Full Text Journal Articles by
Author Adam Grant

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Cell intrinsic signaling in MEN1 mutant pancreatic neuroendocrine tumors unveils novel signaling pathways associated with de-differentiation

Brenna Rheinheimer, Ronald Heimark, Adam Grant, Luis Camacho, Megha Padi, Tun Jie,

Abstract Objectives Preliminary genomic analysis of primary pancreatic neuroendocrine tumors revealed a complex mutational landscape with four common oncogenic events; however, critical activation pathways responsible for pancreatic neuroendocrine tumor progression and metastasis have yet to be elucidated. Here, we analyzed six primary pancreatic neuroendocrine tumors to determine which pathways are ... Read more >>

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Generating Ensembles of Gene Regulatory Networks to Assess Robustness of Disease Modules

James Lim, Chen Chen, Adam Grant, Megha Padi,

Abstract The use of biological networks such as protein-protein interaction and transcriptional regulatory networks is becoming an integral part of biological research in the genomics era. However, these networks are not static, and during phenotypic transitions like disease onset, they can acquire new “communities” of genes that carry out key ... Read more >>

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Breast tumor stiffness instructs bone metastasis via mechanical memory

Adam Watson, Adam Grant, Sara Parker, Michael Harman, Mackenzie Roman, Brittany Forte, Cody Gowan, Raul Castro-Portuguez, Christian Franck, Darren Cusanovich, Megha Padi, Casey Romanoski, Ghassan Mouneimne,

The mechanical microenvironment of primary breast tumors plays a substantial role in promoting tumor progression. While the transitory response of cancer cells to pathological stiffness in their native microenvironment has been well described, it is still unclear how mechanical stimuli in the primary tumor influence distant, late-stage metastatic phenotypes across ... Read more >>

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Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations.

Adam D Grant, Paris Vail, Megha Padi, Agnieszka K Witkiewicz, Erik S Knudsen,

Genetic alterations are essential for cancer initiation and progression. However, differentiating mutations that drive the tumor phenotype from mutations that do not affect tumor fitness remains a fundamental challenge in cancer biology. To better understand the impact of a given mutation within cancer, RNA-sequencing data was used to categorize mutations ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):12766]

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Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer.

Erik S Knudsen, Vishnu Kumarasamy, Amanda Ruiz, Jared Sivinski, Sejin Chung, Adam Grant, Paris Vail, Shailender S Chauhan, Tun Jie, Taylor S Riall, Agnieszka K Witkiewicz,

Pancreatic ductal adenocarcinoma (PDAC), like many KRAS-driven tumors, preferentially loses CDKN2A that encodes an endogenous CDK4/6 inhibitor to bypass the RB-mediated cell cycle suppression. Analysis of a panel of patient-derived cell lines and matched xenografts indicated that many pancreatic cancers have intrinsic resistance to CDK4/6 inhibition that is not due ... Read more >>

Oncogene (Oncogene)
[2019, 38(18):3355-3370]

Cited: 5 times

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The mixed effects of online diversity training.

Edward H Chang, Katherine L Milkman, Dena M Gromet, Robert W Rebele, Cade Massey, Angela L Duckworth, Adam M Grant,

We present results from a large (n = 3,016) field experiment at a global organization testing whether a brief science-based online diversity training can change attitudes and behaviors toward women in the workplace. Our preregistered field experiment included an active placebo control and measured participants' attitudes and real workplace decisions ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2019, 116(16):7778-7783]

Cited: 2 times

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Writing a Book for Real People: On Giving the Psychology of Giving Away.

Adam M Grant,

Perspect Psychol Sci (Perspectives on psychological science : a journal of the Association for Psychological Science)
[2019, 14(1):91-95]

Cited: 1 time

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Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations

Adam Grant, Paris Vail, Megha Padi, Agnieszka Witkiewicz, Erik Knudsen,

Abstract Genetic alterations are essential for cancer initiation and progression. However, differentiating mutations that drive the tumor phenotype from mutations that do not affect tumor fitness remains a fundamental challenge in cancer biology. To better understand the impact of a given mutation within cancer, RNA-sequencing data was used to categorize ... Read more >>

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Hale and Hearty Policies: How Psychological Science Can Create and Maintain Healthy Habits.

Alexander J Rothman, Peter M Gollwitzer, Adam M Grant, David T Neal, Paschal Sheeran, Wendy Wood,

Strategies are needed to ensure that the U.S. Government meets its goals for improving the health of the nation (e.g., Healthy People 2020). To date, progress toward these goals has been undermined by a set of discernible challenges: People lack sufficient motivation, they frequently fail to translate healthy intentions into ... Read more >>

Perspect Psychol Sci (Perspectives on psychological science : a journal of the Association for Psychological Science)
[2015, 10(6):701-705]

Cited: 21 times

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When in doubt, seize the day? Security values, prosocial values, and proactivity under ambiguity.

Adam M Grant, Nancy P Rothbard,

Researchers have suggested that both ambiguity and values play important roles in shaping employees' proactive behaviors, but have not theoretically or empirically integrated these factors. Drawing on theories of situational strength and values, we propose that ambiguity constitutes a weak situation that strengthens the relationship between the content of employees' ... Read more >>

J Appl Psychol (The Journal of applied psychology)
[2013, 98(5):810-819]

Cited: 3 times

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Convincing Yourself to Care About Others: An Intervention for Enhancing Benevolence Values.

Sharon Arieli, Adam M Grant, Lilach Sagiv,

To study value change, this research presents an intervention with multiple exercises designed to instigate change through both effortful and automatic routes. Aiming to increase the importance attributed to benevolence values, which reflect the motivation to help and care for others, the intervention combines three mechanisms for value change (self-persuasion, ... Read more >>

J Pers (Journal of personality)
[2014, 82(1):15-24]

Cited: 3 times

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In the company of givers and takers.

Adam Grant,

Employees make decisions every day about whether to contribute to others--and their willingness to help is crucial to group and organizational effectiveness. But in a competitive, often zero-sum, world of work, generosity can be a dangerous path. How can leaders foster it without cutting into productivity, undermining fairness, and allowing ... Read more >>

Harv Bus Rev (Harvard business review)
[2013, 91(4):90-7, 142]

Cited: 1 time

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Rethinking the extraverted sales ideal: the ambivert advantage.

Adam M Grant,

Despite the widespread assumption that extraverts are the most productive salespeople, research has shown weak and conflicting relationships between extraversion and sales performance. In light of these puzzling results, I propose that the relationship between extraversion and sales performance is not linear but curvilinear: Ambiverts achieve greater sales productivity than ... Read more >>

Psychol Sci (Psychological science)
[2013, 24(6):1024-1030]

Cited: 12 times

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Beneficiary or benefactor: are people more prosocial when they reflect on receiving or giving?

Adam Grant, Jane Dutton,

Research shows that reflecting on benefits received can make people happier, but it is unclear whether or not such reflection makes them more helpful. Receiving benefits can promote prosocial behavior through reciprocity and positive affect, but these effects are often relationship-specific, short-lived, and complicated by ambivalent reactions. We propose that ... Read more >>

Psychol Sci (Psychological science)
[2012, 23(9):1033-1039]

Cited: 14 times

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It's not all about me: motivating hand hygiene among health care professionals by focusing on patients.

Adam M Grant, David A Hofmann,

Diseases often spread in hospitals because health care professionals fail to wash their hands. Research suggests that to increase health and safety behaviors, it is important to highlight the personal consequences for the actor. However, because people (and health care professionals in particular) tend to be overconfident about personal immunity, ... Read more >>

Psychol Sci (Psychological science)
[2011, 22(12):1494-1499]

Cited: 24 times

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Too Much of a Good Thing: The Challenge and Opportunity of the Inverted U.

Adam M Grant, Barry Schwartz,

Aristotle proposed that to achieve happiness and success, people should cultivate virtues at mean or intermediate levels between deficiencies and excesses. In stark contrast to this assertion that virtues have costs at high levels, a wealth of psychological research has focused on demonstrating the well-being and performance benefits of positive ... Read more >>

Perspect Psychol Sci (Perspectives on psychological science : a journal of the Association for Psychological Science)
[2011, 6(1):61-76]

Cited: 30 times

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The hidden advantages of quiet bosses.

Adam M Grant, Francesca Gino, David A Hofmann,

Harv Bus Rev (Harvard business review)
[2010, 88(12):28]

Cited: 0 times

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Mission possible? The performance of prosocially motivated employees depends on manager trustworthiness.

Adam M Grant, John J Sumanth,

The authors propose that in mission-driven organizations, prosocially motivated employees are more likely to perform effectively when trust cues enhance their perceptions of task significance. The authors develop and test a model linking prosocial motivation, trust cues, task significance, and performance across 3 studies of fundraisers using 3 different objective ... Read more >>

J Appl Psychol (The Journal of applied psychology)
[2009, 94(4):927-944]

Cited: 4 times

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I won't let you down... or will I? Core self-evaluations, other-orientation, anticipated guilt and gratitude, and job performance.

Adam M Grant, Amy Wrzesniewski,

Although core self-evaluations have been linked to higher job performance, research has shown variability in the strength of this relationship. We propose that high core self-evaluations are more likely to increase job performance for other-oriented employees, who tend to anticipate feelings of guilt and gratitude. We tested these hypotheses across ... Read more >>

J Appl Psychol (The Journal of applied psychology)
[2010, 95(1):108-121]

Cited: 5 times

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A little thanks goes a long way: Explaining why gratitude expressions motivate prosocial behavior.

Adam M Grant, Francesca Gino,

Although research has established that receiving expressions of gratitude increases prosocial behavior, little is known about the psychological mechanisms that mediate this effect. We propose that gratitude expressions can enhance prosocial behavior through both agentic and communal mechanisms, such that when helpers are thanked for their efforts, they experience stronger ... Read more >>

J Pers Soc Psychol (Journal of personality and social psychology)
[2010, 98(6):946-955]

Cited: 41 times

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Seeking help in the shadow of doubt: the sensemaking processes underlying how nurses decide whom to ask for advice.

David A Hofmann, Zhike Lei, Adam M Grant,

Although scholars often assume that individuals seek out experts when they need help, recent research suggests that seeking help from experts can be costly. The authors propose that perceiving potential help providers as accessible or trustworthy can reduce the costs of seeking help and thus encourage individuals to seek help ... Read more >>

J Appl Psychol (The Journal of applied psychology)
[2009, 94(5):1261-1274]

Cited: 6 times

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Good soldiers and good actors: prosocial and impression management motives as interactive predictors of affiliative citizenship behaviors.

Adam M Grant, David M Mayer,

Researchers have discovered inconsistent relationships between prosocial motives and citizenship behaviors. We draw on impression management theory to propose that impression management motives strengthen the association between prosocial motives and affiliative citizenship by encouraging employees to express citizenship in ways that both "do good" and "look good." We report 2 ... Read more >>

J Appl Psychol (The Journal of applied psychology)
[2009, 94(4):900-912]

Cited: 15 times

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The significance of task significance: Job performance effects, relational mechanisms, and boundary conditions.

Adam M Grant,

Does task significance increase job performance? Correlational designs and confounded manipulations have prevented researchers from assessing the causal impact of task significance on job performance. To address this gap, 3 field experiments examined the performance effects, relational mechanisms, and boundary conditions of task significance. In Experiment 1, fundraising callers who ... Read more >>

J Appl Psychol (The Journal of applied psychology)
[2008, 93(1):108-124]

Cited: 25 times

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Does intrinsic motivation fuel the prosocial fire? Motivational synergy in predicting persistence, performance, and productivity.

Adam M Grant,

Researchers have obtained conflicting results about the role of prosocial motivation in persistence, performance, and productivity. To resolve this discrepancy, I draw on self-determination theory, proposing that prosocial motivation is most likely to predict these outcomes when it is accompanied by intrinsic motivation. Two field studies support the hypothesis that ... Read more >>

J Appl Psychol (The Journal of applied psychology)
[2008, 93(1):48-58]

Cited: 48 times

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