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Antifungal Activity of Antimicrobial Peptides and Proteins against Aspergillus fumigatus.

Eloise Ballard, Raif Yucel, Willem J G Melchers, Alistair J P Brown, Paul E Verweij, Adilia Warris,

Antimicrobial peptides and proteins (AMPs) provide an important line of defence against invading microorganisms. However, the activity of AMPs against the human fungal pathogen Aspergillus fumigatus remains poorly understood. Therefore, the aim of this study was to characterise the anti-Aspergillus activity of specific human AMPs, and to determine whether A. ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2020, 6(2):]

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul T Heath, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

BACKGROUND:The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, recruited in single centres or countries, evaluated antibiotics not in clinical use anymore ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0229380]

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Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study.

Adilia Warris, Zoi-Dorothea Pana, Andrea Oletto, Rebecca Lundin, Elio Castagnola, Thomas Lehrnbecher, Andreas H Groll, Emmanuel Roilides, Cecilie T Andersen, Maiken C Arendrup, Valentina Arsic Arsenijevic, Sonia Bianchini, Ulrich von Both, Martin Chmelnik, Tiziana Controzzi, Marieke Emonts, Susanna Esposito, Laura Ferreras-Antolin, Stefanie Henriet, Elias Iosifidis, Adam Irwin, John Kopsidas, Katrien Lagrou, Hermione Lyall, Angela Manzanares Casteleiro, Alessio Mesini, Peter Olbrich, Stephane Paulus, Karen Rokkedal Lausch, Pere Soler-Palacin, Nikos Spyridis, Volker Strenger, Martha Theodoraki, Tom Wolfs, , ,

BACKGROUND:Data on Candida bloodstream infections in pediatric patients in Europe are limited. We performed a retrospective multicenter European study of the epidemiology and outcome of neonatal and pediatric candidemia. MATERIAL AND METHODS:All first positive blood cultures from patients ≤ 18 years of age with candidemia were registered. Patients' demographic and ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, 39(2):114-120]

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Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.

J Peter Donnelly, Sharon C Chen, Carol A Kauffman, William J Steinbach, John W Baddley, Paul E Verweij, Cornelius J Clancy, John R Wingard, Shawn R Lockhart, Andreas H Groll, Tania C Sorrell, Matteo Bassetti, Hamdi Akan, Barbara D Alexander, David Andes, Elie Azoulay, Ralf Bialek, Robert W Bradsher, Stephane Bretagne, Thierry Calandra, Angela M Caliendo, Elio Castagnola, Mario Cruciani, Manuel Cuenca-Estrella, Catherine F Decker, Sujal R Desai, Brian Fisher, Thomas Harrison, Claus Peter Heussel, Henrik E Jensen, Christopher C Kibbler, Dimitrios P Kontoyiannis, Bart-Jan Kullberg, Katrien Lagrou, Frédéric Lamoth, Thomas Lehrnbecher, Jurgen Loeffler, Olivier Lortholary, Johan Maertens, Oscar Marchetti, Kieren A Marr, Henry Masur, Jacques F Meis, C Orla Morrisey, Marcio Nucci, Luis Ostrosky-Zeichner, Livio Pagano, Thomas F Patterson, John R Perfect, Zdenek Racil, Emmanuel Roilides, Marcus Ruhnke, Cornelia Schaefer Prokop, Shmuel Shoham, Monica A Slavin, David A Stevens, George R Thompson, Jose A Vazquez, Claudio Viscoli, Thomas J Walsh, Adilia Warris, L Joseph Wheat, P Lewis White, Theoklis E Zaoutis, Peter G Pappas,

BACKGROUND:Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, :]

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Neonatal Antifungal Consumption Is Dominated by Prophylactic Use; Outcomes From The Pediatric Antifungal Stewardship: Optimizing Antifungal Prescription Study.

Laura Ferreras-Antolín, Adam Irwin, Ayad Atra, Alicia Dermirjian, Simon B Drysdale, Marieke Emonts, Paddy McMaster, Stephane Paulus, Sanjay Patel, Sally Kinsey, Stefania Vergnano, Elisabeth Whittaker, Adilia Warris,

BACKGROUND:Diagnostic challenges combined with the vulnerability of neonates to develop invasive candidiasis (IC) may lead to antifungal administration in the absence of IC. A modified point-prevalence study was performed to obtain an improved insight and understanding of antifungal prescribing in this specific patient population. METHODS:Neonates and infants ≤90 days of ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2019, 38(12):1219-1223]

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Impact of dose adaptations following voriconazole therapeutic drug monitoring in pediatric patients.

Vincent J Lempers, Edmé Meuwese, Annelies M Mavinkurve-Groothuis, Stefanie Henriet, Inge M van der Sluis, Lidwien M Hanff, Adilia Warris, Birgit C P Koch, Roger J Brüggemann,

Voriconazole is the mainstay of treatment for invasive aspergillosis in immunocompromised pediatric patients. Although Therapeutic Drug Monitoring (TDM) of voriconazole is recommended, it remains unknown if TDM-based dose adaptations result in target attainment. Patients <19 years from two pediatric hematologic-oncology wards were retrospectively identified based on unexplained high voriconazole trough ... Read more >>

Med. Mycol. (Medical mycology)
[2019, 57(8):937-943]

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Management of Invasive Fungal Disease in Neonates and Children.

Laura Ferreras-Antolín, Mike Sharland, Adilia Warris,

Invasive fungal diseases (IFD) are an important cause of morbidity and mortality in premature neonates and immunocompromised pediatric patients. Their diagnostic and therapeutic management remains a challenge. A nationwide survey was conducted among 13 of the largest pediatric units in the United Kingdom, to obtain insight in the current management ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2019, 38(6S Suppl 1):S2-S6]

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Introduction.

Nigel Curtis, Adam Finn, Adilia Warris, Andrew J Pollard, Annemarie van Rossum, Octavio Ramilo,

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2019, 38(6S Suppl 1):S1]

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Raw genome sequence data for 13 isogenic Aspergillus fumigatus strains isolated over a 2 year period from a patient with chronic granulomatous disease.

Eloise Ballard, Jan Zoll, Willem J G Melchers, Alistair J P Brown, Adilia Warris, Paul E Verweij,

Azole-resistance in Aspergillus fumigatus is an emerging worldwide threat as it precludes the use of one of the 3 major classes of antifungal drugs to treat chronic and invasive aspergillosis [1]. In addition to the well-known environmental emergence of azole-resistant A. fumigatus strains, associated with the use of fungicides in ... Read more >>

Data Brief (Data in brief)
[2019, 25:104021]

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Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism.

Eloise Ballard, Jakob Weber, Willem J G Melchers, Seshu Tammireddy, Phillip D Whitfield, Axel A Brakhage, Alistair J P Brown, Paul E Verweij, Adilia Warris,

The human host comprises a range of specific niche environments. In order to successfully persist, pathogens such as Aspergillus fumigatus must adapt to these environments. One key example of in-host adaptation is the development of resistance to azole antifungals. Azole resistance in A. fumigatus is increasingly reported worldwide and the ... Read more >>

Fungal Genet. Biol. (Fungal genetics and biology : FG & B)
[2019, 130:98-106]

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Immunopathology of Aspergillus Infections in Children With Chronic Granulomatous Disease and Cystic Fibrosis.

Adilia Warris,

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2019, 38(5):e96-e98]

Cited: 1 time

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Cryptococcal meningitis after ART: Need for proper baseline evaluation in the era of 'Test & Treat'.

Iorhen E Akase, Olamide Olowoyo, Rita O Oladele, Reginald O Obiako, Adilia Warris, Sulaimon A Akanmu,

Cryptococcal meningitis (CM) contributes significantly to high early mortality in the setting of advanced HIV. In resource poor settings, the current HIV disease management approach is focused on commencing antiretroviral therapy (ART) on the same day of HIV diagnosis ('Test and Treat'). The HIV program in Nigeria does not currently ... Read more >>

Med Mycol Case Rep (Medical mycology case reports)
[2019, 24:58-60]

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Aspergillus colonization and antifungal immunity in cystic fibrosis patients.

Adilia Warris, Amelia Bercusson, Darius Armstrong-James,

Cystic fibrosis (CF), caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, is the most common inherited life-limiting disease in North European people affecting 90,000 people worldwide. Progressive lung damage caused by recurrent infection and chronic airway inflammation is the major determinant of survival with a median ... Read more >>

Med. Mycol. (Medical mycology)
[2019, 57(Supplement_2):S118-S126]

Cited: 1 time

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Comment on: T2Candida MR as a predictor of outcome in patients with suspected invasive candidiasis starting empirical antifungal treatment: a prospective pilot study.

P Lewis White, Rosemary A Barnes, Rebecca Gorton, Mario Cruciani, Juergen Loeffler, ,

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2019, 74(2):532-533]

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Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection.

Alistair J P Brown, Neil A R Gow, Adilia Warris, Gordon D Brown,

By analogy with Pavlov's dogs, certain pathogens have evolved anticipatory behaviours that exploit specific signals in the human host to prepare themselves against imminent host challenges. This adaptive prediction, a type of history-dependent microbial behaviour, represents a primitive form of microbial memory. For fungal pathogens, adaptive prediction helps them circumvent ... Read more >>

Trends Microbiol. (Trends in microbiology)
[2019, 27(3):219-230]

Cited: 5 times

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): a randomised controlled trial

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul Heath Frcpch, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

Abstract Background The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, were single centre or country, insufficiently powered, evaluated antibiotics not in ... Read more >>

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Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis.

Amelia Bercusson, Thomas Colley, Anand Shah, Adilia Warris, Darius Armstrong-James,

Blood (Blood)
[2018, 132(18):1985-1988]

Cited: 10 times

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Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

Patrick Van Dijck, Jelmer Sjollema, Bruno P Cammue, Katrien Lagrou, Judith Berman, Christophe d'Enfert, David R Andes, Maiken C Arendrup, Axel A Brakhage, Richard Calderone, Emilia Cantón, Tom Coenye, Paul Cos, Leah E Cowen, Mira Edgerton, Ana Espinel-Ingroff, Scott G Filler, Mahmoud Ghannoum, Neil A R Gow, Hubertus Haas, Mary Ann Jabra-Rizk, Elizabeth M Johnson, Shawn R Lockhart, Jose L Lopez-Ribot, Johan Maertens, Carol A Munro, Jeniel E Nett, Clarissa J Nobile, Michael A Pfaller, Gordon Ramage, Dominique Sanglard, Maurizio Sanguinetti, Isabel Spriet, Paul E Verweij, Adilia Warris, Joost Wauters, Michael R Yeaman, Sebastian A J Zaat, Karin Thevissen,

Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance ... Read more >>

Microb Cell (Microbial cell (Graz, Austria))
[2018, 5(7):300-326]

Cited: 7 times

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Strategic Research Funding: A Success Story for Medical Mycology.

Neil A R Gow, Tehmina Amin, Karen McArdle, Alistair J P Brown, Gordon D Brown, Adilia Warris, The Wtsa-Mmfi Consortium,

The Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology is a unique investment that aimed to bolster capacity, training and research activity throughout the UK. This article summarises the rationale for collective collaboration of multiple institutions to achieve synergies and address a common medical problem. ... Read more >>

Trends Microbiol. (Trends in microbiology)
[2018, 26(10):811-813]

Cited: 1 time

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Microbiome characteristics of induced sputum compared to bronchial fluid and upper airway samples.

Shi-Qi An, Adilia Warris, Steve Turner,

OBJECTIVE:The study of the community of microorganisms (the microbiota) in the lower airways in children is restricted to opportunistic sampling in children undergoing elective general anaesthetic. Here we tested the hypothesis that induced sputum is a valid alternative to directly sampling the lower airways to study lower airway microbiota. METHODS:Children ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2018, 53(7):921-928]

Cited: 2 times

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Aspergillus-induced superoxide production by cystic fibrosis phagocytes is associated with disease severity.

Shan F Brunel, Janet A Willment, Gordon D Brown, Graham Devereux, Adilia Warris,

Aspergillus fumigatus infects up to 50% of cystic fibrosis (CF) patients and may play a role in progressive lung disease. As cystic fibrosis transmembrane conductance regulator is expressed in cells of the innate immune system, we hypothesised that impaired antifungal immune responses play a role in CF-related Aspergillus lung disease. ... Read more >>

ERJ Open Res (ERJ open research)
[2018, 4(2):]

Cited: 1 time

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Candida auris, what do paediatricians need to know?

Adilia Warris, Adilia Warris,

The newly recognised and emerging fungal species, Candida auris, has caused worldwide invasive infections and has been implicated in difficult to control hospital outbreaks. Challenges are encountered in the correct identification of this fungus as commonly used phenotypic and biochemical methods fail to differentiate C. auris from other Candida species. ... Read more >>

Arch. Dis. Child. (Archives of disease in childhood)
[2018, 103(9):891-894]

Cited: 2 times

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In-host microevolution of Aspergillus fumigatus: A phenotypic and genotypic analysis.

Eloise Ballard, Willem J G Melchers, Jan Zoll, Alistair J P Brown, Paul E Verweij, Adilia Warris,

In order to survive, Aspergillus fumigatus must adapt to specific niche environments. Adaptation to the human host includes modifications facilitating persistent colonisation and the development of azole resistance. The aim of this study is to advance understanding of the genetic and physiological adaptation of A. fumigatus in patients during infection ... Read more >>

Fungal Genet. Biol. (Fungal genetics and biology : FG & B)
[2018, 113:1-13]

Cited: 11 times

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Oxidative responses and fungal infection biology.

Adilia Warris, Elizabeth R Ballou,

The balance between reactive oxygen species and reactive nitrogen species production by the host and stress response by fungi is a key axis of the host-pathogen interaction. This review will describe emerging themes in fungal pathogenesis underpinning this axis. ... Read more >>

Semin. Cell Dev. Biol. (Seminars in cell & developmental biology)
[2019, 89:34-46]

Cited: 2 times

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Special Issue: Host-Fungus Interactions.

Adilia Warris, Adilia Warris,

The clinical presentation of fungal disease is strongly determined by the underlying immune defect present [...]. ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2018, 4(1):]

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