop Pediatr (Journal of tropical pediatrics)
[2021, 67(2):]

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Healthcare-Associated Severe Acute Respiratory Syndrome Coronavirus 2 Transmission in a Neonatal Unit: The Importance of Universal Masking, Hand Hygiene, and Symptom Screening in Containment.

Sandi L Holgate, Angela Dramowski, Magriet van Niekerk, Haseena Hassan, Yolande Prinsloo, Adrie Bekker,

Following exposure to a healthcare worker with an influenza-like illness, 2 preterm neonates and 6 staff members developed symptoms and tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This neonatal unit coronavirus disease 2019 outbreak occurred prior to the implementation of universal masking and symptom screening policies. Both ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2021, 10(5):665-668]

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A retrospective analysis of pathogen profile, antimicrobial resistance and mortality in neonatal hospital-acquired bloodstream infections from 2009-2018 at Tygerberg Hospital, South Africa.

Kessendri Reddy, Adrie Bekker, Andrew C Whitelaw, Tonya M Esterhuizen, Angela Dramowski,

<h4>Background</h4>Analysis of hospital-acquired bloodstream infection (HA-BSI) trends is important to monitor emerging antimicrobial resistance (AMR) threats and guide empiric antibiotic choices.<h4>Methods</h4>A retrospective 10-year review of neonatal HA-BSI was performed at Tygerberg Hospital's neonatal unit in Cape Town, South Africa. Neonatal clinical and laboratory data from 2014 to 2018 (Period 2) ... Read more >>

PLoS One (PloS one)
[2021, 16(1):e0245089]

Cited: 1 time

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Laboratory-confirmed bloodstream infections in two large neonatal units in sub-Saharan Africa.

Alemayehu Mekonnen Gezmu, Andre N H Bulabula, Angela Dramowski, Adrie Bekker, Marina Aucamp, Sajini Souda, Britt Nakstad,

<h4>Background</h4>Epidemiological data on neonatal bloodstream infections (BSI) in sub-Saharan Africa are extremely limited.<h4>Methods</h4>A comparative analysis of laboratory-confirmed neonatal BSI episodes was conducted retrospectively in two large neonatal units in Botswana and South Africa (January 1 to December 31, 2017). Routine laboratory and ward register data were used to determine BSI ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2021, 103:201-207]

Cited: 1 time

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Optimizing Pharmacology Studies in Pregnant and Lactating Women Using Lessons From HIV: A Consensus Statement.

Ahizechukwu C Eke, Adeniyi Olagunju, Jeremiah Momper, Martina Penazzato, Elaine J Abrams, Brookie M Best, Edmund V Capparelli, Adrie Bekker, Yodit Belew, Jennifer J Kiser, Kimberly Struble, Graham Taylor, Catriona Waitt, Mark Mirochnick, Tim R Cressey, Angela Colbers, ,

Information on the extent of drug exposure to mothers and infants during pregnancy and lactation normally becomes available years after regulatory approval of a drug. Clinicians face knowledge gaps on drug selection and dosing in pregnancy and infant exposure during breastfeeding. Physiological changes during pregnancy often result in lower drug ... Read more >>

Clin Pharmacol Ther (Clinical pharmacology and therapeutics)
[2021, 110(1):36-48]

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Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: insights from the NeoAMR network.

Grace Li, Julia Anna Bielicki, A S M Nawshad Uddin Ahmed, Mohammad Shahidul Islam, Eitan Naaman Berezin, Clery B Gallacci, Ruth Guinsburg, Carlos Eduardo da Silva Figueiredo, Rosilene Santarone Vieira, Andre Ricardo Silva, Cristiane Teixeira, Paul Turner, Ladin Nhan, Jaime Orrego, Paola Marsela PĂ©rez, Lifeng Qi, Vassiliki Papaevangelou, Pinelope Triantafyllidou, Elias Iosifidis, Emmanuel Roilides, Kosmas Sarafidis, Dasaratha Ramaiah Jinka, Raghuprakash Reddy Nayakanti, Praveen Kumar, Vikas Gautam, Vinayagam Prakash, Arasar Seeralar, Srinivas Murki, Hemasree Kandraju, Sanjeev Singh, Anil Kumar, Leslie Lewis, Jayashree Pukayastha, Sushma Nangia, Yogesha K N, Suman Chaurasia, Harish Chellani, Stephen Obaro, Angela Dramowski, Adrie Bekker, Andrew Whitelaw, Reenu Thomas, Sithembiso Christopher Velaphi, Daynia Elizabeth Ballot, Trusha Nana, Gary Reubenson, Joy Fredericks, Suvaporn Anugulruengkitt, Anongnart Sirisub, Pimol Wong, Sorasak Lochindarat, Suppawat Boonkasidecha, Kanchana Preedisripipat, Tim R Cressey, Pongsatorn Paopongsawan, Pagakrong Lumbiganon, Dounghatai Pongpanut, Pra-Ornsuda Sukrakanchana, Philippa Musoke, Linus Olson, Mattias Larsson, Paul T Heath, Michael Sharland,

<h4>Objective</h4>To gain an understanding of the variation in available resources and clinical practices between neonatal units (NNUs) in the low-income and middle-income country (LMIC) setting to inform the design of an observational study on the burden of unit-level antimicrobial resistance (AMR).<h4>Design</h4>A web-based survey using a REDCap database was circulated to ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, 105(1):26-31]

Cited: 7 times

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A Systematic Review on the Effect of HIV Infection on the Pharmacokinetics of First-Line Tuberculosis Drugs.

Alper Daskapan, Lusiana R Idrus, Maarten J Postma, Bob Wilffert, Jos G W Kosterink, Ymkje Stienstra, Daniel J Touw, Aase B Andersen, Adrie Bekker, Paolo Denti, Agibothu K Hemanth Kumar, Kidola Jeremiah, Awewura Kwara, Helen McIlleron, Graeme Meintjes, Joep J van Oosterhout, Geetha Ramachandran, Neesha Rockwood, Robert J Wilkinson, Tjip S van der Werf, Jan-Willem C Alffenaar,

<h4>Introduction</h4>Contrasting findings have been published regarding the effect of human immunodeficiency virus (HIV) on tuberculosis (TB) drug pharmacokinetics (PK).<h4>Objectives</h4>The aim of this systematic review was to investigate the effect of HIV infection on the PK of the first-line TB drugs (FLDs) rifampicin, isoniazid, pyrazinamide and ethambutol by assessing all published ... Read more >>

Clin Pharmacokinet (Clinical pharmacokinetics)
[2019, 58(6):747-766]

Cited: 17 times

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Culture-confirmed Tuberculosis in South African Infants Younger Than 3 Months of Age: Clinical Presentation and Management of Respiratory Complications.

Lisa Frigati, Adrie Bekker, Silvia Stroebele, Pierre Goussard, H Simon Schaaf,

BACKGROUND:Little is known about the course and management of perinatal tuberculosis (TB). We describe the presentation, medical and surgical management of culture-confirmed TB in infants younger than 3 months of age. METHODS:We conducted a retrospective study including all infants younger than 3 months of age with culture-confirmed TB admitted to ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(4):351-354]

Cited: 1 time

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Acquired neonatal bronchial stenosis after selective intubation: Successful managed with balloon dilatation.

Pierre Goussard, Julie Morrison, Adrie Bekker, Barend Fourie,

Premature babies are prone to airway-related complications. Selective intubation for the management of pulmonary interstitial emphysema may cause acquired bronchial stenosis. Balloon dilatation under fluoroscopy is a safe minimal invasive and successful intervention for acquired bronchial stenosis. Follow-up bronchoscopy is needed due to risk of restenosis. ... Read more >>

Clin Case Rep (Clinical case reports)
[2019, 7(5):917-919]

Cited: 1 time

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Symptom screening for active tuberculosis in pregnant women living with HIV.

Sylvia M LaCourse, Lisa M Cranmer, Adrie Bekker, Karen R Steingart, Danae Black, David J Horne, Eyal Oren, Sherri Pals, Surbhi Modi, Jyoti Mathad,

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To assess the accuracy of the four-symptom screen (cough, fever, night sweats, or weight loss) for identifying active TB in pregnant PLHIV who are screened in an outpatient or community setting. To investigate potential ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2018, 2018(1):]

Cited: 2 times

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Tuberculosis Disease during Pregnancy and Treatment Outcomes in HIV-Infected and Uninfected Women at a Referral Hospital in Cape Town.

Adrie Bekker, Hendrik S Schaaf, Heather R Draper, Magdalena Kriel, Anneke C Hesseling,

<h4>Background</h4>Tuberculosis during pregnancy and treatment outcomes are poorly defined in high prevalence tuberculosis and HIV settings.<h4>Methods</h4>A prospective cohort study of pregnant and postpartum women identified to be routinely on antituberculosis treatment was conducted at Tygerberg Hospital, Cape Town, South Africa, from January 2011 through December 2011. Maternal tuberculosis disease spectrum ... Read more >>

PLoS One (PloS one)
[2016, 11(11):e0164249]

Cited: 8 times

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Neonatal nosocomial bloodstream infections at a referral hospital in a middle-income country: burden, pathogens, antimicrobial resistance and mortality.

Angela Dramowski, Ayanda Madide, Adrie Bekker,

<h4>Background</h4>Data on nosocomial bloodstream infection (BSI) rates, pathogens, mortality and antimicrobial resistance in African neonates are limited.<h4>Methods</h4>Nosocomial neonatal BSI at Tygerberg Hospital, Cape Town were retrospectively reviewed between 1 January 2009 and 31 December 2013. Laboratory and hospital data were used to determine BSI rates, pathogen profile, mortality and antimicrobial ... Read more >>

Paediatr Int Child Health (Paediatrics and international child health)
[2015, 35(3):265-272]

Cited: 20 times

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Congenital anterior mediastinal teratoma causing severe airway compression in a neonate.

Adrie Bekker, Pierre Goussard, Robert Gie, Savvas Andronikou,

BMJ Case Rep (BMJ case reports)
[2013, 2013:]

Cited: 1 time

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The outcome of ELBW infants treated with NCPAP and InSurE in a resource-limited institution.

Gerhardus Francois Kirsten, Cheryl Linda Kirsten, Philippus Arnold Henning, Johan Smith, Sandi Lee Holgate, Adrie Bekker, Gugulabatembunamahlubi Tenjiwe Jabulile Kali, Justin Harvey,

<h4>Background and objective</h4>Nasal continuous positive airway pressure (NCPAP) plus intubation, surfactant, and extubation (InSurE) with the option of back-up ventilation for those infants for whom noninvasive ventilatory support failed resulted in a significant increase in survival in extremely low birth weight (ELBW) infants. The authors sought to determine the outcome ... Read more >>

Pediatrics (Pediatrics)
[2012, 129(4):e952-9]

Cited: 12 times

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Oseltamivir use in low-birth weight infants during the 2009 nH1N1 influenza a outbreak in the Western Cape, South Africa.

Sandi L Holgate, Adrie Bekker, Helena Rabie, Mark F Cotton,

Before vaccination against nH1N1 influenza was available in South Africa our hospital experienced an outbreak of nH1N1 infection on the maternal and neonatal platform. Oseltamivir was administered to nine low birth weight infants, five for therapy and four for prophylaxis. The median gestational age was 31 (27-37) weeks and the ... Read more >>

J Trop Pediatr (Journal of tropical pediatrics)
[2012, 58(2):102-106]

Cited: 6 times

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Tuberculosis at extremes of age.

H Simon Schaaf, Andrea Collins, Adrie Bekker, Peter D O Davies,

ABSTRACT Although tuberculosis (TB) has its highest burden among young adults, especially since the advent of HIV infection, two other groups with low immunity, the very young (<1 year) with immature immunity and the elderly (>65 years) with waning immunity, are vulnerable groups not to be forgotten. This review describes ... Read more >>

Respirology (Respirology (Carlton, Vic.))
[2010, 15(5):747-763]

Cited: 49 times

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Donor breastmilk saved infant lives during an outbreak of rotavirus in South Africa.

Maria Rinaldi, Elizabeth Brierley, Adrie Bekker,

Breastfeed Med (Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine)
[2009, 4(2):133-134]

Cited: 5 times

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Induced hypothermia for infants with hypoxic- ischemic encephalopathy using a servo-controlled fan: an exploratory pilot study.

Alan Horn, Clare Thompson, David Woods, Alida Nel, Adrie Bekker, Natasha Rhoda, Clarissa Pieper,

<h4>Objective</h4>Several trials suggest that hypothermia is beneficial in selected infants with hypoxic-ischemic encephalopathy. However, the cooling methods used required repeated interventions and were either expensive or reported significant temperature variation. The objective of this pilot study was to describe the use, efficacy, and physiologic impact of an inexpensive servo-controlled cooling ... Read more >>

Pediatrics (Pediatrics)
[2009, 123(6):e1090-8]

Cited: 18 times

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