Full Text Journal Articles by
Author Abdul Basit

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I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets.

Patricija Januskaite, Xiaoyan Xu, Sejal R Ranmal, Simon Gaisford, Abdul W Basit, Catherine Tuleu, Alvaro Goyanes,

3D printing (3DP) in the pharmaceutical field is a disruptive technology that allows the preparation of personalised medicines at the point of dispensing. The paediatric population presents a variety of pharmaceutical formulation challenges such as dose flexibility, patient compliance, taste masking and the fear or difficulty to swallow tablets, all ... Read more >>

Pharmaceutics (Pharmaceutics)
[2020, 12(11):]

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Multi-Method Determination of Antioxidant Capacity, Phytochemical and Biological Investigation of Four Different Solvent Extractives of Leucophyllum frutescens (cenizo)

Imtiaz Ahmad, Saeed Ahmad, Huma Rao, Umer Shaukat, Muhammad Nadeem Shahzad, Sajid-ur- Rehman, Abdul Basit, Adeel Arshad, Bilal Ahmad,

The four solvent extractives obtained from aerial parts of Leucophyllum frutescens were evaluated for their Total Antioxidant Activity (TAA) by ammonium molybdate method, scavenging potential by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Trolox-Equivalent Antioxidant Capacity (TEAC) assays, metal-reducing potential by Cupric Reducing Antioxidant Capacity (CUPRAC) and Ferric Reducing Antioxidant Power (FRAP) assays, Total ... Read more >>

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Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants.

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BACKGROUND:Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. METHODS:For this pooled ... Read more >>

Lancet (Lancet (London, England))
[2020, 396(10261):1511-1524]

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Bitter-blockers as a taste masking strategy: a systematic review towards their utility in pharmaceuticals.

Danielle Andrews, Smita Salunke, Anne Cram, Joanne Bennett, Robert S Ives, Abdul W Basit, Catherine Tuleu,

Acceptable palatability of an oral dosage form is crucial to patient compliance. Excipients can be utilised within a formulation to mask the bitterness of a drug. One such category is the bitter-blockers. This term is used inconsistently within the literature and has historically been used to describe any additive which ... Read more >>

Eur J Pharm Biopharm (European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V)
[2020, :]

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Electrochemical biosensors: a nexus for precision medicine.

Thomas D Pollard, Jun Jie Ong, Alvaro Goyanes, Mine Orlu, Simon Gaisford, Mohammed Elbadawi, Abdul W Basit,

Precision medicine is a field with huge potential for improving a patient's quality of life, wherein therapeutic drug monitoring (TDM) can provide actionable insights. More importantly, incorrect drug dose is a common contributor to medical errors. However, current TDM practice is time-consuming and expensive, and requires specialised technicians. One solution ... Read more >>

Drug Discov Today (Drug discovery today)
[2020, :]

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OxyR controls magnetosome formation by regulating magnetosome island (MAI) genes, iron metabolism, and redox state.

Wei Niu, Yunpeng Zhang, Junquan Liu, Tong Wen, Ting Miao, Abdul Basit, Wei Jiang,

Magnetospirillum gryphiswaldense MSR-1 uses chains of magnetosomes, membrane-enveloped magnetite (Fe(II)Fe(III)2O4) nanocrystals, to align along magnetic field. The process of magnetosome biomineralization requires a precise biological control of redox conditions to maintain a balanced amounts of ferric and ferrous iron. Here, we identified functions of the global regulator OxyR (MGMSRv2_4250, OxyR-4250) ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2020, 161:272-282]

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The potential of Streptococcus salivarius oral films in the management of dental caries: An inkjet printing approach.

Cornelius C Dodoo, Paul Stapleton, Abdul W Basit, Simon Gaisford,

The use of probiotics, which can be administered in oro-dispersible films (ODFs) and have prolonged activity in the mouth, was explored. ODFs made of xylitol and containing Streptococcus salivarius were formulated using inkjet printing and tested against Streptococcus mutans - a causative organism of dental caries. The testing of the ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 591:119962]

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Idiopathic Bilateral Ovarian Vein Thrombosis in a Non-Pregnant Healthy Patient: A Case Report and Review of the Literature

Alexander Muacevic, John R Adler, Abdul Basit, Pushpinder Kaur, Diana M Villanueva, Muhammad Tahir, Mark Sonnenschine,

Ovarian vein thrombosis (OVT) is a potentially life-threatening condition, and it is typically related to the peripartum period; however, it is also associated with pelvic inflammatory disease, recent pelvic or abdominal surgery, inflammatory bowel disease, thrombophilia, malignancy, and sepsis. Idiopathic isolated OVT is rare and is usually presented as case ... Read more >>

Cureus (Cureus)
[0, 12(8):]

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Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human.

Abdul Basit, Naveen K Neradugomma, Christopher Wolford, Peter W Fan, Bernard Murray, Ryan H Takahashi, S Cyrus Khojasteh, Bill J Smith, Scott Heyward, Rheem A Totah, Edward J Kelly, Bhagwat Prasad,

The availability of assays that predict the contribution of cytochrome P450 (CYP) metabolism allows for the design of new chemical entities (NCEs) with minimal oxidative metabolism. These NCEs are often substrates of non-CYP drug-metabolizing enzymes (DMEs), such as UDP-glucuronosyltransferases (UGTs), sulfotransferases (SULTs), carboxylesterases (CESs), and aldehyde oxidase (AO). Nearly 30% ... Read more >>

Mol Pharm (Molecular pharmaceutics)
[2020, 17(11):4114-4124]

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Vat photopolymerization 3D printing for advanced drug delivery and medical device applications.

Xiaoyan Xu, Atheer Awad, Pamela Robles-Martinez, Simon Gaisford, Alvaro Goyanes, Abdul W Basit,

Three-dimensional (3D) printing is transforming manufacturing paradigms within healthcare. Vat photopolymerization 3D printing technology combines the benefits of high resolution and favourable printing speed, offering a sophisticated approach to fabricate bespoke medical devices and drug delivery systems. Herein, an overview of the vat polymerization techniques, their unique applications in the ... Read more >>

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2020, :]

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RNA-Seq profiling reveals the plant hormones and molecular mechanisms stimulating the early ripening in apple.

Iqra Nawaz, Rezwan Tariq, Talha Nazir, Imran Khan, Abdul Basit, Hera Gul, Tauqir Anwar, Samrah Afzal Awan, Syed Asim Shah Bacha, Liyi Zhang, Caixia Zhang, Peihua Cong,

Fruit development and ripening are essential components of human and animal diets. Fruit ripening is also a vital plant trait for plant shelf life at the commercial level. In the present study, two apple cultivars, Hanfu wild (HC) and Hanfu mutant (HM), were employed for RNA-Sequencing (RNA-Seq) to explore the ... Read more >>

Genomics (Genomics)
[2020, :]

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M3DISEEN: A novel machine learning approach for predicting the 3D printability of medicines.

Moe Elbadawi, Brais Muñiz Castro, Francesca K H Gavins, Jun Jie Ong, Simon Gaisford, Gilberto Pérez, Abdul W Basit, Pedro Cabalar, Alvaro Goyanes,

Artificial intelligence (AI) has the potential to reshape pharmaceutical formulation development through its ability to analyze and continuously monitor large datasets. Fused deposition modeling (FDM) three-dimensional printing (3DP) has made significant advancements in the field of oral drug delivery with personalized drug-loaded formulations being designed, developed and dispensed for the ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 590:119837]

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Social Stigmatization of Drug Abusers in a Developing Country: A Cross-Sectional Study.

Farhan Khalid, Ali Jaan, Mian Muhammad Salman Aslam, Zahoor Ahmed, Aniqa Raheem, Zubair H Bodla, Abdul Basit, Bilal Hussain, Aqsa Iftikhar, Muhammad Tayyeb, Awais Khalid, Usama Rehman,

INTRODUCTION: Stigma is a label that differentiates a person from others and associates them with unenviable attributes. There are various forms of stigma: enacted stigma, perceived stigma, and self-stigma manifesting as stereotyping and harboring negative thoughts about the stigmatized group. Stigmatization of the drug abuser leads to effects such as low ... Read more >>

Cureus (Cureus)
[2020, 12(9):e10661]

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Increased risk of disseminated cryptococcal infection in a patient with multiple sclerosis on fingolimod.

Pushpinder Kaur, Alana Lewis, Abdul Basit, Nikolas St Cyr, Zaman Muhammad,

Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS), with an estimated 2.3 million people being affected globally, and is a major cause of permanent disability. About 90 % of the affected patients with MS have relapsing-remitting type. Fingolimod became the first FDA approved ... Read more >>

IDCases (IDCases)
[2020, 22:e00961]

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3D printing tablets: Predicting printability and drug dissolution from rheological data.

Moe Elbadawi, Thomas Gustaffson, Simon Gaisford, Abdul W Basit,

Rheology is an indispensable tool for formulation development, which when harnessed, can both predict a material's performance and provide valuable insight regarding the material's macrostructure. However, rheological characterizations are under-utilized in 3D printing of drug formulations. In this study, viscosity measurements were used to establish a mathematical model for predicting ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 590:119868]

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Relationship between diabetic retinopathy and diabetic nephropathy; A longitudinal follow-up study from a tertiary care unit of Karachi, Pakistan.

Anum Butt, Nida Mustafa, Asher Fawwad, Saima Askari, Muhammad Saiful Haque, Bilal Tahir, Abdul Basit,

OBJECTIVE:To determine the development and progression of diabetic retinopathy in subjects with diabetic nephropathy. METHODOLOGY:This retrospective longitudinal follow up study was conducted in outpatient department of Baqai Institute of Diabetology and Endocrinology (BIDE), a tertiary care diabetes unit of Karachi Pakistan, from January 2005 to December 2016. Type 2 diabetic ... Read more >>

Diabetes Metab Syndr (Diabetes & metabolic syndrome)
[2020, 14(6):1659-1663]

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Calcium ion binding to calmodulin: binding free energy calculation using the molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) method by incorporating implicit polarization.

Abdul Basit, Rakesh Kumar Mishra, Pradipta Bandyopadhyay,

Binding of calcium ion to calcium-binding proteins (CBP) triggers a large number of biological processes in a cell. CBP are known to play important roles in various diseases, such as cancer, alzheimer, and neuronal problems. However, the calculation of the binding affinity of calcium ion to CBP still possesses a ... Read more >>

J Biomol Struct Dyn (Journal of biomolecular structure & dynamics)
[2020, :1-10]

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Idiopathic Bilateral Ovarian Vein Thrombosis in a Non-Pregnant Healthy Patient: A Case Report and Review of the Literature.

Abdul Basit, Pushpinder Kaur, Diana M Villanueva, Muhammad Tahir, Mark Sonnenschine,

Ovarian vein thrombosis (OVT) is a potentially life-threatening condition, and it is typically related to the peripartum period; however, it is also associated with pelvic inflammatory disease, recent pelvic or abdominal surgery, inflammatory bowel disease, thrombophilia, malignancy, and sepsis. Idiopathic isolated OVT is rare and is usually presented as case ... Read more >>

Cureus (Cureus)
[2020, 12(8):e10111]

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An Association of Mucinous Adenocarcinoma With Chronic Peri-Anal Fistula: A Brief Review of Pathophysiology of Rare Tumor

Alexander Muacevic, John R Adler, Muhammad Tahir, Jawaria Rahman, Tayyaba Zubair, Abdul Basit,

An anal fistula is a condition that has been discussed by various authors without coming to a consensus. The fistula of the anus is a passage that leads from the rectum to the anus. A peri-anal adenocarcinoma is an abnormal growth of cells in the anal rectal area. Establishing the ... Read more >>

Cureus (Cureus)
[0, 12(6):]

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Boosting drug bioavailability in men but not women through the action of an excipient.

Yang Mai, Diane A I Ashiru-Oredope, Zhicheng Yao, Liu Dou, Christine M Madla, Farhan Taherali, Sudaxshina Murdan, Abdul W Basit,

Active pharmaceutical ingredients are routinely formulated with a range of excipients in the manufacture of drug products. Excipients are considered to be inert components of the formulations, although recent research has contested its inactive behaviour. This study investigated the effect of the excipient polyethylene glycol 400 (PEG 400) on the ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 587:119678]

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Chondrosarcoma of the Ribs.

Muhammad Tahir, Jawaria Rahman, Hassan Arekemase, Tayyaba Zubair, Abdul Basit,

Chondrosarcoma is a unique kind of tumor that originates from the cartilage-producing neoplastic mesenchymal cells and appears in both the appendicular and atlantoaxial skeleton. It is the second most prevalent neoplastic bone tumor, with an occurrence of 0.79/100,000/year. The biological presentation of this cancer fluctuates extensively, depending on the grade ... Read more >>

Cureus (Cureus)
[2020, 12(7):e9158]

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A 4-strain probiotic supplement influences gut microbiota composition and gut wall function in patients with ulcerative colitis.

Jonas Ghyselinck, Lynn Verstrepen, Frédéric Moens, Pieter Van den Abbeele, Jawal Said, Barry Smith, Ingvar Bjarnason, Abdul W Basit, Simon Gaisford,

Symprove, a multi-strain probiotic, has been shown to exert a mild anti-inflammatory effect in patients with ulcerative colitis (UC). We examined stool samples from 3 patients with UC in order to create microbiotas in an in-vitro gut model. The effects of Symprove on bacterial diversity and metabolic activity in the ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 587:119648]

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Effects of Inclusion of Different Doses of Persicaria odorata Leaf Meal (POLM) in Broiler Chicken Feed on Biochemical and Haematological Blood Indicators and Liver Histomorphological Changes.

Muhammad Abdul Basit, Arifah Abdul Kadir, Teck Chwen Loh, Saleha Abdul Aziz, Annas Salleh, Ubedullah Kaka, Sherifat Banke Idris,

This research was conducted to estimate the effects of Persicaria odorata leaf meal (POLM) on haematological indices, serum biochemical attributes, and internal organs parameters, including histomorphological features of the liver, in broiler chickens. A total of 120 one-day-old male broiler chicks (Cobb-500) were randomly allocated into four experimental groups. The ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2020, 10(7):]

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3D printing: Principles and pharmaceutical applications of selective laser sintering.

Atheer Awad, Fabrizio Fina, Alvaro Goyanes, Simon Gaisford, Abdul W Basit,

Pharmaceutical three-dimensional (3D) printing is a modern fabrication process with the potential to create bespoke drug products of virtually any shape and size from a computer-aided design model. Selective laser sintering (SLS) 3D printing combines the benefits of high printing precision and capability, enabling the manufacture of medicines with unique ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 586:119594]

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An Association of Mucinous Adenocarcinoma With Chronic Peri-Anal Fistula: A Brief Review of Pathophysiology of Rare Tumor.

Muhammad Tahir, Jawaria Rahman, Tayyaba Zubair, Abdul Basit,

An anal fistula is a condition that has been discussed by various authors without coming to a consensus. The fistula of the anus is a passage that leads from the rectum to the anus. A peri-anal adenocarcinoma is an abnormal growth of cells in the anal rectal area. Establishing the ... Read more >>

Cureus (Cureus)
[2020, 12(6):e8882]

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