Full Text Journal Articles by
Author Adam T Hill

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The benefits of non-invasive ventilation for Community-Acquired Pneumonia: A meta-analysis.

Giovana Klefti, Adam T Hill,

BACKGROUND:There is an observed international increase in NIV application as an alternative to endotracheal intubation in non-COPD patients admitted with community acquired pneumonia despite the lack of strong evidence for its use. The aim of this study is the meta-analysis of data from randomised-controlled trials on the effectiveness of non-invasive ... Read more >>

QJM (QJM : monthly journal of the Association of Physicians)
[2020, :]

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Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report.

Anne B Chang, John J Oppenheimer, Richard S Irwin, ,

BACKGROUND:Cough is one of the most common presenting symptoms to general practitioners. The objective of this article is to collate the pediatric components of the CHEST chronic cough guidelines that have recently updated the 2006 guidelines to assist general and specialist medical practitioners in the evaluation and management of children ... Read more >>

Chest (Chest)
[2020, :]

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Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report.

Mark A Malesker, Priscilla Callahan-Lyon, J Mark Madison, Belinda Ireland, Richard S Irwin, ,

BACKGROUND:Chronic cough due to chronic bronchitis (CB) causes significant impairment in quality of life, and effective treatment strategies are needed. We conducted a systematic review on the management of chronic cough due to CB to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline ... Read more >>

Chest (Chest)
[2020, :]

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Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients: CHEST Expert Panel Report.

Maeve P Smith, Mark Lown, Sonal Singh, Belinda Ireland, Adam T Hill, Jeffrey A Linder, Richard S Irwin, ,

BACKGROUND:Evidence for the diagnosis and management of cough due to acute bronchitis in immunocompetent adult outpatients was reviewed as an update to the 2006 "Chronic Cough Due to Acute Bronchitis: American College of Chest Physicians (ACCP) Evidence-Based Clinical Practice Guidelines." METHODS:Acute bronchitis was defined as an acute lower respiratory tract ... Read more >>

Chest (Chest)
[2020, 157(5):1256-1265]

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A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial.

Judy Martina Bradley, Rohan Anand, Brenda O'Neill, Kathryn Ferguson, Mike Clarke, Mary Carroll, James Chalmers, Anthony De Soyza, Jamie Duckers, Adam T Hill, Michael R Loebinger, Fiona Copeland, Evie Gardner, Christina Campbell, Ashley Agus, Alistair McGuire, Roisin Boyle, Fionnuala McKinney, Naomi Dickson, Danny F McAuley, Stuart Elborn, ,

BACKGROUND:Current guidelines for the management of bronchiectasis (BE) highlight the lack of evidence to recommend mucoactive agents, such as hypertonic saline (HTS) and carbocisteine, to aid sputum removal as part of standard care. We hypothesise that mucoactive agents (HTS or carbocisteine, or a combination) are effective in reducing exacerbations over ... Read more >>

Trials (Trials)
[2019, 20(1):747]

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Managing Chronic Cough due to Asthma and NAEB in Adults and Adolescents: CHEST Expert Panel Report.

Andreanne Côté, Richard J Russell, Louis-Philippe Boulet, Peter G Gibson, Kefang Lai, Richard S Irwin, Christopher E Brightling, ,

BACKGROUND:Asthma and non-asthmatic eosinophilic bronchitis (NAEB) are among the commonest causes of chronic cough in adults. We sought to determine the role of non-invasive measurements of airway inflammation, including induced sputum and fractional exhaled nitric oxide, in the evaluation of cough associated with asthma, and what the best treatment is ... Read more >>

Chest (Chest)
[2020, :]

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Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia. A Pilot Randomized Controlled Clinical Trial.

Elizabeth Sapey, Jaimin M Patel, Hannah Greenwood, Georgia M Walton, Frances Grudzinska, Dhruv Parekh, Rahul Y Mahida, Rachel C A Dancer, Sebastian T Lugg, Philip A Howells, Jon Hazeldine, Paul Newby, Aaron Scott, Peter Nightingale, Adam T Hill, David R Thickett,

Rationale: Population studies suggest improved sepsis outcomes with statins, but the results of randomized controlled trials in patients with sepsis and organ dysfunction in critical care settings have broadly been negative. In vitro data suggest that statins modulate age-related neutrophil functions, improving neutrophil responses to infection, but only in older ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 200(10):1282-1293]

Cited: 1 time

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Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia.

David Villafuerte, Stefano Aliberti, Nilam J Soni, Paola Faverio, Pedro J Marcos, Richard G Wunderink, Alejandro Rodriguez, Oriol Sibila, Francisco Sanz, Ignacio Martin-Loeches, Francesco Menzella, Luis F Reyes, Mateja Jankovic, Marc Spielmanns, Marcos I Restrepo, ,

BACKGROUND AND OBJECTIVE:Enterobacteriaceae (EB) spp. family is known to include potentially multidrug-resistant (MDR) microorganisms, and remains as an important cause of community-acquired pneumonia (CAP) associated with high mortality. The aim of this study was to determine the prevalence and specific risk factors associated with EB and MDR-EB in a cohort ... Read more >>

Respirology (Respirology (Carlton, Vic.))
[2020, 25(5):543-551]

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Efficacy and safety of tobramycin inhalation powder in bronchiectasis patients with P. aeruginosa infection: Design of a dose-finding study (iBEST-1).

Michael R Loebinger, Eva Polverino, Francesco Blasi, Stuart J Elborn, James D Chalmers, Harm Awm Tiddens, Herman Goossens, Michael Tunney, Wenchun Zhou, Gerhild Angyalosi, Adam T Hill, Charles S Haworth, ,

In patients with bronchiectasis (BE), infection with Pseudomonas aeruginosa (Pa) results in disease progression, frequent pulmonary exacerbations and lung function decline. However, at present, no inhaled antibiotics have been approved for the treatment of these patients. Tobramycin inhalation powder (TIP), approved for treatment of Pa infection in cystic fibrosis, could ... Read more >>

Pulm Pharmacol Ther (Pulmonary pharmacology & therapeutics)
[2019, 58:101834]

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Moving forward: Bronchiectasis and chronic suppurative lung disease in children and adults in the 21st century.

Adam T Hill, Anne B Chang,

Respirology (Respirology (Carlton, Vic.))
[2019, 24(11):1051-1052]

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Primary care implications of the British Thoracic Society Guidelines for bronchiectasis in adults 2019.

Kevin Gruffydd-Jones, Duncan Keeley, Vikki Knowles, Ximena Recabarren, Alex Woodward, Anita L Sullivan, Michael R Loebinger, Karen Payne, Alex Harvey, Lizzie Grillo, Sally A Welham, Adam T Hill,

The British Thoracic Society (BTS) Guidelines for Bronchiectasis in adults were published in January 2019, and comprise recommendations for treatment from primary to tertiary care. Here, we outline the practical implications of these guidelines for primary care practitioners. A diagnosis of bronchiectasis should be considered when a patient presents with ... Read more >>

NPJ Prim Care Respir Med (NPJ primary care respiratory medicine)
[2019, 29(1):24]

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Response.

Adam T Hill, Philip M Gold, Ali A El Solh, Joshua P Metlay, Belinda Ireland, Richard S Irwin, ,

Chest (Chest)
[2019, 155(5):1082-1083]

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Advances in bronchiectasis.

Karuna Sapru, Adam T Hill,

Bronchiectasis is a chronic inflammatory condition with a diverse aetiology including recurrent infections, genetic abnormalities, immunodeficiency and autoimmune disorders. The prevalence has increased over the past few years and this may be due to better imaging and diagnostic techniques. Management remains the emphasis for improving symptoms and reducing exacerbations. This ... Read more >>

Clin Med (Lond) (Clinical medicine (London, England))
[2019, 19(3):230-233]

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Prevalence and Etiology of Community-acquired Pneumonia in Immunocompromised Patients.

Marta Francesca Di Pasquale, Giovanni Sotgiu, Andrea Gramegna, Dejan Radovanovic, Silvia Terraneo, Luis F Reyes, Jan Rupp, Juan González Del Castillo, Francesco Blasi, Stefano Aliberti, Marcos I Restrepo, ,

BACKGROUND:The correct management of immunocompromised patients with pneumonia is debated. We evaluated the prevalence, risk factors, and characteristics of immunocompromised patients coming from the community with pneumonia. METHODS:We conducted a secondary analysis of an international, multicenter study enrolling adult patients coming from the community with pneumonia and hospitalized in 222 ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 68(9):1482-1493]

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Chronic Cough and Gastroesophageal Reflux in Children: CHEST Guideline and Expert Panel Report.

Anne B Chang, John J Oppenheimer, Peter J Kahrilas, Ahmad Kantar, Bruce K Rubin, Miles Weinberger, Richard S Irwin, ,

BACKGROUND:Whether gastroesophageal reflux (GER) or GER disease (GERD) causes chronic cough in children is controversial. Using the Population, Intervention, Comparison, Outcome (PICO) format, we undertook four systematic reviews. For children with chronic cough (> 4-weeks duration) and without underlying lung disease: (1) who do not have gastrointestinal GER symptoms, should ... Read more >>

Chest (Chest)
[2019, 156(1):131-140]

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British Thoracic Society Guideline for bronchiectasis in adults.

Adam T Hill, Anita L Sullivan, James D Chalmers, Anthony De Soyza, Stuart J Elborn, Andres R Floto, Lizzie Grillo, Kevin Gruffydd-Jones, Alex Harvey, Charles S Haworth, Edwin Hiscocks, John R Hurst, Christopher Johnson, Peter W Kelleher, Pallavi Bedi, Karen Payne, Hashem Saleh, Nicholas J Screaton, Maeve Smith, Michael Tunney, Deborah Whitters, Robert Wilson, Michael R Loebinger,

Thorax (Thorax)
[2019, 74(Suppl 1):1-69]

Cited: 8 times

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Updated BTS Adult Bronchiectasis Guideline 2018: a multidisciplinary approach to comprehensive care.

Adam T Hill, Sally A Welham, Anita L Sullivan, Michael R Loebinger,

The new British Thoracic Society (BTS) Guideline for Bronchiectasis in Adults has been published. This article provides a summary of key highlights of the new BTS Guideline and covers who to investigate, what investigations should be carried out and a management strategy. ... Read more >>

Thorax (Thorax)
[2019, 74(1):1-3]

Cited: 2 times

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British Thoracic Society guideline for bronchiectasis in adults.

Adam T Hill, Anita L Sullivan, James D Chalmers, Anthony De Soyza, J Stuart Elborn, R Andres Floto, Lizzie Grillo, Kevin Gruffydd-Jones, Alex Harvey, Charles S Haworth, Edwin Hiscocks, John R Hurst, Christopher Johnson, W Peter Kelleher, Pallavi Bedi, Karen Payne, Hesham Saleh, NIcholas J Screaton, Maeve Smith, Michael Tunney, Deborah Whitters, Robert Wilson, Michael R Loebinger,

The full British Thoracic Society Guideline for Bronchiectasis in Adults is published in Thorax. The following is a summary of the recommendations and good practice points. The sections referred to in the summary refer to the full guideline. The appendices are available in the full guideline. ... Read more >>

BMJ Open Respir Res (BMJ open respiratory research)
[2018, 5(1):e000348]

Cited: 1 time

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Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT). A Prospective, Open-Label, Randomized Study.

David E Griffith, Gina Eagle, Rachel Thomson, Timothy R Aksamit, Naoki Hasegawa, Kozo Morimoto, Doreen J Addrizzo-Harris, Anne E O'Donnell, Theodore K Marras, Patrick A Flume, Michael R Loebinger, Lucy Morgan, Luigi R Codecasa, Adam T Hill, Stephen J Ruoss, Jae-Joon Yim, Felix C Ringshausen, Stephen K Field, Julie V Philley, Richard J Wallace, Jakko van Ingen, Chris Coulter, James Nezamis, Kevin L Winthrop, ,

Rationale: Improved therapeutic options are needed for patients with treatment-refractory nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex (MAC). Objectives: To evaluate the efficacy and safety of daily amikacin liposome inhalation suspension (ALIS) added to standard guideline-based therapy (GBT) in patients with refractory MAC lung disease. Methods: Adults with ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2018, 198(12):1559-1569]

Cited: 8 times

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An international perspective on hospitalized patients with viral community-acquired pneumonia.

Dejan Radovanovic, Giovanni Sotgiu, Mateja Jankovic, Padukudru Anand Mahesh, Pedro Jorge Marcos, Mohamed I Abdalla, Marta Francesca Di Pasquale, Andrea Gramegna, Silvia Terraneo, Francesco Blasi, Pierachille Santus, Stefano Aliberti, Luis F Reyes, Marcos I Restrepo, ,

BACKGROUND:Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. METHODS:Secondary analysis of GLIMP, an international, ... Read more >>

Eur. J. Intern. Med. (European journal of internal medicine)
[2019, 60:54-70]

Cited: 1 time

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Validation of the Incremental Shuttle Walk Test as a Clinical End Point in Bronchiectasis.

Manjit K Cartlidge, Maeve P Smith, Pallavi Bedi, Samantha Donaldson, Andrea Clarke, Leandro C Mantoani, Roberto A Rabinovich, Adriano G Rossi, Adam T Hill,

BACKGROUND:A validated clinical end point is needed to assess response to therapies in bronchiectasis. OBJECTIVES:The goal of this study was to assess the reliability, validity, and responsiveness of the incremental shuttle walk test (ISWT) as a clinical end point in bronchiectasis. METHODS:In clinically stable patients (n = 30), the ISWT was ... Read more >>

Chest (Chest)
[2018, 154(6):1321-1329]

Cited: 1 time

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Clinically Diagnosing Pertussis-associated Cough in Adults and Children: CHEST Guideline and Expert Panel Report.

Abigail Moore, Anthony Harnden, Cameron C Grant, Sheena Patel, Richard S Irwin, ,

BACKGROUND:The decision to treat a suspected case of pertussis with antibiotics is usually based on a clinical diagnosis rather than waiting for laboratory confirmation. The current guideline focuses on making the clinical diagnosis of pertussis-associated cough in adults and children. METHODS:The American College of Chest Physicians (CHEST) methodologic guidelines and ... Read more >>

Chest (Chest)
[2019, 155(1):147-154]

Cited: 0 times

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In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A.

Ahsan R Akram, Sunay V Chankeshwara, Emma Scholefield, Tashfeen Aslam, Neil McDonald, Alicia Megia-Fernandez, Adam Marshall, Bethany Mills, Nicolaos Avlonitis, Thomas H Craven, Annya M Smyth, David S Collie, Calum Gray, Nik Hirani, Adam T Hill, John R Govan, Timothy Walsh, Christopher Haslett, Mark Bradley, Kevin Dhaliwal,

Respiratory infections in mechanically ventilated patients caused by Gram-negative bacteria are a major cause of morbidity. Rapid and unequivocal determination of the presence, localization, and abundance of bacteria is critical for positive resolution of the infections and could be used for patient stratification and for monitoring treatment efficacy. Here, we ... Read more >>

Sci Transl Med (Science translational medicine)
[2018, 10(464):]

Cited: 4 times

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Adult Outpatients With Acute Cough Due to Suspected Pneumonia or Influenza: CHEST Guideline and Expert Panel Report.

Adam T Hill, Philip M Gold, Ali A El Solh, Joshua P Metlay, Belinda Ireland, Richard S Irwin, ,

BACKGROUND:Patients commonly present to primary care services with upper and lower respiratory tract infections, and guidelines to help physicians investigate and treat acute cough due to suspected pneumonia and influenza are needed. METHODS:A systematic search was carried out with eight patient, intervention, comparison, outcome questions related to acute cough due ... Read more >>

Chest (Chest)
[2019, 155(1):155-167]

Cited: 0 times

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Blood Neutrophils Are Reprogrammed in Bronchiectasis.

Pallavi Bedi, Donald J Davidson, Brian J McHugh, Adriano G Rossi, Adam T Hill,

RATIONALE:Excessive neutrophilic airway inflammation is the central feature of bronchiectasis, but little is known about neutrophils in bronchiectasis. OBJECTIVES:To assess blood neutrophil phenotype in patients with bronchiectasis while stable and during exacerbations. METHODS:In the clinically stable arm of this study, there were eight healthy volunteers, eight patients with mild bronchiectasis, ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2018, 198(7):880-890]

Cited: 8 times

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