Full Text Journal Articles by
Author Adam C Levine

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Association between Age, Weight, and Dose and Clinical Response to Probiotics in Children with Acute Gastroenteritis.

David Schnadower, Robert E Sapien, T Charles Casper, Cheryl Vance, Phillip I Tarr, Karen J O'Connell, Adam C Levine, Cindy G Roskind, Alexander J Rogers, Seema R Bhatt, Prashant Mahajan, Elizabeth C Powell, Cody S Olsen, Marc H Gorelick, J Michael Dean, Stephen B Freedman, ,

<h4>Background</h4>Gastroenteritis is a common and impactful disease in childhood. Probiotics are often used to treat acute gastroenteritis (AGE); however, in a large multicenter randomized controlled trial (RCT) in 971 children, Lactobacillus rhamnosus GG (LGG) was no better than placebo in improving patient outcomes.<h4>Objectives</h4>We sought to determine whether the effect of ... Read more >>

J Nutr (The Journal of nutrition)
[2021, 151(1):65-72]

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Academic-humanitarian partnerships: leveraging strengths to combat COVID-19.

Adam R Aluisio, Emily Zhu, Gabriela Gil, Thomas Kenyon, Vlatko Uzevski, Adam C Levine,

The Coronavirus Disease 2019 (COVID-19) pandemic has overwhelmed many health systems globally. Innovative initiatives are needed to combat the pandemic and scaleup response efforts. This communication describes a collaborative partnership between an international humanitarian organization and an academic university to develop and rapidly deploy a remote digital COVID-19 trainer-of-trainers (TOT) ... Read more >>

Glob Health Action (Global health action)
[2020, 13(1):1797296]

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Clinical predictors for etiology of acute diarrhea in children in resource-limited settings.

Ben J Brintz, Joel I Howard, Benjamin Haaland, James A Platts-Mills, Tom Greene, Adam C Levine, Eric J Nelson, Andrew T Pavia, Karen L Kotloff, Daniel T Leung,

<h4>Background</h4>Diarrhea is one of the leading causes of childhood morbidity and mortality in lower- and middle-income countries. In such settings, access to laboratory diagnostics are often limited, and decisions for use of antimicrobials often empiric. Clinical predictors are a potential non-laboratory method to more accurately assess diarrheal etiology, the knowledge ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2020, 14(10):e0008677]

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From Concerts to COVID: Transforming the RI Convention Center into an Alternate Hospital Site in under a Month.

Sonya Naganathan, Kelly Meehan-Coussee, Scott Pasichow, Heather Rybasack-Smith, William Binder, Francesca Beaudoin, Andrew N Musits, Elizabeth Sutton, Gianna Petrone, Adam C Levine, Selim Suner,

Field hospitals have long been used to extend health care capabilities in times of crisis. In response to the pandemic and an anticipated surge in patients, Rhode Island Gov. Gina Raimondo announced a plan to create three field hospitals, or "alternate hospital sites" (AHS), totaling 1,000 beds, in order to ... Read more >>

R I Med J (2013) (Rhode Island medical journal (2013))
[2020, 103(6):8-13]

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Evaluation of blood product transfusion therapies in acute injury care in low- and middle-income countries: a systematic review.

Lanbo Yang, John Slate-Romano, Catalina González Marqués, Chantal Uwamahoro, Francois Regis Twagirumukiza, Sonya Naganathan, Katelyn Moretti, Ling Jing, Adam C Levine, Andrew Stephen, Adam R Aluisio,

BACKGROUND:Worldwide, injuries account for approximately five million mortalities annually, with 90% occurring in low- and middle-income countries (LMICs). Although guidelines characterizing data for blood product transfusion in injury resuscitation have been established for high-income countries (HICs), no such information on use of blood products in LMICs exists. This systematic review ... Read more >>

Injury (Injury)
[2020, 51(7):1468-1476]

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Electronic decision support and diarrhoeal disease guideline adherence (mHDM): a cluster randomised controlled trial.

Ashraful I Khan, Jasmine A Mack, M Salimuzzaman, Mazharul I Zion, Hasnat Sujon, Robyn L Ball, Stace Maples, Md Mahbubur Rashid, Mohammod J Chisti, Shafiqul A Sarker, Debashish Biswas, Raduan Hossin, Kevin L Bardosh, Yasmin A Begum, Azimuddin Ahmed, Dane Pieri, Farhana Haque, Mahmudur Rahman, Adam C Levine, Firdausi Qadri, Meerjady S Flora, Matthew J Gurka, Eric J Nelson,

<h4>Background</h4>Acute diarrhoeal disease management often requires rehydration alone without antibiotics. However, non-indicated antibiotics are frequently ordered and this is an important driver of antimicrobial resistance. The mHealth Diarrhoea Management (mHDM) trial aimed to establish whether electronic decision support improves rehydration and antibiotic guideline adherence in resource-limited settings.<h4>Methods</h4>A cluster randomised controlled ... Read more >>

Lancet Digit Health (The Lancet. Digital health)
[2020, 2(5):e250-e258]

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Impact of Intravenous Fluid Therapy on Survival Among Patients With Ebola Virus Disease: An International Multisite Retrospective Cohort Study.

Adam R Aluisio, Derrick Yam, Jillian L Peters, Daniel K Cho, Shiromi M Perera, Stephen B Kennedy, Moses Massaquoi, Foday Sahr, Michael A Smit, Tao Liu, Adam C Levine,

<h4>Background</h4>Intravenous fluid (IVF) is a frequently recommended intervention in Ebola virus disease (EVD), yet its impact on patient outcomes remains unclear.<h4>Methods</h4>This retrospective cohort study evaluated patients with EVD admitted to 5 Ebola treatment units (ETUs) in West Africa. The primary outcome was the difference in 28-day survival between cases treated ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(6):1038-1047]

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Association between treatment with oral third-generation cephalosporin antibiotics and mortality outcomes in Ebola virus disease: a multinational retrospective cohort study.

Adam R Aluisio, Shiromi M Perera, Derrick Yam, Stephanie Garbern, Jillian L Peters, Logan Abel, Daniel K Cho, Dayan Woldemichael, Stephen B Kennedy, Moses Massaquoi, Foday Sahr, Tao Liu, Adam C Levine,

OBJECTIVE:To evaluate the association between oral third-generation cephalosporin antibiotic treatment and mortality in Ebola virus disease (EVD). METHODS:This retrospective cohort studied EVD-infected patients admitted to five Ebola Treatment Units in Sierra Leone and Liberia during 2014-15. Empiric treatment with cefixime 400 mg once daily for five days was the clinical protocol; ... Read more >>

Trop Med Int Health (Tropical medicine & international health : TM & IH)
[2020, 25(4):433-441]

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How Should the WHO Guide Access and Benefit Sharing During Infectious Disease Outbreaks?

Nicholas G Evans, Kelly Hills, Adam C Levine,

In response to the 2013-2016 Ebola virus disease (EVD) outbreak primarily affecting Guinea, Sierra Leone, and Liberia, the World Health Organization (WHO) set out <i>Guidance for Managing Ethical Issues in Infectious Disease Outbreaks</i>, which covered social distancing, research in outbreak settings, and clinical care. This article assesses the <i>Guidance</i>'s recommendations ... Read more >>

AMA J Ethics (AMA journal of ethics)
[2020, 22(1):E28-35]

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A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics.

Sabue Mulangu, Lori E Dodd, Richard T Davey, Olivier Tshiani Mbaya, Michael Proschan, Daniel Mukadi, Mariano Lusakibanza Manzo, Didier Nzolo, Antoine Tshomba Oloma, Augustin Ibanda, Rosine Ali, Sinaré Coulibaly, Adam C Levine, Rebecca Grais, Janet Diaz, H Clifford Lane, Jean-Jacques Muyembe-Tamfum, , Billy Sivahera, Modet Camara, Richard Kojan, Robert Walker, Bonnie Dighero-Kemp, Huyen Cao, Philippe Mukumbayi, Placide Mbala-Kingebeni, Steve Ahuka, Sarah Albert, Tyler Bonnett, Ian Crozier, Michael Duvenhage, Calvin Proffitt, Marc Teitelbaum, Thomas Moench, Jamila Aboulhab, Kevin Barrett, Kelly Cahill, Katherine Cone, Risa Eckes, Lisa Hensley, Betsey Herpin, Elizabeth Higgs, Julie Ledgerwood, Jerome Pierson, Mary Smolskis, Ydrissa Sow, John Tierney, Sumathi Sivapalasingam, Wendy Holman, Nikki Gettinger, David Vallée, Jacqueline Nordwall, ,

<h4>Background</h4>Although several experimental therapeutics for Ebola virus disease (EVD) have been developed, the safety and efficacy of the most promising therapies need to be assessed in the context of a randomized, controlled trial.<h4>Methods</h4>We conducted a trial of four investigational therapies for EVD in the Democratic Republic of Congo, where an ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 381(24):2293-2303]

Cited: 203 times

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Evaluation of a modified South African Triage Score as a predictor of patient disposition at a tertiary hospital in Rwanda.

Chantal Uwamahoro, Adam R Aluisio, Esther Chu, Ellen Reibling, Zeta Mutabazi, Naz Karim, Jean Claude Byiringiro, Adam C Levine, Mindi Guptill,

Background:Triage is essential for efficient and effective delivery of care in emergency centers (ECs) where numerous patients present simultaneously with varying acuity of conditions. Implementing EC triage systems provides a method of recognizing which patients may require admission and are at higher risks for poor health outcomes. Rwanda is experiencing ... Read more >>

Afr J Emerg Med (African journal of emergency medicine : Revue africaine de la medecine d'urgence)
[2020, 10(1):17-22]

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Association between multivitamin supplementation and mortality among patients with Ebola virus disease: An international multisite cohort study.

Derrick Yam, Adam R Aluisio, Shiromi M Perera, Jillian L Peters, Daniel K Cho, Stephen B Kennedy, Moses Massaquoi, Foday Sahr, Michael A Smit, Lindsey Locks, Tao Liu, Adam C Levine,

Introduction:Micronutrient supplementation is recommended in Ebola Virus Disease (EVD) care; however, there is limited data on its therapeutic effects. Methods:This retrospective cohort study included patients with EVD admitted to five Ebola Treatment Units (ETU) in Sierra Leone and Liberia during September 2014 to December 2015. A uniform protocol was used ... Read more >>

Afr J Emerg Med (African journal of emergency medicine : Revue africaine de la medecine d'urgence)
[2020, 10(1):23-29]

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Vitamin A Supplementation Was Associated with Reduced Mortality in Patients with Ebola Virus Disease during the West African Outbreak.

Adam R Aluisio, Shiromi M Perera, Derrick Yam, Stephanie Garbern, Jillian L Peters, Logan Abel, Daniel K Cho, Stephen B Kennedy, Moses Massaquoi, Foday Sahr, Suzanne Brinkmann, Lindsey Locks, Tao Liu, Adam C Levine,

BACKGROUND:Micronutrient supplementation is recommended in Ebola virus disease (EVD); however, there are limited data on therapeutic impacts of specific micronutrients. OBJECTIVE:To evaluate the association between vitamin A supplementation and mortality in EVD. METHODS:This retrospective cohort included patients with EVD admitted to 5 International Medical Corps Ebola Treatment Units (ETUs) in ... Read more >>

J Nutr (The Journal of nutrition)
[2019, 149(10):1757-1765]

Cited: 2 times

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Developing a Novel Mobile Health (mHealth) Tool to Improve Dehydration Assessment and Management in Patients with Acute Diarrhea in Resource-Limited Settings.

Monique Gainey, Meagan Barry, Adam C Levine, Sabiha Nasrin,

Dehydration due to diarrhea is one of the main causes of death worldwide, yet no clinical tools for accurately assessing and managing dehydration in patients with acute diarrhea have been created for low- and middle-income countries (LMICs). In 2012, Brown University's Department of Emergency Medicine began partnering with the International ... Read more >>

R I Med J (2013) (Rhode Island medical journal (2013))
[2019, 102(7):36-39]

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Building and Sustaining Partnerships in Health Workforce and Research Capacity in Rwanda.

Stephanie C Garbern, Kyle D Martin, Catalina Gonzalez-Marques, Olivier Félix Umuhire, Doris Lorette Uwamahoro, Adam R Aluisio, Adam C Levine,

Rwanda's ambitious Human Resources for Health (HRH) program comes to an end this year, having made great strides towards achieving its aim to create a large, diverse and competent health workforce, and will have graduated over 4,500 healthcare professionals since its inception in 2012. The HRH program was based on ... Read more >>

R I Med J (2013) (Rhode Island medical journal (2013))
[2019, 102(7):32-35]

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Little Rhody Goes Global.

Adam C Levine, Alison S Hayward,

R I Med J (2013) (Rhode Island medical journal (2013))
[2019, 102(7):16]

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Musculoskeletal Injuries and Outcomes Pre- and Post- Emergency Medicine Training Program.

Peter Mattson, Ezechiel Nteziryayo, Adam R Aluisio, Michael Henry, Noah Rosenberg, Zeta A Mutabazi, Jeanne D'Arc Nyinawankusi, Jean Claude Byiringiro, Adam C Levine, Naz Karim,

<h4>Introduction</h4>Musculoskeletal injuries (MSI) comprise a large portion of the trauma burden in low- and middle-income countries (LMIC). Rwanda recently launched its first emergency medicine training program (EMTP) at the University Teaching Hospital-Kigali (UTH-K), which may help to treat such injuries; yet no current epidemiological data is available on MSI in ... Read more >>

West J Emerg Med (The western journal of emergency medicine)
[2019, 20(6):857-864]

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Clinical emergency care research in low-income and middle-income countries: opportunities and challenges.

Adam R Aluisio, Shahan Waheed, Peter Cameron, Jermey Hess, Shevin T Jacob, Niranjan Kissoon, Adam C Levine, Asad Mian, Shammi Ramlakhan, Hendry R Sawe, Junaid Razzak,

Disease processes that frequently require emergency care constitute approximately 50% of the total disease burden in low-income and middle-income countries (LMICs). Many LMICs continue to deal with emergencies caused by communicable disease states such as pneumonia, diarrhoea, malaria and meningitis, while also experiencing a marked increase in non-communicable diseases, such ... Read more >>

BMJ Glob Health (BMJ global health)
[2019, 4(Suppl 6):e001289]

Cited: 1 time

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Global Emergency Medicine: A Review of the Literature from 2018.

Indi Trehan, Maxwell Osei-Ampofo, Kamna S Balhara, Braden J Hexom, Sean M Kivlehan, Payal Modi, Amelia Y Pousson, Anand Selvam, Nana Serwaa A Quao, Daniel K Cho, Torben K Becker, Adam C Levine, ,

<h4>Objectives</h4>The Global Emergency Medicine Literature Review (GEMLR) conducts a systematic annual search of peer-reviewed and gray literature relevant to global emergency medicine (EM) to identify, review, and disseminate the most rigorously conducted and widely relevant research in global EM.<h4>Methods</h4>An electronic search of PubMed, a comprehensive retrieval of articles from specific ... Read more >>

Acad Emerg Med (Academic emergency medicine : official journal of the Society for Academic Emergency Medicine)
[2019, 26(10):1186-1196]

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118 Predictors of intravenous rehydration in children with acute gastroenteritis in the United States and Canada

Naveen Poonai, Elizabeth C Powell, David Schnadower, Charlie Casper, Cindy Roskind, Cody Olsen, Philip Tarr, Prashant Mahajan, Alexander J Rogers, Suzanne Schuh, Katrina Hurley, Serge Gouin, Cheryl Vance, Ken Farion, Robert E Sapien, Karen J O’Connell, Adam C Levine, Seema Bhatt, Stephen B Freedman,

Abstract <h4>Background</h4> Although oral rehydration therapy is recommended for children with acute gastroenteritis (AGE) with none to some dehydration, intravenous (IV) rehydration is still commonly administered to these children in high-income countries. IV rehydration is associated with pain, anxiety, and emergency department (ED) revisits in children with AGE. <h4>Objectives</h4> We ... Read more >>

Paediatr Child Health (Paediatrics & child health)
[2019, 24(Suppl 2):e45-e45]

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Effect of Mass Artesunate-Amodiaquine Distribution on Mortality of Patients With Ebola Virus Disease During West African Outbreak.

Stephanie C Garbern, Derrick Yam, Adam R Aluisio, Daniel K Cho, Stephen B Kennedy, Moses Massaquoi, Foday Sahr, Shiromi M Perera, Adam C Levine, Tao Liu,

<h4>Background</h4>Experiments in vitro have shown that the drug amodiaquine may inhibit Ebola virus activity. During the Ebola virus disease (EVD) epidemic in West Africa in 2014-2016, 2 mass drug administrations (MDAs) of artesunate-amodiaquine (ASAQ) were implemented to decrease the burden of malaria. The objective of this study was to assess ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(7):ofz250]

Cited: 3 times

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Machine-learning Prognostic Models from the 2014-16 Ebola Outbreak: Data-harmonization Challenges, Validation Strategies, and mHealth Applications.

Andres Colubri, Mary-Anne Hartley, Matthew Siakor, Vanessa Wolfman, August Felix, Tom Sesay, Jeffrey G Shaffer, Robert F Garry, Donald S Grant, Adam C Levine, Pardis C Sabeti,

<h4>Background</h4>Ebola virus disease (EVD) plagues low-resource and difficult-to-access settings. Machine learning prognostic models and mHealth tools could improve the understanding and use of evidence-based care guidelines in such settings. However, data incompleteness and lack of interoperability limit model generalizability. This study harmonizes diverse datasets from the 2014-16 EVD epidemic and ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2019, 11:54-64]

Cited: 4 times

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Validation of a wearable biosensor device for vital sign monitoring in septic emergency department patients in Rwanda.

Stephanie C Garbern, Gabin Mbanjumucyo, Christian Umuhoza, Vinay K Sharma, James Mackey, Oliver Tang, Kyle D Martin, Francois R Twagirumukiza, Samantha L Rosman, Natalie McCall, Stephan W Wegerich, Adam C Levine,

Objective:Critical care capabilities needed for the management of septic patients, such as continuous vital sign monitoring, are largely unavailable in most emergency departments (EDs) in low- and middle-income country (LMIC) settings. This study aimed to assess the feasibility and accuracy of using a wireless wearable biosensor device for continuous vital ... Read more >>

Digit Health (Digital health)
[2019, 5:2055207619879349]

Cited: 0 times

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Sex and Gender Differences in Acute Pediatric Diarrhea: A Secondary Analysis of the DHAKA Study.

Angela F Jarman, Sara E Long, Sarah E Robertson, Sabiha Nasrin, Nur Haque Alam, Alyson J McGregor, Adam C Levine,

Pediatric diarrheal disease is a significant source of morbidity and mortality in the developing world. While several studies have demonstrated an increased incidence of diarrheal illness in boys compared with girls in low- and middle-income countries (LMIC), the reasons for this difference are unclear. This secondary analysis of the dehydration: ... Read more >>

J Epidemiol Glob Health (Journal of epidemiology and global health)
[2018, 8(1-2):42-47]

Cited: 1 time

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Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children.

David Schnadower, Phillip I Tarr, T Charles Casper, Marc H Gorelick, J Michael Dean, Karen J O'Connell, Prashant Mahajan, Adam C Levine, Seema R Bhatt, Cindy G Roskind, Elizabeth C Powell, Alexander J Rogers, Cheryl Vance, Robert E Sapien, Cody S Olsen, Melissa Metheney, Viani P Dickey, Carla Hall-Moore, Stephen B Freedman,

<h4>Background</h4>Acute gastroenteritis develops in millions of children in the United States every year, and treatment with probiotics is common. However, data to support the use of probiotics in this population are limited.<h4>Methods</h4>We conducted a prospective, randomized, double-blind trial involving children 3 months to 4 years of age with acute gastroenteritis ... Read more >>

N Engl J Med (The New England journal of medicine)
[2018, 379(21):2002-2014]

Cited: 24 times

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