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Author Abbas Agaimy

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Adenomatoid Tumor of the Uterus: A Report of 6 Unusual Cases With Prominent Cysts Including 4 With Diffuse Myometrial Involvement, 4 With Uterine Serosal Involvement, and 2 Presenting in Curettage Specimens.

Sofia Lerias, Chai Ariyasriwatana, Abbas Agaimy, Ramona Erber, Robert H Young, Esther Oliva,

We evaluated the clinicopathologic features of 6 adenomatoid tumors of the uterus with unusual features. All the tumors differed grossly from the usual adenomatoid tumor, typically being ill-defined and occupying >50% of the myometrium, essentially replacing it in 4. The neoplasm extended to the endometrium in 2 cases and in ... Read more >>

Int J Gynecol Pathol (International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists)
[2021, 40(3):248-256]

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Emerging Entities and New Diagnostic Markers for Head and Neck Soft Tissue and Bone Tumors.

Alessandro Franchi, Lester D R Thompson, Juan C Hernandez-Prera, Abbas Agaimy, Michelle D Williams, Lauge H Mikkelsen, Justin A Bishop, Stefan M Willems, Henrik Hellquist, Alfio Ferlito,

Bone and soft tissue tumors of the head and neck are relatively uncommon tumors that often represent a diagnostic challenge because of the wide range of entities that must be considered in the differential diagnosis. Over the past few years, classification of bone and soft tissue tumors has evolved primarily ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):139-149]

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Pediatric Mesothelioma With ALK Fusions: A Molecular and Pathologic Study of 5 Cases.

Pedram Argani, Derrick W Q Lian, Abbas Agaimy, Markus Metzler, Sara E Wobker, Andres Matoso, Jonathan I Epstein, Yun-Shao Sung, Lei Zhang, Cristina R Antonescu,

Pediatric mesotheliomas are rare and their pathogenesis remains undefined. In this study, we report 5 cases of malignant mesothelioma in children, characterized by fusions involving the anaplastic lymphoma kinase (ALK) gene. Four cases occurred in females involving the abdominal cavity and were characterized by a pure epithelioid morphology. The fifth ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(5):653-661]

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High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.

Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H W Simpson, Göran Stenman, Vincent Vander Poorten, Justin A Bishop, Alessandro Franchi, Juan C Hernandez-Prera, David Slouka, Stefan M Willems, Kerry D Olsen, Alfio Ferlito,

High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):107-118]

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Postinflammatory Medial Meatal Fibrosis: Histopathologic Features and Outcomes of Surgical Management.

Konstantinos Mantsopoulos, Vivian Thimsen, Sarina Katrin Müller, Matti Sievert, Miguel Goncalves, Heinrich Iro, Abbas Agaimy, Joachim Hornung,

<h4>Objectives</h4>The aims of our study were to investigate the clinical and audiometric outcome of the surgical treatment of postinflammatory medial meatal fibrosis (PIMMF) and to review the histopathologic changes in the specimens of the fibrotic plug, in order to try to shed light on the pathogenesis of the disease.<h4>Materials and ... Read more >>

Ear Nose Throat J (Ear, nose, & throat journal)
[2021, :1455613211001134]

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Recurrent novel HMGA2-NCOR2 fusions characterize a subset of keratin-positive giant cell-rich soft tissue tumors.

Abbas Agaimy, Michael Michal, Robert Stoehr, Fulvia Ferrazzi, Pavel Fabian, Michal Michal, Alessandro Franchi, Florian Haller, Andrew L Folpe, Kemal Kösemehmetoğlu,

Giant cell tumors of soft tissue (GCT-ST) are rare low-grade neoplasms that were at one time thought to represent the soft tissue counterparts of GCT of bone (GCT-B) but are now known to lack the H3F3 mutations characteristic of osseous GCT. We present six distinctive giant cell-rich soft tissue neoplasms ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, :]

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The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma.

Manuel Ruh, Marc P Stemmler, Isabell Frisch, Kathrin Fuchs, Ruthger van Roey, Julia Kleemann, Maike Roas, Harald Schuhwerk, Rebecca L Eccles, Abbas Agaimy, Daniel Baumhoer, Geert Berx, Fabian Müller, Thomas Brabletz, Simone Brabletz,

Osteosarcoma is an often-fatal mesenchyme-derived malignancy in children and young adults. Overexpression of EMT-transcription factors (EMT-TFs) has been associated with poor clinical outcome. Here, we demonstrated that the EMT-TF ZEB1 is able to block osteoblastic differentiation in normal bone development as well as in osteosarcoma cells. Consequently, overexpression of ZEB1 ... Read more >>

J Pathol (The Journal of pathology)
[2021, :]

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Validation of the "Inflammatory Bowel Disease - Distribution, Chronicity, Activity (IBD-DCA) Score" for Ulcerative Colitis and Crohn´s disease.

Corinna Lang-Schwarz, Miriam Angeloni, Abbas Agaimy, Raja Atreya, Christoph Becker, Theresa Dregelies, Silvio Danese, Jean-François Fléjou, Nikolaus Gaßler, Heike I Grabsch, Arndt Hartmann, Kateřina Kamarádová, Anja A Kühl, Gregory Y Lauwers, Alessandro Lugli, Iris Nagtegaal, Markus F Neurath, Georg Oberhuber, Laurent Peyrin-Biroulet, Timo Rath, Robert Riddell, Carlos A Rubio, Kieran Sheahan, Britta Siegmund, Herbert Tilg, Vincenzo Villanacci, Maria Westerhoff, Fulvia Ferrazzi, Michael Vieth,

<h4>Background and aims</h4>Histological scoring plays a key role in the assessment of disease activity in ulcerative colitis (UC) and is also important in Crohn´s disease (CD). Currently, there is no common scoring available for UC and CD. We aimed to validate the Inflammatory Bowel Disease (IBD) - Distribution (D), Chronicity ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2021, :]

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Histopathological comparison of pleomorphic adenomas of the parotid and submandibular gland.

Konstantinos Mantsopoulos, Matti Sievert, Ann-Kristin Iro, Sarina Katrin Müller, Michael Koch, Mirco Schapher, Abbas Agaimy, Heinrich Iro,

<h4>Objective</h4>The aim of this study was to investigate and compare the histopathological findings in pleomorphic adenomas (PA) of the parotid and submandibular gland with emphasis on the histological subtype and capsular characteristics.<h4>Materials and methods</h4>The histopathological specimens of all patients with PAs of the parotid and submandibular gland between 2000 and ... Read more >>

Oral Dis (Oral diseases)
[2021, :]

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Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation.

Carina Heydt, Christina B Wölwer, Oscar Velazquez Camacho, Svenja Wagener-Ryczek, Roberto Pappesch, Janna Siemanowski, Jan Rehker, Florian Haller, Abbas Agaimy, Karl Worm, Thomas Herold, Nicole Pfarr, Wilko Weichert, Thomas Kirchner, Andreas Jung, Jörg Kumbrink, Wolfgang Goering, Irene Esposito, Reinhard Buettner, Axel M Hillmer, Sabine Merkelbach-Bruse,

<h4>Background</h4>Gene fusions represent promising targets for cancer therapy in lung cancer. Reliable detection of multiple gene fusions is therefore essential.<h4>Methods</h4>Five commercially available parallel sequencing assays were evaluated for their ability to detect gene fusions in eight cell lines and 18 FFPE tissue samples carrying a variety of known gene fusions. ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2021, 14(1):62]

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Importance of the PD-1/PD-L1 Axis for Malignant Transformation and Risk Assessment of Oral Leukoplakia.

Jutta Ries, Abbas Agaimy, Falk Wehrhan, Christoph Baran, Stella Bolze, Eva Danzer, Silke Frey, Jonathan Jantsch, Tobias Möst, Maike Büttner-Herold, Claudia Wickenhauser, Marco Kesting, Manuel Weber,

<h4>Background</h4>The programmed cell death ligand 1/programmed cell death receptor 1 (PD-L1/PD-1) Immune Checkpoint is an important modulator of the immune response. Overexpression of the receptor and its ligands is involved in immunosuppression and the failure of an immune response against tumor cells. PD-1/PD-L1 overexpression in oral squamous cell carcinoma (OSCC) ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(2):]

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Moving from "single gene" concept to "functionally homologous multigene complex": The SWI/SNF paradigm.

Abbas Agaimy,

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2021, :]

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Satellite nodules in pleomorphic adenomas of the parotid gland: A nightmare for less invasive parotid surgery?

Ann-Kristin Iro, Abbas Agaimy, Sarina Katrin Müller, Matti Sievert, Heinrich Iro, Konstantinos Mantsopoulos,

<h4>Objectives</h4>The aim of this study was to thoroughly investigate the incidence of satellite nodules (SN) and some of their characteristics (number, distance to main lesion) in a large series of pleomorphic adenomas (PA) and to compare several surgical modalities regarding their efficacy in addressing this critical morphological feature.<h4>Materials and methods</h4>The ... Read more >>

Oral Oncol (Oral oncology)
[2021, 115:105218]

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Tumour-Infiltrating Lymphocytes (TILs) and PD-L1 Expression Correlate with Lymph Node Metastasis, High-Grade Transformation and Shorter Metastasis-Free Survival in Patients with Acinic Cell Carcinoma (AciCC) of the Salivary Glands.

Selina Hiss, Markus Eckstein, Patricia Segschneider, Konstantinos Mantsopoulos, Heinrich Iro, Arndt Hartmann, Abbas Agaimy, Florian Haller, Sarina K Mueller,

<h4>Objectives</h4>The aim of this study was to assess the number of tumour-infiltrating lymphocytes (TILs) and the expression of <i>Programmed Cell Death 1 Ligand 1</i> (PD-L1) in Acinic Cell Carcinoma (AciCC) of the salivary glands, to enable a correlation with clinico-pathological features and to analyse their prognostic impact.<h4>Methods</h4>This single centre retrospective ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(5):]

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Correction to: Novel, emerging and provisional renal entities: the Genitourinary Pathology Society (GUPS) update on renal neoplasia.

Kiril Trpkov, Sean R Williamson, Anthony J Gill, Adebowale J Adeniran, Abbas Agaimy, Reza Alaghehbandan, Mahul B Amin, Pedram Argani, Ying-Bei Chen, Liang Cheng, Jonathan I Epstein, John C Cheville, Eva Comperat, Isabela Werneck da Cunha, Jennifer B Gordetsky, Sounak Gupta, Huiying He, Michelle S Hirsch, Peter A Humphrey, Payal Kapur, Fumiyoshi Kojima, Jose I Lopez, Fiona Maclean, Cristina Magi-Galluzzi, Jesse K McKenney, Rohit Mehra, Santosh Menon, George J Netto, Christopher G Przybycin, Priya Rao, Qiu Rao, Victor E Reuter, Rola M Saleeb, Rajal B Shah, Steven C Smith, Satish Tickoo, Maria S Tretiakova, Lawrence True, Virginie Verkarre, Sara E Wobker, Ming Zhou, Ondrej Hes,

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, :]

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New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.

Kiril Trpkov, Ondrej Hes, Sean R Williamson, Adebowale J Adeniran, Abbas Agaimy, Reza Alaghehbandan, Mahul B Amin, Pedram Argani, Ying-Bei Chen, Liang Cheng, Jonathan I Epstein, John C Cheville, Eva Comperat, Isabela Werneck da Cunha, Jennifer B Gordetsky, Sounak Gupta, Huiying He, Michelle S Hirsch, Peter A Humphrey, Payal Kapur, Fumiyoshi Kojima, Jose I Lopez, Fiona Maclean, Cristina Magi-Galluzzi, Jesse K McKenney, Rohit Mehra, Santosh Menon, George J Netto, Christopher G Przybycin, Priya Rao, Qiu Rao, Victor E Reuter, Rola M Saleeb, Rajal B Shah, Steven C Smith, Satish Tickoo, Maria S Tretiakova, Lawrence True, Virginie Verkarre, Sara E Wobker, Ming Zhou, Anthony J Gill,

The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide an update on existing entities, including diagnostic criteria, molecular correlates, and updated nomenclature. Key prognostic features for clear cell renal cell carcinoma (RCC) remain WHO/ISUP grade, AJCC/pTNM stage, coagulative necrosis, ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, :]

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Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.

Kiril Trpkov, Sean R Williamson, Anthony J Gill, Adebowale J Adeniran, Abbas Agaimy, Reza Alaghehbandan, Mahul B Amin, Pedram Argani, Ying-Bei Chen, Liang Cheng, Jonathan I Epstein, John C Cheville, Eva Comperat, Isabela Werneck da Cunha, Jennifer B Gordetsky, Sounak Gupta, Huiying He, Michelle S Hirsch, Peter A Humphrey, Payal Kapur, Fumiyoshi Kojima, Jose I Lopez, Fiona Maclean, Cristina Magi-Galluzzi, Jesse K McKenney, Rohit Mehra, Santosh Menon, George J Netto, Christopher G Przybycin, Priya Rao, Qiu Rao, Victor E Reuter, Rola M Saleeb, Rajal B Shah, Steven C Smith, Satish Tickoo, Maria S Tretiakova, Lawrence True, Virginie Verkarre, Sara E Wobker, Ming Zhou, Ondrej Hes,

The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in renal neoplasia, particularly focusing on the newly accumulated evidence post-2016 World Health Organization (WHO) classification. In the era of evolving histo-molecular classification of renal neoplasia, morphology is still key. However, entities (or groups of entities) are ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, :]

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Undifferentiated large cell/rhabdoid carcinoma presenting in the intestines of patients with concurrent or recent non-small cell lung cancer (NSCLC): clinicopathologic and molecular analysis of 14 cases indicates an unusual pattern of dedifferentiated metastases.

Abbas Agaimy, Ondrej Daum, Michal Michal, Mona W Schmidt, Robert Stoehr, Arndt Hartmann, Gregory Y Lauwers,

Undifferentiated carcinoma metastatic to the bowel is uncommon in surgical pathology practice and might be confused with primary gastrointestinal carcinoma, melanoma, lymphoma, and others. We present 14 cases of uni- (n = 9) or multifocal (n = 5) undifferentiated large cell/rhabdoid carcinoma presenting in the bowel of patients with concurrent ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2021, :]

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SWI/SNF-deficient head and neck neoplasms: An overview.

Abbas Agaimy, Justin A Bishop,

With wide-spread use of next generation sequencing tools in surgical pathology, a variety of neoplasms have been increasingly recognized to be associated with specific recurrent defining genetic abnormalities. This has led to recognition of new genetically defined entities and refinements of preexisting heterogeneous neoplastic categories. Among these, neoplasms associated with ... Read more >>

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2021, :]

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Neoadjuvant concurrent chemoradiotherapy with and without hyperthermia in retroperitoneal and intra-abdominal sarcomas: Feasibility, efficacy, toxicity and long-term outcome

Alexander Willner, Katja Fechner, Abbas Agaimy, Florian Haller, Markus Eckstein, Oliver Ott, Florian Putz, Udo Gaipl, Stephan Kersting, Norbert Meidenbauer, Robert Grützmann, Rainer Fietkau, Sabine Semrau,

<h4>Background: </h4> Retroperitoneal (RPS) and intra-abdominal sarcomas (IAS) are associated with poor local and abdominal tumor control. Yet, the benefit of preoperative radio- or chemotherapy alone for these entities currently is unclear. Moreover, as intermediate- and high-grade sarcomas have a tendency for early metastasis, exploration of neoadjuvant strategies is of ... Read more >>

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Gene Expression in Solitary Fibrous Tumors (SFTs) Correlates with Anatomic Localization and NAB2-STAT6 Gene Fusion Variants.

Matthias Bieg, Evgeny A Moskalev, Rainer Will, Simone Hebele, Matthias Schwarzbach, Sanja Schmeck, Peter Hohenberger, Jens Jakob, Bernd Kasper, Timo Gaiser, Philip Ströbel, Eva Wardelmann, Udo Kontny, Till Braunschweig, Horia Sirbu, Robert Grützmann, Norbert Meidenbauer, Naveed Ishaque, Roland Eils, Stefan Wiemann, Arndt Hartmann, Abbas Agaimy, Karen Fritchie, Caterina Giannini, Florian Haller,

Solitary fibrous tumors (SFTs) harbor recurrent NAB2-STAT6 gene fusions, promoting constitutional up-regulation of oncogenic early growth response 1 (EGR1)-dependent gene expression. SFTs with the most common canonical NAB2 exon 4-STAT6 exon 2 fusion variant are often located in the thorax (pleuropulmonary) and are less cellular with abundant collagen. In contrast, ... Read more >>

Am J Pathol (The American journal of pathology)
[2021, 191(4):602-617]

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Feasibility of intraoperative assessment of safe surgical margins during laryngectomy with confocal laser endomicroscopy: A pilot study.

Matti Sievert, Nicolai Oetter, Marc Aubreville, Florian Stelzle, Andreas Maier, Markus Eckstein, Konstantinos Mantsopoulos, Antoniu-Oreste Gostian, Sarina K Mueller, Michael Koch, Abbas Agaimy, Heinrich Iro, Miguel Goncalves,

<h4>Objective</h4>This pilot study aimed to assess the feasibility of intraoperative assessment of safe margins with Confocal Laser Endomicroscopy (CLE) during planned partial or total laryngectomy.<h4>Methods</h4>Eight patients with confirmed larynx squamous cell carcinoma (SCC) and planned partial or total laryngectomy were included in this study in March 2020. Two head and ... Read more >>

Auris Nasus Larynx (Auris, nasus, larynx)
[2021, :]

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Refinement of the surgical indication and increasing expertise are associated with a better quality of pathology specimen in pleomorphic adenomas.

Konstantinos Mantsopoulos, Ann-Kristin Iro, Matti Sievert, Sarina Katrin Müller, Abbas Agaimy, Michael Koch, Heinrich Iro,

<h4>Background</h4>Traditional surgical philosophy condemns extracapsular dissection for pleomorphic adenoma as a euphemism for the enucleation of this lesion.<h4>Objectives</h4>The aims of the study were to trace the development of surgical treatment by pleomorphic adenomas of the parotid gland over the last 15 years and explore its effects on the histopathology specimen.<h4>Materials and ... Read more >>

Acta Otolaryngol (Acta oto-laryngologica)
[2021, 141(4):414-418]

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Primary and Secondary/ Metastatic Salivary Duct Carcinoma Presenting within the Sinonasal Tract.

Abbas Agaimy, Sarina K Mueller, Justin A Bishop, Simion I Chiosea,

Traditionally, sinonasal adenocarcinomas have been subdivided into intestinal (ITAC) and non-intestinal (non-ITAC) categories. The latter encompasses salivary-type adenocarcinomas originating from the seromucinous glands of the sinonasal mucosa and non-salivary adenocarcinomas. The non-salivary adenocarcinoma category is further subdivided into low-and high-grade variants. Among salivary-type sinonasal adenocarcinomas, tumors recapitulating salivary duct carcinoma ... Read more >>

Head Neck Pathol (Head and neck pathology)
[2021, :]

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Maximizing the diagnostic information from biopsies in chronic inflammatory bowel diseases: recommendations from the Erlangen International Consensus Conference on Inflammatory Bowel Diseases and presentation of the IBD-DCA score as a proposal for a new index for histologic activity assessment in ulcerative colitis and Crohn's disease.

Corinna Lang-Schwarz, Abbas Agaimy, Raja Atreya, Christoph Becker, Silvio Danese, Jean-François Fléjou, Nikolaus Gaßler, Heike I Grabsch, Arndt Hartmann, Kateřina Kamarádová, Anja A Kühl, Gregory Y Lauwers, Alessandro Lugli, Iris Nagtegaal, Markus F Neurath, Georg Oberhuber, Laurent Peyrin-Biroulet, Timo Rath, Robert Riddell, Carlos A Rubio, Kieran Sheahan, Herbert Tilg, Vincenzo Villanacci, Maria Westerhoff, Michael Vieth,

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2021, 478(3):581-594]

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